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At least 1,657 records · Page 92Linked to original sources
PubMed1976

[Mechanism of biogenic monoamine stimulation of the enzymatic reduction of disulfides].

A possibility is shown to study the catecholamine (CA) action mechanism on the simple and available object, the liver supernatant fraction. Under these conditions the physiological concentrations of CA increase the disulphide reductase (DSR) activity. The effect of adrenaline, noradrenaline and isadrine (isopropylnoradrenaline) is realized through beta-receptors, the mesaton (phenylephrine) effect is realized through receptors differing from the classic ones. Serotonin stimulates DSR too but in an order higher concentration; this effect is blocked by beta-adrenolytic. For CA action the membrane factor is necessary, as the effect takes place only at protracted homogenization or preliminary solubilization by detergents. The additional data are obtained in favour of the hypothesis on the DSR activation through the chain: adenylate cyclase-3',5'-AMP-protein kinase.

Animals↗
PubMed1990

[A comparative study of the biogenic amine receptors in the muscle tissue of mollusks, echinoderms and tunicates].

Smooth muscles of Mollusca, Echinodermata and Tunicata contain one class of adrenoreceptors with the dissociation constant and maximal specific binding 2.5 and 82 in Anodonta, 2.3 and 320 in Holothuria, 4.9 pM and 232.5 fmol/mg of protein in ascidia. Catecholamines and their antagonists can be ranged in the row as follows: isoproterenol greater than adrenalin greater than propranolol-noradrenaline greater than phentolamine. Negative regulation of the beta-adrenoreceptor affinity to isoproterenol by means of guanine nucleotides (GN) was shown. The muscular tissues of Mollusca, Echinodermata and Tunicata have only one class of the serotonin receptors with the dissociation constant and maximal specific binding 120 and 13.2 in Anodonta, 88 and 192 in Holothuria, 2.6 pM and 54 fmol/mg of protein in ascidia. The GTP negative regulation of serotonin receptors affinity to the hormone was found. The GN regulation of the above receptors affinity to agonist suggests that muscle tissue of the above species has specific GTP [correction of GTR]-binding proteins capable of coupling with these receptors.

Animals↗
PubMed1990

[The biogenic amine level of patients with functional and inflammatory diseases of the large intestine].

Patients with functional and inflammatory diseases of large intestine revealed changes of the activity of the sympathetic-adrenal system both in the hormonal and peripheral mediator links, i. e. against the background of pronounced deficit of noradrenaline all groups of patients showed an increased level of adrenalin indicating tension of medullary layer of the adrenal. The blood serotonin content was of value in the differential diagnosis of irritation syndrome of the colon and unspecific ulcerative colitis.

Adult↗
PubMed1990

[The effect of Cu2+, Zn2+ cations and biogenic amines on the nuclear poly(ADP-ribose) polymerase activity in the rat brain].

Study of the effects of Cu2+, Zn2+ cations and polyamines, spermine and spermidine, on the nuclear poly(ADP-ribose)polymerase activity of rat brain was carried out. It was shown that low concentrations of Cu2+ stimulate the activity of purified poly(ADP-ribose)polymerase. The poly(ADP-ribose)polymerase activity was increased 1.4-fold at 5 microM Cu2+. A further increase of Cu2+ concentration inhibited the enzymatic activity; at 50 microM Cu2+ the polymerase activity appeared to be fully inhibited. It was shown that Zn2+ inhibited only the poly(ADP-ribose)polymerase activity. Zn2+ at a concentration of 125 microM fully inhibited the enzymatic activity. Spermine and spermidine stimulated the poly(ADP-ribose)polymerase activity of brain nuclei of newborn and old rats.

Aging↗
PubMed1990

Experimental acute inorganic boron toxicosis in the goat: effects on serum chemistry and CSF biogenic amines.

Following acute accidental death of 26 cows exposed to boron fertilizer, effects of inorganic boron treatment in goats were studied. Goats were orally dosed with toxic but sublethal amounts of the fertilizer. Multiple hematologic and serum chemistry parameters were assessed, as were cerebrospinal fluid (CSF) neurotransmitters and some of their metabolites. Significant increases in packed cell volume, hemoglobin, inorganic phosphate, creatine phosphokinase, conjugated bilirubin, sodium, glucose, cholesterol, and aspartate transaminase were recorded. The following serum components were significantly decreased after boron dosing: alkaline phosphatase, magnesium, glutamyltransferase and potassium. There was evidence of a stimulatory effect on both serotonergic and dopaminergic neurons as reflected in elevated CSF monoamine metabolites. Aberrations in clinical behavior, including seizure-like activity, also suggested a central nervous system effect of inorganic boron.

Animals↗
PubMed1990

[Biogenic amines in the ganglia of the autonomic nervous system in emotional stress].

Rabbits with different stability of cardiovascular functions were shown to have different activity of sympathetic nervous system under emotional stress. A small enhancement of the system activity occurred in animals with practically unchanged arterial pressure, whereas its hyperactivity was found in the animals with a progressive decrease of arterial pressure. Different changes of catecholamines in the nodose ganglia of these two groups of animals seem to reflect the participation of those ganglia in the maintenance of stable cardiovascular functions in extreme conditions.

Acute Disease↗
PubMed1990

Effects of a chronic administration of the new antidepressant pirlindole on biogenic amine receptors in rat prefrontal cortex and hippocampus. Comparison with desipramine, nomifensine and zimelidine.

Chronic effects of the new antidepressant pirlindole on adrenergic and 5-HT2-receptors in rat prefrontal cortex and hippocampus were investigated in comparison to desipramine, nomifensine and zimelidine. The effects of pirlindole could be clearly distinguished from those of the monoamine reuptake blockers: chronic administration (20 days) of pirlindole (10 mg/kg per day, p.o.) increased prefrontal cortical alpha 2-receptor numbers and did not affect alpha 1-, beta-, and 5-HT2-receptor numbers. In hippocampus its action caused significant increases in alpha 1- and alpha 2-adrenoceptor densities. Administration of the monoamine reuptake blockers desipramine, nomifensine and zimelidine (10 mg/kg per day, p.o.) for 20 days mainly induced reductions of central adrenergic and 5-HT2-receptor numbers. Type-specific increases in monoamine receptor affinities were induced by the four antidepressants investigated, an effect not consistently described in other studies. The results on monoamine receptor numbers and the type specific increases in receptor affinities help to understand the contradiction in binding data versus physiological and behavioural findings.

Animals↗
PubMed1990

[Status of the pituitary-adrenal system and biogenic amine levels after extensive resection of the intestines].

A clinico-experimental investigations for the determination of contents of serotonin, histamine, 11-OCS and ACTH in blood as well as excretion of adrenaline and noradrenaline after extensive resection of the intestine are described. It was shown that the dynamics of contents of biologically active substances in the blood depended on the level of resection and terms after operation. Extensive resection of the intestine is followed by inhibition of the sympatho-adrenal system resulting in reduction of noradrenaline in blood and its excretion with increased excretion of adrenaline.

11-Hydroxycorticosteroids↗
PubMed1990

Biogenic amine binding sites in rabbit spermatozoa.

The binding of the neuroleptic, [3H] spiperone, to rabbit spermatozoa was investigated. Binding was partially inhibited by haloperidol, mianserin or epinephrine. Mixtures of two of the three inhibitors reduced binding further, but binding of the radioligand to spermatozoa was lowest in the presence of all three inhibitors. Unlabeled spiperone eliminated binding. Cholinergic ligands, GABA, and beta-adrenergic ligands, had little effect on binding. Spiperone binding occurred to both heads and tails suggesting that alpha 1-adrenergic, D2-dopamine and S2-serotonin binding sites are present in the head and/or tail of rabbit spermatozoa.

Animals↗
PubMed1977

Synthetic melanocyte stimulating hormone release-inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover.

The effect of the factor that inhibits the release of melanocyte stimulating hormone (MSH), i.e., L-prolyl-L-leucyl-glycinamide (MIF), and L-prolyl-N-methyl-D-leucyl-glycinamide, an analog, on brain norepinephrine (NE), dopamine (DA) and serotonin (5-HT) turnover was examined in rats. The analog (40 mg/kg i.p.), in a fashion similar to MIF (40 and 5 mg/kg i.p.), increased brain DA turnover; only MIF (40 mg/kg i.p.) increased endogenous DA levels. The analog (40 and 5 mg/kg i.p.) decreased brain NE turnover; MIF at the same doses was ineffective. Neither MIF nor the analog affected rat brain 5-HT turnover or the 5-HTP-induced behavioural syndrome in the mouse. These results indicate that the analog, like MIF, exerts effects on central catecholamine turnover. The different biochemical profile of the analog compared to MIF may be importance with regard to potential clinical use in the treatment of Parkinson's disease and depression.

5-Hydroxytryptophan↗