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PubMed1976

Nitrogen metabolism and reproductive response of gravid swine fed an arginine-free diet during the last 84 days of gestation.

Based upon nitrogen retention and urinary excretion of orotic and citric acid, previous experiments have shown that the gravid gilt does not require a dietary source of arginine during late gestation. This experiment was designed to evaluate effects of feeding an arginine-free diet for a major portion of gestation. Three diets, 0% L-arginine, 0.38% L-arginine and a fortified corn-soybean meal control, were fed to two litter-mate trios from day 30 of gestation until parturition. The experimental diets contained crystalline amino acids as the sole source of nitrogen and provided 12.6% crude protein equivalent. All gilts received 2 kg of diet daily and were housed throughout the 84-day feeding period in metabolism crates. Nitrogen retention tended to increase with advancing pregnancy, but was uninfluenced by dietary treatment. Averaged across all three gestational trimester periods, nitrogen retention was 11.2, 9.7 and 12.0 g/day for the 0% arginine, 0.38% arginine and cor-soybean meal diet, respectively. Urinary excretion of orotic acid was not significantly affected by arginine intake. Moreover, number and weight of pigs at birth and weaning were unaltered by dietary treatment. Thus, it is evident that satisfactory reproductive response can be achieved with gravid swine fed an arginine-free diet during the last 84 days of pregnancy.

Animals↗
PubMed1980

Effect of l-ascorbate 2-sulfate on fatty liver and hyperlipidemia induced by various treatments in rats and guinea pigs.

Effects of L-ascorbate 2-sulfate (AAS) on fatty liver and hyperlipidemia induced by various treatments were studied in rats and guinea pigs. L-Ascorbic acid (AA) (50 or 175 mg/kg), a reference compound, lowered the lipid levels in the serum and/or liver in guinea pigs, while AA had little effect in rats. On the other hand, AAS (300 mg/kg) was effective in both animals. In rats, AAS lowered cholesterol and triglycerides in the serum from ethionine-treated animals and in the liver from orotic acid-supplemented animals. In guinea pigs, this compound lowered cholesterol and triglycerides in the serum from ethionine-treated animals, lipids in the liver from cholesterol-supplemented animals, and lipids in the serum and liver from scorbutic animals. AA markedly increased the content of AA in the organs in all experiments, while AAS had a slight effect. Thus, it is suggested that AAS exerts its hypolipidemic and lipotropic effects by the specific actions of AAS.

Animals↗