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Shortage of binocular cells in area 17 of visual cortex in cats with congenital strabismus.

Twenty-nine pigmented offspring of an innately esotropic female cat exhibited varying deficits in the number of binocular cells recorded in area 17 of the visual cortex as compared to 12 normal cats. Misalignment of the two eyes in these cats was found in the awake as well as in the paralysed state. Pupillography combined with measurements of visual disparity yielded abnormal esotropia of up to 8.4 degrees under paralysis, which corresponds to an abnormal convergence of the freely moving eyes of up to 14 degrees (average 7.4 degrees). In the majority of animals cortical binocularity was found reduced by the two eyes controlling independent sets of separate units (U-shaped ocular dominance distribution) whereas in 7 cats the reduction was due to a partial loss of one eye's influence. The proportion of monocular units correlated with the degree of crossover of the visual axes (r = 0.73). Anatomical investigation of the retinofugal projections revealed normal appearance in three previously recorded cats in which more than 50% of cortical units had been monocularly driven. The small angles of esotropia and the "normal" appearance of eye position judged by the pupillary positions in the orbit of these cats, might suggest that we found an animal model for microstrabismus.

Anesthesia, General↗

Secondary hyperfunction of unoperated inferior oblique muscle after surgical treatment of strabismus.

Secondary hyperfunction of the inferior oblique muscle IO of one of the eyes is a frequent complication after unilateral recession of the overacting IO of the fellow's eye. It is often observed in cases with bilateral asymmetric hyperfunction of the IO's when these are surgically decreased. The pathogenesis of this secondary hyperfunction is not sufficiently explained yet. We evaluated the condition of unoperated IO in 42 children with unilateral hyperfunction of the IO. In all cases the operation we performed was recession combined with a fixed anteroposition. During the two years follow up period we found no secondary hyperfunction of the unoperated oblique muscle in 31 of the children, mild level of elevation in 7 of them, middle--in 2, and severe in 2 of the children. This observation confirmed our conviction of refraining from simultaneous surgical intervention on both IO muscles when there is hyperfunction of one of them.

Child↗

Preoperative prism adaptation test in normosensoric strabismus.

In 19 patients with normosensoric esotropia, the squint angles measured with the alternate cover test were compared with those after prolonged prismatic correction of the squint angle and with those after prolonged occlusion of one eye. All patients showed an increase of the squint angle after prism adaptation. The angle was generally smaller after diagnostic occlusion of one eye than after prism adaptation. We assume that the increase in the squint angle after prism adaptation is caused by an anomalous sensorial relationship between the two eyes that was not detected with the usual psychophysical tests. Surgery tailored to the squint angle after prism adaptation seems advisable in patients with normosensoric esotropia.

Adaptation, Ocular↗

Role of the central field in disparity-induced vergence movements in strabismus.

Disparity-induced vergence movements (fusional movements) were analyzed in esotropic patients by calculating the time required for compensation of a prismatic correction of their angle of deviation. The effect of central and peripheral field stimulation on these movements was studied by masking the central or the peripheral field. Both the center and the periphery were effective in triggering disparity-induced vergence movements. The center even seemed to prevail over the periphery. It is concluded that in comitant esotropia motor fusion is present not only in the periphery but also in the center, if appropriately tested.

Adolescent↗