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PubMed1988

B-chronic lymphocytic leukemia. Disease progression in 150 untreated stage A and B patients as predicted by bone marrow pattern.

Previous studies have shown that the pattern of bone marrow (bm) involvement in B-CLL patients is the single most important prognostic factor. In the present study we analyse the disease progression observed in 45 out of 150 untreated stages A and B, B-CLL patients in relation to their pattern of bm involvement. The mean treatment free period was 45 months (10-130). The distribution of bm patterns and disease progression in our series was as follows: in stage A, Bm patterns diffuse in 24 cases (21.8%); in stage B: in 21 cases (52.5%). Disease progression from stage A to stage B or C and from stage B to stage C was found 50% of the A and B-diffuse patients as compared to 10% of the A and B-nondiffuse. The mean period during which this progression occurred was 18 months for the stages A and B with a diffuse pattern and 59 months for the stages A and B with a nondiffuse pattern. No differences could be observed in the nondiffuse group when our patients were analysed on the basis of nodular, interstitial and mixed pattern of bm involvement. All progressed patients required therapy. These findings support our previous observations, and present further evidence that in B-CLL patients with a diffuse pattern of bm disease at diagnosis, treatment should be initiated independently of their clinical stage.

Adult↗
PubMed1987

"Theta pattern coma" occurring in younger adults.

Since our previous report, where "theta pattern coma" was described in 2 elderly patients as an EEG pattern with a grave prognosis, we have had the opportunity to see another 9 affected patients. In this article, 3 men with a mean age of 36 years who died after cardiorespiratory arrest presented a "theta coma pattern." The EEG activity was initially reactive to and attenuated by external stimulation in 2, but prior to death the pattern became arreactive. This article shows that "theta pattern coma" is not an age related phenomenon as previously considered. So far, 11 patients with this type of EEG abnormality have been seen in our department; all have died, and all were over 30 years of age. An expanded definition of "theta pattern coma" is given in the discussion. The pathophysiological mechanisms involved in generation of this abnormality are not known. This abnormality, when seen in the unconscious patient, should be classified as a grade 4 abnormality on the EEG coma scale and should be differentiated from rather diffuse theta activity in coma. The prognostic significance of "theta pattern coma" appears to be similar to that of "alpha pattern coma."

Adult↗
PubMed1985

Metabolism of benzo(a)pyrene by subcellular fractions of rat liver: evidence for similar patterns of cytochrome P-450 in rough and smooth endoplasmic reticulum but not in nuclei and plasma membrane.

Since our earlier work (P. Stasiecki, F. Oesch, G. Bruder, E.D. Jarasch, and W.W. Franke, Eur. J. Cell Biol., 21: 79-92, 1980) had shown that carcinogen-metabolizing monooxygenase activity was present in almost all investigated cellular membranes, the possibility of differential control of the various metabolic pathways in the individual cellular membranes arose. Using high pressure liquid chromatography we have now studied the benzo(a)pyrene metabolites formed by rough and smooth endoplasmic reticulum, nuclei, and plasma membrane as well as mitochondrial fractions and investigated the metabolic cooperation between the monooxygenases and epoxide hydrolase in these fractions. Since various cytochrome P-450 isozymes catalyze the oxidative attack on the benzo(a)pyrene molecule at defined preferential sites, this analysis also provides an indirect trace of potential differences in the pattern of cytochrome P-450 isozymes present in the individual membranes. The metabolic profiles produced by the two most active fractions, smooth and rough endoplasmic reticulum, were very similar to each other but different from those produced by the other three preparations. The metabolite pattern produced by incubations containing nuclear fractions differed slightly from that produced by the fractions of endoplasmic reticulum, but plasma membrane and mitochondria produced markedly different patterns. Since the similarity of the benzo(a)pyrene metabolite pattern produced by the smooth and rough endoplasmic reticulum suggested similar cytochrome P-450 isozyme patterns in these two subfractions, they were further investigated by the use of selective inducers as well as a broad spectrum substrate, 7-ethoxy-coumarin, in the absence and presence of selective inhibitors. Treatment of animals with trans-stilbene oxide or phenobarbital (a) increased the total amount of metabolites per protein mass and time, (b) changed the pattern of metabolites, but (c) induced a pattern of metabolites which was again very similar in rough and smooth endoplasmic reticulum. Even more distinct changes were found following treatment with 3-methylcholanthrene or beta-naphthoflavone. Both of these compounds (a) preferentially induced the activity of rough endoplasmic reticulum, (b) changed the profile of metabolites, but (c) again did not disturb the similarities of the benzo(a)pyrene metabolite pattern between both fractions.(ABSTRACT TRUNCATED AT 400 WORDS)

7-Alkoxycoumarin O-Dealkylase↗
PubMed1983

Visual-evoked potentials elicited by laser speckle patterns. Studies on the characteristics and assessment of visual function in patients with ocular media opacities.

Visual-evoked potentials (VEPs) were recorded using a laser speckle pattern. Stimulation with a speckle pattern was elicited either by pattern appearance-disappearance or by pattern shift. The VEPs obtained by this method were similar in properties to the previous pattern VEPs that were obtained either by pattern appearance-disappearance or by pattern reversal. Patients in whom dense and diffuse ocular media opacity defied measurement by the interferometric visual acuity method were studied to test if the speckle pattern generated by diffusion from lens opacity itself could act as a stimulus for obtaining VEPs. It is concluded that the present method enables one to obtain a reliable VEP and to assess the visual function of the retino-cortical system, even in patients with mature cataracts.

Adult↗
PubMed1983

[Hepatic vein blood flow pattern measured by Doppler echocardiography as an evaluation of tricuspid valve insufficiency].

Evaluation of tricuspid regurgitation was attempted by analyzing the blood flow pattern in the hepatic vein using a combined system of a pulsed Doppler technique and two-dimensional echocardiography. The Doppler incident angle to the hepatic vein from the subcostal approach was approximately 0 degrees to 30 degrees, and the Doppler output was easily recognized as a narrow frequency-band pattern on the sound spectrogram. The study population consisted of 60 patients with valvular heart disease and 17 healthy subjects. Inferior vena cava dimension (IVCD), hepatic vein dimension (HVD) and the blood flow pattern in the hepatic vein were compared with the severity (negative, mild, moderate and severe) of tricuspid regurgitation (TR) assessed by right ventriculography and with right atrial and ventricular pressures. The following conclusions were derived from the study: IVCD and HVD in a group of TR severe were significantly larger than those of the other groups. The normal flow pattern of the hepatic vein was biphasic with a systolic flow greater than a diastolic flow. In cases of valvular heart disease with atrial fibrillation, three types of abnormal blood flow patterns were demonstrated; Type 1 had a slower systolic flow than a diastolic flow. Type 2 had no flow signal during systole, and had only a diastolic flow. Type 3 had a reversed systolic flow with several variations. By this hepatic flow patterns, it was possible to differentiate the TR of severe and moderate groups from the TR of mild group, because 81% of the former groups showed a Type 3 of a flow pattern. The Doppler shifts from the base line on the sound spectrogram were well correlated with right atrial pressure and right ventricular end-diastolic pressure (r = -0.72 and -0.64, respectively). The early changes of the hepatic blood flow pattern after operation were due to the improvement of TR by tricuspid annuloplasty, and also seemed to be affected by the postoperative changes of right atrial compliance and contraction.

Adult↗
PubMed1980

Patterns of forced expiratory flows in groups at risk for chronic obstructive pulmonary disease.

In a modified case-control study of obstructive pulmonary disease (COPD), airways obstruction has been found to be associated with age, sex, protease inhibitor type, socioeconomic status (SES) and smoking. In this paper patterns of forced expiratory flows are examined in persons demonstrating various risk factors. Two broad patterns of flow limitation emerge. The first pattern, characterized by lower flows at high lung volumes, is found in first-degree relatives of patients with COPD and subjects with a low SES. This pattern, consistent dysfunction of large airways, may reflect reversible decreases of airway caliber. The second pattern, characterized by lower flows at low lung volumes, is found in older subjects. This pattern, consistent with nonhomogeneously emptying lungs or dysfunction of small airways, may reflect more chronic irreversible changes. Smokers and male subjects exhibit both patterns of flow limitation when compared with subjects who had never smoked and female subjects. It is possible that the combination of the patterns reflects a particularly high risk for the development of COPD in male smokers.

Adult↗
PubMed1993

[Changes in TXB2/6-keto-PGF1 alpha ratio and their relation to blood lipids of Type A behavioral patterns].

To study the pathophysiological relation between Type A behavioral pattern and coronary artery disease, we analyzed the Type A behavioral pattern, serum triglycerides (TG), cholesterol (TC), high density lipoprotein cholesterol (HDLc), and TXB2, 6-keto-PGF1 alpha in 60 patients with coronary artery disease and 60 age-sex-matched healthy subjects. All of them had normal blood pressure. The results showed Type A behavioral pattern was more prevalent than Type B behavioral pattern in coronary artery diseased patients and the reverse was true in the controlled subjects (P < 0.025); TG, TC and TXB2/6-keto-PGF1 alpha ratio increased significantly in Type A behavioral pattern compared with Type B behavioral patients, but HDLc/(TC+TG) and the level of HDLc decreased significantly in the Type A behavioral pattern than in the Type B behavioral pattern (P < 0.05). The TG, TC increased significantly and 6-keto-PGF1 alpha HDLc decreased significantly in the coronary artery diseased patients (P < 0.05). However, the ratio of TXB2/6-keto-PGF1 alpha was inversely related to HDLc/(TC+TG) among the coronary artery diseased patients. The results of this cross-sectional study suggest that coronary artery disease is associated with Type A behavioral pattern through the metabolism of lipids and prostaglandins in various ways.

6-Ketoprostaglandin F1 alpha↗
PubMed1993

Step-tracking movements of the wrist. III. Influence of changes in load on patterns of muscle activity.

Human subjects performed step-tracking movements of the wrist in the radial direction. Movement amplitude, external load, and accuracy instructions were varied. We used surface electrodes to record muscle activity from an agonist, extensor carpi radialis longus, and an antagonist, extensor carpi ulnaris. When subjects performed movements "as fast as possible" that were opposed by different external loads, we observed two distinct patterns of modulation of the agonist burst. In one pattern, termed pulse-height modulation, the force of the agonist muscle was graded by varying the peak amplitude of a short-duration agonist burst. This pattern occurred when subjects performed movements of different amplitudes with a lightweight manipulandum. In the other pattern, termed pulse-width modulation, the force of the agonist muscle was graded by varying the duration of an agonist burst of nearly maximal amplitude. When the agonist burst was prolonged, the onset of antagonist activity was delayed. This pattern occurred when subjects performed movements of different amplitudes that were opposed by elastic or viscoelastic loads applied to a heavy manipulandum. The strongest subject exhibited more pulse-height modulation and less pulse-width modulation of the agonist burst than other subjects. Conversely, the weakest subject displayed more pulse-width modulation of the agonist burst than other subjects. These observations indicate that the force requirements of a task, relative to the force generating capacity of a subject's agonist muscle(s), have a significant influence on the pattern of agonist modulation. In a second experiment using three nonhuman primates, we observed that agonist bursts in wrist flexor and extensor muscles exhibited strikingly different patterns of modulation. For wrist flexion, agonist bursts in wrist flexors were brief and displayed pulse-height modulation when movement amplitude was varied. For wrist extension, agonist bursts in wrist extensors were prolonged and displayed largely pulse-width modulation when movement amplitude was varied. We suggest that the distinct patterns of modulation observed in the wrist muscles of monkeys were due to differences in the strength of wrist flexors and extensors, rather than to alterations in movement strategy. In a third experiment, we instructed human subjects to be "accurate" when they made step-tracking movements. When subjects performed movements with a lightweight manipulandum, most displayed short-duration agonist bursts that were pulse-height modulated. When subjects performed "accurate" movements that were opposed by elastic loads, they displayed pulse-width modulation of a small-amplitude agonist burst.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1993

[The EEG pattern in the growing Japanese black calves].

Developmental EEG examination was performed in ten Japanese Black calves aged from 1 week to 10 weeks. The EEG was markedly influenced by the level of consciousness. In the alert wakefulness, the EEG was high frequency, low voltage pattern. In the wakefulness, the dominant activity was low frequency, and low voltage, high frequency activity was superimposed. In the drowsiness, the EEG was high voltage, low frequency activity pattern. In the sleep, markedly high voltage, low frequency activity was dominant. These four EEG patterns observed from the 1st week to the 10th week. During the course of the examination, high frequency, low voltage activity increased, so the EEG pattern gradually developed to the 10th week of age. In the wakefulness, theta wave and alpha wave dominant pattern was observed in seven calves. This pattern was observed after the 2nd week of age, thereafter incidence of this pattern increased to the 5th or 6th week. The frequency of theta wave and alpha wave dominant pattern increased from 6.0-7.5 Hz at the 3rd week to 7.5-9.0 Hz at the 10th week. As described above, the development of the central nervous system has attained the considerable level in the newborn calves, and thereafter continue to develop.

Age Factors↗
PubMedDate not supplied

[A e year study of the electrophoretic RNA patterns of rotavirus in Valladolid].

BACKGROUND: To study the electrophoretic RNA patterns of human rotavirus (RV) during three years in Valladolid (Spain). MATERIAL AND METHODS: From october 1986 to october 1989 we have studied the electrophoretic RNA patterns of RV in 104 fecal samples. Stools were first screened by a latex agglutination test (LA) and reactive samples were confirmed by a commercial enzymeimmunoassay (EIA) and electron microscopy (EM) (negative stain). Electropherotyping was made according to conventional methods. RESULTS: 96.2% of the samples studied yield a defined electropherotype. We have found 8 different types of patterns of genomic RV-RNA circulating in these three years. Two of them belonged to short pattern (C and E) and six to long pattern (A, B, D, F, G and H). CONCLUSIONS: 98.0% of the genomic RNA founded were of long pattern, from which pattern A was the most prevalent (72%) during the study, without a seasonal distribution. Pattern B was found in 20% of cases, while the rest were found only occasionally.

Child↗
PubMed1998

Phasic firing time locked to cocaine self-infusion and locomotion: dissociable firing patterns of single nucleus accumbens neurons in the rat.

The activity of single nucleus accumbens (NAcc) neurons of rats was extracellularly recorded during intravenous cocaine self-administration sessions (0.7 mg/kg per infusion, fixed ratio 1). We reported previously that NAcc neurons showed a change, usually a decrease, in firing rate during the first 1 min after the cocaine-reinforced lever press. This postpress change was followed by a progressive reversal of that change, which began within the first 2 min after the press and was not complete until the last 1 min before the next lever press (termed the change + progressive reversal firing pattern). In the present study we documented a regular pattern of locomotion that occurred in parallel with the change + progressive reversal firing pattern. This observation suggested that discharges time locked to locomotion may determine the change + progressive reversal firing pattern. However, 55% of the neurons failed to show firing time locked to locomotion that could have contributed to the change + progressive reversal firing pattern. Moreover, for all neurons, the change + progressive reversal firing pattern was apparent even if the calculation of firing rate excluded all periods of locomotion. The present data showed that the change + progressive reversal firing pattern is not solely attributable to phasic changes in firing time locked to the execution of locomotion. The change + progressive reversal firing pattern closely mirrors changes in drug level and dopamine overflow observed by previous researchers and may thus be a component of the neurophysiological mechanism by which drug level regulates drug-taking behavior during an ongoing self-administration session.

Action Potentials↗
PubMed1998

Quantification (grading) of inferior oblique muscle recession for V-pattern strabismus.

PURPOSE: To determine the effectiveness of grading such surgery according to the magnitude of the V pattern and inferior oblique muscle overaction (IOOA). METHODS: We retrospectively reviewed all 53 cases we operated since 1984 for V pattern with IOOA, who had undergone graded inferior oblique recession, recessed according to the anatomical recession table of Apt and Call, ranging from 8mm for V pattern of 12 PD with +1 IOOA to 12mm for 30+ PD with +3 IOOA. RESULTS: A "satisfactory outcome" (defined as = V pattern of 8 PD or less) was observed in 75% of the cases with a preoperative V pattern less than 20 PD, in 70% of those with a preop' V pattern between 20 PD and 29 PD, and in 57% of those with a preop' V pattern greater than 29 PD. There were no overcorrections. All unsatisfactory outcomes were undercorrections. CONCLUSIONS: The principle of grading this surgery is supported and affirmed by these results. However, the results also suggest a need to increase the amount of surgery for all categories and add anterior transposition for larger V patterns.

Adolescent↗
PubMed1999

Relationship between afferent and central temporal patterns in the locust olfactory system.

Odors evoke synchronized oscillations and slow temporal patterns in antennal lobe neurons and fast oscillations in the mushroom body local field potential (LFP) of the locust. What is the contribution of primary afferents in the generation of these dynamics? We addressed this question in two ways. First, we recorded odor-evoked afferent activity in both isolated antennae and intact preparations. Odor-evoked population activity in the antenna and the antennal nerve consisted of a slow potential deflection, similar for many odors. This deflection contained neither oscillatory nor odor-specific slow temporal patterns, whereas simultaneously recorded mushroom body LFPs exhibited clear 20-30 Hz oscillations. This suggests that the temporal patterning of antennal lobe and mushroom body neurons is generated downstream of the olfactory receptor axons. Second, we electrically stimulated arrays of primary afferents in vivo. A brief shock to the antennal nerve produced compound PSPs in antennal lobe projection neurons, with two peaks at an approximately 50 msec interval. Prolonged afferent stimulation with step, ramp, or slow sine-shaped voltage waveforms evoked sustained 20-30 Hz oscillations in projection neuron membrane potential and in the mushroom body LFP. Projection neuron and mushroom body oscillations were phase-locked and reliable across trials. Synchronization of projection neurons was seen directly in paired intracellular recordings. Pressure injection of picrotoxin into the antennal lobe eliminated the oscillations evoked by electrical stimulation. Different projection neurons could express different temporal patterns in response to the same electrical stimulus, as seen for odor-evoked responses. Conversely, individual projection neurons could express different temporal patterns of activity in response to step stimulation of different spatial arrays of olfactory afferents. These patterns were reliable and remained distinct across different stimulus intensities. We conclude that oscillatory synchronization of olfactory neurons originates in the antennal lobe and that slow temporal patterns in projection neurons can arise in the absence of temporal patterning of the afferent input.

Afferent Pathways↗
PubMed1998

Use of pattern analysis to predict differential relapse of remitted patients with major depression during 1 year of treatment with fluoxetine or placebo.

BACKGROUND: Delayed and persistent ("true drug") improvement characterizes the response to antidepressant medication. Early or nonpersistent ("placebo") benefit is typical of a placebo response. The prediction was that patients with a true drug response would sustain their benefit best if they continued to receive the drug and that patients with a placebo response would have an equivalent prognosis whether they continued to receive the drug or were switched to placebo. METHODS: Patients with major depression who met the study's response criteria (a modified Hamilton Depression Rating Scale score < or =7 and failure to meet major depression criteria after each of the last 3 weeks following 12 to 14 weeks of treatment with fluoxetine hydrochloride, 20 mg/d) were enrolled in a 50-week randomized placebo substitution trial during which the return of depressive symptoms defined relapse. The timing and persistency of response during initial treatment defined true drug or placebo response patterns. RESULTS: Patients with a true drug response pattern relapsed significantly more frequently if they were switched to placebo than if they continued to receive fluoxetine (P<.001 for weeks 12-26, P<.005 for weeks 26-50, and P<.41 for weeks 50-62). Patients with a placebo response pattern had an equivalent outcome whether maintained on fluoxetine therapy or placebo (P< .20 for weeks 12-26, test invalid for weeks 26-50, and P<.67 for weeks 50-62). Patients with a placebo response pattern relapsed more often when they continued to receive fluoxetine than patients with a true drug response pattern (P<.01 for weeks 12-26, P<.10 for weeks 26-50, and P<.36 for weeks 50-62). CONCLUSIONS: These findings confirm that pattern analysis validly differentiates true drug from nonspecific initial responses and extend its use to the continuation and maintenance phases of treatment for depression. Investigations into the mechanisms of antidepressant activity might best be limited to those that can account for delayed efficacy. Fluoxetine's efficacy during the continuation and maintenance phases of treatment may be limited to patients with a true drug pattern of initial response.

Adolescent↗
PubMed2001

Development of GABA-immunoreactive neuron patterning in the spinal cord.

In the frog Xenopus laevis, gamma-aminobutyric acid (GABA)-immunoreactive spinal cord neurons (Kolmer-Agduhr cells) formed a dispersed pattern within two columns on either side of the midline. The cellular pattern became established during embryonic and larval development. The GABA-immunoreactive cells are cerebrospinal fluid (CSF)-contacting neurons that began to appear by 1.2 days (st 26) of development. This stage occurred shortly after neural tube closure (0.9 days, st 21) and followed the appearance of ultrastructural characteristics of CSF-contacting neurons. The pattern of GABA-immunoreactive cells emerged during embryogenesis, as their density increased. Each longitudinal column was heterogeneous, containing cells with and without GABA immunoreactivity. Spatial analysis at several embryonic and larval stages showed that the cells in each column formed a nonrandom, dispersed pattern even at early stages of differentiation. This one-dimensional pattern resembled that of dopamine-immunoreactive neurons, which are also located in the ventral spinal cord. The patterning of both cell types followed a different time course, but the ultimate spacing of the neurons remained comparable. These results suggested that the mechanism patterning the two cell types within the same region was similar but not identical and may involve related molecular mechanisms.

Aging↗
PubMed2005

Expression of the zebrafish Iroquois genes during early nervous system formation and patterning.

Iroquois genes are involved in many patterning processes during development. In particular, they act as prepattern genes to control proneural gene expression both in Drosophila and in vertebrates. In this paper, we have analyzed the expression during embryogenesis of the 11 zebrafish Iroquois genes, with special interest for nervous system formation and patterning. During the first 2 days of development, Iroquois genes are expressed in distinct domains in the neuroepithelium, as well as in groups of neuronal progenitors and neurons. They are also expressed at different stages of placodal development. These expression patterns are similar to the patterns of the murine irx genes and also show features specific to teleosts. For the zebrafish Iroquois gene family, we find both specific patterns and patterns conserved within a cluster, between paralogues, or in most genes of the family. Overall, these expression data suggest functions for the Iroquois family of transcription factors in neural and placodal patterning, neurogenesis, and neuronal specification.

Animals↗
PubMed2005

Pigment cell distributions in different tissues of the zebrafish, with special reference to the striped pigment pattern.

The orderly pigment pattern of zebrafish (Danio rerio) is a good model system for studying how spatial patterns form in animals. Recent molecular genetic studies have shown that interactions between the pigment cells play major roles in pattern formation. In the present study, we performed comparative transmission electron microscopy of pigment cells, in order to clarify the structural interactions of pigment cells in tissues with and without a striped pattern. In patterned tissues, pigment cells were distributed as a one-cell-thick sheet. The layer order of the sheets is always kept strictly. In tissues without a striped pattern, the layer order was often disturbed or the cells were distributed in a scattered, double-sheeted, or an accumulated pile. Our observations suggest that the underlying mechanism that controls the vertical order of the pigment cells is related to that controlling the stripe pattern.

Animals↗
PubMed2001

Homology and evolutionary novelty in the deployment of extracellular matrix molecules during pigment pattern formation in the salamanders Taricha torosa and T. rivularis (Salamandridae).

Salamander larvae exhibit a diverse array of pigment patterns shortly after hatching. Previous studies have identified roles for the extracellular matrix and lateral line sensory system in promoting the development of a phylogenetically common pattern of horizontal melanophore stripes. In contrast, salamanders in the genus Taricha exhibit evolutionarily derived pigment patterns and pattern-forming mechanisms. Taricha torosa larvae exhibit compact melanophore stripes that develop via redundant, lateral line-independent mechanisms, whereas T. rivularis larvae lack stripes and instead have melanophores uniformly distributed over the flank. In this study, I test roles for candidate patterning molecules of the extracellular matrix in promoting the development of species-specific pigment patterns in Taricha. I show that tenascin deposition is negatively correlated with melanophore distributions both intraspecifically and interspecifically: this matrix molecule is present where melanophores do not localize in T. torosa and is absent from these same regions where melanophores are abundant in T. rivularis. Embryological manipulations further indicate that transient expression of tenascin in a prospective interstripe region of T. torosa reflects a phylogenetically conserved effect of lateral line development. Finally, anti-laminin immunoreactivity is negatively correlated with melanophore distributions in T. torosa, and this species exhibits a general retardation of extracellular matrix development that may allow persistent, evolutionarily novel melanophore motility in this species. Together these findings identify tenascin and laminin, or molecules co-regulated with these matrix components, as candidates for promoting early larval pigment pattern development in Taricha.

Animals↗