Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “computer sciences”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,657 records · Page 92Linked to original sources
PubMed2006

Application of electron tomography to fungal ultrastructure studies.

Access to structural information at the nanoscale enables fundamental insights into many complex biological systems. The development of the transmission electron microscope (TEM) has vastly increased our understanding of multiple biological systems. However, when attempting to visualize and understand the organizational and functional complexities that are typical of cells and tissues, the standard 2-D analyses that TEM affords often fall short. In recent years, high-resolution electron tomography methods, coupled with advances in specimen preparation and instrumentation and computational speed, have resulted in a revolution in the biological sciences. Electron tomography is analogous to medical computerized axial tomography (CAT-scan imaging) except at a far finer scale. It utilizes the TEM to assemble multiple projections of an object which are then combined for 3-D analyses. For biological specimens, tomography enables the highest 3-D resolution (5 nm spatial resolution) of internal structures in relatively thick slices of material (0.2-0.4 microm) without requiring the collection and alignment of large numbers of thin serial sections. Thus accurate and revealing 3-D reconstructions of complex cytoplasmic entities and architecture can be obtained. Electron tomography is now being applied to a variety of biological questions with great success. This review gives a brief introduction into cryopreservation and electron tomography relative to aspects of cytoplasmic organization in the hyphal tip of Aspergillus nidulans.

Aspergillus nidulans↗
PubMed2001

A comparison of CAL with a conventional method of delivery of cell biology to undergraduate nursing students using an experimental design.

This paper describes the development and evaluation of a series of computer assisted learning (CAL) packages on cell biology produced for an undergraduate nursing course. The CAL packages were based on the material originally delivered in Kindermann's slide practical classes. The decision to convert this teaching material into CAL packages was taken for a number of reasons, but mainly in response to student evaluations and lack of equipment and staff resources needed to adequately deliver the sessions. Student feedback showed that CAL was preferred to the slide classes. Two studies were carried out to compare the CAL method of delivery with the conventional method using an experimental design. Students taught using CAL felt more confident that they would be able to use the material they had learnt if required as a basis for future work. The distributions rating 'how necessary was the contribution of a teacher in the session' were skewed towards the 'essential' end of the scale for the slide group but towards the 'unnecessary' end for the CAL group. Learning effectiveness was not compromised by the introduction of CAL, even though this meant that no lecturer was on hand to deal with questions.

Attitude of Health Personnel↗
PubMedDate not supplied

Computer-mediated distributed learning. An innovative program design in midwifery education.

The State University of New York, Stony Brook (SUNY-SB) Pathways to Midwifery Program offers a distributed learning curriculum that is unique among American nurse-midwifery education programs. The Pathways to Midwifery Program provides asynchronic, computer-mediated instruction. Community-based faculty coordinate, supervise, and evaluate the clinical education of students. The SUNY-SB model offers an opportunity to increase dramatically the number of students who can receive the curriculum. It also provides distinct advantages in maintaining a curriculum database that reflects rapidly changing clinical science and that takes advantage of vast educational resources available through related computer networks. By creating a classroom without walls, the program is cost-effective.

Computer Communication Networks↗
PubMed2002

Novel inorganic frameworks constructed from double-four-ring (D4R) units: computational design, structures, and lattice energies of silicate, aluminophosphate, and gallophosphate candidates.

The design of new and interesting inorganic frameworks is an ongoing challenge in materials sciences. New structures containing double-four-ring (D4R) units have recently received particular attention. The present work focuses on the computational design of new three-dimensional frameworks made of D4R units exclusively. In a first step, our simulations explore the possible ways to assemble predefined D4R units in 3D space using a sophisticated cascade of simulated annealing/minimizations steps (autoassembly of secondary building units method). While the existing zeotype topologies were successfully generated, new topologies were predicted including very open frameworks containing new types of cages. In a second step, lattice energy minimizations were performed to estimate the viability of these hypothetical frameworks as silicate, aluminophosphaste, and gallophosphate candidates. When comparing the hypothetical structures to existing compounds, our results raise the challenging question of the appropriate chemical composition that should be aimed at for a given framework topology of interest.

Journal Article↗
PubMed2000

A computer-based epidemiological skills module for medical undergraduates in Nepal.

OBJECTIVE: To ascertain whether undergraduate medical students could acquire the basic competence needed to design, analyze and use a computer-compatible database in an epidemiologically meaningful way. SETTING: Since 1998 the Manipal College of Medical Sciences (MCOMS) of Kathmandu University (KU), Nepal has included in its undergraduate medical curriculum a training module that incorporates knowledge and skills in doing computer-assisted data analyses of epidemiological questions. The present study was designed around the implementation of this module. SUBJECTS: All 96 students of the seventh semester (first six months of the fourth year) of the MBBS course at the MCOMS. METHODS: The teaching-learning activities for the module were carried out mainly in six 2-hour sessions, for groups of 16 students at a time. The software used was EPI-INFO. MAIN OUTCOME MEASURES: Knowledge and skills of computer-assisted data analyses were assessed. In addition, feedback was obtained from the students and scored on seven dimensions. FINDINGS: The pre-test/post-test questionnaire score difference, which evaluated the knowledge component, was highly significant (t = 51.3, p < 0.001). In the skills assessment session, 83% were successful. The students gave high average scores on the satisfaction, small group learning environment, curricular relevance and evaluation dimensions; but the scores were relatively low on the time, other resources and confidence dimensions. CONCLUSION: The module was successful in achieving its objectives and can be implemented even under tight resource constraints. Our plans for improving upon this first run of the module are outlined in the paper.

Journal Article↗
PubMed2006

Using a portable wireless computer lab to provide outreach training to public health workers.

Librarians at Louisiana State University Health Sciences Center in Shreveport developed an outreach program for public health workers in north Louisiana. This program provided hands-on training on how to find health information resources on the Web. Several challenges arose during this project. Public health units in the region lacked suitable teaching labs and faced limited travel budgets and tight staffing requirements, which made it impractical for public health workers to travel. One solution to these problems is a portable wireless computer lab that can be set up at each site. The outreach program utilized this approach to present on-site training to public health workers in the region. The paper discusses operational and technical issues encountered in implementing this public health outreach project.

Community-Institutional Relations↗
PubMed1985

Toxicology information systems: a historical perspective.

Toxicology information systems have evolved swiftly from early, library-based bibliographic tools to advanced packages utilizing sophisticated computer and telecommunication technologies. These systems have evolved concurrently with the rapid expansion of the science of toxicology itself. Bibliographic files such as TOXLINE represent first attempts to handle the toxicology literature through on-line retrieval. Subsequent approaches applied the use of computers to provide literature-derived data, as in TDB or RTECS, or to capture data directly in the laboratory. Societal concerns about hazardous substances, manifested in legislation and regulations, have been responsible for the creation of many computerized systems. Advanced, integrated information management systems are being explored as a method of accessing a large number of independently maintained toxicology databases. Changes in information technologies such as the trend toward microcomputers and novel high-density storage devices will affect the future of toxicology information systems as will impending developments in toxicology itself related to biotechnology, analytical methodology, and alternatives to whole animal testing.

History, 20th Century↗
PubMed2002

Developments in the instruction of biostatistics at the Kuwait University Health Science Centre in a decade.

BACKGROUND: Kuwait has witnessed many changes that influenced, among other things, the structure of medical education including biostatistics. This article describes the developments in biostatistics instruction and curriculum in the Health Science Centre, University of Kuwait, during the past 10 years. DESCRIPTION: Instead of teaching biostatistics as an independent component, the university has developed an integrated course (35 hr of lectures and 12 hr of tutorial sessions) of biostatistics, epidemiology, and demography that is taught to undergraduate medical and dentistry students to ensure interdisciplinary interaction, to remove redundancies, and to standardize terminology across the three disciplines. The core curriculum of the biostatistics course is compatible with the recommendations of the American Statistical Association. Separate biostatistics courses are also offered to pharmacy and allied health students to address their diverse interests. In addition, new biostatistics and computer applications instruction courses were developed and are taught to the students of the Master of Science (MSc), Master of Public Health (MPH), and PhD programs. For continuing medical education, a workshop on biostatistics and computer applications is organized annually for the medical profession as a collaboration between the Health Science Centre and the Kuwait Institute for Medical Specialization. EVALUATION: The instructor and curriculum content of the biostatistics courses are confidentially evaluated and independently analyzed by the office of the Vice Dean for Academic Affairs. Overall, students evaluate the biostatistics instructors highly and are pleased with the content of the biostatistics curriculum. CONCLUSIONS: During the last decade, biostatistics instruction in the Kuwait Health Science Centre had many new developments. An integrated course on biostatistics, epidemiology, and demography was developed with emphasis on problem solving and small group learning. Another biostatistics course is offered to the students of the new faculty of pharmacy. Further biostatistics courses became operational for the postgraduate programs: (MSc), (MPH), and PhD. Continuing medical education is supported by workshops, which is a sign of collaboration with the health community, and a consultancy office has been established. Overall, biostatistics instruction is well received by students, and the role of biostatistics is recognized by researchers from the medical profession.

Biometry↗