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[Zinc in medicin].

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Acrodermatitis↗

Diagnostic criteria for Gianotti-Crosti syndrome: a prospective case-control study for validity assessment.

No criteria exist for the modern diagnosis of Gianotti-Crosti syndrome (GCS). Our study objectives were to determine diagnostic criteria for GCS and to assess their validity using a prospective case-control design. We reviewed the clinical features of children with GCS who were reported in the literature from 1996 to 2000 and proposed a set of diagnostic criteria. We documented clinical features of children younger than 18 years who were diagnosed over a period of 18 months as having GCS and of control subjects given (over the same period) differential diagnoses of GCS. Forty-two children were recruited (11 with GCS and 31 controls with differential diagnoses of GCS). All children with GCS, and none of the controls, fulfilled the set of diagnostic criteria as a whole. We conclude that the proposed criteria are practical valid criteria for diagnosing GCS.

Acrodermatitis↗

[Acroangiodermatitis and acral hyperstomia (author's transl)].

Acroangiodermatitis is a special form of the 'angiodermite' of Favre and Chaix in patients presenting with chronic venous insufficiency localized on the dorsal areas of the feet and toes. Different stages including exulceration may occur. 60% of our male and 38% of our female patients with postthrombotic syndrome showed signs of acroangiodermatitis. Developmental arteriovenous malformations in the feet (acral hyperstomia, Malan's syndrome; 1 patient) which may present similar clinical and histological pictures are rare and should be differentiated from acroangiodermatitis because their prognosis is more severe, necessitating amputation in some instances. The determination of shunt volume by means of radioactive-labelled macroalbumin or microspheres helps to differentiate these two conditions. Because both conditions may present similarities with Kaposi sarcoma, the term 'pseudo-Kaposi' was chosen by some authors. One factor of pathogenetic importance for the terminal vascular changes underlying both conditions is the insufficiency of the calf muscle pump resulting in an elevated capillary pressure (anatomical insufficiency in acroangiodermatitis, functional insufficiency in acral hyperstomia).

Acrodermatitis↗

Acrogeric Ehlers-Danlos syndrome type IV: report of a new patient with additional findings.

We report a 21 year-old Turkish male with acrogeric Ehlers-Danlos syndrome type IV, a rare autosomal dominant disorder. In addition to the usual findings, the patient also had glaucoma and some unusual skeletal features including impressio digitalis in the skull, prognathism of the lower jaw and maxiller hypoplasia, not previously described as part of acrogeric Ehlers-Danlos syndrome type IV. These features expand the phenotypic spectrum of acrogeric Ehlers-Danlos syndrome type IV.

Abnormalities, Multiple↗