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[Contact allergy to mephenesin].

A case of erythema multiforme-like allergic contact dermatitis due to midysalb, an ointment containing mephenesine is described. Patch testing showed marked sensitization to mephenesine, with positive reactions to different dilutions down to 0.1%. It is unlikely that the weak reaction to a further component, ethylene glycol monosalicylic acid ester, is responsible for the allergy. There are several other reports in the literature, so that mephenesine must be classed as one of the few allergens that cause reactions reminiscent of erythema multiforme.

Administration, Topical↗

Observations on the cytological diagnosis of an infectious erythema.

The clinical features of an infectious erythema which affected children and young people are described. Other writers have described the same disease and have suggested a viral origin. A cytological method is described which may establish the diagnosis, and the cytological appearances might also be useful in differentiating between erythema and measles.

Child↗

Urticarial papular and plaque eruptions. A noneczematous manifestation of allergic contact dermatitis.

A noneczematous eruption associated with allergic contact dermatitis is described. Five patients had disseminated erythematous urticarial papular and plaque eruptions secondary to contact allergy to two substances (four to proflavine and one to a permanent waving lotion). The eruption appeared to be similar to the previously described "erythema multiforme-like eruption" associated with allergic contact dermatitis. A review of the previous report indicated that the eruptions currently being reported do not have the typical clinical and histologic features of erythema multiforme. The term "urticarial papular and plaque eruption of contact allergy" is suggested to describe the eruption. The exact mechanism of the eruption remained speculative.

Adult↗

[Skin manifestations in human yersiniosis (author's transl)].

Yersinia infections in 8 adults are reported. 6 patients had erythema nodosum, in 2 cases associated with maculo-papular rashes. In one patient an erythema multiforme-like rash was observed, in another one a papulo-vesicular rash. All patients were females. Yersinia infection was demonstrated serologically, in 3 cases also bacteriologically.

Adult↗

Polymorphous light eruption.

Polymorphous light eruption (PLE) is a common photodermatosis of unknown etiology. It afflicts mainly fair-skinned patients, with a preponderance of young females. There is, however, no absolute restriction as to age, sex, or race. Clinical variants include the papular, vesiculo-bullous, and hemorrhagic variety, as well as plaque, erythema multiforme-like, and insect bite (strophulus)-like types. Skin lesions appear only in certain exposed areas hours or a few days after intense sunshine, and are nearly always monomorphous in the same patient. The rash subsides spontaneously within several days without leaving scars. The histopathologic picture is characteristic and shows a perivascular lymphocytic infiltrate in the upper and middle corium with subepidermal edema, vacuolization of basal cells, and spongiosis in the lower epidermis. The most important differential diagnoses are solar urticaria, photosensitive erythema multiforme, and lupus erythematosus. The action spectrum of PLE is under debate. Reproduction of skin lesions has been reported with UVB, UVA, and, rarely, visible light, with UVA probably being the most effective part of the spectrum. More important than treatment of PLE is prophylaxis. UVA- and UVB-effective sunscreens are of some help. Phototherapy and especially photochemotherapy (psoralen + UVA; PUVA) offer effective ways to decrease light sensitivity. Systemic treatment with chloroquine or beta-carotene has been disappointing.

Female↗