Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Selenium Compounds”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,639 records · Page 91Linked to original sources
PubMed1984

[Seasonal characteristics of the effectiveness of vitamin E and sodium selenate in tetracycline-induced liver damage].

The seasonal characteristics of the efficacy of vitamin E and sodium selenite in tetracycline affections of the liver were studied on 128 noninbred male albino rats. It was shown that in comparison to vitamin E sodium selenite more actively retarded activation of lipid peroxidation in the liver and activation of alanine aminotransferase and alkaline phosphatase in the blood serum in autumn and winter. A more pronounced inhibition of the increased levels of the dienic conjugates and alanine aminotransferase was observed in spring and summer and malonic dialdehyde and aspartate aminotransferase in summer by tocopherol acetate as compared to sodium selenite. The level of the thiol-disulfide equilibrium on the separate use of the drugs in spring and summer was higher than the control one. However, it did not reach the control level in autumn and winter. The combined use of sodium selenite and vitamin E prevented the toxic effect of tetracycline on the liver in autumn, spring and summer. Still, in the winter no such prevention was observed. The mechanisms of the seasonal differences in the tetracycline effect on the liver and the efficacy of the antioxidants in such affections are discussed.

Animals↗
PubMed1982

Selenium sulfide: adjunctive therapy for tinea capitis.

Selenium sulfide lotion used as a shampoo has been shown to be an effective adjunctive agent to griseofulvin in the treatment of tinea capitis. Of 16 children with Trichophyton tonsurans infections 15 had negative fungal cultures at two weeks following a regimen of daily oral griseofulvin and selenium sulfide shampooing twice weekly. All patients treated with griseofulvin alone or in combination with either a bland shampoo or topical clotrimazole had positive cultures not only at the two-week interval but also as long as eight weeks later. In vitro analysis shows selenium sulfide to be sporicidal, correlating well with the in vivo observations. It is postulated that selenium sulfide usage may lessen the chances for spreading of infectious spores to other individuals.

Adolescent↗
PubMed1982

[Attempt to stimulate labor in cows and heifers].

Attempts were made to induce delivery in 79 cows and 20 heifers, using the preparations dexametasone, cloprostenol, and dinolytic. The level of progesterone and estradiol was determined in four cows. A group of 20 heifers were injected with the preparation fortecortin at the rate of 30 mg. Four cows with induced parturition were used to evaluate the changes setting in with the blood level of estradiol 17 beta and progesterone. The following conclusions were made: 1. Best effects with regard to the indices duration of calving parturition and post-partal complications, and independence and service period are produced with the combined application of 50 mg sodium selenite and 680 UI vitamin E with 30 mg dexametasone. 2. The decrease in liveweight of the newborn calves from heifers at an average of 6 kg leads to the prevention of dystocia and the shortening of the post-partal period.

Adrenal Cortex Hormones↗
PubMed1981

Hydrogen selenide evolution-electrothermal atomic absorption method for determining nanogram levels of total selenium.

A hydrogen selenide (H2Se) evolution-electrothermal atomic absorption method is described for determining nanogram concentrations of total selenium (Se) in biological and environmental materials. A mixed acid digestion procedure is used to decompose organic material. Sodium borohydride, a redesigned hydride generator, and an electric-headed absorption tube are used for H2Se evolution and conversion to atomic Se. The method has a detection limit of 4 ng/mL and a sensitivity of 0.6 ng/mL, and is linear from 0 to 90 ng Se/mL. As determined on urine, water, and bovine liver, total and within-run precision had relative and standard deviation values of 5-17.2 and 5.5-12.6% respectively. Accuracy was established with 2 NBS and 3 EPA reference materials, and mean errors of 0 to +0.8 were obtained. Mean recoveries of 109 and 101% were obtained for 10 and 50 ng Se added to human urine.

Borohydrides↗
PubMed1980

[Telogen effluvium following application of selenium disulfide in the guinea pig].

A standard surfactant solution was applied to one side of the back in 29 male guinea pigs and the same surfactant solution with an addition of 2.5% selenium disulfide to the other side. The application was carried out a total of six times at three-day intervals. The detergent was not washed away to provide an intense exposure to the active substance. Investigations of the hair root status before and after treatment showed significant increase in telogen hair. The present results of animal experiments cannot be transferred without reservations to conventional application in man. However, they may explain isolated observations of diffuse hair loss after treatment with selenium disulfide if one presupposes an especially intense penetration of active substance in these cases.

Animals↗
PubMed1995

[The effect of the modified preparation Komplivit on blood coagulation].

Modified medicine "Komplivit" enriched by compounds of selenium, methionine and iodine showed more severe antioxidant effect than original "Komplivit". Ingestion of modified medicine to white rats during 12 days declined significantly hemocoagulation disturbances caused by thrombinemia and decreased frequency of lethal thrombosis. Authors suggest the usefulness of investigations of modified "Komplivit" in clinical cases of thrombinemia.

Animals↗
PubMed1995

Effect of mercury on the seminiferous epithelium of the fowl testis.

Phenylmercuric chloride was applied in three doses (5 ppm, 30 ppm Hg, and 30 ppm Hg + 4 ppm Se) via the food for 60 days. The effect of Hg with an without Se was studied histologically and the data of a shortened spermatogram were evaluated. Treatment with 30 ppm Hg resulted in hypospermia, occurrence of abnormally maturing spermatozoa, reduction of the volume of semen, and decrease in the number of spermatozoa. The dose of 5 ppm Hg only resulted in the appearance of abnormally developing cells and decreased sperm motility. The addition of Se maintained spermatogenesis and the values of semen on the control level.

Animals↗
PubMed1995

Reproductive response of ewes fed alfalfa pellets containing sodium selenate or Astragalus bisulcatus as a selenium source.

Selenium fed to open cycling ewes in the form of sodium selenate or Astragalus bisulcatus (a selenium accumulator plant) at 24 or 29 ppm selenium, respectively, in alfalfa hay pellets did not alter the estrous cycle length, estrus behavior, progesterone or estrogen profiles, pregnancy rate or outcome of parturition (P > 0.05). There was wool loss in some ewes fed seleniferous pellets and the mean whole blood selenium levels were 0.45, 1.3 and 2.4 ppm, respectively, for control, A bisulcatus and sodium selenate; however, ewe condition and appearance remained good. All lambs appeared normal and the number of lambs born and the individual and total lamb weight averages were not significantly (P > 0.05) different between treatment groups and control group.

Animal Feed↗
PubMed1993

Renal retention of selenium after administration of trimethylselenide.

Renal retention of selenium after administration of trimethylselenonium iodide (TMSeI) was studied in vivo in male and female rats during sexual maturation. The selenium level in the kidneys was found to be significantly higher in male rats than in females during the first hour after intravenous (i.v.) administration of TMSeI. The sex-linked difference, manifested already in 21-day old animals, increased markedly during the following four weeks of postnatal life. It was shown that this process may be accelerated by previously increased selenium intake. The sex-linked difference in renal retention of selenium was observed after administration of TMSeI in a wide range of doses: 0.002-10.0 mumol per animal. The size of the applied dose did not affect significantly the kinetic patterns of selenium in the kidneys during the first hour after i.v. injection. The results suggest the existence of a sex-dependent mechanism in the kidneys which may control the rate of excretion of trimethylselenonium ions in urine both under conditions of normal selenium intake and selenium intoxication.

Aging↗
PubMed1993

Biochemical analysis of Escherichia coli selenophosphate synthetase mutants. Lysine 20 is essential for catalytic activity and cysteine 17/19 for 8-azido-ATP derivatization.

A labile selenium donor compound, selenophosphate, is formed from selenide and ATP by selenophosphate synthetase. A cysteine residue (Cys-17) that is essential for catalytic activity of the enzyme (Kim, I.Y., Veres, Z., and Stadtman, T. C. (1992) J. Biol. Chem. 267, 19650-19654) is located in a glycine-rich segment near the N terminus of the protein. The possibility that this peptide sequence (HGAGCGCK) defines the ATP-binding site of the enzyme, as does a conserved ATP or GTP binding sequence (GXXXXGKS/T) found in several other proteins, was tested by site-specific mutagenesis. Thus His-13 and Gly-18 were changed to Asn and Val, respectively, and Lys-20 to Arg or Gln. Catalytic activity was markedly decreased by mutation of Lys-20 to Arg and abolished by mutation of Lys-20 to Gln. The mutation of Cys-19 and His-13 did not substantially alter the ATP Km and Vmax values, whereas the Gly-18 mutation resulted in a 4-fold increase in the ATP Km value compared with that of the wild type. ATP binding properties of the mutant enzymes were determined using Mn-[32P]ATP or Mn-[14C]ATP and gel filtration. Photoaffinity labeling of the proteins with [gamma-32P]8-azido-ATP showed that all mutant enzymes could be labeled with the ATP analog except those in which Cys-17 or Cys-19 were replaced with serine.

Adenosine Triphosphate↗
PubMed1995

Improved glucose tolerance by acute vanadate but not by selenate exposure in genetically obese rats (fa/fa).

OBJECTIVE: To describe the impact of acute vanadate and selenate exposure on glucose tolerance of obese Zucker rats (fa/fa). DESIGN: Intravenous glucose tolerance tests (2.4 mmol/kg, continuously from 0 to 30 min) were performed in conscious Zucker rats exposed to a bolus-continuous infusion of sodium vanadate (2.45 mumol/h) or sodium selenate (0.90 and 2.45 mumol/h) and were compared to intraindividual control experiments with saline infusion. RESULTS: Vanadate infusion improved glucose tolerance and decreased insulin release, as shown by total areas under the curves (0-120 min: Glucose, min.mmol/l: control, 983 +/- 59 vs vanadate, 915 +/- 54, P < 0.02; Insulin min.nmol/l: control, 117.5 +/- 19.9 vs vanadate, 88.5 +/- 26.2, P < 0.01). In contrast, infusion of selenate increased glucose induced insulin release during the first phase of the IVGTT (0-60 min, incremental area under the insulin curve: by 57% and 110% for low and high selenate infusion rate, respectively) and transiently improved glucose tolerance (0-60 min, decrease of incremental area under the glucose curve: 31% and 28%, respectively). That effect of selenate was lost with progression of the experiment during the second hour of the IVGTT, when plasma glucose continued to decline slowly in control experiments, but increased in selenate exposed rats without any adequate insulin secretory response to hyperglycemia. CONCLUSION: The results demonstrate improved glucose tolerance and decreased plasma insulin concentration during acute vanadate exposure. Only a transient insulinotropic effect with improved glucose tolerance is induced during acute selenate exposure, and is followed by progressive development of hyperglycemia indicating selenate toxicity.

Animals↗