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PubMed2002

[Asbestos-related carcinogenic risk].

Exposure to asbestos containing dust and its health effects are underestimated in many countries throughout the world, particularly in Poland. Asbestos has been proved to be carcinogenic to humans. The most specific health effect of asbestos exposure is pleural, pericardial and peritoneal mesothelioma. The relationship between asbestos exposure and primary lung cancer has been also documented. The association between pleural mesothelioma and asbestos exposure can be estimated by assessing the number of asbestos fiber in the lung tissue, or by checking the history of significant asbestos exposure. Minimum latency is 10 years, but in most cases it ranges between 20 and 40 years. Asbestos-related lung cancer occurs at varied frequency, depending on the country. The lung cancer risk is underestimated, but the frequency of its diagnosis is increasing owing to better detectability, despite the asbestos-use limitation. Lung cancer is distinctly more frequent in patients with asbestosis. In case of heavy occupational exposure, lung cancer can occur already after 1 year of work, but as mentioned earlier its minimum latency period is 10 years.

Asbestos↗
PubMedDate not supplied

Immunocytological and mineralogical study of bronchoalveolar lavage in a group of subjects exposed to asbestos.

Twenty-five subjects (24 males and 1 female, mean age 57.4 years) who have been exposed to asbestos underwent chest radiography, high resolution computed tomography (HRCT) of the chest, lung function tests and bronchoalveolar lavage (BAL) for evaluation of cell components (total cell count, percentages of macrophages, lymphocytes, neutrophil and eosinophil granulocytes and the lymphocyte subpopulations CD3+, CD4+, CD8+, CD19+ and HLADR+), soluble factors (IL-8, IL-10, IL-12 and MCP-1 in the supernatant) and concentration of asbestos fibre. The subjects were subdivided according to the degree of their exposure, to the concentration of asbestos fibres in the BAL and to chest X-ray findings using the I.L.O. classification (0/0pl, 0/1 and 1/0 and above). According to the exposure index, we showed statistically significant (p < 0.05) higher lymphocytes percentage in the BAL of subjects with moderate exposure and significantly higher levels of IL-10 (p < 0.05) in the supernatant of subjects showing an absence of asbestos fibres in their BAL. In the group of subjects with a 0/0 and 0/1 radiological profile, the cellular component of the BAL was characterised by a higher percentage of lymphocytes (p < 0.02), whereas a trend toward an increase in the number of neutrophils was noted in subjects with obvious pulmonary fibrosis. The percentage of neutrophils was inversely correlated with some parameters of respiratory function such as vital capacity (p = 0.03) and the partial pressure of oxygen (p = 0.05) in the blood. Investigating the cytokines in the supernatant of the BAL, we found a trend toward lower concentration of IL-10 in the group showing the worst radiological picture (I.L.O. > or = 1/0), and a statistically significant negative correlation between this cytokine and pO2 (p = 0.048). Concerning the other cytokines and chemokines studied (MCP-1, IL-8 and IL-12), no significant differences were found to be associated with the radiological profiles. There were, however, positive correlations between the concentration of IL-8 and the percentage of neutrophils (p = 0.038) and between the concentration of MCP-1 and the percentage of lymphocytes (p = 0.006). A negative relationship between the concentrations of IL-12 and IL-10 has been also observed (p = 0.028). This research allows us to hypothesise that IL-10 may have a pathogenetic role in the evolution of asbestosis.

Adult↗
PubMed1992

[Study on the incidence of coal mine pneumoconiosis and lung cancer in Beijing coal mining district].

Thirty-two cases (20.13%) of primary lung cancer from 159 coal miner autopsies of Beijing coal mining area are reported in this study. The ratio of peripheral type to central type of lung cancer is 1.9:1; among them the adenocarcinoma is the most frequent (56.25%). Pathological examination shows that the diffuse interstitial type is the most common lung cancer. The occurrence of adenocarcinoma and the degree of lung fibrosis is related. The average number of ferruginous bodies is 190.2 +/- 8.06 in adenocarcinoma, 165.4 +/- 2.60 in squamous carcinoma, the difference is statistically significant (P < 0.05). The amount of trace elements-Fe, Al, Al/Si and Zn/Cu in lung with cancer is less than that without cancer. This article also discusses the relationship between coal mine pneumoconiosis with lung cancer of the formation of ferruginous bodies in the lung tissue of coal miner autopsies, which resembles the lung cancer combined with asbestosis. We also discussed the carcinogenesis of trace element in lung.

Adenocarcinoma↗
PubMed1992

Role of lipid peroxidation and antioxidants in aging process and thalassemia.

Oxygen free radicals and other oxygen derived species (Superoxide, O2-; Hydroperoxide, HOO; Singlet oxygen, 1O2-; Hydroxyl radical, OH; and Hydrogen peroxide, H2O2) including lipid peroxides have been suggested as important causative agents of aging and several human diseases, including cancer, multiple sclerosis, Parkinson's disease, autoimmune disease, ischemia, anemia, senile dementia, asbestosis and in thalassemia. This paper aims to communicate some of the theories and rationales in aging process and thalassemia.

Aging↗
PubMed1992

On the relationship between theoretical presumptions asbestos genotoxicity and the practical monitoring of exposed workers.

From the genotoxic viewpoint, there exists a sufficient evidence for asbestos carcinogenicity to human population and animals. Asbestos is a solid cancer promoter (cocarcinogen) of non-mutagenic character having epigenetic effects (15, 16). No data have been published on its mutagenic activity in "in vivo" conditions in man. The only results are those of our pilot study carried out in the period of 1981-1983, which cast doubts on the official view of non-mutagenic character of asbestos--at least under occupational conditions of its processing (34, 36, 37). The study presented here represents ten years' efforts made in the biological (cytogenetic) monitoring of persons occupationally exposed to asbestos in a factory for its processing (occupational risk). Simultaneously, a preliminary answer is given to the question whether the Osinek factory (situated in a housing area) is or is not dangerous for inhabitants of the town of Kostelec nad Orlicí, namely for their genetic apparatus (environmental risk). Using the method of chromosome aberrations analysis in peripheral blood lymphocytes, a total of 431 subjects (245 males and 186 females) were examined in the period of 1981 to 1988. Of these, 111 persons were from control workplaces (from Osinek or--starting from 1984--from other plants in Kostelec nad Orlicí; in addition to that 14 pensioners without any occupational exposure were examined). The average age of workers exposed to asbestos risk was 42.7 years, in the controls it was 43.9 years, in pensioners exposed to asbestos earlier 63.5 years and in those never exposed to asbestos 66.5 years. The average number of years spent at Osinek factory amounted to 21.5 years. About one third of employees were found to suffer from allergies (first of all those of air passages) and one sixth from chronic ailments of the upper air passages (Staphylococcus aureus, Haemophilus influenzae and Streptococcus beta-haemolyticus were diagnosed most frequently). A third part of workers from high-risk workshops are smokers, only a fourth of the controls. About 40% of workers regularly consume alcoholic drinks. The average morbidity rate at Osinek in 1981 to 1988 was 6.3% (in workers as high as 9%), which is about 2% higher as compared with mean values obtained in the district of Rychnov nad Knĕznou and East-Bohemian region. Within the nine-year period (1981-1989), 21 occupational diseases were diagnosed, while in the previous 24 years there were 24 cases of an occupational disease. Earlier they were mainly asbestoses (87%), in the last period mainly cancer diseases coinciding with asbestosis (81%).(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMedDate not supplied

Primary prevention of occupational lung disease: a view from the United States.

Occupational lung diseases are an important source of preventable morbidity and mortality in the United States. A significant proportion of lung cancer, mesothelioma, asbestosis and the other pneumoconioses, asthma, and chronic obstructive pulmonary disease, is caused by well-established occupational agents, especially among selected subgroups of the general population. Primary prevention of this set of diseases requires identification and control of workplace hazards. In the United States, data from inspections undertaken by the Occupational Safety and Health Agency, and from periodic surveys conducted by the National Institute for Occupational Safety and Health, show that respiratory toxins are commonly found in the workplace. Workplace-based education, surveillance and exposure reduction and elimination are essential components of a strategy to prevent occupational lung disorders.

Health Surveys↗
PubMedDate not supplied

Haemorrhagic pericardial effusion in an asbestos worker.

BACKGROUND: Occupational exposure to asbestos may cause pleural and lung disorders and, less frequently, diseases of the peritoneum and pericardium. An exceedingly small number of cases of benign pericardial effusion have been described so far in the medical literature. OBJECTIVES: To report a rare case of haemorrhagic pericardial effusion caused by occupational asbestos exposure in a patient with pre-existent aortic regurgitation, bilateral pleural plaques and no signs of interstitial lung involvement due to asbestosis. METHODS: A thorough clinical and instrumental evaluation (laboratory tests, tuberculin skin test, chest X-rays, transthoracic and transesophageal echocardiography, contrast coronary and aortic angiography, a histological examination of pericardial and pleural surgical specimens) was performed to examine all the known causes of pericardial effusion. RESULTS: The tests performed did not demonstrate any specific cause of pericardial effusion. Surgical assessment three months later, during an aortic valve replacement, showed no signs of aortic dissection or intraparietal hematoma. A nine-year follow up did not reveal any reoccurrence of pericardial effusion. CONCLUSIONS: Asbestos related pericardial effusion is rarely described in the medical literature but must be considered in patients with previous occupational asbestos exposure. There are no specific clinical or pathological aspects indicative of this etiology and the diagnosis remains one of exclusion. A thorough occupational history should be obtained in patients with pericardial effusion of unknown etiology.

Aortic Valve Insufficiency↗
PubMed2003

[Pneumoconiosis and mycobacterial infection].

This symposium was organized to provide recent informations concerning pneumoconiosis and mycobacterial diseases in Japan. Pneumoconiotic workers have been decreasing in number and in severity because of change in industrial structure and improvement of occupational health measures. But radiological figures of dust exposed worker are going to be complex and be difficult for diagnosis due to aging, smoking and of complicated respiratory and non-respiratory diseases. Major complications such as pulmonary tuberculosis and tuberculous pleurisy are decreasing but non-tuberculous mycobacterial infections have become common among dust exposed workers. Dr. Katsuhiro Suzuki (National Kinki-Chuo Hospital) reported pulmonary tuberculosis complicated with pneumoconiosis. A few reports regarding tuberculosis with pneumoconiosis have been published in recent years, particularly in Japan. Thus, clinical characteristics of the cases in our hospital between 1998 and 2003 were summarized here. There were 22 such patients, who consisted of 21 men and one woman and were 49 to 91 years old. There were 19 cases with silicosis, two cases with asbestosis, and one case with siderosis. Bilateral and cavitary lesions in a chest XP were revealed in 82% and 29% of the cases, respectively. Standard chemotherapeutic regimens consisted of three or four drugs with a prolonged period were found to be as effective as that for healthy subjects, judging from the sputum conversion rate after 8 week treatment. Dr. Toshiyuki Yamauchi (Keihai Rosai Hospital) reported, based on autopsy findings, trends in combined-type tuberculosis accompanying pneumoconiosis. The study period was divided into first (1963-1980) and second (1981-2000) stages based on year of patients death. To assess the therapeutic efficacy of antituberculosis agents, patients with combined-type tuberculosis were pathologically divided into those with active tuberculosis and those with inactive tuberculosis. The incidence of active tuberculosis during the second stage was significantly lower than that during the first stage. In both first and second stages, the average age of death for patients with inactive tuberculosis was older than that for those with active tuberculosis. It was shown that active combined-type tuberculosis was resistant to antituberculosis therapy and the prognosis of those patients tends to be poor. But for all patients with active and inactive combined-type tuberculosis, the average age of death was comparable to that of patients without tuberculosis in each stage. The results indicated that the antituberculosis agents were effective to combined-type tuberculosis. Dr. Kiyonobu Kimura (Iwamizawa Rosai Hospital) carried out retrospective studies on some clinico-epidemiologic problems in the cases accumulated in his hospital during the past 49 years. Since his cases consist of various different pathological changes, he has adopted the term "pneumoconiosis complicated with pulmonary tuberculosis" instead of silico-tuberculosis. The results were summarized as follows: (1) The rates of active pulmonary tuberculosis out of 1051 total dead cases were 43.8% (28/64) from 1955 to 1964, 28.8% (62/215) from 1965 to 1974, 24.7% (93/376) from 1975 to 1984, and 10.1% (40/396) from 1985 to 1994. (2) The rates of those who died of pulmonary tuberculosis were 17.2% (11/64) from 1955 to 1964, 9.3% (20/215) from 1965 to 1974, 1.9% (7/376) from 1975 to 1984, and 3.3% (13/396) from 1985 to 1994, respectively. (3) The average age of death of pulmonary tuberculosis has become older and is not significantly different from that of pneumoconiosis patients who died of other cause. (4) The rate of sputum negative conversion was only 9.1% (3/33) during the first 10 years (from 1955 to 1964). On the other hand, 95% (21/22) in the recent 9 years (from 1993 to 2002). (5) Out of the 104 autopsy cases in whom pneumoconiosis and tuberculosis were diagnosed pathologically, 64 cases were combined form of tuberculosis, and other 40 cases were complicated form of tuberculosis. Dr. Hiroki Morita (Asahi Rosai Hospital) studied the nontuberculous mycobacteria (NTM) in the patients with pneumoconiosis and the clinical courses of the 4 types of pneumoconiosis complicated with NTM pulmonary disease. NTM were detected in the 73 (29%) of 252 pneumoconiosis. The 14 species (M. gordonae, M. avium, M. terrae, M. fortuitum, M. nonchromogenicum, M. peregrinum, M. intracellulare, M. szulgai, M. abscessus, M. simiae, M. chelonae, M. scrofulaceum, M. xenopi, M. triviale) were identified. In the long-term follow-up study of the pneumoconiosis patients complicated by NTM pulmonary disease, it was very difficult to catch the onset of NTM pulmonary disease because the clinical signs and symptoms were nonspecific and the radiographic findings moved very slowly. Dr. Mitsunori Sakatani (National Kinki-Chuo Hospital) reviewed the laws related safety and health for dust exposed workers, pneumoconiosis and tuberculosis, and he pointed out importance for prevention, diagnosis, treatment and compensation.

Aged↗
PubMed2002

[Application value of measurement of the regional pulmonary ventilation by electric impedance pneumograph in the clinical diagnosis of pneumoconiosis].

OBJECTIVE: To study the value of clinical application and distribution character of regional pulmonary ventilation of patients with various type of pneumoconiosis. METHODS: 132 patients with various type of pneumoconiosis were observed by electric impedance pneumograph(EIPV) and routine lung function test. The results were compared with the measured value of 100 healthy cases. RESULTS: The regional pulmonary ventilation of the three kinds of pneumoconiosis(founder's pneumoconiosis, silicosis and asbestosis) was increased in both side of upper pulmonary region and decreased in both of lower pulmonary region. The ventilation distribution showed that the right pulmonary ventilation increased predominantly, accounted for 53.03% (70/132) of total lung ventilation. There was significant difference(P < 0.01) compared with the normal healthy men's EIPV, but no difference(P > 0.05) among various type of pneumoconiosis. There was also no difference(P > 0.05) between pneumoconiosis patients with normal ventilation function and various type of ventilation obstacle of pneumoconiosis. One silicosis patient complicated by atelectasis of the left upper lobe, another silicosis patient complicated by lung cancer and their EIPV accorded with their chest X-rays. CONCLUSION: EIPV could not be measured by routine lung function test. It may be the supplement to latter parameter and as a substitute for radio imaging of pulmonary ventilation in pneumoconiosis complicated by other regional pulmonary disorder.

Electric Impedance↗
PubMed2003

[Diffuse interstitial lung disorders caused by the environment and occupation].

Diffuse interstitial lung diseases caused by exogenous factors can be divided into those that arise as a result of a progressive accumulation of (mainly) mineral particles in the lung parenchyma, and those that essentially result from a particular susceptibility of the host for specific agents. The former category consists mainly of silicosis, coal worker's pneumoconiosis and asbestosis, as well as other mineral pneumoconioses. The latter category contains extrinsic allergic alveolitis, which is mainly caused by the inhalation of bio-aerosols, chronic beryllium disease and other sarcoid-like diseases, and hard-metal or cobalt lung. Individual susceptibility is based on a genetic tendency for becoming immunologically sensitized (demonstrated for beryllium) and/or possibly on a poor defense against oxidative stress (probably relevant for cobalt). Recent outbreaks of interstitial lung disease resulting from inhalatory exposure to some polymers ("Ardystil syndrome" and "flock worker's lung") show that one should remain vigilant for the occurrence of novel occupational causes of pulmonary disease.

Disease Susceptibility↗
PubMed2003

Rare findings in high resolution computed tomography (HRCT) in interstitial lung diseases.

High resolution computed tomography (HRCT) is an imaging method, achieving an optimal resolution of lung interstitium images. HRCT enables more accurate diagnosis of interstitial lung diseases, in which it is a diagnostic method of choice. A lot of pathological findings specific only for HRCT were described. Some of them are relatively rare, and therefore not well known. In some cases good knowledge of them is essential in making a correct diagnosis based on HRCT results. The aim of the study was assessment of rare findings on HRCT, their morphology and diagnostic value in interstitial lung disease. The tram track sign and signet-ring sign visible on HRCT are very specific findings in bronchiectases. The tree-in-bud pattern is a specific finding for diseases of small airways, especially involving small bronchioles. The differences in sizes of vessels in hyper-lucent and hyper-dense lung areas enable differentiation of mosaic perfusion from other reasons for inhomogeneous lung density. Rounded atelectasis and comet tail sign are specific findings for asbestosis. The angiogram sign is a very specific finding for bronchoalveolar carcinoma.

Adult↗
PubMed2004

The impact of teleconsultations at a referential centre on the management of pulmonary patients.

Teleconsultation services at referential centres are an important area of telemedicine development. The implementation of such scenarios brings high-level competencies to peripheral hospitals through telecommunication links. Pulmonary teleconsultations were one of the key aspects of Krakow Centre of Telemedicine (KCT) activities conducted in 2002-2003. The role of the referential centre for respiratory medicine was played by the Division of Interventional Pulmonology, Jagiellonian University Medical College. Peripheral centres were pulmonary wards situated in local hospitals or policlinics located 20-80 km from Krakow. These hospitals were equipped with PC-based telemedical workstations and ISDN lines (256 kbps). Dedicated software (Telenegatoscope) was used for real-time discussions among physicians on medical images (X-rays, CTs) sent from peripheral centres to the referential centre. Images inserted in light boxes were cropped at peripheral centres with a high-resolution digital camera. During the pilot phase, about 40 pulmonary patients were referred via telemedical links to the University Hospital. The frequency of soliciting a second opinion at the referential centre was analyzed for each main type of disease. Top positions are currently occupied by diagnoses of lung cancer, pleural fluid of unknown origin, asbestosis and tuberculosis. About 70% of the patients referred for virtual consultation were admitted for further diagnostics and treatment in an ambulatory or inpatient mode at the Division of Interventional Pulmonology. The review of teleconsultations results indicates that teleconferencing contacts, even if conducted through relatively limited bandwidth, may bring considerable benefits to patients requiring complex diagnostic and sophisticated, procedures available at the referential university hospital.

Community Health Services↗
PubMed1995

The pneumoconioses.

Most recent studies have indicated that the incidence and prevalence of the mineral pneumoconioses have been declining as dust control has improved, This finding is particularly true for coal workers' pneumoconiosis, asbestosis, and silicosis. Although the present preoccupation with molecular biology and immunology has led to a spate of studies of the mechanisms involved in the development of these conditions, and although many advances have been made, no convincing complete elucidation of these mechanisms has evolved. Meanwhile, the "paratoxicologic fringe," supported by the National Institute of Occupational Safety and Health and the Environmental Protection Agency, has been presenting the notion that almost every naturally occurring or synthesized mineral ranging from aluminum to silica is a carcinogen. Much of the evidence produced by this consortium has been found wanting, especially in regard to the alleged hazards of talc, beryllium, and silica.

Animals↗
PubMed2005

[Occupational mortality in Italy during 1992, assessed through record-linkage between pension records and death certificates].

BACKGROUND: The creation of a surveillance system of occupational mortality in Italy is limited by the low quality of information on occupation in death certificates, since the information is often incomplete or lacking and because only the occupation at the time of death is registered. OBJECTIVE: To evaluate the possible use of INPS (National Institute of Social Security) records for the purpose of surveillance of occupational mortality, in terms of feasibility of setting up a system and of validity of the results obtained. METHODS: Death records of 218,510 subjects aged 18-74, deceased in the 12 months following the 1991 census, were obtained from ISTAT (Central Statistics Institute). These were combined through record-linkage with the INPS social security archives, which contain the employment records by economic sector going back to 1974, in order to assign these deaths the sector in which they had worked the longest. Mortality by specific causes was evaluated by industry by means of a proportional mortality analysis stratified by sex and occupational status, and adjusted for age, education, marital status, geographical area of birth, drawing a disability pension, employment status at the time of death and work instability. RESULTS: Record-linkage allowed attribution of the longest held job to 70% of the deaths recorded. Results are presented and discussed only on mortality in men due to asbestosis and silicosis, and causes of death with a substantial proportion attributable to occupation: chronic obstructive pulmonary disease (COPD); cancers of the bladder, nasal cavity, larynx, lung and pleura; leukaemia and lymphoma; accidental causes. Among the economic sectors with a significant excess mortality, the following are well documented in the literature: mortality due to COPD in the coal and peat-bog sectors; due to leukaemia among farmers; due to sino-nasal tumours in wood-working and furniture production; due to cancer of the larynx, lung, and pleura in occupations where there was probable exposure to asbestos (fishing and maritime transport, non-metal mining, building industry, and naval, train and aircraft construction); due to silicosis in industries with potential exposure to crystalline silica; due to accidental causes in the building industry and farming. Other mortality excesses and deficits, especially those due to bladder and lympho-haemopoietic cancers, appear to be only partly consistent with those described by other authors. DISCUSSION: The feasibility of developing a surveillance system of occupational mortality based on the INPS source was found to be good, and, at least among males, for 75% of the deceased subjects historical information existed concerning the economic sectors registered in the INPS records. The results obtained would appear to indicate that the system is capable of highlighting risk excesses due to widespread exposure in the industries examined, regarding diseases for which there is a strong association with exposure. On the other hand, due to the inherent limits of the study's design (lack of a complete work history and of precise information on the jobs held) its use is not recommended in the surveillance of diseases with a low proportion attributable to a risk factor, or with wide exposure variability in a given sector among the various jobs.

Adult↗
PubMed1992

Pseudomesotheliomatous adenocarcinoma: a reappraisal.

Adenocarcinomas of or in lung that clinically and pathologically mimic diffuse pleural mesotheliomas are rare. We reviewed selected clinical and pathologic features of 15 autopsy/surgical cases previously reported in the medical literature and of 15 additional cases from the files of the Armed Forces Institute of Pathology (AFIP). Ninety percent of the patients were men. The median age was 61 years. Sixty-three percent of the patients smoked, 17% of them had possible or definite occupational exposure to asbestos, and one patient had microscopically proven asbestosis. Most patients had chest pain, shortness of breath, or cough, and had unilateral pleural effusion in the chest x-ray. At thoracotomy or at autopsy, numerous nodules, plaques, or a continuous rind of tumor was present over the pleural surface. Microscopically, the tumors showed simplified glands, nests, cords, papillary, tubulopapillary or biphasic patterns of growth. The neoplasms contained mucin that stained with diastase-predigested periodic acid-Schiff (PAS), mucicarmine, and alcian blue (with or without hyaluronidase predigestion). All patients died with/of tumor, with a mean survival of 4.7 months for those reported in the medical literature and of 7 months for those in the AFIP files. These adenocarcinomas therefore mimic pleural mesothelioma not only in their clinical and gross and microscopic appearance, but also in their prognosis.

Adenocarcinoma↗
PubMed2005

[Asbestos and malignant pleural mesothelioma: molecular, cellular and physiopathological aspects].

Asbestos is known as mutagenic and carcinogenic for human and is responsible for many pulmonary diseases including asbestosis, bronchogenic carcinoma and malignant pleural mesothelioma. Occupational exposure to asbestos is involved in 70-80% of all malignant pleural mesothelioma. The later presents a growing challenge for both researcher and clinician. The diagnosis of malignant pleural mesothelioma is difficult and the current treatments did not show significant improvement of the survival. The increasing incidence of malignant pleural mesothelioma, its gravity and its human, social and financial consequences are of high concern in public health. In this paper we summarize the so far knowledge on cellular, molecular and pathophysiological events involved in genesis and development of malignant pleural mesothelioma. Finally, the paper also report recent data sourced from the study of malignant pleural mesothelioma transcriptome using high-throughput technologies such as gene expression array. These data should improve the accuracy of mesothelioma diagnosis and therapy.

Asbestos↗
PubMed2005

[Rounded atelectasis: a follow up of 10 years by CT].

We report the case of a 69-year-old man who presented with a rounded atelectasis (RA). During a 10-year follow-up by Computed Tomography (CT), the lobe showed a progressive shrinkage, and a moderate increase in size of the lesion led to a percutaneous biopsy which confirmed the diagnosis. RA is an unusual form of lung consolidation. The major cause of RA is asbestosis. RA is usually asymptomatic and may simulate a pulmonary neoplasm on chest Xray. The diagnosis is made by CT, demonstrating the pathognomonic "comet tail sign". No treatment is required.

Aged↗
PubMedDate not supplied

[Intrahepatic cholangiocarcinoma: case report].

The primitive tumors of the liver are relatively rare in the Western countries (around the 0.7% of all the neoplasms) while they present more elevated incidence in Africa and in the South Asian East. While the hepatocellular carcinoma rises up in the 50-70% of the cases in livers cirrosis, this correlation is not valid for the form of carcinoma to departure from the learned intra and extra biliar. The etiology of the intrahepatic colangiocarcinoma (CC) stays unknown. They have stayed observe, on the other hand, of the conditions sometimes correlated to the development of the CC (Carolí morbs, ulcerative colitis, asbestosis). The CC usually rises up from the epithelial cells of surface that delimit the biliary ducts, although different studies suggest that these tumors can also originate from the learned smaller biliary ducts, from the hepatic cysts of the policistic illness and from the complexes of von Meyenburg. The low incidence of the CC, the clinical atypical debut, the not facility of a precise diagnosis have aroused our interest so that the present job wants to be a modest scientific contribution to this type of pathology.

Adult↗