[Maternal deficiencies in pantothenic and folic acid].
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An increased need for vitamins and microelements supplementation is observed in both pregnant and breast-feeding women. Proper vitamin supply seems to be essential for normal deficiency of a few vitamins may lead to congenital defects. It needs to be remember however, that too large doses of vitamins may act as toxic agents, disturb homeostasis and proper metabolism of other vitamins.
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The actual nutrition of children in nurseries taking into account the losses of food substances during food cooking and realization is inadequate to the current physiological standards for all food substances, especially, with respect to vitamins and mineral elements. This inadequacy has been proved by the laboratory and clinical parameters of vitamin status of children. In the winter-summer period when vitamin deficiency in the rations is most pronounced, deviations in the content of vitamins and their metabolites in the blood and urine, as well as the incidence of hypovitaminosis symptoms in children are more frequently recorded and in the most pronounced form.
A total of 205 children were under observation (48 children aged 1.5-3 years in a Baby's Home--spring, 1987; 85 children aged 3-6 years in nurseries with 24-hour stay--spring, 1987; 77 children aged 3-6 years in a Children's Home--spring, 1989). As a result of nutrition reorganization in these institutions vitamin consumption increased due to a more rational selection of food products and the vitamin status of children improved. This was more expressed in vitamin excretion levels, than in the incidence rate of microsymptoms of vitamin deficiency. Additional vitaminization with multivitamin compounds is necessary to eliminate vitamin deficiency in preschool children of isolated institutions.
The study of providing with vitamins of schoolchildren in Orenburg conducted in the spring of 1985-1986 has revealed decreased content of ascorbic acid in 92%, vitamin E in 62%, vitamin A in 39%, folic acid in 38%, vitamin B12 in 14% of the children, the incidence rate of vitamin deficiency among the children in the senior forms was higher as compared to that in the junior forms and in boys it was more frequent than in girls. Additional intake of multivitamin "Undevitum" by schoolchildren during 2-4 months led to a significant improvement of their providing with vitamins that was expressed in normal vitamin levels and elimination of cases of deep vitamin deficiency.
The effect of the prophylactic use of multivitamin "Undevitum" on parameters of vitamin providing of schoolchildren in Norilsk was studied. The results of the investigation showed a positive effect of the prophylactic vitamin administration on providing with vitamins of schoolchildren in Norilsk and proved the necessity of conducting mass vitamin administration to schoolchildren.
The investigation of providing with vitamins of river transport workers in Western and Eastern Siberia and of oil men in the Tyumen Region conducted in the summer period of 1984-1986 has revealed significant deficiencies of vitamins C, E, B1, B2, B6, A and carotene in them. Vitamin administration to the workers with "Undevitum" resulted in a significant improvement of their vitamin status that was expressed in elevation of their biochemical parameters and in diminution of the percentage of subjects with vitamin deficiencies.
The investigation of vitamin sufficiency of young basket-ball players 14-16 years old (17 girls and 14 boys) has been carried out 59-77 per cent of the children had the deficiency of B group vitamins, 24-54 per cent--vitamin E insufficiency, most of them (82-100 per cent)--deficit of carotenoids while they were sufficiently vitamins C and A supplied. The girls were supplied with vitamins better than boys. There was no one adequately supplied with all vitamins among boys while 12 per cent of girls had adequately sufficiency. The girls had deficit of 1-2 vitamins more often whereas the combined insufficiency of 3-4 vitamins took place in 1.8-2.3 fold more frequently among boys. Daily intake of multivitamin containing 10 vitamins in daily recommended doses, lipoic acid, methionin and 9 minerals by boys lead to their blood plasma vitamin C, E, B-2 and beta-carotene level increase. Vitamin C insufficiency disappeared. Deficit of beta-carotene and vitamin B-6 became 1.5 fold rarely, vitamin B-2--2 fold, vitamin E--6 fold. Thus daily intake of recommended doses of vitamins eliminates biochemical signs of vitamin deficiency.
The tongue is an organ easy for examination. Pathological changes of the tongue are of local or systemic origin and may accompany many systemic diseases or precede them. The paper shows shortly normal anatomy and function of the tongue and the most common pathological changes in the course of systemic diseases. Also we discussed the aspects of early diagnosis and oncological prophylaxis. The aim of the study was to concentrate on cooperation between different specialists to undertake both local and systemic treatment to provide better care of the patient. The paper was based on literature and our own observations.
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BACKGROUND: The diversity of the Mediterranean diet and the heterogeneity of acquired genetic alterations in colorectal cancer (CRC) led us to examine the possible association between dietary factors and mutations, such as Ki-ras mutations, in genes implicated in the pathogenesis of these neoplasms. PATIENTS AND METHODS: The study was based on 246 cases and 296 controls. For the molecular study only 117 patients with Ki-ras tumor expression were included. Dietary patterns were assessed using a semi-quantitative food frequency questionnaire. RESULTS: Patients with Ki-ras mutations in codon 12 (K12) consumed significantly less vitamin A (p=0.02), B1 (p=0.01), D (p=0.02) and iron (p=0.03) than controls, whereas patients without these mutations had similar intakes of these nutrients to controls. The consumption of fiber, folate, vitamin E and potassium was lower in the two subgroups of patients (K12-positive or -negative) than in controls. Mutation in codon 13 was not associated with any nutrient deficit. CONCLUSION: These results support previous findings that certain micronutrients protect against colorectal neoplasia and emphasize the importance of considering the different molecular forms of CRC as etiologically distinct diseases.