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PubMed1998

Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.

In order to determine the effects of intermittent hormonal manipulation on the promotion stage of rat prostate carcinogenesis, testosterone and/or estrogen were administered to F344 rats for 40 weeks after 20-weeks treatment with the prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl. For this purpose testosterone propionate (TP) and diethylstilbestrol (DES) were introduced into silastic tubes, 2- and 0.5-cm long, respectively, and implanted into the subcutis for seven repeated cycles of 30 days treatment and 10 days withdrawal. Intermittent administration of TP resulted in suppression of ventral prostate adenocarcinoma development and slight but non-significant increases in the incidences of invasive carcinomas of the lateral prostate and seminal vesicles. Intermittent administration of DES completely suppressed tumorigenesis in all sites and the combination of TP and DES generally inhibited prostate tumor development. Thus, under the present experimental conditions, no strong enhancing effects of cyclic hormonal manipulation were observed on rat prostate carcinogenesis. Indeed, the opposite appeared to be the case.

Aminobiphenyl Compounds↗
PubMed1978

Luteinizing hormone response of castrated rabbits to treatment with testosterone propionate and estradiol benzoate.

The effects of sex steroids on luteinizing hormone (LH) secretion in rabbits of both sexes castrated for at least 2 weeks previously were investigated. An intramuscular (i.m.) injection of testosterone propionate (TP) or estradiol benzoate (EB) was given about midway through blood sampling which ranged from 6 to 12 h. LH and steroids were measured by established radioimmunoassay (RIA) procedures. Variable responses were obtained with animals. Castration itself in most instances led to increases in circulating levels of LH which ranged from normal levels to greater than 200 ng/ml with some evidence for episodic variation. EB was more effective than TP in reducing LH levels and inhibiting episodic release.

Animals↗
PubMed1979

Effects of testosterone propionate and pituitary-adrenal hormones on the social behaviour of male ducklings (Anas platyrhynchos L.) in two test situations.

This experiment was designed to study in male ducklings the behavioural influence of testosterone propionate (= TP) injections, combined with pituitary-adrenal hormones administration, in two test situations: in groups of birds from the same residence cage or from visually isolated cages. It appears from the results that TP administration increased sexual but not aggressive behaviour, while pituitary-adrenal hormones induced very few effects. The responses of the birds were however modulated to a large extent by the type of test situation.

Adrenal Cortex Hormones↗
PubMed1976

Effects of testosterone propionate treatment of neonatally ovariectomized rats on growth and subsequent responsiveness to oestrogen.

There was no significant difference in body weight between neonatally ovariectomized (OvX) rats whether given oil treatment or 90 mug testosterone propionate (TP) on day 3, when examined up to 23 weeks of age. When these two animals were injected with oestradiol benzoate (3 mug/day for 2 weeks), the neonatally OvX TP treated rats showed a significantly smaller depression in body weight than did the control neonatally OxX rats. Measurement of food intake also showed that TP treated rats responded significantly less to the depressant effects of oestrogen than did the controls. These data are consistent with the hypothesis that the ovary does restrain body weight in TP rats but that androgen treatment in the neonatal period may not have a specific effect on growth but may alter the sensitivity of growth regulating processes to the inhibitory effects of oestrogen.

Animals↗
PubMed1998

Clobetasol dipropionate 0.05% versus testosterone propionate 2% topical application for severe vulvar lichen sclerosus.

OBJECTIVE: Our goal was to evaluate short-term (3 months) and long-term (1 year) treatment of vulvar lichen sclerosus, by comparing topical application of testosterone propionate 2% in petrolatum with the corticosteroid clobetasol dipropionate 0.05%. STUDY DESIGN: There were 20 women in each treatment group. The patients' symptoms and the gynecologist's examination findings were recorded before treatment, at 3 months, and at 1 year after initiation of therapy. RESULTS: The symptomatic (subjective) effect of clobetasol treatment was similar to that of testosterone at the 3-month follow-up (p < or = 0.34), although objectively the signs of lichen sclerosus had improved more in the clobetasol group (p < or = 0.033). Both symptoms and signs were significantly more improved in the clobetasol-treated group at the 1-year follow-up examination (p < or = 0.02). Seventy percent of women treated by testosterone discontinued treatment because of a lack of response, whereas only 10% of the women treated with clobetasol stopped the treatment for that reason (p < or = 0.00042). CONCLUSION: Clobetasol is more effective than testosterone in the treatment of women with lichen sclerosus, especially in the long term.

Administration, Topical↗
PubMed1983

The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: dose-response studies.

A dose-dependent increase in the mass of flank organ hair was produced in 11-week-old female hamsters by subcutaneously injected testosterone propionate. The mass of androgen-stimulated flank organ hair was decreased bilaterally in a dose-dependent manner by cyproterone acetate applied topically to one flank organ of each hamster.

Administration, Topical↗
PubMed1980

Mechanisms of action of testosterone propionate on LH and FSH release by the pituitary gland in cyclic female rats.

The aim of this work was to determine whether changes in pituitary responsiveness to LRH could account for the effect of testosterone propionate (TP) on the gonadotrophic function of the pituitary in 4-day cyclic female rats. Doses of 250, 500 and 1000 ng LRH were injected ip on pro-oestrus at 15.30 h in rats either pre-treated with 5 mg TP on dioestrus II at 10.00 h or injected with 30 mg/kg pentobarbital (PB) at 13.00 h. LH release induced within 30 min by LRH was higher in PB than in TP-treated rats. Even by using 250 ng LRH full ovulation was observed on the morning of oestrus in PB-treated rats. On the other hand, only partial ovulation occurred whatever the dose of LRH used in TP-treated rats; a great number of luteinized follicles was shown to be constantly associated with post-ovulatory corpora lutea. While LRH caused a significant FSH release (30 min later) in TP-treated rats, no FSH release could be shown in PB-treated rats. The pituitary FSH content appeared to be decreased and the pituitary LH content remained unchanged while a sharp increase in both blood FSH and LH concentrations occurred following injection of 1000 ng LRH in TP-treated rats. Concomitantly a sharp decrease in the number of pituitary gonadotrophs (AB-PAS+) was observed. A significant decrease in the number of the small roundshaped PAS positive cells was also observed. The mechanisms whereby TP influences the function of the pituitary-ovarian axis are discussed in the light of these results.

Animals↗
PubMed1990

Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats by N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate.

Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal models for prostatic cancer. All ten carcinomas examined were located in the dorsolateral prostate region and did not involve the distal parts of the seminal vesicles and coagulating glands. The incidence of urinary obstruction leading to the animals' death was 6 of 10 rats, and metastases in the lung, abdominal lymph nodes, and/or liver also occurred in 6 of 10 rats. The tumors were invasive adenocarcinomas, showing frequent perineural invasion and a variable degree of differentiation. There were ultrastructural similarities with human prostatic carcinomas, such as intracellular lumina. Plasma acid phosphatase was increased. Enzyme histochemical analysis revealed similarities with the Dunning R3327H and -HI prostatic carcinomas but was not helpful in determining the site of origin of the tumors. The gross and microscopic appearance of the tumors and the observation of preneoplastic lesions exclusively located in the dorsolateral prostate suggest this lobe as site of origin of the carcinomas. Preneoplastic lesions (n = 9) included atypical hyperplasias (n = 5) and lesions with all histological characteristics of carcinoma except for local invasion and metastases, which were classified as carcinoma in situ (n = 4). Although androgen sensitivity could not be assessed, the observed characteristics of the tumors [their long latency time (46-80 weeks), the presence of preneoplastic lesions, and the short duration of the treatment, leaving the animals intact] all indicate that the present approach is a valid animal model for the study of prostatic carcinogenesis.

9,10-Dimethyl-1,2-benzanthracene↗
PubMedDate not supplied

Effect of sex, testosterone propionate and trienbolone acetate on the rate of growth and myofibrillar protein degradation in growing young rats.

The urinary output of N tau-methylhistidine (3-methylhistidine: 3-Mehis) was determined to evaluate the effect of testosterone propionate (TP, 1 mg/100g body weight per day) and trienbolone acetate (3-oxo-17 beta-hydroxy-4,9,11-estratriene acetate, TBA 1 mg/100g body weight per day) on the rate of myofibrillar protein breakdown in young growing intact and adrenalectomized (AdX) male and female rats. Injections were given subcutaneously for 14 days. Body weight changes were recorded daily throughout the experiment. Compared with the intact control rats, male-AdX rats had a significant (p less than 0.05) reduction in both growth and 3-Mehis output (and, therefore, a reduction in the rate of myofibrillar protein degradation). Administration of the anabolic steroids to these rats had no significant effect on growth but increased the rate of 3-Mehis output to the normal range in the case of TP, and above the normal range (p less than 0.05) in the case of TBA. However, compared with the intact female rats, female-AdX rats showed a significant (p less than 0.05) increase in 3-Mehis output. Administration of either TP or TBA to these animals significantly (p less than 0.05) increased growth and reduced 3-Mehis output. The response of myofibrillar protein degradation in AdX rats to TP or TBA administration is strongly dependent on the sex of the animals. The anabolic action of TP and TBA, especially in female rats, may be mediated through an antagonistic effect to the catabolic effects of oestrogens and glucocorticoids.

Actins↗
PubMed1983

The influence of testosterone propionate on semen quality and testes morphology in the domestic turkey, Meleagris gallopavo.

Three groups of 6 Large White breeder turkey males producing normal white semen were given either corn oil or 100 or 1000 micrograms of testosterone propionate (TP) in corn oil per day in an attempt to induce the sequelae of the yellow semen syndrome (YSS), viz. elevated seminal plasma protein, macrophage infiltration into the semen and ductuli efferentes hypertrophy, and lipid accumulation (Thurston, 1976; Hess et al., 1982). The two treatments of TP were unsuccessful in producing these characteristics of the YSS. However, TP, particularly at 1000 micrograms, caused testicular regression exemplified as interstitial thickening, lipid accumulation, especially in Leydig and germinal cells, and reduced semen volume and sperm number. Although TP did not significantly affect seminal plasma protein concentration, in some males albumin was reduced concomitant with an increase in the beta-3 protein subfraction, suggesting that the quantity of these protein fractions in seminal plasma may be androgen dependent.

Animals↗
PubMed1981

Effects of neonatally administered-testosterone propionate on the development of target organs of sex hormones and the induction of mammary carcinomas by 7, 8, 12-trimethylbenz (a)anthracene in female Sprague-Dawley rats.

Female Sprague-Dawley rats were given 1.25mg testosterone propionate subcutaneously within 24 hours after birth and 30mg 7, 8, 12-trimethylbenz (a) anthracene per 1 kg of body weight intravenously at 50 days of age. In these neonatally androgenized rats, the increase of the anogenital distance, aplasia or hypoplasia of the vagina, persistent estrus on the vaginal smears and eosinophilic substance in mammary glands were observed, with no corpus luteum formation in the ovaries, and the induction of mammary carcinomas by 7, 8, 12-trimethylbenz (a) anthracene was strongly suppressed.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1993

In vitro effect of testosterone propionate on lactate dehydrogenase and malate dehydrogenase in brain and gonads of Channa punctatus.

The activities of lactate dehydrogenase (LDH), malate dehydrogenase (MDH), and protein levels were measured in vitro incubation of tissue homogenate of brain and gonads with testosterone propionate (TP) in Channa punctatus (teleost). The activities of LDH and MDH were found to be highest in the ovarian tissues in comparison to the testis and the brain in control fish. TP (2 micrograms-4 micrograms/ml) stimulated testicular tissue with increases in LDH by 10-fold and MDH by 15-fold approximately, the ovary with significant increase in LDH and a decrease in MDH and the brain showed only an increase in MDH.

Animals↗
PubMed1977

The treatment of balanitis xerotica obliterans with testosterone propionate ointment.

Balanitis xerotica obliterans (BXO) and kraurosis penis are thought to be synonymous. Clinically and histopathologically they probably represent the same disease process as lichen sclerosus et atrophicus (LSA) but also involve the urethral mucosa. The treatment of choice is considered to be 2 1/2% testosterone propionate ointment which gives better results than strong corticosteroid applications, yet without their side effects.

Adult↗
PubMed1984

Dissociation of luteinizing hormone and follicle-stimulating hormone control mechanisms in male and female rats by neonatal administration of estradiol benzoate or testosterone propionate.

Testicular atrophy (TA) and decreased plasma luteinizing hormone (LH) levels were observed in the adult male rat after treatment with 500 micrograms of estradiol benzoate (EB) on the first day of life, while administration of 1 mg of testosterone propionate (TP) on the same day was also associated with TA but increased LH levels. TA and no changes in plasma LH levels were seen when the treatment was performed with similar doses of both steroids on day 5 of life. In no case were plasma follicle-stimulating hormone (FSH) levels altered by these treatments. No differences in basal LH and FSH levels were found in adult females after treatment with 100 micrograms of EB or 1 mg of TP on day 5. LH response to castration was lower in neonatally androgenized and estrogenized adult male and female rats than in their respective controls, while FSH response was scarcely modified. In conclusion, neonatal treatment with EB or TP in both sexes induced alterations in LH control mechanisms without changing those of FSH.

Animals↗
PubMed1997

Atropine and testosterone propionate induced atretic changes in granulosa cells of house rat (Rattus rattus) ovary.

Degenerative changes in membrana granulosa of ovaries in R. rattus have been studied using scanning electron microscopy. Ovaries from rats treated with atropine (300 mg/kg body weight) and testosterone propionate (10 IU) were used to study sequential course of atresia in granulosa cells. Granulosa cells undergoing atresia showed degenerative changes in following order i) loosening of intercellular matrix, ii) changed morphology and texture of secretory granules, iii) destabilization of granulosa cell membranes, iv) erosion of cell membrane, v) formation of specific degenerative belts, vi) pycnosis, vii) ghost cell formation and their subsequent mixing in hazzy follicular fluid of cyst. Phenomenon of atresia, its duration, course and underlying causes have been discussed.

Animals↗