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Results for “Adrenocortical Hyperfunction”

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PubMedDate not supplied

[Nuclear medicine diagnostic localization in primary aldosteronism and Cushing syndrome].

The main indication for 131J-cholesterol scintigraphy is primary aldosteronism. The preoperative localization of aldosterone - producing adenomas may be obtained with the non-invasive NP-59 - scintigraphy in 75-85% of the patients. Idiopathic bilateral adrenal hyperplasia is diagnosed correctly in 90-100% of the cases. In Cushing's syndrome scintigraphy of the adrenal cortex is indicated only in specific cases such as very small adenomas, primary nodular adrenal hyperplasia and/or for the localization of ectopic adrenal cortex tissue. A false diagnosis may be caused by asymmetric uptake of the radioisotope in idiopathic bilateral hyperplasia or by unspecific absorption in non - adenomatous adrenal cortex tissue with symmetric uptake in patients with unilateral adenomas.

Adenoma↗
PubMed1978

[The deficiency of 17-hydroxylase: a cause of growth and puberty retardation in the girl. One case].

A case of 17-hydroxylase deficiency in a 14 years old girl is reported. She presented with the unique association of hypertension, hypokaliemia, delayed puberty and growth failure. It is suggested that the reduced statural growth starting between 7 and 10 years of age and accompanied by a markedly reduced bone maturation was, at least in part, the consequence of the absence of adrenarche. The secretion rate of cortisol was very low while an increased production of D.O.C. and corticosterone was demonstrated by the elevated levels of their urinary tetrahydroderivatives. A good feminisation and a growth spurt were observed under ethinyl oestradiol substitutive therapy. A progressive normalization of the kaliemia and the blood pressure was obtained with hydrocortisone treatment but long term hydrocortisone therapy appears less satisfactory with easy clinical manifestations of overdosage on the one hand and incomplete maintenance of normal blood pressure of the other hand.

Adolescent↗
PubMed1988

Neurologic, endocrinologic, and pathologic findings associated with large pituitary tumors in dogs: eight cases (1976-1984).

Invasive tumors of the pituitary gland were diagnosed in 8 dogs. Seven of the dogs had been treated for pituitary-dependent hyperadrenocorticism before the onset of neurologic signs. All 8 dogs had behavior abnormalities and similar neurologic signs: 6 dogs had rotary nystagmus and 7 dogs had symmetric tetraparesis. Once neurologic signs developed, the clinical course in all 8 dogs had a mean duration of 4.7 +/- 2.0 months before death or euthanasia; 5 dogs had a clinical course of less than or equal to 2 months. Necropsy was performed in 7 dogs. The histologic diagnosis was malignant pituitary adenocarcinoma in 2 dogs and pituitary adenoma in 5 dogs.

Adenocarcinoma↗
PubMed1988

[Tumors of the adrenal glands in children].

The article presents results of diagnostics and treatment of 26 children with tumors of the adrenals. The diversity of clinical symptoms was dependent on the zone of the adrenal cortex where the adrenocortical tumors were developing and the character of the hormones released. In diagnostics of the localization of adrenal tumors the authors give preference to pneumoretroperitoneography. A conclusion is made that the hormonal background must be studied in each patient with gynecomastia and pneumoretroperitoneography should be performed. Such a watchfulness is thought to be the only condition of the timely diagnostics of esteroma.

Adolescent↗
PubMedDate not supplied

[Metabolism of vitamin D in exogenous hypercorticism in rats].

Short-term administration of hydrocortisone into rats (within 7 days) stimulated 1.25(OH)2D3 synthesis in kidney and led to accumulation of the metabolite in blood serum, small intestinal mucose and bones. After long-term administration of hydrocortisone within 28 days synthesis of 1.25(OH2D3) was decreased in kidney while the content of 24.25(OH)2D3 was was simultaneously increased. Concentration of labelled 1.25 (OH)2D3 and 24.25(OH)2D3 was distinctly decreased in small intestinal mucose and femur bones.

24,25-Dihydroxyvitamin D 3↗