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Abnormal muscle mitochondria in ischemic claudication.

The gastrocnemius and quadriceps muscles findings in 18 patients with chronic arterial insufficiency were reviewed with regard to mitochondrial changes. Prominent mitochondrial alterations were present in eight out of 18 patients. The comparison of clinical data between patients with and without mitochondrial changes revealed that in this latter group all patients were at stage IV, whereas the degree of ischemic disease was milder in the other group: the difference in distribution of patients at stage IV between the two groups was statistically significant. This supports the view that mitochondrial changes are expression of adaptive modification rather than damage.

Adult↗
PubMed1977

[Success of physiotherapeutic interval training combined with standardized hemoderivative in intermittent claudication (author's transl)].

In a cross-over trial with 114 patients, intravenous Actovegin or an oral placebo were administered in addition to basic physiotherapy. In the evaluation 105 of the subjects were taken into consideration. It was shown that the test group (n = 53) achieved a 12% increase in walking distance (measured in the standardized walking distance test) compared with the placebo group (n = 52). The therapeutic success rate, i.e. the evaluation base for the efficacy of basic physiotherapy was comparatively good and statistically confirmed at 69.8% and 73.1% for the two groups. From this it may be concluded that basic physiotherapy can be effectively supported by Actovegin.

Actihaemyl↗