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Effects of clinostat-microgravity on bone and calcium metabolism in rats.

Decreases in bone minerals and tissue volume after space flight have been observed in humans and animals, with a variety of results. Such data obtained from space flight experiments have given unsatisfactory results due to short periods of space flight and differences in age, body weights, and strain of animals used. Therefore, ground-based animal models have been developed in order to elucidate changes in bone affected by space flight. For example, a tail-suspended rat model has been established to study the effects of microgravity on bones by producing hind limb unloading. However, problems with this model due to the remaining forelimb loading and the unusual changes in blood current require the development of a new model simulating the physiological conditions of space flight. So we developed a three-dimension clinostat as an apparatus to produce a simulated microgravity similar to space flight by rotating rats equally in all directions. The purpose of the present study is to examine the effects of clinostat-microgravity on bone metabolism in rats.

Adrenal Glands↗

[Detection of DNA variation after space flight in Datura innoxia by random amplified polymorphic DNA markers].

OBJECTIVE: To substantiate the effect of space environment on medicinal plants, the seeds of Datura innoxia were set up in retrievable satellites. METHODS: After returning to earth, the DNA variation of different groups was detected by random amplified polymorphic DNA (RAPD) markers. RESULTS: From a pre-screening of 65 primers with 20 oligonucleotide lengths, 15 primers that produced distinct profiles for each DNA sample were selected. In contrast with the earth controlled group, 39 polymorphic bands were produced in weightless group, and its degree of gene polymorphism was 23.1%; 45 polymophic bands were produced in hit group, and its degree of gene polymorphism was 24.4%. The polymorphic bands ranged approximately from 200 to 1990 bp. CONCLUSIONS: These results indicate that weightlessness induce DNA variation to some extents in Datura innoxia, while the compound effect of weightlessness and high energy heavy ions is more notable than the effect of single weightlessness.

Cosmic Radiation↗

[Biological detector of weak cosmic fields].

Possibility of use of biological object as a detector of faint cosmophysical fields is discussed. The signals of free induction and electric echo caused by a short-term effect of light with an intensity of approximately 0.2 mWt/sm2 on biological systems were observed. The experiments with Blatella germanica, Muska domestica were performed in vivo and with red and green seaweeds and yeast cells in vitro. The signals were detected by means of the dielectric permeability measurement in a dynamic regime. Main features of the observed responses are described and assumption on mechanisms of their origin are given. An example of registration of the Lunar eclipse on a detector with in active element of Blatella germanica is given.

Animals↗

[Studies of A L. Chizhevskiĭ: Milestones in space biology and biorhythmology].

The authors review the experimental and theoretical studies of eminent Russian scholar A.L. Chizhevsky, and his fruitful collaboration with K.E. Tsiolkovsky, a pioneer of the science of rocket navigation. Highlighted are postulates of the modern space biorhythmology furthering the notions of A.L. Chizhevsky about the harmony in nature, and significance of rhythmic phenomena for living organisms.

Biological Clocks↗

Life sciences.

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Biological Science Disciplines↗

Three kinds of cosmophysical activity: links to temporal distribution of deaths and occurrence of acute myocardial infarction.

BACKGROUND: The purpose of this study was to check for possible links between mortality statistics in a given month, generally from all causes and specifically from selected causes, and three kinds of cosmophysical activity: solar (SA), geomagnetic (GMA), and cosmic ray (CR). We also compared the results obtained for correlation by gender. MATERIAL/METHODS: 504,243 deaths were analyzed from the National Database of Lithuania (1990-2001); 102,604 OP deaths (1988-2000) were also included in this study and compared with data obtained from neutron monitoring data and other physical sources for the same time period. RESULTS: The total monthly number of deaths for 144 consecutive months was significantly and inversely correlated with SA and positively with CR activity, but not with GMA. The number of deaths from cancer, suicide, motor vehicle accidents, and acute myocardial infarction correlated with all three physical factors. SA and GMA show inverse effects as compared to CR. Ischemci heart disease deaths correlated only with GMA, cardiovascular accidents with SA and CR. Non-cardiovascular and suicide deaths were most strongly correlated to CR activity. CONCLUSIONS: The number of deaths is significantly related to physical activity in the space environment. These relationships show differences between kinds of deaths and significant correlation for the number of acute myocardial infarctions. Gender differences in links with physical activity in space were found in some of the compared groups.

Acute Disease↗

Possible "accelerated striatal aging" induced by 56Fe heavy-particle irradiation: implications for manned space flights.

The present experiments were carried out to determine the effects of energy deposition from energetic iron (56Fe particles, an important component of cosmic rays) on motor behavioral performance and to determine if the observed deficits were caused by alterations in the neostriatum (an important motor control area). Neostriatal function was assessed with two correlated parameters, i.e., motor behavioral performance (wire suspension task), and oxotremorine-enhanced K(+)-evoked release of dopamine from perifused striatal slices. Rats were exposed to one of several doses of 56Fe-particle irradiation (0.10-1.0 Gy) and tested on a wire suspension task at 3-180 days postirradiation. Results indicated that profound decrements occurred in both of these indices. The effects on K(+)-evoked release of dopamine were evident for as long as 180 days after irradiation, and a subsequent experiment indicated that these effects appeared as early as 12 h postirradiation. Since similar findings have been observed in aged rats, the results are discussed in terms of these particles producing a possible accelerated striatal aging effect.

Aging↗

The carbon or silicon colonization of the universe?

At the time of the Apollo Programme, a first human mission to Mars was proposed as early as 1984 with the argument that the higher costs of human exploration would be more than justified by the increased effectiveness of human explorers. This was based on the Apollo experience, where "ground truth" measurements and sampling provided the basis for subsequent unmanned exploration of the Solar System. A human Mars mission is now not seen until 2030, at the end of a series of increasingly sophisticated unmanned probes. Each robot mission not only teaches us something about Mars, but also through experience increases our capabilities for the unmanned exploration of that planet. As a consequence, what a human mission would have to do becomes progressively more demanding. Any extended plan for the human exploration of Space will tend to be overtaken by advances in technology, and if this is not factored into the scenario the proposals will become progressively unrealistic.

Astronauts↗