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PubMed2006

Creative thinking in adolescents with attention deficit hyperactivity disorder (ADHD).

A widened attentional focus, that is typically associated with ADHD, has been postulated to be accompanied by enhanced creative ability. However, creativity has been only limitedly examined in ADHD. Performance across several creativity measures were investigated in three groups: adolescents with ADHD, those with conduct disorder, and a healthy control sample. The ADHD group exhibited selective cognitive advantages and disadvantages by demonstrating an enhanced ability in overcoming the constraining influence of examples, but a reduced capacity to generate a functional invention during an imagery task. These findings are interpreted with reference to inhibitory control mechanisms and the contextual modulation of creative cognition.

Adolescent↗
PubMed2006

Developments in pharmacotherapy for tobacco dependence: past, present and future.

In the mid-1970s there were no effective pharmacological treatments for tobacco dependence. The invention of nicotine gum was a major treatment advance and also greatly helped our understanding of the nature of tobacco dependence. There are now eight effective pharmacotherapies (nicotine gum, patch, nasal spray, inhaler, lozenge/tablet, bupropion, nortriptyline and clonidine) available to aid smoking cessation. Other non-nicotine agents that show promise are under investigation, including glucose, rimonabant, selegiline and varenicline. Greater knowledge of the mechanisms of action of the effective non-nicotine agents should lead to better understanding of the nature of tobacco dependence. Future research into optimal treatments should examine long-term combination pharmacotherapy combined with improved psychosocial support that is partly designed to enhance medication compliance. In addition, there is a need for studies designed to evaluate the efficacy of pharmacotherapies in populations such as youth, pregnant smokers and smokers with co-occurring mental health problems.

Adolescent↗
PubMed2006

"Marina-Trinkkur" and a few more modern-time hydrotherapeutic myths from the Kvarner region of NW Croatia.

PURPOSE: The present paper tries to address the rise and decay of the sea-water "cult" in regional health tourism in NW Croatia, concentrating upon and analysing more thoroughly the example of Marina, chemically processed sea water, an invention of Dr Géza Fodor, the Hungarian physician practicing in that part of Croatia. METHOD: The original documents and archived items related to the topic were examined. Furthermore, we investigated numerous communal bulletins and medical authorities' records of respective time. RESULTS: Our research showed that the sea-water baths, introduced thanks to the influence of balneologists (like J. Glax), and "drinking cures" (advocated by M.-J. Ortel, for instance) were surprisingly popular not only among tourists of the time, but also among the physicians that used them extensively for therapeutical purposes. These baths and "drinking cures" enriched and completed the medical offer of the resorts regardless of their sometimes dubious effectiveness. CONCLUSIONS: This simple distilled sea-water preparation, advertised as a real panacea, demonstrates a paradigm that elucidates the mentality of physicians, merchants, and patients/consumers of the time.

Balneology↗
PubMed2004

A brief exploration of neurological art history.

The invention of realistic portraiture to reveal "inner life" is attributed by some art historians to Jan van Eyck who worked in Flanders from 1420 onwards. We show, using clinical neurological examination of the gold mask of Agamemnon dating from 1550-1500 BC and of the portraits of Henry III and his son Edward I -- important English royals -- painted between 1216 and 1307, that realistic portraits were made well before the 15th Century. Thus artists unwittingly used neurology as part of their realistic approach to the presentation of the face. Because neurological diagnosis is often visual, neurology, in turn, has a rich potential to unveil examples of realism in art. We consider the art pieces examined here also pertinent to art historians, as they assess the role of art in documenting history.

Blepharoptosis↗
PubMed2004

Philosophical instruments and toys: optical devices extending the art of seeing.

Philosophical instruments were designed to examine phenomena experimentally, rather than by naturalistic observation alone. In the nineteenth century, some instruments were called philosophical toys because they provided popular amusement as well as experimental assistance. They were applied widely in natural philosophy, but attention here is directed particularly to manipulations of perceived space and time and their influence on art. One of the earliest instruments, which had a profound impact on art as well as science, was the camera obscura. It assisted image formation in art before it was applied as an analogy to the eye at the beginning of the seventeenth century. Later philosophical toys were used to address visual perception of motion and depth. Development was initially driven by the need for stimulus control so that the methods of physics could be applied to the study of perceptual phenomena. The principal instruments were invented in the first half of the nineteenth century, and they consisted of simple contrivances that manipulated time and space in ways that had not previously been appreciated. They included thaumatropes, phenakistoscopes, stroboscopes, anorthoscopes, stereoscopes, tachistoscopes, and chronoscopes. Several of these philosophical toys proved to be phenomenally popular, particularly when combined with photography.

History, 16th Century↗
PubMed2004

When a lie becomes the truth: the effects of self-generated misinformation on eyewitness memory.

This research investigated whether generating misinformation impairs memory for actual information. After watching a videotaped robbery, some witnesses were interviewed about it, but others did not rehearse the event details. One week later, the witnesses tried to remember the robber's appearance. In Experiment 1, those who fabricated a description of the robber during the interview and those who did not rehearse remembered fewer correct details than did truthful witnesses or those who fabricated about another person. Witnesses who fabricated about the robber also reported more incorrect details than did truthful or non-interviewed witnesses. In Experiment 2, witnesses who fabricated about the robber performed as poorly on the memory test as did witnesses who answered interview questions using false information prepared for them. In both experiments deceptive witnesses sometimes reported invented details on the memory test, suggesting that they may have come to believe some fabrications.

Adolescent↗
PubMed2006

Intrusion errors in visuospatial working memory performance.

This study tested the hypothesis that failure in active visuospatial working memory tasks involves a difficulty in avoiding intrusions due to information that is already activated. Two experiments are described, in which participants were required to process several series of locations on a 4 x 4 matrix and then to produce only the final location of each series. Results revealed a higher number of errors due to already activated locations (intrusions) compared with errors due to new locations (inventions). Moreover, when participants were required to pay extra attention to some irrelevant (non-final) locations by tapping on the table, intrusion errors increased. Results are discussed in terms of current models of working memory functioning.

Adolescent↗
PubMed2003

Accomplishing technology transfer: case-based lessons of what works and what does not.

This paper presents lessons drawn from technology transfer case studies that address the persistent question: "What works, what does not, and why?" Each lesson highlights critical factors determining success or failure and is substantiated by case studies that exemplify the lesson. The case examples involve either the commercialization of prototype inventions (supply-push technology transfer) or the acquisition of desired technologies from other fields of application (demand-pull technology transfer). The cases present the chronology of events as they actually occurred, including supporting information from the other participants. Applying the lessons should help avoid common mistakes while increasing the likelihood of accomplishing the desired outcomes.

Commerce↗
PubMed2005

Creating accessible science museums with user-activated environmental audio beacons (ping!).

In 2003, Touch Graphics Company carried out research on a new invention that promises to improve accessibility to science museums for visitors who are visually impaired. The system, nicknamed Ping!, allows users to navigate an exhibit area, listen to audio descriptions, and interact with exhibits using a cell phone-based interface. The system relies on computer telephony, and it incorporates a network of wireless environmental audio beacons that can be triggered by users wishing to travel to destinations they choose. User testing indicates that the system is effective, both as a way-finding tool and as a means of providing accessible information on museum content. Follow-up development projects will determine if this approach can be successfully implemented in other settings and for other user populations.

Architectural Accessibility↗
PubMed2006

Absinthe--a review.

The alcoholic beverage absinthe is recently experiencing a revival after a yearlong prohibition. This review article provides information on all aspects of this bitter spirit and its major components, especially wormwood (Artemisia absinthium L.), which contains the toxic monoterpene thujone. Over 100 references on historic and current literature are provided. The topics comprise the history of the alcoholic drink starting from its invention in the eighteenth century. Historical and modern recipes are discussed in the context of different quality categories and possibilities to reduce the content of thujone are given. The analytical techniques used to verify compliance with the maximum limit of thujone as well as further possibilities for quality control of absinthe are discussed. The toxicology of absinthe is reviewed with regard to the cause of a syndrome called "absinthism," which was described after chronic abuse of the spirit in the nineteenth century. Finally, a food regulatory and food chemical evaluation is provided and minimum requirements for absinthe are suggested. Absinthe should have a recognizable wormwood flavor and after dilution with water the characteristic clouding should arise (louche-effect). Products, which are advertized as being of premium grade should be made by distillation, should have an alcoholic strength of at least 45%vol, and should not contain artificial dye.

Absinthe↗
PubMedDate not supplied

Prebiotic chemistry and the origin of the RNA world.

The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World. The central problem for origin-of-life studies, therefore, is to understand how a protein-free RNA World became established on the primitive Earth. We first review the literature on the prebiotic synthesis of the nucleotides, the nonenzymatic synthesis and copying of polynucleotides, and the selection of ribozyme catalysts of a kind that might have facilitated polynucleotide replication. This leads to a brief outline of the Molecular Biologists' Dream, an optimistic scenario for the origin of the RNA World. In the second part of the review we point out the many unresolved problems presented by the Molecular Biologists' Dream. This in turn leads to a discussion of genetic systems simpler than RNA that might have "invented" RNA. Finally, we review studies of prebiotic membrane formation.

Catalysis↗
PubMedDate not supplied

Health communication: making the most of new media technologies--an international overview.

Not since the hundred years following Gutenberg's invention of the printing press in c. 1450 has there been such a tidal wave of change in the way humans communicate. We are moving from the Age of Mass Communication into the Age of Interactive Communication, in which many of the old communication models will be insufficient or redundant. The rate of diffusion of these new media technologies almost defies comprehension. The convergence of computer, telecommunication, and televisual technologies is presenting the consumer with a myriad of choices. The challenge for the communicator is to find a way through this maze and to ensure that the message is received. For the health communication professional, the urgency of the message often adds further difficulty to the task. Differing rates of diffusion internationally and a confusion of technologies do not make the problem any easier.

Communication↗
PubMedDate not supplied

William Penn and the peace of Europe.

The Quaker William Penn proposed a European Union to ensure peace in the continent in 1693. Penn was unusual among Quakers in being of the landed upper classes. When converted, he became a leader of the Quakers and other Dissenters. He had the two related ideals of peace and religious toleration, and dreamed of realizing both ideals in the New World. A practical idealist, he took advantage of four factors: friends at Court made through his social position; King Charles II's gratitude for services rendered by his father, Admiral Sir William Penn; the King's desire to conciliate the City merchants, who were ready to invest in Penn's scheme; and above all the King's concern to get North America settled by British colonists. Penn received a charter to found Pennsylvania in 1681. In England he worked hard, especially in collaboration with James II, for toleration for the cruelly persecuted Quakers and other Dissenters. In Pennsylvania he was able to establish complete toleration and his fair and friendly treatment gave the colony 70 years of peaceful co-existence with the Indians. In his essay on the peace of Europe, he virtually invented collective security and with amazing foresight planned in detail something very like the present European Union.

Christianity↗
PubMedDate not supplied

The eight myths of Operation 'Desert Storm' and Gulf War syndrome.

Several conventional claims regarding Gulf War Syndrome are criticized: that Gulf War veterans are no sicker than the civilian population as a whole; that Gulf War Syndrome is a myth invented by the press; that GWS cannot be defined as a legitimate medical syndrome; that since its cause cannot be determined, it is not a problem associated with Operation 'Desert Storm'; that the US and UK governments are doing all they can to investigate and treat illness in veterans or deny existence of over 100,000 cases in veterans and their families; that GWS will settle without treatment; that the armed forces were well prepared for integrated conflict involving chemical and biological warfare in the Middle East, increasing the risk of this in the future.

Diagnosis, Differential↗
PubMed1997

Pioneers of the intrauterine device.

The history of the intrauterine device is remarkably short and its survival has been jeopardized several times from the beginning when Gräfenberg introduced the intrauterine ring in 1928, and later when product liability claims in the USA forced companies to withdraw the IUD from the market. However, a revival is happening, and one of the withdrawn copper IUDs has been re-introduced in the USA. In the 1980s, pessimism about the future of the IUD was based on the fact that there are still two major imperfections inherent in intrauterine contraception: its lack of protection against both 'gyne' and sexually transmitted disease. That IUDs, in contrast with some other methods, do not protect the wearer against microbiological invasion from the lower genital tract is correct, and will probably remain so notwithstanding the prophylactic use of antibiotics at the time of insertion. However, the solution to this imperfection is quite simple: clinicians must learn once and for all to adhere to the principle that bilateral monogamy is the first prerequisite for the safe use of this method of contraception. The second drawback of the IUD is the absence of so-called 'gyne' protection. Although seldom threatening women's health, menorrhagia, occasionally accompanied by pain, is a nuisance, and bleeding problems remain the most frequent single reason for the removal of an IUD. Consequently, research should concentrate on the alleviation of abnormal vaginal bleeding. Prevention is difficult, mainly because the etiopathology of abnormal bleeding is insufficiently understood. Menstrual hemostasis is a complex phenomenon and attempts at etiological treatment give poor results. However, because bleeding is, in all probability, related to an endometrial trauma caused by the geometric incompatibility between the frame of the IUD and the uterine cavity, it was logical for research to concentrate on correcting this factor. This review provides some historical notes about the pioneers who contributed to the improvement of intrauterine contraception since the introduction of the intrauterine ring by Gräfenberg in 1928 until the invention of the frameless device by Wildemeersch in 1984.

Consumer Product Safety↗
PubMed2004

MEDISIGN: Educating designers for the operating room.

One of the interesting things about medical technology is that it addresses so many diverse subjects, which is indeed the case in all departments of a hospital, in general practice and in other care agencies. Medical technology contributes to the diagnosis, treatment and prevention of disease and disorders. Designing for medical applications demands a high level of creativity and inventivity, both in low-tech and in high-tech applications. In over 200 projects with hospitals and companies in the medical field the Delft industrial designer has therefore played an important part in designing innovative products [ 1 ]. In the new program Medisign the expertise and networks that have been built up in this area over the past 20 years are being passed on to students. The program is based upon the idea that education of engineers in human anatomy, physiology, medical technoloy, health care systems and even basic surgical techniques will lead to better communication with the medical professionals and to better design solutions in this area. To our knowledge this is the first initiative in Europe in which structural education in anatomy is offered to industrial design engineers.

Journal Article↗
PubMedDate not supplied

The Early Reading Screening Instrument: a method for identifying kindergarteners at risk for learning to read.

This study was designed to provide speech-language pathologists and educators with a method for identifying children at risk for reading failure. The Early Reading Screening Instrument (ERSI) was given to 149 end-of-the-year kindergarten children. Half of the sample was tested 1 year later with standardized reading measures. Total ERSI scores from the kindergarten children strongly correlated with reading skills in first grade. Reading comprehension in first grade was the skill most strongly predicted by the subjects' total ERSI scores. The word recognition and invented spelling subtests of the ERSI were the best variables to be selected as predictors of first grade word analysis, word identification, and passage comprehension skills. A split-half reliability study of the ERSI showed that a shortened form could be used with the same degree of predictive validity. The ERSI or similar tools can be used to assess reading readiness in kindergarten children so that we can promptly begin an intervention to prevent or, at the very least, to diminish risk for reading failure. For screening reading readiness across different languages or cultures, the content of the four ERSI subtests can easily be modified.

Analysis of Variance↗
PubMed2007

Aging and the intrusion superiority effect in visuo-spatial working memory.

This study investigated the active component of visuo-spatial working memory (VSWM) in younger and older adults testing the hypotheses that elderly individuals have a poorer performance than younger ones and that errors in active VSWM tasks depend, at least partially, on difficulties in avoiding intrusions (i.e., avoiding already activated information). In two experiments, participants were presented with sequences of matrices on which three positions were pointed out sequentially: their task was to process all the positions but indicate only the final position of each sequence. Results showed a poorer performance in the elderly compared to the younger group and a higher number of intrusion (errors due to activated but irrelevant positions) rather than invention (errors consisting of pointing out a position never indicated by the experiementer) errors. The number of errors increased when a concurrent task was introduced (Experiment 1) and it was affected by different patterns of matrices (Experiment 2). In general, results show that elderly people have an impaired VSWM and produce a large number of errors due to inhibition failures. However, both the younger and the older adults' visuo-spatial working memory was affected by the presence of activated irrelevant information, the reduction of the available resources, and task constraints.

Adolescent↗