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At least 1,639 records · Page 91Linked to original sources
PubMed1988

Milk production and composition in cows and goats fed alpha-ketoisocaproate.

To examine whether alpha-ketoisocaproate supplementation affects milk production, 10 goats were fed either 0 or 1.1% calcium-alpha-ketoisocaproate for 2 wk and 12 cows were fed either 0 or .75% Na alpha-ketoisocaproate for 3 wk. Supplementation with alpha-ketoisocaproate increased milk fat content, milk fat yield, and 4% FCM yield in cows by an average of 5, 10, and 8%, respectively, for the treatment period. In cows, response of milk fat yield to alpha-ketoisocaproate was 120 g during wk 1 of treatment but diminished to 55 g by wk 3. Milk yield and milk protein yield tended to be greater in cows fed alpha-ketoisocaproate, but milk production efficiency and body weight were not altered by treatment in either species. Supplementation with alpha-ketoisocaproate had no significant effect on fatty acid composition of milk but tended to increase the percentage of C10 and C12 fatty acids. In goats, supplementation with alpha-ketoisocaproate had no significant effect on milk production or composition, but trends toward increased milk fat and protein content were observed. Results indicate that alpha-ketoisocaproate acutely stimulates milk fat production in lactating cows and that this effect seems to diminish with time.

Animals↗
PubMed2005

Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors.

Branched-chain alpha-keto acid dehydrogenase kinase (BDK) phosphorylates and inactivates the branched-chain alpha-keto acid dehydrogenase complex (BCKDC), which is the rate-limiting enzyme in the branched-chain amino acid catabolism. BDK has been believed to be bound to the BCKDC. However, recent our studies demonstrated that protein-protein interaction between BDK and BCKDC is one of the factors to regulate BDK activity. Furthermore, only the bound form of BDK appears to have its activity. In the present study, we examined effects of BDK inhibitors on the amount of BDK bound to the BCKDC using rat liver extracts. The bound form of BDK in the extracts of liver from low protein diet-fed rats was measured by an immunoprecipitation pull down assay with or without BDK inhibitors. Among the BDK inhibitors. alpha-ketoisocaproate, alpha-chloroisocaproate, and a-ketoisovalerate released the BDK from the complex. Furthermore, the releasing effect of these inhibitors on the BDK appeared to depend on their inhibition constants. On the other hand, clofibric acid and thiamine pyrophosphate had no effect on the protein-protein interaction between two enzymes. These results suggest that the dissociation of the BDK from the BCKDC is one of the mechanisms responsible for the action of some inhibitors to BDK.

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)↗
PubMed1975

Myocardial extraction of labeled long-chain fatty acid analogs (38509).

The single circulation myocardial extraction of terminally iodinated hexadecenoic acid (77 plus or minus 11.0%) is approximately two times the extraction of 18 carbon fatty acids (33 plus or minus 5.2%) prepared by iodination of double bonds. The results compare favorably with natural 28 carbon steraic (70 plus or minus 7.5%) and oleic (61 plus or minus 7.8%) acids labeled with carbon-11 in the carboxyl group. It is concluded that terminally radioiodinated long chain fatty acids can be used as substitues for in vivo investigations of fatty acid distribution and in particular may be useful as a regional mycardial blood flow indicator.

Animals↗
PubMed1977

The effect of caproic acid, handling technique and storage times on the fertility of fowl spermatozoa.

The effects of three levels of caproic acid in glycine-citrate extender on preservation of fertilizing capacity of fowl spermatozoa were tested. Extended semen stored for 6 and 28 hours was used for insemination in diluted or reconcentrated forms. The results indicated that semen stored in the extender with the highest concentration of caproic acid provided superior fertility and showed the importance of proper handling of hens during insemination.

Animals↗
PubMed1980

Evaluation of penicillic acid for toxicity in broiler chickens.

Penicillic acid is a mycotoxin produced by various fungi. It may occur in high concentrations in corn and can also be produced concomitantly with other mycotoxins in poultry feed. This mycotoxin was evaluated for its toxicity in broiler chickens by feeding graded concentrations (0, 100, 200, and 400 microgram/g of diet) to 4 groups of 10 birds per treatment. No significant (P greater than .05) effects were measured on growth rate, feed conversion, relative size of pancreas, spleen, liver, heart, bursa, or kidney or on hemoglobin, packed cell volume, liver lipid, plasma protein, or glucose. The only significant effects were a slight reduction in the size of the proventriculus and gizzard at dose levels of 200 and 400 microgram/g. Neither the salt nor lactone forms of penicillic acid had any detectable effect. The acute oral LD50 for the sodium salt form was 92 +/- 9 mg/kg. These data suggest that penicillic acid by itself has little toxicity (less than 1% of that of aflatoxin) in chickens.

Animals↗
PubMed1981

High pressure liquid chromatographic determination of penicillic acid in chicken tissues.

Penicillic acid (PA) is a mycotoxin with reported cytotoxic, cardiotoxic, and carcinogenic activity and it can occur in high concentration in corn. The occurrence of PA in contaminated poultry feed represents a potential public health hazard. A reverse phase high pressure liquid chromatographic (HPLC) method is proposed for determining PA residues in chicken tissues. Optimization of chromatography was achieved for PA using a mobile phase consisting of acetonitrile: H2O. PA was detected by ultraviolet absorption at 254 nm, identified by retention time, and quantitated by peak area integration. Blood, parenchymal tissues, muscle, and alimentary tract contents were homogenized, sonicated, and acid treated followed by extraction with ethyl acetate and analysis by HPLC. Acute oral dosing of chickens with PA over a range of 50 to 550 mg/kg body weight resulted in detectable levels of the mycotoxin (confirmed by gas liquid chromatography) in gizzard muscle and contents, liver, kidney, heart, and intestinal contents. This method should prove useful both for the rapid and sensitive detection of PA residues in poultry and in further studies on the distribution and metabolism of this mycotoxin.

Animals↗
PubMed1984

The effect of feeding di-(2-ethylhexyl) phthalate and related compounds on lipids in the laying hen.

Di-(2-ethylhexyl) phthalate (DEHP) and three structurally related side-chain analogs were fed to laying hens to determine relationships of structure to effects on lipid metabolism. Hubbard broiler breeder hens were fed either a standard laying mash control diet or the control diet containing DEHP, 2-ethylhexanol (2-EH), 2-ethylhexanal (2-EHALD), or 2-ethylhexanoic acid (2-EHA). Experimental treatments lowered feed consumption, body weight, and egg production. The DEHP and side-chain analog diets lowered plasma total lipids. DEHP, 2% 2-EH, and 1% 2-EHA diets lowered plasma free cholesterol. Liver weights were not significantly changed, but liver fat was reduced. Lipid classes were measured by quantitative thin layer chromatography densitometry. The decreases observed in plasma lipids occurred primarily in the triglyceride fraction. Liver lipid decreases occurred mainly in triglyceride and free fatty acid classes. Hen egg yolk percent fat, lipid classes, and free and total cholesterol were unaffected by any DEHP or side-chain analog diets. Plasma and liver hypolipidemic effects were observed with all of the oxidation state structural analogs of DEHP's side chain, but 2% 2-EH was the most effective treatment. These results suggest that the active portion of DEHP may be the metabolite, 2-EH, formed in vivo by hydrolysis of DEHP's ester bond.

Aldehydes↗