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Triple approach in the diagnosis of dominant breast masses: combined physical examination, mammography, and fine-needle aspiration.

In an attempt to reduce the number of breast biopsies done for benign breast disease in patients with breast lumps, we evaluated prospectively the sensitivity and specificity of the combination of three diagnostic modalities: clinical examination, mammography, and fine-needle aspiration cytologic examination (FNA). A total of 234 patients with a breast mass had a physical examination, a mammogram, and FNA, and were listed as malignant/suspicious or benign. All patients underwent a subsequent biopsy: 110 were found to have breast cancer, and 124 had a benign lesion. The sensitivity and specificity of the individual tests were as follows: 89% and 73%, respectively, for mammographic examination; 93% and 97% for FNA cytologic examination; and 89% and 60% for physical examination. For the combined triad of tests, the sensitivity was 100% and specificity 57%. All patients who had breast cancer had positive findings for malignancy in one or more of the diagnostic tests, i.e., 100% sensitively. All patients who had negative findings for malignancy in all three diagnostic tests had benign lesions, i.e., a negative predictive value of 100%. We conclude that breast masses can be diagnosed with a high degree of accuracy by combined physical, mammographic, and fine-needle aspiration cytologic examination. Patients in whom physical examination, mammography, and FNA were negative for malignancy can be safely observed, obviating the need for an open biopsy.

Adult↗

Development of a self-efficacy scale for mammography.

Mammography screening has been demonstrated to decrease mortality from breast cancer. Although adherence rates have increased, there is still a need to increase annual screening. Self-efficacy is a construct that has been found useful in predicting behaviors. Measurement of self-efficacy needs to be specific to the behavior and to have good validity and reliability. The purpose of this study is to describe development of a self-efficacy instrument to measure confidence in obtaining a mammogram. Bandura's model guided item development. Construct validity was measured using confirmatory factor analysis and logistic regression. Cronbach alpha was used to test internal consistency reliability. A Cronbach alpha coefficient of .87 was obtained. The mammography self-efficacy scale evidenced content and construct validity.

Aged↗

Examining accuracy of screening mammography using an event order model.

Screening mammography is a widely used method for breast cancer detection. For each mammogram we propose a performance model based on order of outcomes. That is, we envision an initial assessment, a follow up assessment if the initial one is positive and, eventually, a determination of whether cancer was present or not. A model can be built at each stage reflecting effects due to patient characteristics, to the facility where mammogram was performed and to the radiologist reading the mammogram. Since assessment is not perfectly associated with outcome, familiar rates of agreement and disagreement are of interest. These rates can be investigated at various levels of risk factors of interest. The approach is illustrated with screening mammography data from the Group Health Cooperative in Seattle, WA. A Bayesian framework is adopted for inference and an analysis of the data set is presented.

Adult↗

Use of screening mammography and clinical breast examinations among black, Hispanic, and white women.

BACKGROUND: Breast cancer screening can be an effective tool in the early detection of breast cancer but remains underused by women in the United States. METHODS: We analyzed data from 22,657 women (2,068 black women, 707 Hispanic women, and 19,882 white women) who participated in the 1990 Behavioral Risk Factor Surveillance state-based telephone survey. Using the recommended guidelines of the American Cancer Society for breast cancer screening, we examined utilization rates by demographic and selected variables, stratified by ethnic groups. RESULTS: Of the women included in the analysis, 47% of both black and Hispanic women and 50% of white women reported having had a recent mammogram, and 68% of black women, 59% of Hispanic women, and 66% of white women reported having had a recent clinical breast examination (CBE). Important predictors of the use of breast cancer screening procedures for each group were having had a routine examination in the past year, having seen an obstetrician or gynecologist or specialist during the last routine examination, and more than a high school education. CONCLUSIONS: Many women are not having mammography and CBEs. Efforts to increase screening must focus on encouraging providers to use CBEs as a screening tool and to recommend mammography. Strategies should be developed to increase the use of these procedures among women, particularly those of low income and low education levels.

Adult↗

Mammography and clinical breast examination among Korean American women in two California counties.

BACKGROUND: Mammography and clinical breast examination (CBE) are underutilized, especially by women from some racial/ethnic minorities. Few published studies of screening practices or correlates for these subgroups exist. METHODS: A population-based telephone survey of 1,090 Korean Americans living in two California counties was conducted. To produce population estimates of mammography and CBE testing, we adjusted frequencies to account for different selection probabilities. Multivariable logistic regression was performed to determine independent correlates of testing. RESULTS: Only 34% [95% confidence intervals (CI) 30%, 39%] of Korean American women age 50 and older were estimated to have had a mammogram in the past 2 years. Only 32% (95% CI 28%, 37%) had had a CBE in the past 2 years. The strongest independent correlate of testing was having a regular medical checkup [odds ratio (OR) for mammogram = 9.21, 95% CI 3.98, 21.35; OR for CBE = 11.58, 95% CI 4.71, 28.46]. CONCLUSIONS: These estimates are lower than the Healthy People 2000 objectives as well as published estimates for other populations in the United States. Planning and implementing tailored programs to improve screening are best done using a community-sensitive approach, which, because racial/ethnic subgroups are growing, will assume increasing public health importance.

Aged↗

Increasing mammography among women aged 40-74 by use of a stage-matched, tailored intervention.

BACKGROUND: Tailoring is a promising technique for encouraging greater performance of health-related behaviors. Tailored interventions are designed to be more individualized to personal characteristics, in contrast to "standard" interventions where all participants receive the same materials. METHODS: A total of N = 1864 women aged 40-74 were recruited from a staff model HMO and randomly assigned to one of three intervention groups: (a) No Educational Materials, (b) Standard Materials, and (c) Stage-Matched Materials. A provider-directed component was common across all three conditions. The Standard and Stage-Matched groups each received two mailed educational packets after baseline and follow-up telephone interviews. The Stage-Matched intervention was based on the Transtheoretical Model of behavior change. RESULTS: Analyses of n = 1397 women (after all attrition) showed that receipt of mammography after the baseline interview was higher for the Stage-Matched group (63.6%) than for the No Materials group (54.9%; OR = 1.43, 95% CI = 1.10, 1.86). The Standard intervention group was intermediate (58. 5%). The Standard group did not differ from the No Materials group, but did differ from the Stage-Matched group in multivariate analysis. CONCLUSIONS: Stage-matched, tailored materials may be a means to encourage screening mammography. Such interventions can be implemented by telephone and mail.

Adult↗

The effectiveness of using standardized patients to improve community physician skills in mammography counseling and clinical breast exam.

BACKGROUND: Traditional didactic continuing education is relatively ineffective in improving physicians' clinical skills. We hypothesized that a centralized course including small group workshops utilizing standardized patients could improve clinical skills for a reasonable cost. METHODS: We designed a 5-h course aimed at improving physicians' counseling skills (re: screening mammography) and clinical breast exam (CBE) skills. The course included lectures, demonstrations, and small group skills sessions utilizing standardized patients and was offered to 156 typical community-based primary care physicians. Pre- and postcourse evaluation included in-office assessments of physician CBE and counseling performance by standardized patients and a written test of knowledge and attitudes. RESULTS: A total of 54.5% of eligible physicians participated. They improved modestly in only one of three areas of counseling skills measured (providing counseling appropriate to the patient's readiness to accept mammography, P = 0.01). The overall CBE score increased substantially from 24.8 to 34.7 (P < 0.0001). Knowledge in all areas measured and confidence in counseling patients also increased. The basic course cost $202 per physician trained. CONCLUSIONS: Most community-based primary care physicians may find small group training and in-office evaluation involving standardized patients acceptable. Such training may be more effective in improving physical exam skills than complex communication skills.

Breast Neoplasms↗

A cross-cultural consumer-based decision aid for screening mammography.

BACKGROUND: "Women should have mammograms" is the usual perspective of educational interventions about screening. The perspective that "women should be informed" about potential risks and benefits so they can make value- and evidence-integrated personal decisions has recently been advocated. However, this perspective has not previously been operationalized. We developed an evidence-based cross-cultural mammography decision aid (MDA), for European American and Mexican American women who are 50-70 years old, at average risk of breast cancer, of varying educational levels, and English- or Spanish-speaking. METHODS: MDA development included: (1) content development by a multidisciplinary team and lay women and (2) testing for validity and reliability. Four parts include: (1) introduction; (2) information about logistics (cost, time, discomfort) and risks (sequelae of false-positive or negative results; (3) probability of developing breast cancer; and (4) benefit of mammography regarding breast cancer outcomes (e.g., death and recurrence). We assessed reliability (stability of decisions with the same information) after 1-2 weeks. We assessed validity (comprehension of information) quantitatively (probabilities were changed to see whether preferences changed predictably) and qualitatively (focus groups, standardized probes for comprehension). Subjects were a convenience sample of 49 European American (50-81 years old) and 54 Mexican American (49-89 years old) women from administrative staff at a medical school, the waiting room of an indigent primary care clinic, and a community center. RESULTS: Reliability was 100%. In quantitative validity testing, 22 of 28 women (89%) changed preference as predicted with changed probabilities. Comprehension was confirmed qualitatively in all phases of testing with both Spanish and English versions. CONCLUSION: The decision aid is valid and reliable in English and Spanish for southwestern Mexican American and European American women at average risk of breast cancer, including those of low educational levels.

Aged↗

Cultural barriers to mammography, clinical breast exam, and breast self-exam among Chinese-American women 60 and older.

BACKGROUND: This study examined screening utilization at least once and regular adherence to mammography, clinical breast exam, and breast self-exam among older Chinese-American women. METHOD: One hundred women were recruited from senior centers in two metropolitan cities. Participants completed a questionnaire that included sections on demographics, health history, health insurance coverage, breast cancer screening, common and cultural barriers to screening, and acculturation. RESULTS: Logistic regression models found insurance coverage for mammography and acculturation to be significant predictors of having had a mammogram at least once. Low perceived need/lack of physician recommendation and recency of physical examination were significant predictors of having had a mammogram in the past year. Acculturation and modesty were significant predictors of having had a clinical breast exam at least once, while recency of physical examination was a significant predictor of having had a clinical breast exam in the past year. Reliance on medial professionals for screening and forgetting were significant predictors of having performed breast self-exam at least once, and forgetting was a significant predictor of regular performance of breast self-exam. CONCLUSIONS: These findings suggest that both common and cultural barriers play a role in breast cancer screening among older Chinese-American women, with cultural factors being more influential in the initiation of cancer screening behavior.

Acculturation↗

Factors associated with continued participation in mammography screening.

BACKGROUND: Relatively little is known about factors that predict ongoing participation in mammography screening at regular intervals. Members of managed care plans have access to this preventive service; yet, many still do not receive it routinely. METHODS: Using administrative data from HIP Health Plan of New York, a group model HMO, 24,215 women ages 50-80 years identified as having a screening mammogram during the baseline period were followed for 2 years to determine demographic and utilization factors that might be related to having a subsequent mammogram within the recommended time interval. RESULTS: Of the 24,215 women with an index mammogram, 71.8;pc had a subsequent screening mammogram within 2 years. Women ages 65-74 years and those with Medicare coverage had the highest mammogram rates among the age and coverage categories. Number of primary care and gynecology physician visits was strongly related to having a subsequent mammogram. The average (mean) time between index and subsequent mammogram was 14.4 months. CONCLUSION: The significance of health plan visits in subsequent mammography underscores the importance of physician-patient communication in a managed care plan and the integration of health plan members into the HMO delivery system. Even in this environment with equal access for all types of coverage, Medicaid members were less likely to receive this preventive service.

Aged↗

Costs and cost-effectiveness of a clinical intervention to increase mammography utilization in an inner city public health hospital.

BACKGROUND: Studies have demonstrated the cost-effectiveness of screening women for breast cancer; however, the cost-effectiveness of strategies to motivate women to receive breast cancer screening has been less well studied. METHODS: A total of 196 women, aged 50 to 74, who were enrolled in a public health hospital clinic, were noncompliant with mammography screening, and had at least one routine clinic appointment during the study period (15 months) were entered into a randomized, controlled trial of a motivational intervention to increase mammography rates. Costs were captured via a modified Delphi technique, accounting records, sampling of staff time logs, and an estimation of miscellaneous and overhead costs. Summary costs were calculated using Excel spread sheets. RESULTS: Overall, 49% of women who received the intervention had a mammogram within 8 weeks of an index visit compared with 22% of control women. Calculation of the cost-effectiveness of the project showed an additional cost of $151 (1996 U.S.$) for each woman receiving the intervention and $559 for each additional woman motivated to receive a mammogram. CONCLUSIONS: Cost tracking and cost-effectiveness analysis can be done when intervening in a clinical setting, thereby allowing clinics to make informed decisions about implementing programs to increase motivation of their patients to receive screening.

Aged↗

Hypothetical breast cancer risk from mammography.

The existence of low-dose risk has neither been proven nor disproven. If there is a risk from the low doses used in current mammographic techniques, it is immeasurably small, especially when compared to the overwhelmingly large incidence of naturally occurring breast cancers, many of which could be detected by mammography at an early curable stage. The risk, if it does exist, would be lowest among women exposed over 30 years of age, a fortunate circumstance since this group would benefit most from mammography.

Adolescent↗

Fifteen years of mammography in cosmetic surgery of the breast.

In a series of 1149 cases of cosmetic surgery of the breast performed from 1973 to 1989, early diagnosis of breast cancer in 34 cases was possible by relying mainly on the use of mammography for the diagnosis. It is strongly recommended that a policy of mandatory preoperative mammography be implemented so that all patients can be protected from a lethal disease that has a far better prognosis when detected early.

Breast↗

Comparison of breast tumours evaluated by ultrasound, mammography, and clinical investigation.

One hundred eleven palpable breast tumours were evaluated clinically, by mammography, and by ultrasound; upon histological examination 51 of the tumours turned out to be malignant and 60 benign. In 44 tumours, which appeared malignant on the ultrasound scan, the axilla was also scanned and the findings were compared with the results of histological examination of excised lymph nodes. The diagnostic accuracy for malignancy of breast tumours was 86.3% for ultrasound scans, 80.4% for mammography, and 78.4% for clinical evaluation; the respective diagnostic accuracy for benign lesions was 88.3%, 85%, and 91.7%. Of 36 enlarged reactive or malignant lymph nodes, 32 were detected by ultrasound and only 18 by clinical examination.

Axilla↗

Silicone gel granuloma following compressive mammography.

Silicone implant rupture is well recognized, particularly with the thin-walled implants inserted some years ago. On occasions a chronic granulomatous inflammation has been noted if silicone globules have infiltrated the tissues. The rupture may occur apparently spontaneously or after trauma, including attempts at external closed capsulotomy. The case report presented in this article documents rupture and dissemination of silicone caused by compressive mammography. Recent practice suggests that in order to enhance the image produced by mammography, particularly in the presence of the masking of a silicone implant, extreme compression is the preferred technique but perhaps should be regarded with some caution in patients with breast implants.

Breast Diseases↗

Microcontrolled pyro-electric instrument for measuring X-ray intensity in mammography.

A novel instrument for measurement of X-ray intensity from mammography consists of a sensitive pyro-electric detector, a high-sensitivity, low-noise current-to-voltage converter, a microcontroller and a digital display. The heart of this device, and what makes it unique is the pyro-electric detector, which measures radiation by converting heat from absorbed incident X-rays into an electric current. This current is then converted to a voltage and digitised. The detector consists of a ferro-electric crystal; two types were tested: lithium tantalate and lithium niobate. X-ray measurement in mammography is challenging because of its relatively low photon energy range, from 11 keV to 15 keV equivalent mean energy, corresponding to a peak tube potential from 22 to 36 kV. Consequently, energy fluence rate or intensity is low compared with that of common diagnostic X-ray. The instrument is capable of measuring intensities as low as 0.25 mW m(-2) with precision greater than 99%. Not only was the instrument capable of performing in the clinical environment, with high background electromagnetic interference and vibration, but its performance was not degraded after being subjected to 140 roentgen (3.6 x 10(-2) C kg(-2) air) as measured by piezo-electric (d33) or pyro-electric coefficients.

Equipment Design↗

Dynamic helical CT mammography of breast cancer.

PURPOSE: The purpose of this study was to determine whether dynamic helical computed tomography (CT)-mammography could assist in selecting the most appropriate surgical method in women with breast cancer. MATERIALS AND METHODS: Preoperative contrast-enhanced helical CT scanning of the breast was performed on 133 female patients with suspicion of breast cancer at the same time as clinical, mammographic, and/or ultrasonographic examinations. The patients were scanned in the prone position with a specially designed CT-compatible device. A helical scan was made with rapid intravenous bolus injection (3 ml/s) of 100 ml of iodine contrast material. Three-dimensional maximum intensity projection (MIP) images were reconstructed, and CT findings were correlated with surgical and histopathological findings. RESULTS: Histopathological analysis revealed 84 malignant lesions and seven benign lesions. The sensitivity, specificity, and accuracy levels of the CT scanning were 94.6%, 58.6%, and 78.9%. Helical scanning alone revealed additional contralateral carcinomas in three of four patients and additional ipsilateral carcinomas in three of five patients. However, the technique gave false-positive readings in 24 patients. The preoperative CT-mammogram altered the surgical method in six patients. CONCLUSION: Dynamic helical CT-mammography in the prone position may be one of the choices of adjunct imaging in patients with suspected breast cancer scheduled for surgery.

Adult↗

Screening mammography in the elderly: a case-control study.

This case-control study tested the hypothesis that elderly women with metastatic breast cancer were previously screened less than controls. Cases included women over 60 years old who had metastatic breast cancer; the tumor registry provided controls. Identical criteria yielded comparable groups (cases = 109, controls = 211) receiving primary care at this tertiary center. Radiology and medical records were examined for mammograms; these were blindly categorized "diagnostic," "screening," or "indeterminant." The major, unexpected finding was that less than 6% of controls had ever had screening mammography. The associations between screening and metastatic cancer (odds ratios) suggest a beneficial effect of screening: OR/0.73 for ever screened and OR/0.71 if screened within the year of cancer diagnosis. All confidence intervals include one; however, low screening participation leaves this study with little power. The major implication is that despite the current recommendations, the elderly are not being included in screening mammography programs.

Aged↗