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PubMed1990

Corticosteroid regulation of gonadotropin secretion and induction of ovulation in the rat.

In the human polycystic ovarian syndrome, glucocorticoids have been demonstrated to have beneficial effects in inducing ovulation in a number of cases. These beneficial effects were assumed to be due to suppression of adrenal overproduction of androgens. However, the possibility exists that glucocorticoids may directly regulate gonadotropin secretion and thereby improve menstrual rhythm and ovulatory activity. Herein, we report that the corticoid, deoxycorticosterone, and the synthetic glucocorticoid, triamcinolone acetonide, like progesterone (P4), are able to induce luteinizing hormone and follicle-stimulating hormone surges and facilitate ovulation in the pregnant mare serum gonadotropin-primed rat. This effect is not shared by cortisol. Prolactin release was also stimulated by deoxycorticosterone, cortisol, and progesterone, but not by triamcinolone acetonide. Similar to progesterone, triamcinolone acetonide and deoxycorticosterone administration caused a loss of fluid retention in the uterus. This effect of triamcinolone acetonide and deoxycorticosterone may be related to progesterone action as opposed to anti-inflammatory action since cortisol had no effect on uterine fluid retention. These findings raise the possibility that the beneficial effects seen with glucocorticoids in inducing ovulation in polycystic ovarian syndrome may be due in part to their direct effects upon the release of gonadotropins.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Induction of ovulation by antiestrogens].

The mode of action of antioestrogens is in blocking oestrogen receptors in the target cell cytoplasm. For this reason they can be used only in cases where basal oestrogen activity is present. We treated two groups of patients with antioestrogens. In the first group (30 patients) with oligomenarrhoe and an ovulatory sterility we had 15 pregnancies. In the second group of 26 patients with amenorrhoe and sterility we had 4 of pregnancies and 12 menstruations. In this very small group a child with enterocoele was born to a 38-years old patient. All other patients' children were normal. Out of 19 pregnancies 4 were completed by early abortion.

Clomiphene↗
PubMed1975

[Induction of ovulation with Epimestrol (author's transl)].

Epimestrol 5 mg. daily for 10 days was administered in 119 treatment cycles to 21 women with normal gonadotropins and 33 ovulations were induced. Of the 21 patients, 7 had secondary amenorrhea, 10 had anovulatory oligomenorrhea and 4 had ovulatory oligomenorrhea. 17 patients desired pregnancies and 6 became pregnant. There was 1 pregnancy among 5 women with secondary amenorrhea. There were 3 pregnancies among 9 patients with anovulatory oligomenorrhea and 2 pregnancies in 3 patients with ovulatory oligomenorrhea. The pregnancy rate was 35%. Side effects were not observed.

Adult↗