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At least 1,621 records · Page 90Linked to original sources
PubMed2005

Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: a six-month longitudinal follow-up study.

Twenty-six chemical elements and oxidative status were determined in serum of 12 patients with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried out. The results were compared with values obtained from healthy subjects living in the same geographic area. Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and Zn--elements strictly body regulated. Significant difference (p < or = 0.05) in mean concentrations of Ba, Ca, Cd, Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.

Adult↗
PubMed1991

An American approach to health system reform.

In terms of the major objectives one would have for health system reform, this plan makes the following choices: 1. It would cover everyone, through Medicare (the elderly), employer-based coverage (some workers and dependents) or a state-level public program that would replace Medicaid (the poor, unemployed, and other workers and dependents). 2. There would be a standard minimum package of required benefits for employer-based and public programs, with legislative requirements on maximum cost-sharing. Choice of provider might be restricted in some states. 3. Administration of the private programs would be the responsibility, as now, of the employers and/or insurance companies. Administration of the public program would be the responsibility of the states, with the objective of maximizing responsiveness to local needs and conditions. 4. It would control costs through giving the states a substantial financial stake in ensuring that the public program costs did not grow faster than nominal GNP. State control would also allow the testing of different mechanisms for cost control, with the ultimate objective of identifying the most effective cost-containment strategies. 5. The cost would be borne by employers, employees, and taxpayers. Employers would be protected from exorbitant costs by being allowed the option of paying into a public plan rather than providing health insurance themselves. The poor and unemployed would be protected by having their coverage under the public program subsidized on a sliding scale. 6. The political feasibility test would be met by retaining a major role for insurance companies and by retaining the role of employer-based coverage--thus reducing the tax increase needed to ensure universal coverage. By allowing flexibility in design of cost-containment strategy, some of the controversy over this issue would also be deflected. Our proposal is also not without problems. First, our approach would still have adverse effects on the profitability of small businesses and on the employment prospects for low-wage workers--although these effects would be less than under conventional mandates and less than under proposals with higher tax rates. Second, some states may not want the responsibility we envision or have the capacity to carry it out. But several Canadian provinces are relatively small and are able to perform the same administrative functions within the Canadian national health system. In addition, since the federal government would continue to administer the Medicare program, states would have the option of tying their policies for hospital and physician payment and utilization control to those of Medicare.(ABSTRACT TRUNCATED AT 400 WORDS)

Canada↗
PubMed1990

[Coronary arteriography after acute myocardial infarction].

On the basis of a population of 1,848 patients with acute myocardial infarction (AMI), prognostic stratification has been developed for detection of patients with high risks of death and repeated AMI in the first year after admission for coronary arteriography (KA). Patients with ischaemia at rest during hospitalization (17% of the patients, 18% one-year mortality), with previous AMI and cardiac failure during hospitalization (8%, 25% mortality), with positive exercise ECG (6%, 11% mortality) and patients with left ventricular ejection fraction (LVEF) between 0.22 and 0.44 (12%, 12% mortality) are recommended for coronary arteriography. Patients over the age of 75 years (31% mortality), patients with very low LVEF (less than 0.20) (33% mortality), patients with negative exercise ECG (3% mortality) and patients with normal LVEF (greater than 0.45) (5% mortality) are not recommended for investigation by coronary arteriography. These guidelines for coronary arteriography after AMI, based on recommendations from abroad should be considered in Denmark in relation to the capacity for carrying out this examination.

Aged↗
PubMed1989

[Longitudinal study of the functional capacity of aged persons in Upper Normandy, 1978-1985].

A longitudinal study of 1,082 elderly persons was conducted by INSERM over a six-year period in order to identify risk factor in pathological ageing. Several functional capacities were selected for study on the basis of their relevance to independent daily living. This article describes the methodology and the extent to which research objectives were able to be fulfilled. The initial survey took place in 1978-79. A follow-up study targeted two distinct areas of interest: the monitoring of mortality rates and the re-evaluation of the performance of survivors at three and six year intervals. Re-evaluation of performance involved the exploration of the individual's mobility, capacity to carry out activities of daily living etc. The consistency of the entire data set assembled over the six-year period was assessed in various ways. At six year follow-up survival rate could be determined for 98.8% of the initial cohort, and 87.1% of the survivors were able to be reinterviewed. The different probabilities of healthy survival, by sex and age, are tabulated in the appendices.

Activities of Daily Living↗
PubMed1985

[Modulating action of barium and other ions on the sensory activity of frog labyrinth].

The effect of Ba2+, TEA, 4-AP and CoCl2 on the EPSP and spike discharges recorded from single fibres of the posterior nerve in the isolated frog labyrinth has been investigated. In Ca-free solution Ba2+ preserved, at low concentration (0.3 mM), the resting activity and at higher levels (up to 6 mM) it resulted in a pronounced facilitation of the EPSP and spike discharges. Facilitation increased on increasing Ba2+ concentration up to 4-5 mM and it was more evident in those units exhibiting a low resting spike firing. The effect of Ba2+ (1 mM) was completely antagonized by 10 mM Ca2+ X CoCl2 (3 mM) suppressed the resting rate at the normal external Ca2+ concentration; the Co2+ block was partially relieved by 1.8 mM Ba2+ X TEA (20 mM) evoked a clear-cut increase in the EPSP and spike discharges which, however, was less consistent than that produced by Ba2+. By comparing the effect of TEA on the spike frequency with that obtained at different Ba2+ levels, the Ba2+ capacity to carry the Ca2+ current was dissected. Such an effect is dose-dependent and it is more evident in low-frequency units. Conversely, 4-AP did not affect the resting discharge frequency. These results indicate that either the Ca2+ or the Ba2+ current sustain the transmitter release at the cyto-neural junction. The effect of TEA suggests that the Ca2+-dependent K+ current may play an important role in supporting the neurosecretory process by controlling the membrane potential of the hair cells.

4-Aminopyridine↗
PubMed1987

Method of separate bronchospirography with the use of bronchofibroscope and its clinical value in lung cancer patients.

In this paper the authors describe: a method of bronchospirography with the use of bronchofibroscope; a method of simultaneous performance of bronchospirography and bronchofibroscopy; criteria of indices and staging of each lung ventilation capacity; patterns of interrelation of the "healthy" and disabled lung according to the degrees of lung ventilation disturbance; indications and contraindications to operative treatment based on bronchospirographic data. For evaluation of the operability bronchospirographic investigations of the lung ventilation capacity were carried out in 225 lung cancer patients.

Adult↗
PubMed1979

[Data processing in clinical nuclear medicine (author's transl)].

Since the introduction of data processing into clinical nuclear medicine, significant advances could be achieved above all through the development of quantitative gamma camera scintigraphy, which is nowadays one of the most important fields of computer application. The technological properties of an adequate computer system for nuclear medicine use are dependent on a scale on the necessities of gamma camera sequential scintigraphy. If the computer capacity to carry out fast sequential scintigraphy is available, the system can be used for all modern scintigraphic procedures as well as for other tasks. If we look back on the experience gathered in more than ten years, the following areas can be named in which the use of computers appears worthwile and desirable: 1. scintigraphic diagnostics 2. functional diagnostics 3. medical record printout 4. operational management of the department, documentation and retrieval of the patients data 5. planning of therapy. Because of the importance of quantitative sequential scintigraphy, in many nuclear medicine departments two or more gamma camera computer systems are used. For reasons of costs, however, it will not be justifiable to connect each gamma camera with a separate effective data system. Therefore systems have been tested in which several gamma cameras are connected to a host computer via microprocessor-controlled buffer systems and by means of DMA interfaces. From practical experience, critera were worked out to draw up a computer concept for data processing in clinical nuclear medicine.

Computers↗