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At least 163 records · Page 9Linked to original sources
PubMed1996

[Pregnancy toxemia. Oxygen input/extraction in preeclampsia-eclampsia].

We tried to determine if the toxemia of pregnancy has during its clinical evolution a dependent DO2/VO2 relationship and determine its critical DO2 and finally define if this has a prognostic value. There were included patients with diagnosis of preeclampsia/eclampsia that were enter at the Intensive Care Unit for treatment and monitoring. It was placed a catheter in the pulmonary artery and it was determine the cardiac output and by means of standard formulas the DO2, VO2 and EO2 were calculated. The critical delivery of oxygen was stablished in agree at the Gutiérrez's method. At the same time it was monitorised the base excess which was gotten from arterial and venous blood gases. 36 patients (29 with preclampsia and 7 with eclampsia) were included, with a mean age of 26.3 years old. The mean gestational age was 36.1 weeks. The critical delivery for preeclamptic patients was stablished in 924 mL/min and at the eclamptic patients in 830 mL/min: both values had prognostic correlation with survival and nonsurvival patients (p < 0.001, x2 = 28.29). In survival patients it was a dependent DO2/VO2 relationship during the first 72 hours of study and then it was independent; this fact was accompaniment of a positive increase in the base excess and a decreasing in the EO2 values (< 27%). In the nonsurvival group, these mainteined a DO2/VO2 relationship in a dependent way during all the study and it was accompaniment with a continuous negative base excess with values of EO2 > 30%. The toxemia of pregnancy had a behaviour like state accompaniment of a dependent DO2/VO2 relationship causing an important oxygen deficient that was improved was improved in the survival patients that reach values over the critical delivery. These facts suggesting the presence of a metabolic blockade in variable degree that can improve or increase agree a therapeutic manipulations in the critic DO2.

Adolescent↗
PubMed1977

Hemodynamic studies in experimental toxemia of the dog.

The following experiments demonstrate that the severity of toxemia is proportional to the degree of reduction in blood flow to the pregnant uterus. Blood pressure and blood flow variations were studied in 21 nonpregnant and pregnant dogs following the placement of a progressive stricture on the abdominal aorta below the renal arteries. The immediate effect of the stricture was a mild hypertension in half of the pregnant dogs; in addition, in all the dogs, the blood flow progressively dropped in the arteries below the stricture (femoral and uterine) while it remained constant in the arteries above (ovarian and renal). In 3 of 5 pregnant dogs the delayed effect of the aortic stricture was hypertension associated with all the other signs of experimental toxemia. Removal of the aortic stricture after 10 days immediately improved the blood flow below the stricture. No noticeable preferential distribution of blood toward the pregnant uterus was noted during the constriction.

Animals↗
PubMed1976

Midtrimester preeclamptic toxemia in triploid pregnancies.

Nineteen advanced triploid pregnancies reported in the literature are reviewed. In 8 of 14 pregnancies for which reliable data were available, severe preeclamptic toxemia (EPH gestosis) developed, most often from the 16th to the 24th week of gestation. In all the toxemic cases, the placenta was large for the stage of pregnancy, the placental coefficient was high (mean 0.83) and extensive areas of molar degeneration were present. Advanced triploid pregnancy is considered a further example of hyperplacentosis causing preeclamptic toxemia. The study of toxemic and nontoxemic advanced triploid pregnancies supports the assumption that hyperplacentosis, rather than being related to excessive placental size, is the expression of trophoblastic hyperactivity.

Adult↗
PubMed1976

Sex ratio in the progeny of mothers with toxemia of pregnancy.

Maternal-fetal incompatibility may be an essential component in the etiology of toxemia of pregnancy. A prior study found an abnormally high sex (male:female) ratio, suggestuve of Y-dependent histoincompatibility. We studied the records of 373 patients alleged to have some indication of toxemia among 3,246 births and applied standard criteria for classification. There were no significant differences for any group compared with the sexondary sex ratio expected of the population(94.6% Black).

Adult↗
PubMed2005

Progressive toxemia with acetaldehyde in a reactive form of alcohol withdrawal syndrome.

We carried out a complex clinical and laboratory examination of 169 patients with reactive form of alcohol withdrawal syndrome. Progressive toxemia with acetaldehyde (key pathogenetic stage) and volemic changes were followed by homeostasis disorders and gradual decompensation of the natural detoxification system. The patients with this form of alcohol withdrawal syndrome did not exhibit physical and psychic dependence on alcohol. The proposed therapeutic algorithm for the treatment of various pathogenetic stages rapidly and efficiently restored homeostasis parameters and prevented the development of serious and life-threating complications.

Acetaldehyde↗
PubMed1999

Intestinal toxemia botulism in two young people, caused by Clostridium butyricum type E.

Two unconnected cases of type E botulism involving a 19-year-old woman and a 9-year-old child are described. The hospital courses of their illness were similar and included initial acute abdominal pain accompanied by progressive neurological impairment. Both patients were suspected of having appendicitis and underwent laparotomy, during which voluminous Meckel's diverticula were resected. Unusual neurotoxigenic Clostridium butyricum strains that produced botulinum-like toxin type E were isolated from the feces of the patients. These isolates were genotypically and phenotypically identical to other neurotoxigenic C. butyricum strains discovered in Italy in 1985-1986. No cytotoxic activity of the strains that might explain the associated gastrointestinal symptoms was demonstrated. The clinical picture of the illness and the persistence of neurotoxigenic clostridia in the feces of these patients suggested a colonization of the large intestine, with in vivo toxin production. The possibility that Meckel's diverticulum may predispose to intestinal toxemia botulism may warrant further investigation.

Adult↗
PubMed1973

Studies on the mode of action of diphtheria toxin. V. Protein metabolism in a guinea pig model simulating chronic diphtheritic toxemia.

An experimental model of "chronic" diphtheria intoxication in the guinea pig was developed. Adult guinea pigs, subjected to a regimen of multiple sublethal doses of purified diphtheria toxin (total of 1.4 minimum lethal doses divided equally in four daily doses), developed a toxemia which terminated in death between 6 and 8 days. During an advanced stage of illness, de novo protein synthesis was assessed by in vivo incorporation of tritiated leucine into tissue proteins. With the exception of pancreas and skeletal muscle, protein synthesis in healthy, control and toxin-treated guinea pigs was comparable. The absence of notable impairment of protein synthesis in this experimental situation is discussed in terms of the mode of action of the diphtheria toxin and the pathophysiology of the disease.

Animals↗
PubMed2004

Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.

The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.

Animals↗
PubMed2006

NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer.

The transcription factor NF-kappaB is an important regulator of homeostatic growth and inflammation. Although gene-targeting studies have revealed important roles for NF-kappaB, they have been complicated by component redundancy and lethal phenotypes. To examine the role of NF-kappaB in endothelial tissues, Tie2 promoter/enhancer-IkappaBalpha(S32A/S36A) transgenic mice were generated. These mice grew normally but exhibited enhanced sensitivity to LPS-induced toxemia, notable for an increase in vascular permeability and apoptosis. Moreover, B16-BL6 tumors grew significantly more aggressively in transgenic mice, underscoring a new role for NF-kappaB in the homeostatic response to cancer. Tumor vasculature in transgenic mice was extensive and disorganized. This correlated with a marked loss in tight junction formation and suggests that NF-kappaB plays an important role in the maintenance of vascular integrity and response to stress.

Animals↗
PubMedDate not supplied

[Hemosorption in serotherapy (serosorption) in experimental acute diphtheric toxemia with the use of affinity sorbents].

In modeling acute diphtheric toxemia in guinea pigs, the authors propose to perform hemosorption using selective sorbents under continuous introduction of antitoxic immune sera into extracorporeal contour in front of sorption column. Combination of hemosorption with serotherapy in the same time interval may be denoted as serosorption. As specific sorbents, affine preparations imasorb A-700 and Imasorb G-700 were used. They selectively eliminate from the blood flow CIC produced by diphtheric toxin (anatoxin) and antitoxic rabbit and horse antibodies. Changes in the titers of the diphtheric toxin (anatoxin) and CIC in blood evidence for efficiency of selective sorbents were confirmed by immunohistochemical analysis of the preparations' granules after hemoperfusion.

Animals↗
PubMedDate not supplied

[Decrease in bacterial toxemia after radiation-thermal injury in the restoration of motor-evacuation function of the gastrointestinal tract].

Experiments were conducted on male Wistar rats to study the possibility of restoration of the motor-evacuative function (MEF) of the gastrointestinal tract (GIT) after radiothermal injury (irradiation with a dose of 6 Gr+Stage IIIb burn). Changes in the development of bacterial intoxication in the injured organism were analysed. Restoration of GIT MEF in the injured rats leads to simultaneous diminution of the degree of bacterial toxemia which plays an important role in the pathogenesis of radiothermic injury.

Animals↗
PubMed1991

[Neurological manifestations in the vertebro-basilar system suggesting pregnancy toxemia].

Early CT scan showed a large hypodensity throughout midbrain. Brainstem auditory evoked potential showed initially an abolition of III and V pikes suggesting brainstem injury. Two days later neurologic examination and brain stem auditory evoked potential returned to normal. CT scan performed three weeks after the onset was normal. These finding suggest a vasospasm; in this case betasympathomimetic agents given two weeks before the onset of toxemia for preterm labor could lead to the vasospasm.

Adult↗
PubMedDate not supplied

[Pancreatic kallikrein, a protector of small intestine damage in post-ischemic toxemia].

The morphofunctional state of the small intestine was studied on a tourniquet shock model. The development of postischemic toxemia is followed by disorders of microcirculation leading to irreversible changes in the small intestine. The processes are associated with an increase of the proteolytic activity of the intestinal contents. An oral administration of andecaline prevents ischemia of the intestine, contributes to the preservation of its mucosa.

Animals↗
PubMedDate not supplied

[Effect of pancreatic kallikrein and trypsin inhibitors on the course of postischemic toxemia].

By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to pancreatic kallikrein (200 gamma/ml), when introduced parenterally (1 ml per 100 g of the mass), increases the survival time of the animals and prevents the development of gangrene in the ischemic limbs. The curative effect of the antikallikrein serum resembles the action of ingitril, a polyvalent inhibitor (1.5 Un. per 100 g of the mass). The antitryptic serum employed in analogous doses stands by its action close to the normal rabbit's serum.

Animals↗
PubMed1987

[Changes in the lung parenchyma in the early phases of bacterial toxemia and acute diffuse peritonitis in an experiment].

A comparative study of changes in the pulmonary parenchyma of guinea pigs with toxemia caused by intraperitoneal injection of staphylococcal toxin or Pseudomonas aeruginosa endotoxin and in those with peritonitis induced by i. p. injection of a suspension of human or guinea-pig feces has shown the changes to be rather similar in these conditions. In particular, as soon as 10 min after the onset of disease, signs of damage were detected in lung cells and capillary endotheliocytes of the blood-air barrier; later on, microthrombi were detected in pulmonary capillaries. In guinea pigs with feces-induced peritonitis, microfoci of pneumonia were seen. Following the injection of human fecal suspension, early signs of the sludge syndrome were present. The observed changes resembled those described for the adult respiratory distress syndrome (shock lung).

Animals↗
PubMedDate not supplied

[The rate of synthesis of proteins, nucleic acids and peptides in experimental burn toxemia].

After thermal burns total concentration of protein, RNA and peptides as well as their specific radioactivity were decreased during the period of early toxemia. At the same time, specific radioactivity of some middle weight proteins and peptides was increased after the burns in blood plasma of experimental animal. The reactions responsible for the rate and intensity of these substances metabolism in blood plasma, erythrocytes and liver tissue are discussed.

Animals↗