Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “TOXICOLOGY”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed2006

Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology.

Reactive intermediates formed during the metabolism of drugs have been investigated extensively over the past decades. Today, interest in reactive intermediates in drug discovery is focused on minimising bioactivation in hopes of reducing the risk of causing so-called idiosyncratic toxicity. These efforts are justified based on the 'hapten hypothesis', namely, that on binding to protein, reactive intermediates may elicit an immune response to the modified protein, leading to a cascade of events that ultimately manifests as a toxic outcome. However, the pharmacological action of certain drugs depends on reactive intermediates that modify critical amino acid residues of proteins, typically enzymes, thereby altering their activity. Thus, the notion that reactive intermediates are inherently dangerous is unjustified. When a reactive intermediate is necessary for the desired pharmacological effect of a drug, the selectivity it displays towards the target protein is crucial, as off-target binding may produce unwanted toxicities. On the other hand, reactive intermediates may play no role in toxicity. This review provides a balanced perspective, primarily focusing on the proposed role of reactive intermediates in drug toxicity, while also highlighting examples in which they are involved in causing the desired pharmacology. It is hoped that this knowledge can help scientists involved in drug discovery and development in their challenging task of producing safe and effective drugs.

Animals↗
PubMedDate not supplied

[Botanicus and phytotox: data base of plant toxicology. Interest in emergency toxicology and in phytovigilance].

The purposes of this project were to summarize more than 279 standard botanical names and their 2294 vernacular ones (French common names, Arabic common names and Moroccan common names) for the first part of database named "Botanicus". The second part of this data base named "Phytotox", concerns relevant toxic data of 120 plants available in Mediterranean region. The database will be useful for emergency physicians, particularly of Maghreb and French- speaking countries. Botanicus and Phytotox permit to assist them in providing fast and appropriate answers to questions concerning adverse effects associated with plant use.

Databases, Factual↗