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The "Canadian model" in the international context.

The focus of this commentary is on the relevance of the Canadian experience for developing countries. It highlights the growing urgency poor countries face in preserving their major human and social capital--community solidarity and family care. Developing countries face a double burden of disease--communicable and non-communicable diseases alike, with very few, and often shrinking, resources. While poorer countries will be able to learn about the essential elements of home-based care from the examples of Canada and other industrialized countries, they do need to develop their own systems based upon their economic, social, political and cultural realities. The primary health care system would seem to provide a foundation for the provision of long-term care on a sustainable and cost-effective basis. In contrast to the often-prevailing practice in developed countries, home-based care services could be integrated into the overall health and social system. Functional disability, regardless of disease aetiology or age of the care recipient, as well as the needs of family caregivers would thus become the defining elements of service eligibility. While the question remains open as to how much poor countries can learn from the experience of others, developing countries do have the opportunity to initiate a rational process where they first provide support to communities and informal caregivers and help to maintain patients in their homes and only later develop other service elements.

Canada↗

An exploratory study of services marketing in global markets: major areas of inquiry for the health care services industry.

It has been stated that one of the major challenges for the international marketer is the design of an efficient strategy for marketing services to international markets. This paper reviews some of the issues associated with services marketing in global markets along with the basic variables of service industries. An exploratory assessment of the health care services industry results in a list composed of several inquiry areas which should be examined by multinational companies. It is hoped that the review of the issues raised in this paper provides a basis for decision making and further research.

Demography↗

A ten year update on the marketing life cycle for hospital information technologies.

This is a 1999 update of an original article based on 1989-90 data published in the Journal of Hospital Marketing. The adoption of hospital information technologies shows that most of these technologies were no longer in the innovator or early adopter stages. Infrastructure building technologies such as clinical information links, PC networking with the mainframe, MD links between doctors and hospital and E-mail showed the highest percentage of increase. Bar coding for inventory (transactional) also made great increases. Opinions on barriers to the adoption of hospital information technology are ranked and are studied by age of respondent, public vs. private hospitals, and job function.

Attitude of Health Personnel↗

The role of public health improvements in health advances: the twentieth-century United States.

Mortality rates in the United States fell more rapidly during the late nineteenth and early twentieth centuries than in any other period in American history. This decline coincided with an epidemiological transition and the disappearance of a mortality "penalty" associated with living in urban areas. There is little empirical evidence and much unresolved debate about what caused these improvements, however. In this article, we report the causal influence of clean water technologies--filtration and chlorination--on mortality in major cities during the early twentieth century. Plausibly exogenous variation in the timing and location of technology adoption was used to identify these effects, and the validity of this identifying assumption is examined in detail. We found that clean water was responsible for nearly half the total mortality reduction in major cities, three quarters of the infant mortality reduction, and nearly two thirds of the child mortality reduction. Rough calculations suggest that the social rate of return to these technologies was greater than 23 to 1, with a cost per person-year saved by clean water of about dollar 500 in 2003 dollars. Implications for developing countries are briefly considered.

Adolescent↗

Intellectual property and biotechnology: the U.S. internal experience--Part II.

Continuing the discussion begun in the March 2006 issue of the Kennedy Institute of Ethics Journal, this paper further documents the failure of the United States to adequately consider possible modifications in the traditional robust system of intellectual property rights as applied to biotechnology. It discusses concrete suggestions for alternative disclosure requirements, for exemptions for research tools, and for improved access to clinical advances. In each of these cases, the modifications might be more responsive to the full set of relevant values.

Access to Information↗

Growing pains for new academic/industry relationships.

Five decades of almost unwavering federal support of university research in biomedicine have spawned a biotechnology revolution that holds dramatic promise for the public health and the U.S. economy. To make that promise a reality, the federal government now strongly encourages universities to facilitate the practical application of research results by by participating in academic/industry relationships. These relationships are yielding important health and economic benefits, but the new economic entanglements of U.S. universities also could undermine the public trust that has sustained federal support of biomedical research. Thus, efforts to speed the transfer of technologies through academic/industry relationships may have enormous effects on the government/university partnership that gave birth to those technologies.

Ethics, Institutional↗

Gene delivery into primary T cells: overview and characterization of a transgenic model for efficient adenoviral transduction.

Technologies for transfer of exogenous genes into primary T cells have been limited until recently. The introduction of new approaches for gene transfer via different viral vectors has expanded the options for genetic manipulation of primary T cells and has provided powerful tools for studies of T cell activation and differentiation. We provide a brief overview of the systems currently available and contrast the advantages and disadvantages of each. We also describe a new transgenic model that enables highly efficient gene delivery into primary T cells by nonreplicating adenoviral vectors.

Adenoviridae↗

Protective coatings for tooth crowns.

Transfer of technology to the dental office could provide thin polymeric coatings over tooth crowns and accessible root surfaces. These coatings can be prepared from relatively inexpensive, commercially available materials in one-step reactions. When the monomer technique becomes available, it will provide caries protection for all of your patients.

Benzoates↗

Using the modified Schirmer test to measure mouth dryness: a preliminary study.

BACKGROUND: Current methods of measuring saliva volume often are difficult to perform in a general dental or medical office setting. This study seeks to determine whether the Schirmer test for measuring eye dryness can be modified to measure mouth dryness. METHODS: The authors performed a modified Schirmer test (MST) on a control group composed of 41 healthy adult volunteers and a study group composed of 10 patients who had received head and neck radiation and 10 patients who had oral chronic graft-versus-host disease (CGVHD). The authors placed the strip on the floor of each subject's mouth and took readings at one minute, two minutes and three minutes. Fourteen control subjects also spat into a container over a five-minute interval, and the authors weighed the collected saliva. RESULTS: The mean reading for the control subjects at three minutes was 29.5 millimeters, while the mean reading for the test subjects was 6.9 mm (P < .00005). CONCLUSIONS: The results of the MST were able to distinguish between healthy adult volunteers and subjects who experienced profound xerostomia and hyposalivation. CLINICAL IMPLICATIONS: The MST as used in this preliminary study is an objective, inexpensive, easy-to-perform and well-tolerated test for measuring mouth dryness. It readily distinguishes between patients who are healthy and asymptomatic and those who experienced profound xerostomia and hyposalivation.

Adult↗

Energy for the new millennium.

The evolution of thinking about energy is discussed. When the authors began collaborating 20 years ago, energy was typically considered from a growth-oriented, supply-side perspective, with a focus on consumption trends and how to expand supplies to meet rising demand. They were deeply troubled by the environmental, security and equity implications of that approach. For instance, about two billion people lack access to affordable modern energy, seriously limiting their opportunities for a better life. And energy is a significant contributor to environmental problems, including indoor air pollution, urban air pollution, acidification, and global warming. The authors saw the need to evolve a different perspective in which energy is provided in ways that help solve such serious problems. They argued that energy must become an instrument for advancing sustainable development--economically viable, need-oriented, self-reliant and environmentally sound development--and that the focus should be on the end uses of energy and the services that energy provides. Energy technological options that can help meet sustainable development goals are discussed. The necessity of developing and employing innovative technological solutions is stressed. The possibilities of technological leap-frogging that could enable developing countries to avoid repeating the mistakes of the industrialized countries is illustrated with a discussion of ethanol in Brazil. The role foreign direct investment might play in bringing advanced technologies to developing countries is highlighted. Near- and long-term strategies for rural energy are discussed. Finally, policy issues are considered for evolving the energy system so that it will be consistent with and supportive of sustainable development.

Brazil↗

Energy, industry and nitrogen: strategies for decreasing reactive nitrogen emissions.

Nitrogen oxides are released during atmospheric combustion of fossil fuels and biomass, and during the production of certain chemicals and products. They can react with natural or man-made volatile organic compounds to produce smog, or else can be further oxidized to produce particulate haze, or acid rain that can eutrophy land and water. The reactive nitrogen that begins in the energy sector thus cascades through the atmosphere, the hydrosphere and soils before being eventually partially denitrifed to the global warming and stratospheric ozone-depleting gas nitrous oxide or molecular nitrogen. This paper will suggest how an economic analysis of the nitrogen cycle can identify the most cost-effective places to intervene. Nitrogen oxides released during fossil-fuel combustion in vehicles, power plants and heating boilers can either be controlled by add-on emission control technology, or can be eliminated by many of the same technical options that lead to carbon dioxide reduction. These integrated strategies also address sustainability, economic development and national security issues. Similarly in industrial production, it is more effective to focus on redesigning industrial processes rather than on nitrogen oxide pollution elimination from the current system. This paper will suggest which strategies might be utilized to address multiple benefits rather than focusing on single pollutants.

Acid Rain↗

Controlled-release local delivery antimicrobials in periodontics: prospects for the future.

New knowledge about the microbial etiology of periodontal diseases emerged in the 1970s and 1980s and led to widespread interest in the use of antimicrobial agents to treat periodontitis. The controlled-release delivery of antimicrobials directly into the periodontal pocket has received great interest and appears to hold some promise in periodontal therapy. Some techniques for applying antimicrobials subgingivally, such as subgingival irrigation, involve local delivery but not controlled-release. Controlled-release local delivery systems, in which the antimicrobial is available at therapeutic levels for several days, have been evaluated in several forms and using different antimicrobials. Although most studies with such systems have focused on drug delivery kinetics and "proof of principle" evaluations, some controlled clinical trials have recently been reported. The most widely tested system, monolithic tetracycline-containing fibers, has shown significant clinical benefit when used alone as compared to no subgingival therapy. Similarly, controlled trials involving chlorhexidine strips used subgingivally every 3 months in place of routine supportive periodontal therapy have shown significant clinical benefit for up to 2 years. Although these data are now emerging, many questions concerning the optimal use and role of this therapy in clinical practice remain. This review attempts to summarize and interpret current data and to outline key remaining questions that must be addressed as this technology is transferred into clinical practice.

Administration, Topical↗