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PubMed1995

Resin-modified glass ionomer cements: fluoride release and uptake.

The aim was to study the short- and long-term fluoride release from resin-modified glass ionomer cements (GIC). The aim was also to determine the effect of fluoride treatment of 9-month-old specimens, consistency of the mix, and pH of the environment on the fluoride release. GIC test specimens were continually exposed to running water, and the fluoride release was measured periodically by storing the specimens in 5 ml deionized water for 1 week and measuring the fluoride content of the solution. After 24 h, 1 month, 9 months, and 11 months in running water four of the six resin-modified GICs released as much as or more fluoride than the auto-curing GIC tested for comparison. Fluoride treatment after 9 months also increased the fluoride release of these four brands, as was the case with the conventional GIC. At 24 h and 1 month two of the resin-modified GICs released smaller amounts of fluoride than the other materials, and the fluoride treatment used on those had no or only a minimal effect. Thin consistency of a mix resulted in higher fluoride release for one resin-modified material than a thick mix. Low pH increased the fluoride release for all materials.

Acrylic Resins↗
PubMed1999

Association of tibolone and fluoride displays a pronounced effect on bone mineral density in postmenopausal osteoporotic women.

A double-blind, placebo-controlled, randomized, prospective two-center study was carried out to assess the effects of tibolone + fluoride versus placebo + fluoride therapy on trabecular and cortical bone in postmenopausal osteoporotic women. Ninety-four subjects (mean age 61.1 years, postmenopausal 13.5 years on average) with low bone mineral density (BMD) at baseline were randomized to 2.5 mg of tibolone (Org OD 14, Livial) plus 26.4 mg of fluoride (Fluocalcic) or placebo plus 26.4 mg of fluoride daily over 2 years; 55 (58.5%) subjects completed the study, the main reason for discontinuation being untoward gastrointestinal effects. BMD at the lumbar spine was measured by both dual photon absorptiometry (DPA) and dual-energy X-ray absorptiometry (DXA), and at the hip by DXA at 6-month intervals. Baseline values (DXA, g/cm2) for tibolone + fluoride and placebo + fluoride groups were 0.733 and 0.744 for the lumbar spine, and 0.761 and 0.788 for the hip. Change from baseline and percentage change from baseline were calculated for the intent-to-treat and completers groups. An analysis of variance (ANOVA) model or Wilcoxon test was used for statistical evaluation. There was a mean increase in BMD at the lumbar spine measured by DPA of 25.3% and 12.3% in tibolone + fluoride and placebo + fluoride groups, respectively (p = 0.01); with DXA, respective changes were 32.6% and 14.0% (p = 0.013). Data on BMD at the hip showed mean increases of 7.9% and 2.6% for the tibolone + fluoride and placebo + fluoride groups, respectively. We conclude that combined tibolone + fluoride treatment induces a highly significant increase in BMD at the lumbar spine without simultaneous loss of the cortical bone allowing for a meaningful reduction of the fluoride dose when given in combination with tibolone.

Absorptiometry, Photon↗
PubMedDate not supplied

Urinary fluoride as an exposure index in aluminum smelting.

Urinary fluoride was evaluated as an exposure index for a prospective study of asthma in an aluminum smelter. Two studies were conducted to evaluate the relationship between airborne exposure and urinary excretion over a workweek, and to describe exposures among jobs and over time. Thirty-two subjects were evaluated on Days 1 and 3 of a 3-day workweek. On each day, spot urine samples were collected prior to the start of work and again at the end of the shift. Samples were analyzed for fluoride and expressed as milligrams fluoride per gram of creatinine. Airborne exposures to total particulate, fluoride particulate, and hydrogen fluoride (HF; using a 37-mm filter cassette containing a filter and treated back-up pad) were also evaluated on each subject. In the second study, postshift urine samples were collected from asthma study volunteers in three surveys extending over 1.5 years and analyzed for fluoride. Average airborne exposures were 15.7, 4.1, and 0.7 mg/m3 for particulates, particulate fluorides and HF, respectively, and were substantially higher among carbon setters than other workers. However, average urine fluorides among the same workers were reasonably low, 1.3 and 3.0 mg/g creatinine in pre- and postshift urine samples, respectively. Carbon setters, who routinely wore respiratory protection during high exposure periods, had urinary fluoride levels similar to those of other potroom personnel. A significant variation in dose, as expressed by postshift urinary fluoride levels, was observed between potroom and nonpotroom jobs and over three survey periods. These results suggest that postshift urinary fluorides provide a reasonable exposure index for surveillance of exposure levels for an epidemiologic study, and that a substantial variation of exposure occurs between jobs and over time. Although urinary fluorides may be used for exposure surveillance, additional details on individual exposure agents and patterns of exposure over time are required for complete assessment.

Air Pollutants, Occupational↗
PubMed1975

Retention of fluoride with time in man.

Fluoride retention is high during fluoride supplementation and increases with increasing fluoride intake. When large amounts of fluoride were given for several months the retention of fluoride was about the same as in the initial phase of fluoride supplementation, whether the supplemental dose of fluoride was 10, 20, or 45 mg per day. The rapid return of the fluoride balance to control values after the high fluoride intake was discontinued indicates that there is not only a tendency for continued retention of fluoride during the high fluoride intake but also after large amounts of fluoride have already been retained.

Adult↗
PubMed1989

[Prevalence of caries and fluorides].

In the whole of Switzerland, caries prevalence was high until 1960. Dental health education programs which included topical fluorides were introduced in the 1960's. Substantial declines of dental caries prevalence have been documented since 1968. In the canton of Zurich e.g. fourteen year-old children had an average of 23.8 cavities (most of them filled) in 1963 which was reduced to only 3.8 in 1987. Similar reductions, primarily due to multiple uses of fluorides, have also been obtained in younger age-groups and in other parts of Switzerland. On an epidemiological basis fluoridated salt reduced dental caries prevalence better than fluoride tablets. This is because tablets are only preferable for a minority of well-motivated families and required good compliance by the children. Modern research reveals that it is not the amount of ingested fluoride (acting systemically) but the frequency and duration of the contact of the fluoride with the erupted teeth which is most important. During pregnancy fluoride tablets benefit the mother's teeth and ensures a satisfactory fluoride level in the fetal skeleton. This is considered desirable as mothers' milk consistently contains only approximately 0.02 ppm fluoride. No caries-protective effect of the fetal fluoride, however, has been substantiated by pertinent research. Only a negligible cariostatic effect results by supplying fluoride to the infant. Caries prevention by fluoride begins to be important during the eruption of the primary teeth, at the latest at the eruption of the primary molars.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1985

Fluoride in sugar.

Results of caries model studies in vitro and in animals suggest that the tooth-protective potential of fluoride may be best utilized if fluoride is brought to the local caries milieu at the moment of each caries attack. Two clinical trials performed so far indicate that a reduction in caries increment of about 40 per cent can be obtained within 3 years through small (0.5-1.0 mg) daily intakes of fluoride when it is incorporated in highly cariogenic sucrose products or in tablets having a sucrose base. When incorporated in sucrose products, fluoride caused a complete arrest of caries during the third year. There was substantial accumulation of the supplemental fluoride in surface and subsurface enamel beneath the plaque fermenting the F-supplemented sucrose. This may be one of the preventive mechanisms involved. In plaque fluid, the supplemental fluoride, together with fluoride released from the plaque material and by the action of acid on the surface enamel of high fluoride content, may strongly reduce further enamel dissolution and promote its remineralization. Further metabolism of the plaque bacteria including their acid production may also be inhibited. Among the many advantages of using this principle are that: the supplemental fluoride in sugar automatically seeks the caries risk subjects who use sugary products; the amount of fluoride needed per kg of sugar may remain low and thus the risk of excessive intake of fluoride may also be low; the technical process is low in cost and easily performed; and the products are easily distributed nationwide. Furthermore, non-fluoridated sugary products may still be distributed to those who may continue to prefer them.

Adult↗
PubMedDate not supplied

Attitudes of dentists and physicians toward the use of dietary fluoride supplements.

One of the major goals of the reported research was to determine how consistent health practitioners' knowledge, attitudes and practices are with the consensus of the public health and research communities regarding caries prevention. Both professions are aware of current caries preventive methods, but have very mixed reactions toward their relative effectiveness in the United States, today. Dentists and physicians see a great deal of value in community water fluoridation and see some effectiveness from fluoridating school water supplies. They regard the prescription of dietary fluoride supplements as an effective caries prevention measure, but to a much lesser extent, and base their use of these prescriptions on the age of the child and the level of fluoride in the community's water system. Topical fluoride applications and fluoride dentifrices, as well, are thought to be very effective preventive measures by only a small proportion of dentists and physicians, as are fluoride mouth rinses. Dentists and physicians rate systemic fluorides as effective more often than they do other selected methods, as would the research community; but they are not as solidly behind these, as evidence would suggest they should be. Both community water fluoridation and dietary fluoride supplements are known to be very effective caries prevention measures, yet only 66 percent of the physicians think community water fluoridation is very effective and only 37 percent think dietary fluoride supplements are very effective.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Effects of aluminum hydroxide on fluoride and calcium metabolism.

In order to determine whether and to what extent aluminum affects the absorption of fluoride in man, a study of the effect of aluminum hydroxide on fluoride metabolism was carried out under strictly controlled dietary conditions. Relatively small amounts of aluminum hydroxide were used: 30 ml given three times daily, containing a total of 1.8 gm aluminum. Fluoride and calcium balances were determined in control studies and during the intake of aluminum hydroxide. The fluoride intake of approximately 4 mg/day was due to the fluoride content of the diet and the drinking water. A study was also carried out in patients with osteoporosis who received a high fluoride intake of approximately 50 mg/day of sodium fluoride therapeutically for osteoporosis. The intake of aluminum hydroxide was associated with a significant increase of the fecal fluoride and with a significant decrease of the net absorption of fluoride, by an average of 57%, irrespective of the intake of fluoride. The-plasma fluoride levels decreased by 41%. The fluoride balances were either negative or less positive. Relatively small amounts of aluminum hydroxide resulted in phosphorus depletion, in an increase of the urinary calcium, and in negative calcium balances.

Adult↗
PubMed1993

A comparison of daily fluoride intakes from food samples in Japan and Brazil.

The purpose of this study was to analyse the fluoride content of Japanese infant foods and foods in Brazil and to estimate daily fluoride intake calculated for a 6-month-old infant which reflects supplemental fluoride increased from infant foods and decreasing breast-feeding and commercial milk-feeding. Fluoride concentrations of 26 samples were assessed by a modified microdiffusion method and fluoride ion selective electrode. The fluoride content varied from 0.53 to 1.33 microgram/g for milk-base formulas, from 0.46 to 2.94 micrograms/g for infant foods in Japan, and from 0.06 to 0.25 microgram/g for foods in Brazil. The daily fluoride intake was calculated according to feeding pattern. The minimum and maximum fluoride values were 0.080 mg/day and 0.248 mg/day, respectively. These fluoride intakes, expressed in milligrams per kg of fluoride intake, ranged from 0.010 to 0.033 mg F/kg body weight. No significant differences in fluoride intake values were found between Japanese infant foods and foods in Brazil. The results of this study indicate that daily fluoride intakes of Japanese infant foods and foods in Brazil could be considered within the optimal recommended level.

Animals↗
PubMed1996

Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 7. Fluoride therapy for osteoporosis.

OBJECTIVE: To present the latest findings on the use of fluoride in the treatment of osteoporosis. OPTIONS: Plain sodium fluoride (NaF), enteric-coated sodium fluoride (EC-NaF), sodium monofluorophosphate (Na2FPO4), slow-release sodium fluoride (SR-NaF); fluoride with a calcium supplement. OUTCOMES: Fracture and loss of bone mineral density in osteoporosis; increased bone mass, prevention of fractures and improved quality of life associated with treatment. EVIDENCE: Relevant clinical studies and reports were examined, with an emphasis on recent prospective, randomized, controlled trials. Clinical practices in European countries were also considered. VALUES: Reducing fractures, increasing bone mineral density and minimizing side effects of treatment were given a high value. BENEFITS, HARMS AND COSTS: NaF therapy stimulates bone formation and may be effective in preventing osteoporotic fractures. It may be an acceptable alternative treatment to estrogen or bisphosphonate therapy and useful in premenopausal and corticosteroid-induced osteoporosis and in some patients with mild osteogenesis imperfecta. Toxic effects are dependent on formulation and dosage. They include a range of gastrointestinal and musculoskeletal conditions. EC-NaF is associated with less toxicity than plain NaF; its gastrointestinal toxicity is negligible. Na2FPO4 has no gastrointestinal toxicity, but can give rise to skeletal toxicity. SR-NaF appears to have no side effects when given intermittently. Carcinogenicity has not been found in vivo with fluoride therapy, despite in vitro results. RECOMMENDATIONS: New data indicate that fluoride therapy should be re-evaluated as a potentially effective treatment of osteoporosis with minimal side effects. More studies are needed of slow-release fluoride formulations, intermittent treatment schedules and calcium supplementation of fluoride. Studies should be undertaken to see if it is advantageous to initiate treatment with antiresorptive agents before or in combination with fluoride. Conclusive data have not been presented regarding the benefit of any specific type of calcium supplement. Further studies on the basic mechanism of action of fluoride on the skeleton are necessary to evaluate fluoride's potential to stimulate bone formation therapeutically.

Aged↗
PubMed2005

Position of the American Dietetic Association: the impact of fluoride on health.

The American Dietetic Association reaffirms that fluoride is an important element for all mineralized tissues in the body. Appropriate fluoride exposure and usage is beneficial to bone and tooth integrity and, as such, has an important, positive impact on oral health as well as general health throughout life. Fluoride is an important element in the mineralization of bone and teeth. The proper use of topical and systemic fluoride has resulted in major reductions in dental caries (tooth decay) and its associated disability. The Centers for Disease Control and Prevention have named fluoridation of water as one of the 10 most important public health measures of the 20th century. Nearly 100 national and international organizations recognize the public health benefits of community water fluoridation for preventing dental caries. However, by the year 2000, over one third of the US population (over 100 million people) were still without this critical public health measure. Fluoride also plays a role in bone health. However, the use of high doses of fluoride for prevention of osteoporosis is considered experimental at this point. Dietetics professionals should routinely monitor and promote the use of systemic and topical fluorides, especially in children and adolescents. The American Dietetic Association strongly reaffirms its endorsement of the appropriate use of systemic and topical fluorides, including water fluoridation, at appropriate levels as an important public health measure throughout the life span.

Bone and Bones↗
PubMed2000

Position of the American Dietetic Association: the impact of fluoride on health.

Fluoride is an important element for mineralization of body tissues. The use of topical and systemic fluoride for oral health has resulted in major reductions in dental caries and its associated disability. Fluoridation of public water supplies has been endorsed by over 90 professional health organizations as the most effective dental public health measure in existence. Still, about half of the US population fails to receive the maximum benefits possible from community water fluoridation and the use of fluoride products. Fluoride also plays a role in bone health. The role of high doses of fluoride for prevention of osteoporosis is undergoing active study and is considered experimental at this point. Dietetics professionals should routinely monitor and promote the use of systemic and topical fluorides, especially in children and adolescents. The American Dietetic Association strongly reaffirms its endorsement of the use of systemic and topical fluorides, including water fluoridation, at appropriate levels of intake, as an important public health measure. However, clients should be cautioned that experimental use of high intakes of fluoride should be avoided unless they are participating in clinical trials.

Adult↗
PubMed2000

In vitro sodium fluoride exposure decreases torsional and bending strength and increases ductility of mouse femora.

Fluoride exposure in vivo can reduce the material strength of bone, an effect that has been attributed to a change in mineral structure. An in vitro model of fluoride exposure offers the potential to study directly the effects of fluoride on bone mineral. Previous investigators have reported that soaking bones in sodium fluoride in vitro reduces bone strength. However, long soaking times and the absence of physiological buffering ions from their treatment solutions may have caused mineral dissolution that contributed to the decrease in bone strength. Our objectives were to further characterize the effects of in vitro fluoride exposure on bone mechanical properties and to determine if the changes reported in previous studies of bovine cortical bone would be observed for whole rodent bones. We soaked 60 mouse femora in sodium fluoride solutions, with and without physiological buffering ions, and evaluated their torsional and bending properties. Fluoride soaked bones had a 30-fold increase in fluoride content and a 23% increase in water content compared to controls. These changes were associated with average reductions in ultimate load of 45%, reductions in rigidity of 70%, and increases in deformation to failure of 80%. The effect of fluoride was similar for bones treated in buffered and non-buffered solutions, and was observed in both torsion and bending. Our findings confirm those of previous studies and highlight the strong effect that in vitro fluoride exposure has on bone mechanical properties. The in vitro model of fluoride exposure offers a tool to further study the effects of ion substitution in bone.

Animals↗
PubMed2004

Effect of fluoride addition on the properties of dental alginate impression materials.

Fluoride-containing dental alginate impression materials can exert a considerable reduction in enamel solubility. The objective was to evaluate the effects of fluoride addition in the alginate impression materials on the properties and subsequent release of fluoride. Four experimental alginate impression materials were studied. Materials were mixed with distilled water (control) or 100-ppm fluoride solution. One or two percent NaF, or 1% SnF2 was added to the materials, which were mixed with distilled water. Fluoride release, flexibility, recovery from deformation, setting time, compressive strength and elastic modulus were determined in accordance with the ISO 1563 and ANSI/ADA Spec. 18. Fluoride release increased after addition of fluoride, and the released amount was 0.762-14.761 ppm. Addition of NaF or SnF2 resulted in higher fluoride release than the control group (p < 0.05). After fluoride addition, flexibility was 15.45-20.27%, and the recovery from deformation did not change except one material. Compressive strength after fluoride addition was 0.36-1.12 MPa. Addition of NaF or SnF2 in an alginate impression material may result in effective release of fluoride without deteriorating the properties of material itself.

Alginates↗
PubMed2001

Effect of fluoride on glucose incorporation and metabolism in biofilm cells of Streptococcus mutans.

The aim of this study was two-fold: firstly, to study the effect of high fluoride concentrations on carbohydrate metabolism in Streptococcus mutans present in biofilms on hydroxyapatite; and, secondly, to evaluate the effect of fluoride-bound hydroxyapatite on lactic acid formation in growing biofilms of Strep. mutans. Biofilms of a clinical strain of Strep. mutans on saliva-coated hydroxyapatite beads were incubated with sodium fluoride over a wide range of concentrations. At high fluoride concentrations (>10 mM) the incorporation of [14C]-labeled glucose decreased by 80-85%, at both pH 7.0 and 5.6. At lower fluoride concentrations, the effect of fluoride on the incorporation of labeled glucose was pH-dependent in both biofilm cells and in planktonic cells. At pH 7.0, fluoride at concentrations < 10 mM had little or no effect. Pretreatment of hydroxyapatite discs with fluoride varnish (Fluor Protector) or fluoride solutions caused a statistically significant reduction of lactic acid formation in associated, growing biofilms of Strep. mutans. Fluoride varnish and 0.2% (47.6 mM) sodium fluoride solution exhibited a statistically significant inhibitory effect on lactate production.

Biofilms↗
PubMed1997

Dental caries and dental fluorosis at varying water fluoride concentrations.

OBJECTIVES: The purpose of this study was to investigate the relationships between caries experience and dental fluorosis at different fluoride concentrations in drinking water. The impact of other fluoride products also was assessed. METHODS: This study used data from the 1986-87 National Survey of US School-children. Fluoride levels of school water were used as an indicator of the children's water fluoride exposure. The use of fluoride drops, tablets, professional fluoride treatments, and school fluoride rinses were ascertained from caregiver questionnaires. Only children with a single continuous residence (n = 18,755) were included in this analysis. RESULTS: The sharpest declines in dfs and DMFS were associated with increases in water fluoride levels between 0 and 0.7 ppm F, with little additional decline between 0.7 and 1.2 ppm F. Fluorosis prevalence was 13.5 percent, 21.7 percent, 29.9 percent, and 41.4 percent for children who consumed < 0.3, 0.3 to < 0.7, 0.7 to 1.2, and > 1.2 ppm F water. In addition to fluoridated water, the use of fluoride supplements was associated with both lower caries and increased fluorosis. CONCLUSIONS: A suitable trade-off between caries and fluorosis appears to occur around 0.7 ppm F. Data from this study suggest that a reconsideration of the policies concerning the most appropriate concentrations for water fluoridation might be appropriate for the United States.

Adolescent↗
PubMed2006

Prevention of erosion and abrasion by a high fluoride concentration gel applied at high frequencies.

The aim of this study was to determine maximum attainable protection of enamel from erosion and erosion abrasion using a highly fluoridated gel with and without additional fluoride from toothpaste. Thirty-six bovine enamel specimens were subjected to six erosive attacks per day (1% citric acid with pH 2.3 for 30 s), while the rest of the day the specimens were in artificial saliva. There were four treatment groups (9 specimens in each group): fluoride-free toothpaste/saliva slurry twice daily (group T0), fluoride-containing toothpaste/saliva slurry twice daily using 1,250 ppm F toothpaste (group TF), fluoride-containing toothpaste/saliva slurry twice per day plus application of a highly fluoridated gel (12,500 ppm F) twice a day for 120 s (group 2F) and a group with gel application 8 times a day (group 8F). Additionally, half of each specimen in all groups was subjected to brushing abrasion during application of the toothpaste/saliva slurry. Brushing abrasion alone led to no observable enamel loss measured with profilometry. After 14 days of cycling of erosion without toothbrushing abrasion, high-fluoride gel application 2 or 8 times daily showed significantly less enamel loss (median 24/19 microm) than with toothpaste with or without fluoride (41/45 microm). After 14 days of cycling of erosion and toothbrushing abrasion, gel application 2 or 8 times daily (33/29 microm) showed significantly less enamel loss than toothpaste with or without fluoride (57/62 microm). We conclude that a highly fluoridated acidic gel is able to protect enamel from erosion and toothbrushing abrasion while fluoridated tooth paste provides little protection.

Amines↗
PubMed2005

Comparison of three topical fluorides using computer imaging.

The purpose of this in vitro study was to evaluate the short and long-term effectiveness of fluoride varnish and compare it with the two most commonly used topical fluorides, i.e., fluoride gel and foam. A second purpose of the study was to compare the effectiveness of these preparations on primary and permanent teeth. Enamel slabs with a thickness of 500 microns were obtained from caries free primary molars and premolars. They were divided into four groups: control, foam (F), gel (G) and varnish (V). Fluorides were applied to the enamel slabs according to the manufacturer's instructions and were placed in a 5.1 pH acidic gel for one week. The amount of demineralization from the enamel was measured by calculating the amount of light reflected from these surfaces. This was done by using a Charged Couple Device attached to a high resolution microscope with image processing software, Optima 5.22. The enamel slabs were placed in a freshly prepared acidic gel for a second week without application of fluorides. This was done to mimic a situation where fluoride is eventually brushed away from teeth. Reflective images were recorded under the previously described conditions. A two-way analysis of covariance was used to compare the treatments. The results showed no statistically significant difference (with Bonferroni correction) in the effectiveness of different fluoride preparations over the short-term (Week I comparison; p-values: F vs. G 0.079, F vs. V 0.030, G vs. V 0.44). However, the long-term protection provided by fluoride varnish was far more than fluoride gel and foam (Week II comparison; p-values: F vs. G 9X10-5, F vs. V 7X10-8, G vs. V 1X10-4). Fluorides were equally effective for both primary and permanent enamels (p-value 0.24). The results of this study suggest that fluoride varnish is beneficial for use with white spot lesions, newly erupted permanent teeth and early decalcification in primary dentition.

Acidulated Phosphate Fluoride↗