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[Radiologic characteristics of the thorax during therapy with interleukin-2].

Interleukin-2 is a glycoprotein physiologically produced by human lymphocytes which is capable of mediating some still unknown immunologic reactions. In vitro, interleukin-2 was seen to induce a lytic reaction against tumor cells through the activation of a cytolytic system of natural killer cells. If administered to man in heavy doses, it causes a clinical response in the treatment of metastases from melanoma and renal cell carcinoma in 20-40% of cases. However, the clinical use of the drug, in therapeutic doses, is prevented by the occurrence of several side-effects, the major one being increased permeability of alveolar vessels with capillary leak and interstitial pulmonary edema (Vascular Leak Syndrome in the English literature). Thus, this work was aimed at evaluating chest radiographs during interleukin-2 treatment to detect, in the pulmonary district, the early stages of the vascular leak syndrome--i.e., pulmonary edema, pleural and pericardial effusions. Forty-three patients had been treated for metastases from renal cell carcinoma and melanoma November 1989 through September 1991: standard chest radiographs demonstrated 26 cases (60%) of pulmonary edema, 14 cases (32%) of bilateral pleural effusions and 12 cases (27%) of pericardial effusions. Daily chest films of the patients undergoing interleukin-2 therapy allowed the early stage of the vascular leak syndrome to be depicted, thus enabling the physician to use the highest tolerated doses and eventually to stop infusion before marked respiratory distress develops.

Humans↗

[Surgical treatment of post-burn cicatricial deformities of the anterior surface of the thorax].

Operations were carried out on 11 patients with postburn keloidal cicatrix of the anterior chest wall the area of which ranged from 27 to 240 cm2. To, correct the deformity, extensive mobilization of the skin-fat layers of the axillae, subclavicular, region' anterior surface of the shoulder joints, and lateral surfaces of the chest is conducted. After excision of the cicatrix the layers are transposed to the wound and the skin covering is restored. Peripheral necrosis occurred in two patients but did not influence the outcome of the plastic procedures. Tailoring flaps from the mobilized layers causes a poorer cosmetic effect. Study of the results in follow-up periods of 2 to 18 months showed a good esthetic outcome in all patients, which allows the method to be recommended for the management of cicatricial deformities of the anterior chest surface.

Adipose Tissue↗

[Radiologic manifestations of AIDS in the thorax].

In AIDS, pulmonary involvement is the main cause of morbidity and death. In this article the author makes a short report of the illness and a review of its radiological pulmonary images, in what concerns infections, tumoral, non-infections and non-tumoral pathology. Finally, the author proposes a radiological follow-up of great interest for the early diagnosis and treatment of the illness.

Acquired Immunodeficiency Syndrome↗