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A magnetoencephalography spatiotemporal analysis of neural activities during feature binding.

Previous literature shows that feature binding processes elicit fronto-hippocampal areas. The time course of this process, however, remains unknown. This is the first study that investigates feature binding using magnetoencephalography. Synthetic aperture magnetometry analysis was used to localize sources of increased power in the theta band during the encoding phases of a feature-binding task in the left and right medial frontal gyri (Brodmann's area 10) and left and right anterior cingulate gyri. Theta band synchronization was observed in many of these same areas, but also in other areas not noted to have increased theta band power suggesting a broad network of regions subserving the encoding phase of feature binding.

Adult↗

Tactile recognition in infantile nephropathic cystinosis.

Previous studies have demonstrated that individuals with cystinosis, an inherited metabolic disorder, have difficulty processing visual information, and may be selectively impaired in the ability to mentally rotate figures, despite having normal IQs and normal primary sensory function. In our novel task-the 'Black Box'-subjects identified objects solely by feeling the contours. Twenty-three subjects with cystinosis, aged 4 to 34 years, were individually matched with controls on age, sex, handedness, and test form. Subjects with cystinosis performed significantly worse in identifying objects than did controls. In addition, when only subjects over 7 years of age were included, those with cystinosis took significantly longer to correctly identify objects than did controls. Our findings suggest that individuals with cystinosis have difficulty with tactile recognition of common objects. These results support the hypothesis that a genetic disorder may have specific behavioral correlates.

Adolescent↗

Developmental psychopathology in adolescence: findings from a Swiss study--the NAPE Lecture 2005.

OBJECTIVE: Presentations of selective findings coming from the Zurich Adolescent Psychology and Psychopathology Study with two major aims: i) the study of the prevalence, course, and correlates of mental disorders in adolescence, and ii) the study of the determinants and processes of mental disorders in adolescence. METHOD: A representative sample of n = 1964 children and adolescents was studied in the canton of Zurich in 1994. Additional waves of data collection took place in 1997 and 2000/2001. Mean ages at these three assessments were 13, 16, and 20 years. Each wave contained a two-stage procedure of assessment with screening by questionnaires and consecutive interviewing. The main constructs used were general and specific measures of psychopathology, life events, coping styles, self-related cognitions, and quality of the social network. RESULTS: Prevalence rates of any mental disorder in school-age at the time of assessment was 22.5% fitting into a transcultural range of 18-26% based on DSM-III-R criteria. Furthermore, the derivation and validation of a four-group adolescent drinker typology was demonstrated. Additionally, the prevalence and continuity of functional-somatic symptoms from adolescence to young adulthood was shown. Another piece of the research tested for the identification of risk, compensatory, vulnerability, and protective factors influencing behaviour problems and found remarkably different frequencies across the four types of moderating factors. CONCLUSION: The presented findings provide further understanding of the developmental psychology and psychopathology of adolescence and the service, intervention, and prevention needs of this age-group.

Adolescent↗

Hemispheric asymmetry for visual information processing.

The left and right hemispheres of humans do not handle all aspects of visual information processing with equal ability. This is illustrated by a review of research concerning the processing of global versus local stimulus properties, low versus high spatial frequencies, and coordinate versus categorical spatial relationships. In general, the right hemisphere is dominant for processing global aspects of visual stimuli that are carried by low spatial frequencies, for the processing of coordinate spatial relationships and, perhaps, for extracting information from the magnocellular visual pathway. In something of a complementary manner, the left hemisphere is dominant for processing local aspects of visual stimuli that are carried by high spatial frequencies and, perhaps, for processing categorical spatial relationships and for extracting information from parvocellular visual pathway. Consideration is given to developmental mechanisms that may underlie the emergence of hemispheric asymmetry for these interrelated aspects of visual information processing.

Brain↗

Artificial intelligence: the clinician of the future.

Human beings have long been fascinated with the idea of artificial intelligence. This fascination is fueled by popular films such as Stanley Kubrick's 2001: A Space Odyssey and Stephen Spielberg's recent film, AI. However intriguing artificial intelligence may be, Hubert and Spencer Dreyfus contend that qualities exist that are uniquely human--the qualities thought to be inaccessible to the computer "mind." Patricia Benner further investigated the qualities that guide clinicians in making decisions and assessments that are not entirely evidence-based or grounded in scientific data. Perhaps it is the intuitive nature of the human being that separates us from the machine. The state of artificial intelligence is described herein, along with a discussion of computerized clinical decision-making and the role of the human being in these decisions.

Artificial Intelligence↗