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At least 1,639 records · Page 91Linked to original sources
PubMed2005

Introducing a freely accessible internet database for identification of cerebral aneurysm clips to determine magnetic resonance imaging compatibility.

OBJECTIVE: Knowledge of the magnetic properties of cerebral aneurysm clips in patients undergoing magnetic resonance imaging (MRI) is imperative. In daily practice, however, it is often impossible to derive this information from previous medical records. The aim of this study was to develop a freely accessible internet database to identify unknown cerebral aneurysm clips on the basis of conventional x-ray images of the cranium and to provide reliable information about their magnetic properties to allow safe MRI investigations in these patients. METHODS: The 17 most commonly used clip series of the past 50 years were selected. The ferromagnetic properties of 47 example clips were examined by means of the Food and Drug Administration-approved "deflection angle test." An HTML-based database has been developed using standard x-ray images in two planes and photographs of the clips. Furthermore, details about alloy, ferromagnetic properties, MRI compatibility, year of construction, and other characteristics identifiable on x-rays were included. RESULTS: Seven aneurysm clips (of four clip models) were judged to be not MRI-compatible. The database named "ClipFinder" allows easy identification of cerebral aneurysm clips on standard cranial x-rays by comparing the films with the databank images supported by information on unique features of the clip design. CONCLUSION: On exemplary applications, ClipFinder provides a fast and easy-to-use database to identify unknown cerebral aneurysm clips via the internet and determine their MRI compatibility. The reliability of the identification system needs to be further evaluated in clinical practice before it can be recommended for widespread use.

Contraindications↗
PubMed2002

An evaluation of the applicability of quantitative clinical standards for the management of genital chlamydial infection using an electronic database.

A prototype electronic database was designed for use as a retrospective audit tool to provide data that allowed comparison of genital chlamydial infection management performance with a series of quantitative operational consensus standards. However, some of the terms used by the standards require further definition for translation into database fields to improve accuracy and general application as an audit tool. Construction of the database involved differentiation between prior and clinic diagnostic points, as well as a forward contact trail of specific quantitative indicators of contact tracing. More definition is needed of the meaning of diagnosis and contact in the standards. For clinic-diagnosed patients, the time to treatment was mainly dependent on clinical factors, not on the availability of a chlamydial test result. For about one-third of patients (with prior management), several standards cannot be applied because data are not available, and this raises the issue of data sharing between various agencies involved in chlamydial testing. More data from other clinics may help both to test the appropriateness of, and inform, some of the operational standards. The database could be developed as a real-time audit tool for use with electronic patient records.

Ambulatory Care↗
PubMed2005

[Guideline on radiation protection in medicine requires documentation of radioiodine therapy and follow-up: What are the benefits of an electronic database?].

AIM: The lately updated German guideline on radiation protection in medicine (Richtlinie Strahlenschutz in der Medizin) requires the physician who administers radioactive substances for therapy, to perform and document follow-ups. In order to decrease the administrative burden, an electronic database was developed that interfaces with a word processing software to generate written reports and statistic analysis. METHODS: Based on Microsoft Access and Microsoft Visual Basic a database was created to monitor patients with benign and malignant thyroid disorders after radioiodine therapy. It permits automatic creation of therapy documents and necessary patient reports in Microsoft Word. Intuitive handling, third level of normalization in database architecture and automatic plausibility checks guarantee integrity of the data and the efficacy of the database. RESULTS, CONCLUSION: The new software has been a success in over 1500 patients and over 3800 in- and outpatient therapies and visits. The effort of data entry is easily offset by the automatic generation of the necessary patient reports. The required supervision of the follow-up appointments is now also user-friendly and efficient.

Databases, Factual↗
PubMed1991

Predicting mammalian mutagenesis by submammalian assays: an application of database GEN.

A database containing qualitative information on the genotoxic activity of about 3000 chemicals is described. The initial aim for the construction of the database was to develop an instrument for comparing the performance of different genotoxicity assay systems. One application of the database is the prediction of expected results in any genotoxicity assay for chemicals that were tested in a small number of genotoxicity assays. The Bayesian prediction is calculated based on the sensitivities and specificities between any predictive test and the target test for which the prediction is to be determined. The predictivity of the system for in vivo mammalian assays is at present (with the exception of the micronucleus assay and the in vivo sister chromatid exchanges) limited, in particular because of the limited number of chemicals tested in the expensive in vivo assays and, in addition, due to the lack of sufficient information on negative compounds. A continued updating of the database will possibly help to overcome some of the present difficulties.

Animals↗
PubMed1999

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature in 1993 to 1994 and by the National Toxicology Program in 1995 to 1996.

The Carcinogenic Potency Database (CPDB) is a systematic and unifying analysis of results of chronic, long-term cancer tests. This paper presents a supplemental plot of the CPDB, including 513 experiments on 157 test compounds published in the general literature in 1993 and 1994 and in Technical Reports of the National Toxicology Program in 1995 and 1996. The plot standardizes the experimental results (whether positive or negative for carcinogenicity), including qualitative data on strain, sex, route of compound administration, target organ, histopathology, and author's opinion and reference to the published paper, as well as quantitative data on carcinogenic potency, statistical significance, tumor incidence, dose-response curve shape, length of experiment, duration of dosing, and dose rate. A numerical description of carcinogenic potency, the TD(subscript)50(/subscript), is estimated for each set of tumor incidence data reported. When added to the data published earlier, the CPDB now includes results of 5,620 experiments on 1,372 chemicals that have been reported in 1,250 published papers and 414 National Cancer Institute/National Toxicology Program Technical Reports. The plot presented here includes detailed analyses of 25 chemicals tested in monkeys for up to 32 years by the National Cancer Institute. Half the rodent carcinogens that were tested in monkeys were not carcinogenic, despite usually strong evidence of carcinogenicity in rodents and/or humans. Our analysis of possible explanatory factors indicates that this result is due in part to the fact that the monkey studies lacked power to detect an effect compared to standard rodent bioassays. Factors that contributed to the lack of power are the small number of animals on test; a stop-exposure protocol for model rodent carcinogens; in a few cases, toxic doses that resulted in stoppage of dosing or termination of the experiment; and in a few cases, low doses administered to monkeys or early termination of the experiment even though the doses were not toxic. Among chemicals carcinogenic in both monkeys and rodents, there is some support for target site concordance, but it is primarily restricted to liver tumors. Potency values are highly correlated between rodents and monkeys. The plot in this paper can be used in conjunction with the earlier results published in the CRC Handbook of Carcinogenic Potency and Genotoxicity Databases [Gold LS, Zeiger E, eds. Boca Raton FL:CRC Press, 1997] and with our web site (http://potency.berkeley.edu), which includes a guide to the plot of the database, a complete description of the numerical index of carcinogenic potency (TD50), and a discussion of the sources of data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. Two summary tables permit easy access to the literature of animal cancer tests by target organ and by chemical. For readers using the CPDB extensively, a combined plot on diskette or other format is available from the first author. It includes all results published earlier and in this paper, ordered alphabetically by chemical. A SAS database is also available.

Animals↗
PubMedDate not supplied

Sharing best practice: developing a Web-based database.

This article reports on the development of a web-based interactive database that was designed to facilitate the dissemination of practice development, research and audit projects across a large NHS trust. A multidisciplinary team worked collaboratively to design the database in order to ensure that it incorporated features which made it easy for the end user. Concise structured information on each project was recorded and search facilities incorporated to facilitate access to information. Hyperlinks to other web pages on the Internet and the Trust intranet were created and full reports/publications of projects were included for those who wanted more information. The subsequent implementation across the organization involved promoting the database, helping practitioners develop skills to access information, setting up quality review procedures for projects and evaluating its use. The development of the database has highlighted that time, the availability of computers in clinical areas and skills development are important considerations when taking forward information technology (IT) initiatives.

Benchmarking↗
PubMed1987

Application of a general database manager in a clinical medical librarian program.

The morning report reference file was automated at the Stollerman Library because the manual system was time-intensive to maintain and cumbersome to search. A general database management system (DBMS) was chosen so that it could be used in the future for other data management functions in the library. DBMS features that should be examined before use with a bibliographic application include size limitations, data entry forms, data types, search options, index files, sort options, report generation, query and programming languages, command and/or menu files, file interaction, interface with other software, and documentation. Desired requirements for this application are discussed. It is noted that a general database manager probably will not meet all of the desired requirements. For some bibliographic applications, software specifically designed for bibliographic information management and retrieval should be used. A database for the purposes of searching the morning report reference file and producing a weekly reference list and a yearly index was developed using CONDOR 3. The structure of the database is described, and examples of the reports are given. The system has been in operation since December 1984 and has been well-received by staff and patrons.

Database Management Systems↗
PubMed2001

Accessing the literature: using bibliographic databases to find journal articles. Part 1.

Research in primary dental care, recertification, continuing professional development, lifelong learning, peer review and quality healthcare are all informed by the published literature. Dental practitioners can find out about reliable and up-to-date information available in the published literature by searching bibliographic databases. Published in two parts, this article describes the databases relevant to clinical dental practice and explains the generic skills required to search them effectively, focusing on MEDLINE, the database most relevant for the majority of dental practitioners, which is freely available via the World Wide Web (WWW). The article differentiates between sensitivity (maximum recall) and specificity (relevance of recall), and suggests how to identify a manageable number of relevant citations, how to save the citations, and how to obtain the full text. In part 2, the article concludes by alerting readers to some of the limitations and pitfalls of database-searching.

Abstracting and Indexing↗
PubMed2000

A skeletal gene database.

Systematic organization of documented data coupled with ready accessibility is of great value to research. Catalogs and databases are created specifically to meet this purpose. The Skeletal Gene Database evolves as part of the Skeletal Genome Anatomy Project (SGAP), an ongoing multi-institute collaborative effort, to study the functional genome of bone and other skeletal tissues. The primary objective of the Skeletal Gene Database is to create a contemporary list of skeletal-related genes, offering the following information for each gene: gene name, protein name, cellular function, disease(s) caused by mutation of the corresponding gene, chromosomal location, LocusLink number, gene size, exon/intron numbers, messenger RNA (mRNA) coding region size, protein size/molecular weight, Online Mendelian Inheritance in Man (OMIM) number of the gene, UniGene assignment, and PubMed reference. The database includes genes already known and published in the literature as well as novel genes not yet characterized but known to be expressed in skeletal tissue. It will be posted on the web for easy access and swift referencing. The data will be updated in tempo with current and future research, thereby providing an invaluable service to the scientific community interested in obtaining information on bone-related genes.

Bone and Bones↗
PubMed2006

Online database for documenting clinical pathology resident education.

BACKGROUND: Training of clinical pathologists is evolving and must now address the 6 core competencies described by the Accreditation Council for Graduate Medical Education (ACGME), which include patient care. A substantial portion of the patient care performed by the clinical pathology resident takes place while the resident is on call for the laboratory, a practice that provides the resident with clinical experience and assists the laboratory in providing quality service to clinicians in the hospital and surrounding community. Documenting the educational value of these on-call experiences and providing evidence of competence is difficult for residency directors. An online database of these calls, entered by residents and reviewed by faculty, would provide a mechanism for documenting and improving the education of clinical pathology residents. METHODS: With Microsoft Access we developed an online database that uses active server pages and secure sockets layer encryption to document calls to the clinical pathology resident. Using the data collected, we evaluated the efficacy of 3 interventions aimed at improving resident education. RESULTS: The database facilitated the documentation of more than 4 700 calls in the first 21 months it was online, provided archived resident-generated data to assist in serving clients, and demonstrated that 2 interventions aimed at improving resident education were successful. CONCLUSIONS: We have developed a secure online database, accessible from any computer with Internet access, that can be used to easily document clinical pathology resident education and competency.

Clinical Competence↗
PubMed2004

Parasite genome databases and web-based resources.

In the last decade, high-throughput genome sequencing and complementary techniques such as microarray and proteomics have generated, and will continue to generate, ever-increasing amounts of data. These technologies of gene discovery, expression, and functional analysis have been applied to a vast array of organisms, including parasites. In most instances, the data are freely available via the Internet, and researchers are becoming increasingly reliant on up-to-date, centralized data repositories to complement wet bench science. This chapter presents an overview of resources relevant to researchers with an interest in para-site genomics and biology. After briefly touching on some of the publicly available nucleotide and protein sequence as well as domain databases, the focus turns to parasite genome projects and associated Web-based resources. A list of parasite sequencing projects current at the time of writing, including relevant Web site addresses, is provided. The available resources range from network sites and project pages at sequencing institutes to databases that integrate and curate sequence data and associated annotation with diverse biological datasets. Particular attention is given to three databases, GeneDB (http://www.genedb.org/), PlasmoDB (http://plasmodb. org/), and tigr db, detailing the scope of each database and the tools available for data querying and retrieval.

Animals↗
PubMed1999

The EMBL Nucleotide Sequence Database. Contributing and accessing data.

The European Molecular Biology Laboratory Nucleotide Sequence Database receives sequence and sequence annotation data from genome projects, sequencing centers, individual scientists, and patent offices. Data may be most efficiently submitted to the database using the Internet based submission tool WEBIN or via previously established genome project accounts. Biologist curators will review the data and provide accession numbers within two working days. Non-confidential data are exchanged daily in an international collaboration between EMBL. DDBJ (the DNA Databank of Japan) and GenBank (USA) and may be accessed and retrieved via the Internet with the Sequence Retrieval System (SRS). Sequence database searching algorithms (e.g., Blitz, Fasta, Blast) are available for comparison of query to database sequences.

Amino Acid Sequence↗
PubMed2002

Searching sequence databases via de novo peptide sequencing by tandem mass spectrometry.

There are many computer programs that can match tandem mass spectra of peptides to database-derived sequences; however, situations can arise where mass spectral data cannot be correlated with any database sequence. In such cases, sequences can be automatically deduced de novo, without recourse to sequence databases, and the resulting peptide sequences can be used to perform homologous nonexact searches of sequence databases. This article describes details on how to implement both a de novo sequencing program called "Lutefisk," and a version of FASTA that has been modified to account for sequence ambiguities inherent in tandem mass spectrometry data.

Algorithms↗
PubMed2004

A review of the Vaccine Adverse Event Reporting System database.

The Vaccine Adverse Event Reporting System (VAERS) is an epidemiological database that has been maintained by the FDA and Centers for Disease Control and Prevention (CDC) since 1990. Authors from the National Immunization Programme of the CDC have previously described an epidemiological technique to make qualitative and quantitative measurement in the VAERS database. Application of this technique by ourselves (with further refinements and additions) have resulted in numerous publications showing the VAERS database has good positive predictive value in evaluating vaccine safety concerns that are compatible with observations by many other authors who have analysed different databases. In conclusion, VAERS studies will be particularly critical in the evaluation of the safety of many new or radically changed vaccines expected to be introduced in the relative near future.

Adverse Drug Reaction Reporting Systems↗
PubMed2006

Journals in surgery and gastroenterology: indexing in databases and bibliometric indicators.

INTRODUCTION: Publishing research results as journal articles is the most common format used by researchers for dissemination of advancements in science. To select where to publish, authors must know how to identify the most recognized journals in each field, adopting quality criteria. PURPOSE: To discuss journal selection criteria and bibliometric indicators for evaluation of scientific production and to analyze the status of indexing of Brazilian and international journals in health science databases, mainly for journals in surgery and gastroenterology fields. RESULTS: The totals of journals indexed in health science databases are presented, highlighting the relative participation of journals in surgery and gastroenterology in each database. CONCLUSION: The decision to publish in a national or international journal should be based on bibliometric indicators and status of indexing in databases, but the objectives of the research must be the main point considered by authors.

Abstracting and Indexing↗
PubMed2005

Analysis of a database of pesticide residues on plants for wildlife risk assessment.

Current methods to estimate exposure of wildlife to pesticides from diet depend on a database of published residue concentrations on crop plants normalized to a standard application rate to obtain a residue from a unit dosage (RUD). This database, first published in the early 1970s, was updated in the 1990s. For each category of crops, maximum and mean residues are determined and used to extrapolate concentrations on plants across application rates in calculations of risk. The present study aims to update the database, to examine the validity of extrapolating RUD values across application rates, and to improve the categorization of crops using crop morphology and cultivation methods. The slope of the linear regression of residue concentrations against application rate in 41 trials was significantly different from one in all but five cases. This supports the assumption that residue concentrations are directly proportional to the application rate, although less than half the variance in residue concentrations was explained by the linear model. Residues on leaves were partitioned into eight categories of crops using information regarding plant morphology and cultivation method. Fruit size was an additional variable useful for segregating residues into four categories: Small fruits, large fruits, pods, and grains. The proposed changes increase the amount of variance explained in the residue database from 19 to 32%. Depending on the crop category, residues on fruits were 2- to 16-fold lower than those on leaves. Residue concentrations on leaves of short plants were more than fourfold higher than those on leaves of tall plants. Descriptive statistics are provided for each of the proposed crop categories.

Analysis of Variance↗
PubMed2002

Development of the spray drift task force database for aerial applications.

This article is part of a series describing the development of the Spray Drift Task Force (SDTF) database and its application to agricultural chemical exposure risk assessment modeling. The series describes the development of a large generic database (assuming that active ingredient rate is not a factor affecting physical drift) and its use in estimating spray movement immediately following application by aerial methods. The components of the database are described. In agreement with field trials in the open literature, the database shows that the major variables affecting off-target spray deposition are droplet size, spray release position (boom height and length), and wind speed and direction. In addition, secondary parameters that can affect these variables and drift are also discussed.

Aerosols↗
PubMed2004

Use of web-enabled databases for complex animal health investigations.

Web-enabled databases developed in the late 1990s to help organise large web sites and allow data capture via browser-based forms. By enabling users outside a closed network access to a central database, they permit greater flexibility than traditional 'client-server' systems. Accordingly, web-enabled databases introduce a new tool for epidemiologists, permitting direct data capture at source and thus avoiding many of the delays and errors arising from paper forms and manual data entry. In addition, real-time data collection permits sophisticated decision support and reporting, and thus improved project co-ordination and participation. Nevertheless, the technology is complex and the development of a web-application requires an attention to information technology project management equal to that of the scientific trial or investigation. The potential and problems of web database applications are illustrated by a bespoke system ('PathMan') developed by the Veterinary Laboratories Agency of the United Kingdom Department for Environment, Food and Rural Affairs to manage a large multi-site study investigating the pathogenesis of bovine tuberculosis in England and Wales.

Animal Diseases↗