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At least 1,639 records · Page 91Linked to original sources
PubMed1990

[Prognosis of gastric carcinoma sited in the cardiac part determined by the type of esophageal invasion].

A study has been made of type and prognosis of esophageal invasions exhibited by gastric carcinomas sited in the cardiac part of the stomach. Examined were 14 such cases of an adenocarcinoma with an esophageal invasion. Histopathologically, the invasions into the esophagus were classified into 4 types of severity, from 1 to 4, according to the depth of the invasion into the esophago-gastric junction (EGJ) and the pattern of the invasion to the oral side (thoracic side). The prognosis was found to be good for EGJ invasion that had penetrated to the pm and/or sm layer only, whereas it was very bad if the invasion had penetrated the entire EGJ wall (the pm, sm, mp, and the sa) and the infiltrative pattern had reached the oral side (thoracic side). Almost all patients given a type 4 classification soon had a recurrence after surgery and did not live beyond two years. Thus, a close relationship has been noted between the type of invasion into the esophagus and the prognosis.

Adenocarcinoma↗
PubMed1990

[Prognosis factors in adenocarcinoma of the kidney. II. Microscopic factors].

The prognostic value of several microscopic parameters were evaluated in 95 cases of renal adenocarcinoma (32 stage I, 18 II, 26 III and 19 IV) submitted to radical nephrectomy and hilar lymphadenectomy with a 5-year follow-up. No prognostic significance was observed for cell type, architectural pattern, borders, and degree of peritumoral lymphocyte infiltration. A worse prognosis was observed for the high (G 3 + 4) in comparison with the low (G 1 + 2) nuclear grade (p less than 0.01). However, analysis according to stage revealed this parameter only affected prognosis in those cases pertaining to intermediate stages II and III. The mean proliferation rate was 2.97 mitoses/10 fields (500 x). A worse prognosis was observed for a proliferation rate greater than 5 mitoses/10 fields (500 x) in comparison to those with a lower rate (p less than 0.01) but evolves parallel to stage.

Adenocarcinoma↗
PubMed1989

[Detection and prognosis of medullary cancer of the thyroid gland. Influence of national multidisciplinary cooperation].

Medullary thyroid carcinoma is a rare and sometimes hereditary disease. The tumour can be diagnosed and followed up by measuring the amounts of calcitonin it secretes. The prognosis of this cancer largely depends on an early diagnosis and treatment. From the clinical and laboratory (calcitonin assays) data recorded in our department, we have endeavoured to determine the influence of a national multidisciplinary co-operative group (GETC: French medullary study group) on the diagnosis and prognosis of this malignancy. We are able to show that the number of medullary thyroid carcinomas detected (principally in their familial forms) has increased by 141 per cent after the GETC was created. Calcitonin levels at the time of diagnosis are significantly lower (P less than 0.05) in familial cases, which reflects an early detection. The same applies to post-operative calcitonin levels (P less than 0.005), so that in the long run a better prognosis can be expected. It seems therefore that together with a better knowledge of this cancer and its detection, the setting up of a national multidisciplinary co-operative group results in a better clinical and therapeutic approach of these patients, and particularly of the familial cases of medullary thyroid carcinoma.

Calcitonin↗
PubMedDate not supplied

[Wilms tumor. Evaluation of the important prognosis factors in 22 treated cases].

Twenty-two cases of treated Wilms tumor with more than two years of follow-up were classified according to Beckwith (favorable and unfavorable histology) and to Jereb & Sandstedt (histologic types I, II and III). The authors found a good correlation between histologic types I and II and prognosis (72% of the children with type I were free of tumor and of type II only 25%), but in type III no correlation was found between the histologic grading and prognosis, possibly due to the small number of cases observed. The three cases classified as unfavorable histology corresponded to histologic type III. All the children less than two years old at the time of diagnosis were free of tumor, in this group six out of seven cases were of histologic type I. In the older age group only one third of the cases were free of tumor. Otherwise, 70% of the cases with unfavorable prognosis were four or more years old, but only one had unfavorable histology. The present paper shows that the age and the histologic type determined according to the criteria of Jereb & Sandstedt are important data in the prognostic evaluation of Wilm's tumor.

Female↗
PubMed1989

[The obstetric prognosis and neonatal outcome of pregnant women with psychiatric disorders].

Obstetric prognosis and neonatal outcome of pregnant women with psychiatric disorders were retrospectively investigated. 1. Out of 1.472 deliveries at Saga Medical School from April 1983 to July 1988, there were fourteen cases (0.95%) involving psychiatric disorders-six of epilepsy, one of anxiety neurosis and seven of schizophrenias. 2. Total blood loss was relatively great in four epileptic patients. However, the general prognosis for each was good and the neonatal outcome was uneventful. 3. As for schizophrenic patients, six out of seven cases grew worse during the pregnancy and four in the postpartum period. Three cases underwent cesarean section due to their mental illness. 4. We made inquiries about the postpartum life of schizophrenic mothers and children, and received five answers (70.1%). It was found that schizophrenic mothers could not bring up the baby by themselves; they needed the help of their husbands and their own mothers. It is concluded that consistent management by both psychiatrist and obstetrician from the antepartum period to postpartum life are required for psychotic mothers and their children to obtain a favorable prognosis, and a follow-up system is desirable for the physical as well as the mental growth of the infants.

Adult↗
PubMed1989

[A clinicopathological studies on gastrointestinal leiomyosarcomas, with special reference to prognosis].

Twenty-five cases of gastrointestinal leiomyosarcomas were subjected to clinico-pathological studies in an attempt to correlate the prognosis with tumor size, mitosis, cellularity and DNA ploidy pattern. Leiomyosarcomas greater than 5cm in diameter had poorer prognosis. Those with mitotic index larger than 3.0/mm2, cellularity larger than 3.0/0.0004mm2, DNA aneuploidy had poorer prognosis. By multiple regression analysis, mitotic index was useful for the prediction of tumor recurrence in earlier postoperative period, but cellularity, tumor size were useful for the prediction of recurrence in later postoperative period. As for the type of tumor recurrence, hematogenous metastasis was observed in 7 cases, peritoneal dissemination in 2 and local recurrence in 4. Four cases with local recurrence had all hematogenous metastasis. Two cases of gastric leiomyosarcomas developing local recurrence were greater than 10cm in diameter and gastric local resection was done for them. One case was diagnosed benign leiomyoma in the rectum histologically, but after trans-anal tumor resection local recurrence and metastasis to the lung occurred. We must pay attention to the surgical margin and the surface of tumor dissection during of the tumor, especially in larger tumors. Aggressive surgical resection is efficient for the treatment of recurrent tumors.

Cell Count↗
PubMed1989

[Relation of maximum diameters of plantar malignant melanoma to various prognostic factors and prognosis of patients].

The following factors were investigated in 43 cases of plantar malignant melanoma: maximum diameters of primary lesions, Clark's subtypes, clinical stages, UICC's stages, Clark's levels of invasion, Breslow's tumor thickness, and prognosis of patients. Relation of maximum diameter of primary lesions to various prognostic factors and prognosis of the patients was analysed. It was revealed that there were no statistically significant relationships between maximum diameters and other various factors. In our series, however, all patients with plantar malignant melanoma less than 14 mm in diameter are alive without metastasis. Judging from our previous and present studies, the following two points are the most important for improving the prognosis of patients with plantar malignant melanoma: 1) Catching all pigmented lesions on the sole that are more than 7 mm in diameter and examining them histologically, if they have no possibility of being congenital melanocytic nevus or black heel. 2) Treating plantar malignant melanomas adequately before they become 14 mm in maximum diameter.

Foot Diseases↗
PubMed1989

[Prognosis of recurrence of peptic ulcer after isolated selective proximal vagotomy].

The joint work of doctors and mathematicians is based upon their 20-years experience with performing vagotomy in the clinic. Prognosis of recurrence of ulcer disease was elaborated on materials of 141 operations of isolated selective proximal vagotomy for chronic duodenal ulcer. The dispensary principle of managing the patients after operation allowed obtaining objective data both in the nearest and remote (over 10 years) periods. A group of 20 patients with recurrent ulcers and 13 patients with hypersecretion gastroduodenitis was considered to have unfavorable postoperative status. The prognosis developed may be used to make the indications to isolated selective proximal vagotomy more exact. The prognosis was correct in 80% of the observations.

Adult↗
PubMed1977

Juxtacortical (parosteal) osteogenic sarcoma: histological grading and prognosis.

In twenty-four cases of juxtacortical osteogenic sarcoma, three histological grades of malignancy were identified and correlated with the prognosis. The eighteen patients with Grade-I or II tumors had a significantly better prognosis than the six with Grade-III lesions. The three grades could not be distinguished roentgenographically. Grade I and II tumors, which showed a high cure rate after amputation, may be amenable to en block resection, provided the entire tumor can be removed with a good margin of uninvolved soft tissue and underlying bone. Grade-III tumors, on the other hand, had a poor prognosis despite early radical surgery.

Adolescent↗
PubMed1989

Malignant melanoma--prognosis and actual treatment strategies with chemotherapy and biological response modifiers.

The prognosis of malignant melanoma (MM) depends on the level of invasion, vertical tumour size, location of the primary, clinical stage, and sex. Whereas MMs are potentially curable in the early stage of disease, the therapeutic possibilities are very limited in advanced and disseminated MM. Most chemotherapeutic agents lack sufficient activity in MM especially with regard to survival. Dacarbazine (DTIC) is the most effective drug in MM with response rates of 20-25% followed by other drugs such as melphalan with 15-20%, hydroxyurea and platin derivates. Multidrug regimens were not shown to be more effective than DTIC alone. Radiotherapy may be relevant in local treatment of metastases. With regard to the poor prognosis and limited therapeutic approaches in advanced and disseminated MM, new strategies are required. In this context immunotherapeutic strategies with biological response modifiers are of interest for adjuvant or palliative approaches. Earlier trials with Bacillus Calmette-Guerin (BCG) +/- DTIC as adjuvant or palliative treatment revealed no effect of BCG on the prognosis. Alpha-interferon (alpha-IFN) was shown to induce remissions in about 15% and gamma-IFN in about 10% of patients. A very interesting new approach is the induction and/or activation of autologous cytotoxic cells by systemic administration of recombinant interleukin-2 (rIL-2) with response rates of 20-25% and the in vivo propagation and transfer of so-called tumour infiltrating lymphocytes. Further trials combining rIL-2 with other cytokines, chemotherapy, tumour vaccination or monoclonals against melanoma cells are required.

Humans↗
PubMed1989

[Atherosclerotic lesions of the coronary arteries in acute myocardial infarction: effects on myocardial contraction, disease course and prognosis].

Coronary arterial affection (CAA) is an objective indicator, closely related to cardiac contractility as well as clinical severity and immediate prognosis of myocardial infarction. The progress of CAA is associated with more pronounced disorders of cardiac contractility, higher rates of severe complications and less optimistic immediate prognosis. Long-term prognosis is not affected by the magnitude of CAA in postmyocardial-infarction patients.

Adult↗
PubMed1989

[Treatment and prognosis of sacrococcygeal chordoma--study of bone tumor registry in Japan].

Prognosis of chordoma arising in the sacrococcygeal area is difficult to assess because of the small number cases and lack of statistics in Japan. From the bone tumor registry we selected records on sacrococcygeal chordoma cases and sent a questionnaire to many hospitals regarding staging, surgical approach, surgical procedure, radiotherapy, chemotherapy, complications and prognosis of this tumor. The results of the questionnaire (32 cases) showed that combined surgery and radiotherapy were the best methods. This survival rate was 85% in five years and 43% in ten years. In the surgical procedure the extralesional excision resulted in a high recurrence rate (73%) three years after operation, and in the case of intralesional excision an even higher rate (91%). We assume this is a problem of the excisional method. In the staging system, the intracompartment tumors have a better prognosis. Early stage discovery and surgical treatment is of vital importance.

Adult↗
PubMed1989

[Early prognosis of the state of osteogenesis in bone lengthening].

The authors present their results of early prognosis of the outcomes of the treatment of 68 patients with consequences of injuries and with orthopaedic diseases of tubular bones applying the method of distraction for the recovery of the intact state and the length of the extremity. The method of prognosing the course of the bone tissue regeneration was used. It was established that this method of prognosis was characterized by low diagnosis errors (4.4%), allowed to reveal 71.5% of the patients with disturbances of osteogenesis and to recognize practically all patients with a favourable course of the process. Early prognosis allows to make corrections in the therapeutic tactics, which contributes to reduction in the number of unfavourable outcomes connected with the use of distraction osteosynthesis in clinical practice.

Adolescent↗
PubMed1989

[Analysis of factors influencing prognosis in patients with advanced ovarian cancer].

Sixty-eight patients with advanced ovarian cancer were evaluated to determine factors influencing prognosis. In the background between 49 patients who died within three years after treatment and 19 still living after more than 3 years, there is no significant difference in age. Performance Status (PS), clinical stage, pathological type, mode of operation, number of PAC chemotherapy, use of radiation therapy, the volume of ascites, the degree of peritonitis carcinomatosa or the preoperative serum CA125 level. On the other hand, factors affecting prognosis are the presence of retroperitoneal lymph node metastasis, liver metastasis, and a decrease in the decline rate of serum CA125. The factors which worsened prognosis in the patients who died were: (1) advanced stage of PS (2) the mode of surgery (non-curative surgery), (3) ascites more than 2,000ml, (4) severe peritonitis carcinomatosa, (5) liver metastasis, (6) retroperitoneal lymph node metastasis, (7) mucinous cystadenocarcinoma as to pathological type, (8) the low decline rate of serum CA125.

Adult↗
PubMed1989

[Clinical course and prognosis of primary biliary cirrhosis--multivariant analysis on cases of national survey].

In order to predict prognosis and clinical course of BPC, theory quantification was applied and the discriminated rate was calculated concerning the cases of PBC national survey in Japan. We examined the prediction of three and five year's survival about all cases, the prediction of appearance of symptoms about asymptomatic PBC and that of jaundice about asymptomatic PBC and symptomatic PBC alone with pruritus. The useful items for the prediction of prognosis were serum bilirubin, albumin and the presence of esophageal varices at first medical examination. Fairly good discriminated rate was obtained on the prediction of three and five year's survival. However poor results were obtained concerning the prediction of appearance of symptoms. In conclusion we can predict the prognosis of PBC based on clinical features.

Aged↗
PubMed1989

[Prognosis and prevention of obstetric and perinatal pathology in threatened miscarriage].

To reveal risk factors for pregnancy miscarriage 1104 pregnant females (including 620 patients from the risk-group and 484 controls) were studied. 226 factors allocated to 16 groups were found to affect the outcome of pregnancy. The computer-assisted system for individual prognosis and stepwise dispensary observation with regard to fetoplacental function was developed. With its help, programme stages have been distinguished as follows: the formation of risk-groups and development of the pathogenetic prevention policy; prognosis for reasonabless of therapeutic maintenance of pregnancy in case of a developed risk for pregnancy miscarriage, prognosis for maternal and fetal outcomes in the initial stages of the delivery.

Abortion, Threatened↗
PubMed1989

[Short-term prognosis of schizophrenia in developed and developing countries. WHO international study program].

Two years of the catamnestic study of primary schizophrenia in a number of developed and underdeveloped countries using a common technique yielded a conclusion of likehood in short-term prognosis of the disease manifested in common types of its course. Nevertheless, a range of parameters reflecting clinical and social characteristics taken into account, the prognosis proved more benign in the developing countries. In discussion the possible explanation implying an increased rate of acute manifestations of schizophrenia in developing countries is rejected, for the benign prognosis of the disease takes shape in any type of the debute, regardless of its acuteness. The role of socio-cultural factors is assumed to be most pronounced in the above prognostic divergences.

Cross-Cultural Comparison↗
PubMed1989

[Factors responsible for prognosis of chronic subdural hematomas].

239 adult patients with chronic subdural hematoma were reviewed in order to analyse recent characteristics, and the responsible factors affecting functional prognosis. Patients with hygroma, diagnosed by the nature of the subdural fluid, were included since the mode of treatment is regarded as the same. 226 cases were surgically treated with standardized two burr-holes and irrigation, within which 24 cases required reoperation and 13 cases were medically treated since the hematoma was small and there was no mass effect. Functional outcome was evaluated by the Glasgow Outcome Scale. The number of cases have gradually increased, especially among elderly patients and in female ones. 179 patients were categorised as having good recovery, 25 as moderately disabled, 27 as severely disabled, 3 as persistently vegetative, and 5 patients died. Aged patients with preoperative mental change and a disturbance of consciousness, with low dense or mixed dense hematoma without sizable mass effect, with watery-clear or xanthochromic fluid cavity tended to have poorer outcome. Also the prognosis of patients not operated on was poor despite the spontaneous disappearance of the cavity. The delay in re-expansion of the brain had less bearing on the functional prognosis than might be expected. The factors which impeded good recovery were primary brain damage due to preceding diseases such as cerebral infarct or hemorrhage, initial head injury, parkinsonism, and postoperative psychiatric disturbances. The mean age of these patients was significantly higher than those with good recovery.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗