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PubMed1994

Cerebellar contributions to instrumental learning.

There is emerging evidence that the cerebellum is involved in spatial and nonspatial instrumental learning tasks. Cerebellar-lesioned animals have deficits in water maze learning tasks that may be explained by two-way interactions with higher order brain regions. There is suggestive evidence that cerebellar modulation extends to shock avoidance and discrimination learning. Although this evidence needs to be confirmed by a wider range of lesion methods and choice of learning tasks, it is in line with the hypothesis that the cerebellum affects cognitive processes and is not strictly concerned with motor control and the acquisition and retention of conditioned reflexes.

Animals↗
PubMed1993

Effects of medetomidine, a selective alpha 2-agonist, on position discrimination and reversal learning in aged rats.

The effect of a low dose (3 micrograms/kg) of medetomidine on cognitive performance of aged rats was examined in position discrimination and reversal learning in a T-maze. In Experiment 1, the reversal was introduced after 3 days of position habit acquisition and in Experiment 2 in the same session. Open-field and novelty-suppressed feeding tests were undertaken before drug testing to relate the cognitive effect of medetomidine with exploratory activity and neophobia of individual rats. Medetomidine slightly impaired the acquisition of position discrimination in both sexes and decreased perseveration in the reversal of a well-established position habit in females. The correlation of these findings with exploratory activity and neophobia is discussed.

Adrenergic alpha-Agonists↗
PubMed1999

Disrupted allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function.

Spatial and non-spatial learning of mice with an incorporated antisense RNA complementary to a fragment of cDNA coding for the glucocorticoid receptor (GR) were evaluated in allocentric and egocentric radial maze and water maze tasks, and in spontaneous object recognition and sensorimotor learning paradigms. Mice with impaired GR function did not acquire two maze paradigms based on allocentric spatial navigation, radial maze non-matching to position and water maze spatial discrimination learning. Comparison of performance in spaced and massed trials indicated that this may be due to a general inability to store information into allocentric reference memory or in retrieval processes. However, both groups of animals learned the rules of an egocentric radial maze task at similar rates and there was no difference in their ability to recognise objects once animals had equal opportunity to explore the sample objects. Sensorimotor performance was impaired in transgenic animals, but it is suggested that this is due to non-specific factors rather than to disrupted sensorimotor learning per se. These results are consistent with a disruption of hippocampal function. Histological examination of the hippocampus revealed no obvious structural abnormalities in transgenic animals. Therefore, the data suggest that functional underactivity of GRs at the level of the hippocampus induces a deficit in allocentric navigation while sparing egocentric navigation and object recognition.

Animals↗
PubMed1988

Strength of scopolamine-induced amnesia as a function of time between training and testing.

Variations in the strength of scopolamine-induced amnesia as a function of age of the habit were studied in Swiss Webster mice. Animals were trained in an active avoidance task to a criterion of 9/10 avoidances and immediately following training injected with scopolamine hydrochloride (1.0 mg/kg) or saline. Retention of the avoidance learning was evaluated by testing different groups of animals 1, 3, 7, 10, 14, and 28 days following training. The retention test consisted of five trials in which the CS but not the UCS was presented. Results indicated that saline-treated mice exhibited near-perfect retention up to 14 days post-training with forgetting beginning to be apparent at 28 days. Scopolamine treatment produced strong amnesia in animals tested 1 and 3 days post-training but normal retention in animals tested 7 and 10 days after learning. The amnesia abruptly reappeared at 14 days after which time it remained stable. The marked similarity of the scopolamine retention curve to changes in the strength of memory of discrimination learning in undertrained rats reported by Deutsch suggested that scopolamine resulted in the storage of a weak memory of the avoidance response. To explore this idea further we trained mice to a criterion (4/5) which would result in a weak avoidance response and tested different groups 1, 3, 10, 14, and 28 days following learning. Results showed that strength of the memory of avoidance learning increased up to 10 days and then decreased abruptly at 14 days thus replicating the general shape of the retention curve produced by injecting scopolamine following strong training. These data suggest that scopolamine disrupts processes essential for the formation of durable memories.

Animals↗
PubMed1975

Differential response control by isopropamide: a peripherally induced discriminative cue.

The peripherally acting anticholinergic drug isopropamide (0.02 mg/kg s.c.) is shown to produce a discriminative stimulus complex in rats. In rats trained to discriminate isopropamide from saline, dexetimide and methylscopolamine were generalized with isopropamide treatment. The results indicate that drug discrimination learning does not necessarily require a central drug action.

Animals↗
PubMed1996

Differential effects of anticholinergic drugs on paired discrimination performance.

Working and reference memory processes were simultaneously evaluated during the performance of a paired discrimination (PD) task in which visual and spatial discrimination trials were combined within the same session. Atropine (1 and 5 mg/kg), scopolamine (0.02-0.20 mg/kg), benactyzine (1-4 mg/kg), trihexyphenidyl (1-10 mg/kg), and aprophen (5-20 mg/kg) were all found to increase the number of errors performed by overtrained rats during the spatial but not during the visual trials. Although all the anticholinergic drugs tested induced specific working memory impairment at low doses, they differentially affected other, simultaneously recorded, behavioral parameters. Thus, while atropine affected most of the recorded parameters, aprophen induced only a mild effect. Benactyzine was found to have the most specific effect on working memory, with only minimal side effects, a combination that supports its use as the preferred psychopharmacological model of working memory impairment.

Animals↗
PubMed1999

Effects of hippocampal lesions on spatial operant discrimination in pigeons.

In experiment 1, pigeons were trained on spatial or color autodiscrimination. Presentation of one of two keys or one of two colors was followed by food presentation. However, the other side of the keys or the other color was not. The hippocampal lesions disturbed the acquisition of spatial discrimination but not of color discrimination. In experiment 2, pigeons were preoperatively trained the spatial autodiscrimination, then received the hippocampal lesions. The subjects maintained the discrimination. These results suggest that the avian hippocampus plays a crucial role in acquisition of spatial discrimination.

Animals↗
PubMed1994

Effects of excitotoxic lesions of the septum and vertical limb nucleus of the diagonal band of Broca on conditional visual discrimination: relationship between performance and choline acetyltransferase activity in the cingulate cortex.

Four experiments examined the role of the cholinergic projections from the septum and vertical limb nucleus of the diagonal band of Broca (VDB) in acquisition and performance of a conditional visual discrimination. In experiments 1-3, excitotoxic lesions were made of the septum and VDB in rats using quisqualic acid, which resulted in significant reductions in ChAT activity in the hippocampus and cingulate cortex, but with no effects on cortical monoamines. In experiment 1, there were significant impairments in acquisition of the conditional discrimination, which did not result from motivational impairments. Experiment 2 repeated these results with lesion parameters, which produced variable effects on hippocampal and cingulate ChAT activity. Those rats with reductions in predominantly cingulate ChAT were most impaired in acquisition, but those with predominantly hippocampal reductions were relatively unimpaired. Experiment 3 showed that quisquate-induced lesions of the VDB, but not of the more caudal VDB and horizontal limb nucleus of the diagonal band, produced deficits, and a model incorporating the results of experiments 1-3 showed a highly significant correlation between errors of commission and cingulate cortical ChAT activity (r = -0.82, p < 0.001). Experiment 4 used the excitotoxin AMPA to lesion the VDB in rats pretrained on a modified form of the conditional discrimination task. In one subgroup of rats this excitotoxin produced profound and regionally selective reductions in ChAT activity. This subgroup was also impaired in relearning the discrimination to criterion. Again, there was a significant inverse relationship between the number of errors of commission made in relearning the discrimination and cingulate ChAT activity (r = -0.94, p < 0.001). These experiments suggest that excitotoxic lesions of the septum/VDB produce deficits in conditional discrimination learning and performance, and that the integrity of the projection to the cingulate cortex is more crucial than that to the hippocampus in this effect. Moreover, there is a close relationship between discrimination performance and cholinergic function in the cingulate cortex. In conjunction with other results, these data suggest that different aspects of cognition and memory are modulated by cholinergic activity in different cortical regions.

3,4-Dihydroxyphenylacetic Acid↗
PubMed2002

Dual antennular chemosensory pathways mediate odor-associative learning and odor discrimination in the Caribbean spiny lobster Panulirus argus.

Chemosensory neurons in the antennular flagella of lobsters mediate long-range responses to chemicals. These neurons are part of two parallel chemosensory pathways with different peripheral and central components. Aesthetasc sensilla on the lateral flagella are innervated by chemosensory neurons that project to the olfactory lobes. A diversity of other 'non-aesthetasc' sensilla on both lateral and medial flagella are innervated by mechano- and chemosensory neurons, and most of these non-aesthetasc neurons project to the lateral antennular neuropils. We investigated the roles of these two pathways in odor-associative learning and odor discrimination by selectively removing either aesthetasc or non-aesthetasc sensilla from the spiny lobster Panulirus argus. Lobsters lacking both aesthetasc and non-aesthetasc antennular sensilla show very reduced or no odor-mediated searching behavior. We associatively conditioned lobsters using two paradigms: aversive conditioning with generalization testing (which reveals the similarity in the lobsters' perception of odorants) and discrimination conditioning (which reveals the lobsters' ability to discriminate odorants). Sham-control intact lobsters performed these tasks well, as did lobsters lacking either aesthetascs or non-aesthetasc setae. There was a strong but statistically non-significant trend that lobsters lacking either aesthetascs or non-aesthetasc setae generalized more between complex odor mixtures than did intact lobsters. After aversive conditioning with generalization testing, aesthetasc-ablated lobsters had more difficulty discriminating among the most closely related complex mixtures than did intact or non-aesthetasc-ablated lobsters. However, after discrimination conditioning, aesthetasc-ablated lobsters were as proficient as intact animals in discriminating highly similar mixtures. These results indicate overlap and redundancy in the function of these two chemosensory pathways in odor-associative learning and odor discrimination, but these pathways also complement each other to enable better discrimination. This study presents the first evidence for a role of non-aesthetasc chemosensory neurons in complex odor-mediated behaviors such as learning and discrimination.

Animals↗
PubMed1992

Paraventricular neuron chemosensitivity and activity related to blood pressure control in emotional behavior.

1. Unit activity in the paraventricular nucleus (PVN) and blood pressure (BP) of the rat were recorded during discrimination learning of cue tone (CTS+) predicting reward [glucose and intracranial self stimulation (ICSS)], and cue tone (CTS-) predicting aversion (electric shock or tail pinch). Adrenergic systems in the PVN were investigated by electrophoretic application of norepinephrine (NE), and by electrophoretic application or direct microinjection of its antagonists (prazosin, yohimbine, and propranolol). 2. Of 65 PVN neurons analyzed, 35 responded during CTS learning in one or more phases of an operant task. Of these, activity of 20 neurons was increased nondiscriminatively by CTS+ and CTS-, and reward and aversion. In parallel with these neuronal activity increases, BP (systolic, diastolic, and mean) was also increased by both CTS+ and CTS- (10-35 mmHg), and reward and aversion (20-47 mmHg). Both neuronal activity and BP increases during CTS learning were suppressed during extinction. 3. Paraventricular neurons, the activity of which correlated with BP increase during CTS learning, were excited by electrophoretic application of NE and Na+ and fired phasically during inter-trial intervals. Activity increases of these neurons during CTS learning, which was related to BP increase, were blocked by electrophoretically applied prazosin (alpha 1-antagonist), but not by yohimbine (alpha 2-antagonist) or propranolol (beta-antagonist). 4. Direct microinjection of prazosin into the PVN suppressed BP increase during CTS learning. Operant licking for reward was not suppressed by prazosin injection. Microinjection of yohimbine or propranolol into the PVN did not suppress either BP increase during CTS learning or operant licking to obtain reward. 5. These results suggest that afferent alpha 1-adrenergic input to the PVN is important to the central BP control during CTS learning in emotional behavior.

Acoustic Stimulation↗
PubMed2001

Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor.

Rats fed a semipurified diet supplemented with 3% (w/w) safflower oil [Saf, n-3 fatty acid deficient, high linoleic acid (18:2n-6)] through two generations exhibit decreased correct response ratios in a brightness-discrimination learning test compared with rats fed 3% perilla oil [Per, high alpha-linolenic acid (18:3n-3)]. This is associated with a decreased DHA (22:6n-3)-to-arachidonic acid (20:4n-6) ratio in brain lipids. In the first set of experiments, dietary oil was shifted from Saf to a mixture of 2.4% safflower oil plus 0.6% DHA after weaning (Saf-DHA), but all parameters measured in the learning test were essentially unchanged. Brain 22:6n-3 content of the Saf-DHA group reached that of the Per group but the levels of 20:4n-6 and docosatetraenoic acid (22:4n-6) did not decrease to those of the Per group at the start of the test. In the second set of experiments, dietary oil was shifted to a mixture of 0.6% safflower oil plus 1.2% oleic acid (OA) plus 1.2% DHA (Saf-OA-DHA group) with 18:2n-6 content comparable to that of the Per group. The Saf-OA-DHA group exhibited a learning performance similar to that of the Per group; brain 22:6n-3, 20:4n-6, and 22:4n-6 contents were also comparable to those of the Per group. These results indicate that the altered learning behavior associated with a long-term n-3 fatty acid deficiency is reversed by supplementing 22:6n-3 after weaning, when the levels of competing n-6 fatty acids in the diet and brain lipids are limited.

Aging↗
PubMedDate not supplied

Treatment of anomia using errorless versus errorful learning: are frontal executive skills and feedback important?

BACKGROUND: Studies from the amnesia literature suggest that errorless learning can produce superior results to errorful learning. However, it was found in a previous investigation by the present authors that errorless and errorful therapy produced equivalent results for patients with aphasic word-finding difficulties. A study in the academic literature of phoneme discrimination learning found that errorful learning produced equivalent results to errorless learning when feedback was given. In the authors' previous study, feedback was available to the participants in the errorful therapy. It is possible, therefore, that this feedback may have improved the results from errorless learning -- thereby reducing an underlying difference between the two techniques. Generally, feedback is thought to aid learning, however, there is little information in the speech therapy literature about this factor. AIMS: The present investigation was conducted as a follow-up to authors' original study to compare errorless and errorful therapy for the amelioration of aphasic word-finding difficulties. The second aim was to replicate key findings from the original study: namely, that recognition memory, executive/problem-solving skills and monitoring ability predict immediate and long-term naming improvements but not the participants' remaining language ability. METHODS & PROCEDURES: Seven of the original 11 participants took part in a multiple baseline, crossover, case series design. OUTCOMES & RESULTS: The previous results were replicated: errorless and errorful therapy produced equivalent results immediately post-therapy and at follow-up. There was no effect of omitting feedback - the participants learnt equally well without therapist's feedback about whether or not their response was correct. In addition, executive/problem-solving skills and monitoring ability again predicted immediate naming improvements not language ability. CONCLUSIONS: The findings support the view that cognitive abilities and in particular executive function are important contributors to rehabilitation.

Adult↗
PubMed1986

Neurometrics does not detect 'pure' dyslexics.

Thirty-eight severely dyslexic boys and 38 good readers were evaluated with neurometrics, a diagnostic procedure based on the application of numerical taxonomy to EEG spectra obtained during resting conditions, supplemented by selected evoked potential features. This procedure generates deviance scores for the EEG spectra by comparing each individual's values to those obtained from a normative population and has been reported to discriminate learning disabled children from normal controls (Ahn et al. 1980). In the present study, all subjects, dyslexic and control, passed stringent screening to assure normal intellectual, neurological, sensory and emotional status. The false positive rate obtained in our control group was comparable to that reported earlier. However, none of the deviance scores significantly discriminated dyslexics from controls; most subjects from both groups were classified as normal. Severe dyslexia per se is thus not associated with the specific neurometric abnormalities reported previously in more heterogeneous learning disabled populations.

Adolescent↗
PubMed1998

The uterine environment enhances cognitive competence.

Genetically identical mouse embryos were transferred into same-strain uteri (transfer controls) or into hybrid uteri. A third group was not transferred. When adult, the mice were given a series of behavioral tests. In-strain transfer controls differed from non-transfer mice only on two activity measures, and did not differ on any cognitive variable. In contrast, mice reared in hybrid uteri were found to be superior to in-strain transfer mice on discrimination learning, Lashley maze learning and Morris maze learning; they also showed better adaptation in an avoidance learning shuttlebox. To our knowledge this is the first study showing that the uterine environment can have a general enhancing effect upon cognitive competence across a broad range of behaviors.

Animals↗
PubMed2002

Long-term memory for concepts in a California sea lion ( Zalophus californianus).

An adult California sea lion ( Zalophus californianus) with extensive experience in performing discrimination learning tasks was tested to evaluate her long-term memory for two previously learned concepts. An associative concept, that of equivalence classification, was retested after a retention interval of approximately 1 year. The sea lion had originally shown emergent equivalence classification with nonsimilarity-based classes of stimuli in a simple discrimination repeated-reversal procedure as well as in a matching-to-sample procedure. The 1-year memory test revealed no decrement in classification performance in either procedure. A relational concept, that of generalized identity matching, was retested after approximately 10 years. The sea lion had originally received trial-and-error exemplar training with identity matching-to-sample problems prior to transferring the concept to novel stimulus configurations. In the 10-year memory test, the sea lion immediately and reliably applied the previously established identity concept to familiar and novel sets of matching problems. These are the first reports of long-term conceptual memory in a nonprimate species. The experimental findings are consistent with a variety of observations of sea lions in natural settings, which indicate that natal sites, feeding areas, and individuals may be remembered over long periods of time.

Animals↗
PubMed1999

High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice.

Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability.

Aging↗
PubMedDate not supplied

Collaborative Behavioral Teratology Study: protocol design and testing procedures.

This paper presents background information on the methods used in the Collaborative Behavioral Teratology Study (CBTS), the rationale behind the experimental design, and the design and specific procedures used in the CBTS. Each of the following methods is discussed: negative geotaxis, olfactory discrimination, auditory startle habituation, one-hour activity in the figure-8 maze, visual discrimination learning, 23-hour activity in the figure-8 maze, and amphetamine-stimulated activity. The CBTS was designed to determine the intra- and interlaboratory reliability of these test methods and the detection sensitivity of each method, as well as to determine the importance of several major variables (early test experience, gender, litter). The important design features which permitted these evaluations are discussed. Each laboratory conducted two independent experiments: one using d-amphetamine sulfate as the test agent and one using methylmercuric chloride. Other than the use of different agents and dosing regimens in the two studies, all other characteristics of experimental design were identical. Each study was conducted in four replicates with 4 litters/each of 4 treatment groups/replicate. The replicate design was an important feature which permitted reliability of the tests to be addressed under conditions in which several other sources of variation in responding could be identified and accounted for in the model. Other methods by which optimal testing conditions were implemented in the participating laboratories included the "blind" testing of all subjects in specific orders which were counterbalanced for treatment group, time of day, and the apparatus in which the animals were placed.(ABSTRACT TRUNCATED AT 250 WORDS)

Amphetamine↗