Contact dermatitis to ketoprofen.
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Naphthol AS is a coupling agent of cotton dyeing. 2 elderly women with hyperpigmentation of the neck and limbs are described. Both felt itching on the neck, forearms, and lower extremities and noted hyperpigmentation a month later. Both had worn cotton flannel nightdresses in winter. Patch testing with cotton flannel and methanol extracts were positive, but after estraction with methanol, the residual flannel did not react. The methanol extracts of cotton flannel, were analysed. The patients were tested with 5 extracted components; Naphthol AS was found to be the causative agent.
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A patient developed an erythematous papular, vesicular rash after application of povidone-iodine 10% solution used as a surgical antiseptic. Patch testing revealed positive responses to povidone iodine 10 and 5% in water; 25 controls were negative. Patch testing with iodine, 0.5% in ethanol gave negative results.
9 patients with typical textile dermatitis were found to be allergic to dark polyester blouses. Thin-layer chromatography of the dyes extracted from the fabrics identified the presence of several dyes, from which Disperse Blue 106 was positive in all patients.
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52 (5.4%) of 1063 eczema patients showed a positive reaction to chlorhexidine gluconate 1% aq. and/or 1% pet. on patch testing. At retesting, 21/29 (72%) were still positive and the results of use-test, anamnesis and supplementary testing indicated allergic sensitization in about 50% of these patients. Patients with leg eczema/leg ulcer seem to be particularly at risk.
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