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[Acute dizziness].

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Acute Disease↗

Otoneurology.

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Animals↗

Evaluation of the vestibulospinal reflex by posturography. New perspectives in the otoneurology.

The vestibulospinal aspect of the vestibular function has been neglected in the evaluation of a patient with balance troubles. The attention is focused on vertigo rather than on problems of instability and ataxia, whereas also the examination of the patient is based upon the evaluation of the vestibulo-ocular reflex. Recent technical progress allows us to assess the vestibulospinal reflex in the global balance regulation of the standing patient by means of posturography, i.e. the recording and micro-computer analysis of the postural sway. In this way a precise description of this function is obtained and can be used in the approach to the patient, especially for a functional follow-up.

Humans↗

[Experimental research of autoimmune inner ear disease].

16 guinea pigs were immunized with homologous crude inner ear antigen. Their hearing thresholds were recorded, morphological changes in inner ear were observed, autoantibodies against inner ear were tested. We found that these animals uniformly developed antibodies to inner ear antigen in their sera; 12 of 32 ears showed significant increases in Ap (N1) thresholds (P < 0.01); endolymphatic hydrops, vasculitis of modiolus, degeneration and loss of the cochlear neural elements were the main histopathological lesions; and especially IgG deposition was noted in the modiolar vessels and stria vascularis in most of the examined cochlears. These indicated that an experimental model of AIED can be established in partial immunized guinea pigs.

Animals↗

[Round window membrane pathology in sudden deafness (author's transl)].

Exploration of the middle ear was performed on 15 patients with sudden deafness that had failed to improve after intravenous infusion of Eupaverin and Rheomacrodex. Three patients had abnormalities of the round window membrane, in 2 there was a perilymphatic fistula and in 1 an abnormal bulging of the membrane with no transmission of perilymphatic fluid movement. These 3 patients presented with a history of exertion or stress prior to the onset of symptoms. Surgical closure ofthe 2 fistulae led to improvement of hearing, and perilymphatic decompression in the third patient improved the tinnitus but not the deafness. The possible causes of round window pathology are discussed.

Acute Disease↗