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PubMed2006

Opioid analgesics and rates of fatal drug poisoning in the United States.

OBJECTIVE: To determine whether the variability in rate of sale of prescription opioid analgesics is related to the variability in rates of drug poisoning mortality among states in the United States in 2002. METHODS: Drug poisoning deaths were defined as unintentional deaths or those of undetermined intent whose underlying cause was coded to "narcotics" (X42) or "other and unspecified" drugs (X44) in the National Vital Statistics System. Per capita sales of ten opioid analgesics from the Drug Enforcement Administration and combined sales in morphine equivalents were correlated with drug poisoning mortality rates by state using multivariate linear regression. Regression coefficients between mortality rates and sales rates were adjusted for race (percent white, percent black) and age (percent aged 24 years or younger, and percent aged 65 years and older). RESULTS: There was over a ten-fold variability in sales of some opioid analgesics. Combined sales ranged 3.7-fold, from 218 mg per person in South Dakota to 798 mg per person in Maine. Drug poisoning mortality varied 7.9-fold, from 1.6/100,000 in Iowa to 12.4/100,000 in New Mexico. Drug poisoning mortality correlated most strongly with non-OxyContin oxycodone (r=0.73, p<0.0001), total oxycodone (r=0.68, p<0.0001), and total methadone (r=0.66, p<0.0001) in the multivariate analysis. A scatterplot demonstrated a linear relationship between total opioid analgesic sales and drug poisoning mortality. CONCLUSIONS: The extent of opioid analgesics use varies widely in the United States. Variation in the availability of opioid analgesics is related to the spatial distribution of drug poisoning mortality by state.

Analgesics, Opioid↗
PubMed2005

Is population-wide diuretic use directly associated with the incidence of end-stage renal disease in the United States? A hypothesis.

BACKGROUND: We introduce the hypothesis that population-wide use of diuretics might be associated with acceleration of the incidence of end-stage renal disease (ESRD). METHODS: Based on the technique of data fusion, pooled-data trends in disease incidence and antihypertensive medication use were examined to determine whether changes in drug use patterns are predictive of disease emergence in the United States. National databases for all-cause cardiovascular disease (CVD) mortality and stroke mortality from the National Vital Statistics Registry, renal failure data obtained from the United States Renal Data Service, and drug information obtained from IMS Health (Fairfield, CT) were examined. RESULTS: A statistically significant inverse relationship was observed between all-cause CVD mortality rates and ESRD incidence rates for the period 1980 to 1998 (r = -0.98948; P < .0001). A statistically significant direct time-lagged relationship was found between both annual changes in diuretic distribution and total diuretic expenditure to annual changes in the ESRD growth rate (r = 0.754, P = .03, r(2) = 0.568, 95% CI for slope = 0.08975 to 1.3010). CONCLUSIONS: Increasing annual diuretic distribution in the US is directly associated with accelerated time-lagged growth rates of ESRD incidence. One potential explanation is that diuretic therapy could promote ESRD expression. A large-scale, randomized, controlled trial to investigate acceleration of ESRD by diuretics would be justifiable. The data invites the hypothesis that reliance on nondiuretic antihypertensive therapies such as calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers might attenuate the epidemic rise of ESRD that is prevalent in the United States.

Cardiovascular Diseases↗
PubMed2004

Small area variations in infant mortality in England and Wales in the inter-war period and their link with socio-economic factors.

This paper considers the changing spatial pattern of infant mortality during the inter-war years (1921-1936) at Local Government District level in England and Wales. As well as vital statistics data for these areas, also available are 1921 and 1931 Census data on unemployment, housing, occupational structure and population density, with additional data on unemployment from 1927 to 1936 for the 62 counties in which Districts are located. The statistical analysis relating changing District mortality to these characteristics derives mortality gradients across categorical forms of the social indicators, and assesses impacts of model re-specification to allow for spatio-temporal correlation. Time varying gradients across unemployment, housing and policy status are then investigated with a view to assessing whether there was a widening in mortality inequalities in the regionalized economic depression of the 1930s.

Adolescent↗
PubMed2005

Secular trends in coronary heart disease mortality, hospitalization rates, and major cardiovascular risk factors in Taiwan, 1971-2001.

BACKGROUND: While mortality from coronary heart disease (CHD) has declined substantially in most developed countries in recent decades, discordant rising trends have been observed in many developing and newly developed countries. In this study, we examined the trends of CHD mortality and its hospitalization rate, and correlated the trends with changes in major cardiovascular risk factors in Taiwan. METHODS: Mortality data during the period 1971-2001 were obtained from official vital statistics. Hospitalization rates were calculated using information extracted from the National Health Insurance Database, which was available from 1996 to 2001. Changes in major cardiovascular risk factors were obtained from official statistics and review of previous epidemiologic studies. RESULTS: In 2001, the age-standardized CHD mortality in Taiwan was 28.7 per 100,000 for men and 15.5 per 100,000 for women. For both men and women, age-adjusted CHD mortality increased slowly but steadily from 1971 to 1992, but after that, a downward trend was observed. Hospitalization rates for CHD, however, increased substantially from 1996 to 2001. Levels of per-capita cigarette consumption, dietary fat intake, body mass index, and prevalence of hypertension and diabetes had all increased over the past three decades. CONCLUSIONS: The overall cardiovascular risk profile has worsened in the general population in Taiwan. The decline in CHD mortality observed in recent years was most likely attributable to the improvement in acute cardiac care and medical treatment among patients with CHD. We anticipated that CHD incidence and prevalence would continue to rise in Taiwan.

Body Mass Index↗
PubMed2006

The widening black/white gap in asthma hospitalizations and mortality.

BACKGROUND: Large racial differences in asthma morbidity and mortality have prompted research on new interventions, public awareness, and health policy efforts in the past decade. OBJECTIVE: We sought to characterize recent trends in US asthma hospitalization and mortality for black and white children and adults during the period from 1980 through 2002. METHODS: We conducted a successive representative national cohort study of US residents ages 5 to 34 years using data from the National Hospital Discharge Survey and the US vital statistics system. Outcome measures included black/white (B/W) asthma hospitalization and mortality rates, rate ratios, and rate differences. RESULTS: For asthma hospitalizations from 1980 through 2002, children ages 5 to 18 years had a 50% increase in the B/W rate ratio, and the rate difference increased from 22.8 to 28.3 hospitalizations per 10,000 population. For young adults ages 19 to 34 years, the B/W rate ratio increased from 2.3 to 2.8, and the rate difference decreased from 9.6 to 7.9 hospitalizations per 10,000 population. For asthma mortality from 1980 through 2001, children ages 5 to 19 years had a large increase in the B/W rate ratio from 4.5 to 5.6 and in the rate difference from 5.6 to 8.1 deaths per 1,000,000 population. There did not appear to be a significant change in the B/W differences for adults ages 20 to 34 years. CONCLUSIONS: For children, there have been notable increases in asthma B/W differences in hospitalizations and mortality since 1980, whereas for adults the increase has been smaller. National efforts to improve asthma care over the past decade do not appear to have reduced this B/W gap. When treating children with asthma, it is important to consider the racial-ethnic factors that might lead to avoidable hospitalizations and premature mortality.

Adolescent↗
PubMed2004

Can changes in sexual behaviors among high school students explain the decline in teen pregnancy rates in the 1990s?

PURPOSE: To explore the utility of using national data from high school students to explain changes in national declines in pregnancy rates. Although declines in teen pregnancy and birthrates in the 1990s have been welcome news to those interested in adolescent health and welfare, the reasons for these declines are not readily apparent. Previous attempts to explain these declines focused on the period before 1995 and did not directly calculate the impact of improved contraceptive use. METHODS: The national Youth Risk Behavior Survey provided estimates for sexual activity and contraceptive use among teens aged 15-17 years between 1991 and 2001 (n = 31,058). These data were combined with method-specific contraceptive failure rates (CFRs) derived from the 1988 and 1995 National Survey of Family Growth and pregnancy rates from the National Vital Statistics System. We calculated weighted-average CFRs (WACFR) and used the annual rate of change in the WACFR and sexual activity to estimate their relative contributions to the annual change in risk of pregnancy. Weighted least-squares regression in SUDAAN was used to test change over time. RESULTS: Between 1991 and 2001, annual rates of change in sexual behaviors were -1.7% for sexual experience and -1.6% for the WACFR. Improvements in WACFR resulted primarily from a decline in use of withdrawal (from 20% to 13%) and use of no method (from 17% to 13%) and an increase in condom use (40% to 51%). Recent sexual intercourse (i.e., intercourse during the past 3 months among teens who had ever had intercourse) did not change over time. The change in the estimated risk of pregnancy closely approximated the annual decline in the pregnancy rates for blacks and Hispanics but underestimated the actual decline for whites. Overall, 53% of the decline in pregnancy rates can be attributed to decreased sexual experience (95%CI 26% to 79%) and 47% to improved contraceptive use (95%CI 21% to 74%). CONCLUSIONS: Use of school-based behavior data reflects well the pregnancy experience for school-age black and Hispanic adolescents, but does not track well with the pregnancy risk of white adolescents. Care should be taken in attributing changes in pregnancy rates to changes in behavior, given broad confidence intervals around these estimates. These data suggest that both delayed initiation of sexual intercourse and improved contraceptive practice contributed equally to declines in pregnancy rates among high school-aged teens during the 1990s; however, estimates varied among racial and ethnic groups.

Adolescent↗
PubMed2004

Impact of gastric bypass operation on survival: a population-based analysis.

BACKGROUND: Bariatric procedures are increasingly performed but their impact on survival is unknown. STUDY DESIGN: We evaluated short- and longterm mortality rates of patients undergoing gastric bypass on a population level compared with a nonoperated cohort of patients with morbid obesity in a retrospective study, using the Washington State Comprehensive Hospital Abstract Reporting System database and the Vital Statistics database. The study included all patients (age 18 to 65 years) from 1987 to 2001 who underwent gastric bypass with ICD-9 diagnostic codes for obesity. The comparator group included patients of similar age with a diagnosis of obesity or morbid obesity who did not have a bariatric procedure. Survival analysis was used to determine the association of surgeon experience on 30-day mortality and of the procedure on survival while controlling for age, gender, and comorbidity index. RESULTS: Of the 66,109 obese patients we evaluated, 3,328 had a bariatric procedure. Incidence of the procedure increased from 0.7 to 10.6 per 100,000 from 1987 to 2001, with a 2.5-fold increase in incidence rate of the procedure in the years after 1996 (incidence rate ratio, 2.5; 95% CI, 2.4 to 2.7). Thirty-day mortality was 1.9% and was associated with surgical inexperience. Within the surgeon's first 19 procedures the odds of death within 30 days were 4.7 times higher (95% CI, 1.2 to 18.2) than at later points in a surgeon's case order. At 15 years followup, 16.3% of nonoperated patients had died as compared with 11.8% of patients who had the bariatric procedure. When survival was compared beginning 1 year after the procedure, the adjusted hazard for death was 33% lower than that of nonoperated patients (hazard ratio 0.67; 95% CI, 0.54 to 0.85). CONCLUSIONS: Thirty-day mortality after gastric bypass is higher than previously reported and closely linked to surgeon inexperience. A modest overall survival benefit was associated with the procedure but a marked survival advantage was noted for patients who survive to the first postoperative year.

Adult↗
PubMed2006

Surveillance of methadone-related adverse drug events using multiple public health data sources.

Healthcare safety and quality surveillance is increasingly conducted by public health agencies. We describe a biomedical informatics method that uses multiple public health data sources to perform surveillance of methadone-related adverse drug events. Data from Utah medical examiner records, vital statistics, emergency department encounter administrative data and a database of controlled substances prescriptions are used to examine trends in state-wide adverse events related to methadone. From 1997 to 2004, population-adjusted methadone prescriptions increased 727%, with evidence to suggest the rise in the methadone prescription rate is for treatment of pain, not addiction therapy. During the same period of time, population adjusted, accidental methadone-related deaths in medical examiner data increased 1770%. Population adjusted methadone-related emergency department encounters rose 612% from 1997 to 2003. Our results suggest that the increase in methadone prescription rates from 1997 to 2004 was accompanied by a concurrent increase in methadone-related morbidity and mortality. Although patient data is not linked between data sources, our results demonstrate that utilizing multiple public health data sources captures more cases and provides more clinical detail than individual data sources alone. Our approach is a successful biomedical informatics approach for surveillance of adverse events and utilizes widely available public health data sources, as well as an emerging source of public health data, controlled substance prescription registries.

Adverse Drug Reaction Reporting Systems↗
PubMed2004

Anaphylaxis in the prehospital setting.

Many Emergency Medical Services (EMS) systems have adopted epinephrine auto-injector (EAI) use by Basic Life Support (BLS) personnel, and several states now require that BLS personnel be trained and authorized to use EAIs. The objectives of this observational study were: 1) to examine EMS case definitions of allergy/anaphylaxis, 2) to ascertain the incidence of EMS calls for allergy/anaphylaxis and administration of epinephrine, and 3) to quantify the rate of deaths due to anaphylaxis. Data were solicited by e-mail, mail, and telephone from National Association of State EMS Directors (NASEMSD) members, state EMS offices, and state medical examiner and vital statistics offices. Simple descriptive statistics were used to analyze the data. The following was found: 1) there is no standardization of case definitions among states. Some use the terms "allergic reaction" and "anaphylaxis" in EMS protocols without definition, whereas others provide lengthy, specific definitions, with detailed criteria for epinephrine administration; 2) excluding two outliers at 0.04% and 3.9%, nine EMS system databases totaling over 2.8 million runs contained between 0.34% and 0.82% of runs for allergy/anaphylaxis. Seven of these databases reported on epinephrine administration, with rates between 0.16% and 31.1%, and four of the seven clustered between 8.8% and 14.8%. There was little uniformity in the data provided by seven states on deaths due to anaphylaxis, with rates from 0% to 0.94%. Although limited by the lack of data from many states, roughly 0.5% of EMS runs are for allergy/anaphylaxis complaints, with epinephrine administered in roughly one-tenth of these. State death rates from anaphylaxis vary considerably, with rates from 0% to 0.94% reported.

Anaphylaxis↗
PubMed2004

Accidents will happen? Unintentional childhood injuries and the effects of child care regulations.

Accidents are the leading cause of death and injury among children in the United States, far surpassing diseases as a health threat. We examine the effects of child care regulation on rates of accidental injury using both micro data from the National Longitudinal Survey of Youth, and Vital Statistics mortality records. Estimates from both data sources suggest that requiring day care center directors to have more education reduces the incidence of unintentional injuries. An auxiliary analysis of the choice of child care mode confirms that these regulations are binding and that higher educational requirements tend to crowd some children out of care, as do regulations requiring frequent inspections of child care facilities and lower pupil-teacher ratios. Thus, regulation creates winners and losers: Some children benefit from safer environments, while those who are squeezed out of the regulated sector are placed at higher risk of injury.

Accidents↗
PubMed2006

Effects of infertility insurance mandates on fertility.

Infertility currently affects over 6 million individuals in the United States. While most health insurance plans nationwide do not cover infertility diagnoses or treatments, to date 15 states have enacted some form of infertility insurance mandate. In this paper, I use data from the Vital Statistics Detail Natality Data and Census population estimates to examine whether these state-level mandates were successful in increasing fertility rates. Using a difference-in-differences approach, I exploit variation in the enactment of mandates both across states and over time, and identify treatment and control groups that should have been differentially affected by infertility coverage. My results suggest that the mandates significantly increase first birth rates for women over 35, and these results are robust to a number of specification tests.

Adult↗
PubMed2005

Cystic fibrosis birth rates in Canada: a decreasing trend since the onset of genetic testing.

OBJECTIVE: To estimate cystic fibrosis (CF) birth rates in Canada from 1971 to 2000 and to assess the population impact of genetic testing in families with a history of CF, after identification of the CF transmembrane conductance regulator gene in 1989. STUDY DESIGN: Age-at-diagnosis data were obtained from the Canadian Cystic Fibrosis Foundation Patient Data Registry and Canadian births for the corresponding years from Canadian Vital Statistics. Estimates of the CF birth rate in each year were based on a nonparametric model that allows the birth rate to vary across the years and adjusts for censoring of currently undiagnosed patients. RESULTS: The overall CF birth rate from 1971-1987 was 1/2714 with no increasing or decreasing trend. Beginning in 1988, 1 year before identification of the CF transmembrane conductance regulator gene, estimated CF birth rates followed a linear decline to an estimated rate of 1/3608 in 2000. CF birth rates may have stabilized in the last few years, but further decline may occur with implementation of carrier screening in the general population. CONCLUSIONS: These results demonstrate the temporal association of genetic testing and declining CF birth rates in Canada. They may assist in decisions relating to the allocation of resources for prenatal and neonatal CF screening programs.

Birth Rate↗
PubMed2005

Increasing prevalence of gastroschisis in Utah.

BACKGROUND: Recent studies provide conflicting information about gastroschisis prevalence trends. The authors proposed that prevalence of gastroschisis in live births has increased in Utah and that characteristics of these infants would provide clinically useful information about treatment and outcomes. METHODS: Primary Children's Medical Center (PCMC) is the sole pediatric surgical referral hospital for Utah. The authors used both pediatric surgical and neonatal databases to identify gastroschisis cases at PCMC from 1971 through 2002. Only infants whose mothers had a primary residence in Utah were included. Individual charts were reviewed for infant characteristics for cases from 1998 through 2002. Utah Vital Statistics Reports were used to determine live birth rates and general infant and maternal characteristics. RESULTS: Gastroschisis prevalence increased from 0.36 to 3.92 cases per 10,000 live births over 31 years (P < .001). Young maternal age, primigravida status, and tobacco use were associated risk factors. Using the time required to achieve full enteric feedings at targeted volume and caloric density as a measurement of outcome, we found no association between delivery mode or surgical closure type (primary or secondary) and time to full feedings. Higher birth weight was associated with decreased time to full feedings (P = .03). CONCLUSIONS: Gastroschisis prevalence has increased 10-fold over the past 3 decades in Utah.

Adolescent↗
PubMed2004

Farm fatalities to youth 1995-2000: A comparison by age groups.

PROBLEM: Although a myriad of research illustrates the safety issues related to farm fatalities in youth populations, very little empirical evidence exists that includes work and non-work related farm fatalities to all youths under 20 years of age at the national level. METHODS: This research will use death certificate data for the six years from 1995 to 2000 that were collected by NIOSH from all 50 state vital statistics registries. Demographic data from the 1998 CAIS were used in rate calculations. In addition to providing annual fatality rates and descriptions of the general causes of death, this research will examine the variation between age groups. RESULTS: Analysis of 695 total farm-related youth fatalities shows an average annual fatality rate of 9.3 fatalities per 100,000 youths. Males account for 80% of these fatalities. The most prevalent causes of death are: machinery (25%), motor vehicle (17%), drowning (16%), suicide (8%) and homicide (6%). Of all youth fatalities occurring while at work, 45% are to youths less than 16 years of age. This same age group accounts for 71% of all non-work related fatalities. SUMMARY: This research will provide farm families and researchers more detailed information on farm hazards that contribute to the deaths of youths. As these youths may encounter hazards while working or playing in their daily environment, identification and elimination of these hazards will increase overall safety on the farm. This research also indicates the need to include youths under 16 years of age in future comprehensive farm safety research.

Accidents↗
PubMed2005

Post-operative radiotherapy (PORT) or chemoradiotherapy (CPORT) following resection of stages II and IIIA non-small cell lung cancer (NSCLC) does not increase the expected risk of death from intercurrent disease (DID) in Eastern Cooperative Oncology Group (ECOG) trial E3590.

To determine the influence of adjuvant therapy on the risk of DID following resection of NSCLC, we compared the actuarial rate of non-cancer related deaths of patients who had been entered in Eastern Cooperative Oncology Group E3590 (a phase III trial of adjuvant therapy in patients with completely resected stages II and IIIA NSCLC) to the actuarial death rate of age and gender matched controls. Following surgery, patients were randomized to receive either PORT (5040 cGy in 28 daily fractions) or CPORT (PORT plus four cycles of cisplatin (60 mg/m2, day 1) and etoposide (120 mg/m2, days 1-3) administered concurrently). The study accrued 488 patients, 242 to the PORT only arm and 246 to the CPORT arm. The overall 4 years actuarial rate of DID for the two arms combined, with a median follow-up of 82 months, was 12.9%, not significantly different from the 10.1% expected rate of DID, based on mortality rates for age and gender matched controls derived from US vital statistics and corrected for smoking status (p=0.16). Survival distributions with regard to DID did not differ between the two treatment arms (p=0.96). DID increased with age (treated as a continuous variable, p<0.01), but was not affected by histology, side of chest irradiated, type of surgery, FEV1 or weight loss in the previous 6 months. The risk of DID following resection of stages II and IIIA NSCLC is not increased in patients who received PORT or CPORT.

Age Factors↗
PubMed2005

The use of biomarkers in surveillance, medical screening, and intervention.

Building on mechanistic information, much of molecular epidemiologic research has focused on validating biomarkers, that is, assessing their ability to accurately indicate exposure, effect, disease, or susceptibility. To be of use in surveillance, medical screening, or interventions, biomarkers must already be validated so that they can be used as outcomes or indicators that can serve a particular function. In surveillance, biomarkers can be used as indicators of hazard, exposure, disease, and population risk. However, to obtain rates for these measures, the population at risk will need to be assessed. In medical screening, biomarkers can serve as early indicators of disease in asymptomatic people. This allows for the identification of those who should receive diagnostic confirmation and early treatment. In intervention (which includes risk assessment and communication, risk management, and various prevention efforts), biomarkers can be used to assess the effectiveness of a prevention or control strategy as well as help determine whether the appropriate individuals are assigned to the correct intervention category. Biomarkers can be used to provide group and individual risk assessments that can be the basis for marshalling resources. Critical for using biomarkers in surveillance, medical screening, and intervention is the justification that the biomarkers can provide information not otherwise accessible by a less expensive and easier-to-obtain source of information, such as medical records, surveys, or vital statistics. The ability to use validated biomarkers in surveillance, medical screening, and intervention will depend on the extent to which a strategy for evidence-based procedures for biomarker knowledge transfer can be developed and implemented. This will require the interaction of researchers and decision-makers to collaborate on public health and medical issues.

Biomarkers↗
PubMed2004

Visual impairment in children born at full term from 1972 through 1989 in Finland.

OBJECTIVE: To investigate the incidence, prevalence, and causes of visual impairment in children born at full term and to determine conditions and factors associated with visual impairment. DESIGN: Retrospective, cross-sectional, population-based study. PARTICIPANTS: All visually impaired individuals from 0 to 17 years of age who were born at full term from 1972 through 1989 in Finland and recorded in the Finnish Register of Visual Impairment (n = 556) were eligible for this study. METHODS: Data in the Finnish Register of Visual Impairment relating to 556 subjects were supplemented with data from hospital records and other national registers (Register of Births, Register of Congenital Malformations, Finnish Care Register, and Finnish Cancer Register). Data relating to the children born at full term were compared with Finnish perinatal and vital statistics and with data concerning children born prematurely. The chi-square test (Mantel-Haenszel) and stepwise logistic regression analysis were used in statistical analysis of the data. MAIN OUTCOME MEASURES: Visual acuity, time of onset of visual impairment, ophthalmic diagnosis of visual impairment, systemic disease, multiple handicap, 5-minute Apgar score, prenatal disorders, perinatal disorders, disorders arising during infancy and childhood, and treatment. RESULTS: Four hundred thirty-one of the 556 individuals with visual impairment (78%) had been born at full term. Visual impairment was predominantly associated with genetic (53%) and prenatal (34%) factors. Ocular malformations (34%), retinal diseases (31%), and neuro-ophthalmologic disorders (26%) were the main ophthalmic diagnoses. Optic nerve atrophy (20%) and congenital cataract (13%) were the most common single diagnoses. The occurrence of blindness, systemic disease, and multiple handicap was 40%, 43%, and 45%, respectively. CONCLUSIONS: The incidence of visual impairment in children born at full term did not decline during the 2 decades covered by this study. The findings reflected the lack of treatment for genetic eye diseases. The results also confirmed an obvious need for further understanding of mechanisms underlying congenital anomalies of the human visual system.

Adolescent↗
PubMed2004

United States coronary mortality trends and community services associated with occupational structure, among blacks and whites, 1984-1998.

This paper examines the association between US county occupational structure, services availability, prevalence of risk factors, and coronary mortality rates by sex and race, for 1984-1998. The 3137 US counties were classified into five occupational structure categories; counties with the lowest percentages of the labor force in managerial, professional, and technical occupations were classified in category I (5-16%), counties with the highest percentages were in category V (32-59%). Directly age-adjusted coronary heart disease (CHD) mortality rates, for aged 35-64 years, (from vital statistics and Census data), per-capita services (County Business Patterns), and the prevalence of CHD risk factors (Behavioral Risk Factor Surveillance Surveys data) were calculated for each occupational structure category. CHD mortality rates and the prevalence of risk factors were inversely monotonically associated with occupational structure categories for white men and women but not among black men and women. Numbers of producer services for banking, business credit, overall business services and personnel/employment services were 2-12 times greater in category V versus I counties. Consumer services such as fruit/vegetable markets, fitness facilities, doctor offices and social services were 1.6-3 times greater in category V versus I counties. Residential racial segregation scores remained high in most areas despite declines during 1980-1990; occupational segregation by race and gender were shown indicating continued institutional racism. An ecological model for conceptualizing communities and health and the overall influence of state and national occupational structure is discussed; intervention strategies such as decreased wage disparities and 'living wage' standards and development is discussed.

Adult↗