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PubMed2001

The ascertainment and management of tuberculosis in Tayside, Scotland during 1993-94.

OBJECTIVE: To evaluate whether utilising a database of dispensed prescriptions for anti-tuberculous chemotherapy could improve case ascertainment compared to standard methods. A further objective was to assess whether cases were managed according to standard guidelines. DESIGN: Retrospective case note audit. SETTING: Tayside, Scotland SUBJECTS: Patients identified by conventional (i.e. SMRI diagnostic codes, notifications to the Health Board, microbiology and pathology reports) and the data base (MEMO) as potentially having tuberculosis and receiving treatment between 1st January 1993 and 31st December 1994. One hundred and ninety one potential cases were identified. One hundred and twenty two case notes were obtained for review. Eighty eight of these were initially thought to have tuberculosis and the results below refer to these 88 cases. RESULTS: MEMO identified 43 cases not found by conventional methods. Cases identified by MEMO were more likely to have been managed as outpatients and less likely to have positive microbiology than cases identified by conventional means. Only 26 cases were notified to the Health Board, including all smear positive cases. CONCLUSIONS: Notification of tuberculosis continues to be incomplete. Use of the MEMO system almost doubled case ascertainment. The absence of a firm diagnosis may lead to a reluctance to notify cases being treated as tuberculosis.

Antitubercular Agents↗
PubMedDate not supplied

[Epidemiology of Tuberculosis in Mexico, 1981-1998. Inconsistencies between reports of the WHO and the Ministry of health].

OBJECTIVE: To describe the tuberculosis morbidity and mortality trends in Mexico, by comparing the data reported by the Ministry of Health (MH) and the World Health Organization (WHO) between 1981 and 1998. MATERIAL AND METHODS: The number of cases notified in the past few years, their rates, and the trends of the disease in Mexico were analyzed. The incidence of smear-positive pulmonary tuberculosis was estimated for 1997 and 1998 with the annual tuberculosis infection risk (ATIR), to estimate the percentage of bacilliferous cases in 1997-1998. RESULTS: WHO reported more tuberculosis cases for Mexico than the MH. However, this difference has decreased throughout the years. The notification of smear-positive cases remained stable during 1993-1998. The estimated percentages of detection were 66% for 1997 and 26% for 1998 (based on ATIR of 0.5%). Tuberculosis mortality decreased gradually (6.7% per year) between 1990 and 1998, whereas the number of new cases increased, suggesting the persistence of disease transmission in the population. CONCLUSIONS: Inconsistencies between case notifications from national data and WHO were considerable, but decreased progressively during the study period. According to ATIR estimations, a considerable number of infectious tuberculosis cases are not detected. The English version of this paper is available at: http://www.insp.mx/salud/index.html.

Adolescent↗
PubMedDate not supplied

[Measles in the Italian regions: estimate of infection parameters].

Key epidemiological parameters (forces of infection, contact matrices, reproduction ratios) from the basic SEIR age structured model for childhood infectious diseases are estimated for all Italian regions from pre-vaccination case-notification data. Such parameters allow to summarise the pre-vaccination epidemiology of measles in the Italian regions, particularly the amount of effort needed for the eradication of the disease, consistently with the WHO targets. Despite the limited reliability paid to Italian case notifications data, the results show i) that the estimated eradication coverages are nor distant from the levels estimated from Northern-Europe; ii) that regions seemingly demanding the largest eradication effort seem also to be those characterised, up to now, by the lowest coverages; iii) the importance of achieving high coverages without delays in the age of administration of vaccination.

Adolescent↗
PubMed2003

Improving malaria surveillance in inner city London: is there a need for targeted intervention?

Malaria in south east London is under-notified, and a previous local study has described how available data can underestimate the incidence. An active surveillance system was established and data on malaria cases diagnosed between the 1st January and 31st December 2000 were gathered from local laboratories, the Malaria Reference Laboratory (MRL) and a neighbouring health authority. In total 320 cases were identified in local residents (42.33 per 100,000). Of these 320, 293 were laboratory confirmed (38.75 per 100,000) and there were 47 notifications on clinical suspicion. Only 6.8% (20) laboratory-confirmed cases were formally notified. Males of African descent aged 25-39 years who travelled to West Africa were most affected, and 92.5% of the cases were of P. falciparum infection. The surveillance programme confirmed that formal malaria notifications are unreliable. The most important group of residents for targeted health intervention are members of ethnic minority groups, born in endemic areas and travelling to their countries of origin to visit family or friends.

Adolescent↗
PubMed2004

Strengthening early warning function of surveillance in the Republic of Serbia: lessons learned after a year of implementation.

The Republic of Serbia, with WHO support, has implemented an early warning system (ALERT) for priority communicable diseases, to complement the routine surveillance system which notifies individual confirmed cases. The results of its evaluation, conducted one year after implementation is presented here. ALERT relies on notification of 11 syndromes by primary care facilities. Data is analysed weekly at district level and transmitted to national epidemiologists. ALERT is perceived to be a simple and flexible tool. Acceptability is higher at national level than at district level. Some districts perceive ALERT as a parallel system poorly connected to control measures. Sensitivity of ALERT in detecting cases of meningitis is 93%, and 37% for cases of hepatitis. Retrospective analysis of ALERT data identified 9 outbreaks, 5 of which had been recognized by epidemiologists. ALERT was the timeliest system for detecting 4 outbreaks identified by both systems. ALERT was useful for triggering timely investigation and control of outbreaks of hantavirus and salmonellosis and for detecting the start of the influenza season. However, ALERT did not detect clusters of brucellosis and tularaemia targeted by the unexplained fever syndrome. This evaluation underlined the need for a global review of surveillance activities when implementing new components such as ALERT. While control measures based on notification of individual confirmed cases are well understood and implemented, the investigation and verification process that should result from an increase in ALERT syndromes is not fully understood. Field epidemiology training programmes, such as the EPIET programme, are best suited to bring about this change of perspective.

Communicable Disease Control↗
PubMed2005

[The control of infectious diseases in The Netherlands].

Municipal health services (MHSs) carry out the control and prevention of communicable diseases, under the authority of the municipal councils. Mayors have the authority to enforce measures aimed at individuals, such as isolation and quarantine. The mandatory notification of infectious diseases by physicians, as required by the Infectious Diseases Act, is an essential part of infectious disease control. By collecting these notifications, MHSs obtain a much better picture than the individual physician of the mutual relationships between the reported cases. MHSs monitor current regional developments, while the National Institute for Public Health and the Environment (RIVM) does this for the entire country and elsewhere in the world. By means of electronic message service, the information can be disseminated immediately, if necessary, to health professionals everywhere in The Netherlands. In case of national threats or epidemics, the National Coordination of Infectious Disease Control (LCI) can request expert advice from the Outbreak Management Team and can advise the Minister of Public Health, Welfare and Sport (VWS) as to the best control measures. The Minister is chairman of a board of administrators, defines the policy and bears the final responsibility. The Ministry of VWS creates the necessary conditions. The Minister of VWS has noted structural errors in the organisation of the prevention of infectious diseases and will implement an improved organisational structure in the beginning of 2005. The assignments of the new centre are not only research and advising, but also the overall management of the prevention.

Communicable Disease Control↗
PubMed2005

Incidence of tuberculous meningitis in France, 2000: a capture-recapture analysis.

OBJECTIVE: To estimate the incidence of culture-positive and culture-negative tuberculous meningitis (TBM) in France in 2000. METHODS: Capture-recapture method using two unrelated sources of data: the tuberculosis (TB) mandatory notification system (MNTB), recording patients treated by anti-tuberculosis drugs, and a survey by the National Reference Centre (NRC) for mycobacterial drug resistance, recording culture-positive TBM. RESULTS: Of 112 cases of TBM reported to the MNTB, 28 culture-positive and 34 culture-negative meningitis cases were validated (17 duplicates, 3 cases from outside France, 21 false notifications, and 9 lost records were excluded). The NRC recorded 31 culture-positive cases, including 21 known by the MNTB. When the capture-recapture method was applied to the reported culture-positive meningitis cases, the estimated number of meningitis cases was 41 and the incidence was 0.7 cases per million. Sensitivity was 75.6% for the NRC, 68.3% for the MNTB, and 92.7% for both systems together. When sensitivity of the MNTB for culture-positive cases was applied to culture-negative meningitis, the total estimated number of culture-negative meningitis cases was 50 and the incidence was 0.85 cases per million. CONCLUSION: TBM is underestimated in France. Capture-recapture analysis using different sources to better estimate its incidence is of great interest.

Adult↗
PubMed2006

Ten-year experiences of the tuberculosis control programme in the southern region of Ethiopia.

SETTINGS: The tuberculosis control programme, southern region of Ethiopia. OBJECTIVE: To assess the impact of the expansion of the DOTS strategy on tuberculosis (TB) case finding and treatment outcome. DESIGN: Reports of TB patients treated since the introduction of DOTS in the region were reviewed. Patients were diagnosed and treated according to World Health Organization (WHO) recommendations. Case notification and treatment outcome reports were compiled quarterly at district level and submitted to the regional programme. RESULTS: Of 136,572 cases registered between 1995 and 2004, 47% were smear-positive, 25% were smear-negative and 28% had extra-pulmonary tuberculosis (EPTB). In 2004, 94% of the health institutions were covered by DOTS. Between 1995 and 2004, the smear-positive case notification rate increased from 45 to 143 per 100,000 population, the case detection rate from 22% to 45%, and the treatment success rate from 53% to 85%. The default and failure rates decreased from 26% to 6% and from 7% to 1%, respectively. DISCUSSION: There was a steady increase in the treatment success rate with the decentralisation of DOTS. Although 94% coverage was achieved after 10 years, the stepwise scale-up was important in securing resources and dealing with challenges. The programme achieved 85% treatment success; however, with the current low case detection rate (45%), the 70% WHO target seems unachievable in the absence of alternative case-finding mechanisms.

Communicable Disease Control↗
PubMedDate not supplied

Factors associated with the use of court bypass by minors to obtain abortions.

Interviews with minors at four Minnesota abortion clinics revealed that 43 percent used the court bypass option that is part of that state's parental notification statute. The proportion who did so increased with age and was most common among lower socioeconomic groups. A discriminant function analysis showed that perceived maternal supportiveness was a key difference between those who went to court and those who notified their parents. Young women who attended religious services frequently were less likely than those who did not tell their parents of their abortion plans. Minors who notified only one parent--and still had to go to court under Minnesota law, which requires notification of both parents--were more likely than those who told neither to come from a single-parent household and to have good communication with their mother.

Abortion, Legal↗
PubMed1996

[Surveillance of the HIV-epidemic in Norway].

Surveillance of HIV infection and AIDS is still a cornerstone in the efforts to prevent spread of HIV in Norway. The surveillance system aims at measuring the incidence and prevalence of HIV infection in the country. We describe the development of the surveillance from 1983 until 1996 based on the National Notification System for Infectious Diseases. New cases of HIV infection are reported anonymously but cases of AIDS are reported with name. Key information on each case includes age, gender, residence and the most likely time, place and route of transmission. The notification system is supplemented by screening of pregnant women, military recruits and blood donors, and by surveys of the number of tests performed, and other information. The information is analysed regularly, interpreted and communicated to the health services and the public.

Acquired Immunodeficiency Syndrome↗
PubMed1997

The epidemiology of notified genital Chlamydia trachomatis infection in Victoria, Australia: a survey of diagnosing providers.

Data on 259 notified cases of genital chlamydia infection diagnosed in Victoria Australia in January and February 1995 were augmented by call-back. Risk factor data was available for 221. Patients were primarily adolescents or young adults (median age 23 years); 66% were women. Men were more commonly symptomatic. Persons without symptoms were tested as a result of partner notification, sexual risk, termination of pregnancy, or because of abnormalities on genital examination. Limitations of antigen-based screening tests in low prevalence populations were rarely considered. Although antimicrobial treatment usually accorded with available guidelines, case management was not well geared to reducing the broader issue of risk of this infection in the community. Data management systems for handling name-coded data, and systems for recall and follow-up of diagnosed patients and their partners were often inadequate. Sexual history taking had not generally identified details of sexual partners. Partner notification was generally regarded as the patient's responsibility and professional help with contact tracing was rarely sought. Control of chlamydia will require much greater attention to management issues, particularly contact tracing.

Adolescent↗
PubMed1997

[Medical function in case of death: a final service to the patient and a key factor in legal safeguard].

The final service a doctor gives to his patients is to confirm death and to comfort the relatives. The unequivocal confirmation of death can, with complete justification, be considered the most important diagnosis so that it must be reached with every precaution. Apart from special conditions in intensive care units, where the guidelines of the Swiss Academy of Medical Sciences have to be followed with a view to using organs for transplantation, for example, the presence of reliable signs of death must absolutely be confirmed. The doctor who confirms death plays a key role in detecting so-called unusual deaths which require notification even in "clear", non-suspicious circumstances. This also applies to late deaths in hospital after an accident or other violence, where the clarification of the causal connection between this event and death is of decisive relevance. The detection or unequivocal exclusion of an outside influence in the death thus depend on the quality of the medical post-mortem examination and compliance with the duty of notification. The additional tasks falling to a doctor when he undertakes a legal inspection at the request of the examining authority in the case of an unusual death are discussed here only in passing. These tasks presuppose that the doctor has appropriate experience, which is why only official or district physicians from named institutions are accepted from the legal and forensic points of view in some Cantons.

Autopsy↗
PubMed1997

Cancer of the skin in Zimbabwe: an analysis based on the Cancer Registry 1986 to 1992.

OBJECTIVES: To determine whether skin cancers are increasing. DESIGN: Cancer Registry series. SETTING: Cancer Registry Office in Harare, Zimbabwe. This registry serves the referral hospitals in Harare and Bulawayo. SUBJECTS: All cancer patients (9,029 males, 8,730 females) notified from 1986 to 1992. MAIN OUTCOME MEASURE: Proportion of skin cancer to the total cancers notified. RESULTS: The limitations of the Cancer Registry were noted. In Black Zimbabweans, skin cancers increased from 381 (11% of all notifications) in 1986 to 1,346 (29.7% of all notifications) in 1992. The increase was due to an increase in Kaposi's sarcoma in both men and women although the number notified in women was a quarter of that notified in men. In White Zimbabweans, there was a significant increase in basal cell carcinoma in men and this cancer increased with age from 6.52 per 1,000 population in people 30 to 54 years to 25.04 per 1,000 in those over 54 years of age. CONCLUSION: Our findings show that the number of people with skin cancers is on the increase probably due to the AIDS epidemic and also the aging of the White population, with implications for the demand for health care for treating these cancers in a health service working on a very tight budget.

Adult↗
PubMed2004

Rapid HIV-1 testing during labor: a multicenter study.

CONTEXT: Timely testing of women in labor with undocumented human immunodeficiency virus (HIV) status could enable immediate provision of antiretroviral prophylaxis. OBJECTIVES: To determine the feasibility and acceptance of rapid HIV testing among women in labor and to assess rapid HIV assay performance. DESIGN, SETTING, AND PATIENTS: The Mother-Infant Rapid Intervention At Delivery (MIRIAD) study implemented 24-hour counseling and voluntary rapid HIV testing for women in labor at 16 US hospitals from November 16, 2001, through November 15, 2003. A rapid HIV-1 antibody test for whole blood was used. MAIN OUTCOME MEASURES: Acceptance of HIV testing; sensitivity, specificity, and predictive value of the rapid test; time from blood collection to patient notification of results. RESULTS: There were 91,707 visits to the labor and delivery units in the study, 7381 of which were by eligible women without documentation of HIV testing. Of these, 5744 (78%) women were approached for rapid HIV testing and 4849 (84%) consented. HIV-1 test results were positive for 34 women (prevalence = 7/1000). Sensitivity and specificity of the rapid test were 100% and 99.9%, respectively; positive predictive value was 90% compared with 76% for enzyme immunoassay (EIA). Factors independently associated with higher test acceptance included younger age, being black or Hispanic, gestational age less than 32 weeks, and having had no prenatal care. Lower acceptance was associated with being admitted between 4 pm and midnight, particularly on Friday nights, but this may be explained in part by fewer available personnel. Median time from blood collection to patient notification of result was 66 minutes (interquartile range, 45-120 minutes), compared with 28 hours for EIA (P<.001). CONCLUSIONS: Rapid HIV testing is feasible and delivers accurate and timely test results for women in labor. It provides HIV-positive women prompt access to intrapartum and neonatal antiretroviral prophylaxis, proven to reduce perinatal HIV transmission, and may be particularly applicable to higher-risk populations.

AIDS Serodiagnosis↗
PubMed2005

Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally.

CONTEXT: The United Nations Millennium Development Goals (MDGs) are stimulating more rigorous evaluations of the impact of DOTS (the WHO-recommended approach to tuberculosis control based on 5 essential elements) and other possible strategies for tuberculosis (TB) control. OBJECTIVE: To evaluate the prospects for detecting 70% of new sputum smear-positive cases and successfully treating 85% of these by the end of 2005, for reducing TB incidence, and for halving TB prevalence and deaths globally between 1990 and 2015, as specified by the MDGs. DATA SOURCES: TB case notifications (1980-2003) from DOTS and non-DOTS programs and cohort treatment outcomes (1994-2002) reported annually to the World Health Organization (WHO) by up to 200 countries, TB death registrations, and prevalence surveys of infection and disease. STUDY SELECTION: Case notification series that reflect trends in incidence, treatment outcomes from DOTS cohorts, death statistics from countries with WHO-validated vital registration systems, and national prevalence surveys of infection and disease. DATA EXTRACTION: Case reports, treatment outcomes, prevalence surveys, and death registrations from WHO's global TB database covering 1990-2003 to estimate TB incidence, prevalence, and death rates through 2015 for 9 epidemiologically different world regions. DATA SYNTHESIS: TB incidence increased globally in 2003, but incidence, prevalence, and death rates were approximately stable or decreased in 7 of 9 regions. The exceptions were regions of Africa with low (<4% in adults 15-49 years) and high rates (> or =4%) of HIV infection. The global detection rate of new smear-positive cases by DOTS programs increased from 11% in 1995 to 45% in 2003 (with the lowest case-detection rates in Eastern Europe and the highest rates in the Western Pacific) and could reach 60% by 2005. More than 17 million patients were treated in DOTS programs between 1994 and 2003, with overall treatment success rates more than 80% since 1998. In 2003, overall reported treatment success was 82%, with much variation among regions. The highest rates were reported in the Western Pacific region (89%) and lowest rates in African countries with high and low HIV infection rates (71% and 74%, respectively), in established market economies (77%), and in Eastern Europe (75%). To halve the prevalence rate by 2015, TB control programs must reach global targets for detection (70%) and treatment success (85%) and also reduce the incidence rate by at least 2% annually. To halve the death rate, incidence must decrease more steeply, by at least 5% to 6% annually. CONCLUSION: Reduction of TB incidence, prevalence, and deaths by 2015 could be achieved in most of the world, but the challenge will be greatest in Africa and Eastern Europe.

Africa↗
PubMed1997

First 25 years of the Hungarian congenital abnormality registry.

The Hungarian Congenital Abnormality Registry was established in 1962 based on obligatory notification of cases with congenital abnormalities by physicians. However, continuous and expert evaluation of data started in 1970 when the Registry was moved to the National Institute of Public Health. Later several other systems, including the Nationwide Evaluation of Multimalformed Infants, Case-Control Surveillance of Congenital Abnormalities, and Surveillance of Germinal Mutations, were based on the Registry. Data and results of the first 25 years of the Registry are evaluated from three different aspects: 1) evaluation of the originally planned and later adopted missions of the Registry; 2) quality control of the Registry is based on the proportion of misdiagnoses, completeness of notifications, and pathogenetically oriented classification; 3) outcome evaluation indicated the different quality of recorded data in lethal, severe, and mild congenital abnormalities. The data base of the Registry was appropriate to estimate the proportion of preventable congenital abnormalities due to the four different preventive programs and to evaluate the pregnancy outcomes after the Chernobyl nuclear power plant accident.

Congenital Abnormalities↗
PubMed2003

Comparison of fatal occupational injury surveillance systems between the European Union and the United States.

BACKGROUND: Comparison of workplace injury statistics among countries is often problematic, mainly because work injury statistics are based on different national recording and notification systems. METHODS: Definitions of fatal work-related injuries, identification of the reference population, and rates of fatal work-related injuries, from 1995 to 1998, were compared between the European Statistics on Accidents at Work (ESAW) and the United States (U.S.) Census of Fatal Occupational Injuries (CFOI). RESULTS: Similar definitions for workplace fatalities were found, but CFOI is based on an active search, and ESAW on passive notification. Daily fatal occupational injury numbers were similar in both: about 17 workers die per day, but average annual work-related death rates were higher in the U.S. CONCLUSIONS: There are enough differences to allow direct comparisons between both systems. CFOI is likely to be more comprehensive than ESAW. It is conceivable that the true number of fatal occupational injuries in the European Union (E.U.) could be higher, and thus the apparent difference in U.S. and E.U. fatal injury rates may be an artifact of the different surveillance systems.

Accidents, Occupational↗
PubMed1993

Asbestos screening and education programs for building and construction trades unions.

Worker notification involves informing current and past employees of their risk of disease. It also involves suggesting ways to reduce their risks. The asbestos screening and education programs designed for the building and construction trades unions were a national multisite effort that focused on improving the health of eligible union members and retirees at high risk of developing asbestos-related disease. The asbestos screening and education programs were made available to "high-risk," asbestos-exposed local union members through the efforts of a number of international unions, including the International Union of Elevator Constructors and the Laborers' International Union of North America--both affiliates of the Building and Construction Trades Department, AFL-CIO. Consultation and program assistance in developing and implementing these programs were provided by the Occupational Health Foundation, a labor-sponsored, nonprofit organization with a multidisciplinary safety and health staff. Program components included identification of "high-risk" individuals, notification of risk, education, medical screening, legal referral, and various support services. Community-based physicians and/or physician-staffed mobile testing units provided services on a contractual basis according to a standardized medical protocol. Between 1988 and 1991, 2,136 union members and retirees from 89 local unions affiliated with the Elevator Constructors or the Laborers were screened in 59 regional programs. A general description and historical perspective are offered concerning program implementation, integration into existing union infrastructures. Emphasis is placed on the role of the unions in advancing members' interests when dealing with the health and socioeconomic implications of asbestos-related disease.

Asbestos↗