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PubMed1982

Protection against selenite toxicity by previous administration of selenium compounds.

2-month-old male rats kept on a standard laboratory diet containing 0.06 microgram Se/g dry weight were found to be more sensitive to the toxic action of selenite than female rats of corresponding age. This sex-dependent difference was not found in 20-day-old animals. Previous s.c. administration of 1 mumol of selenium in the form of sodium selenite lowered the sensitivity of male rats to the toxic effects of selenite. The protective effect of this dose persisted for 18 days. A similar protective action against the lethal effects of selenite in adult male rats was exhibited by sodium selenate, selenomethionine, and dimethylselenide, all in an amount equal to 1 mumol of selenium; pretreatment with trimethylselenonium iodide showed only an insignificant mortality decrease. Three days intake of deionized water with an addition of 0.1 or 1.0 microgram selenium/ml also protected male rats against lethal doses of selenite. Peroral pretreatment of adult females did not decrease their sensitivity to the lethal effects of selenite.

Animals↗
PubMed1979

[Protective effect of selenium compounds in the freeze preservation of erythrocytes].

The influence of sodium selenite, selenomethionine and sodium selenite with tocopherols in combination on the survival of cryopreserved erythrocytes was investigated. Percent hemolysis is marked decreased after a three-hour incubation of the whole blood with addition of selenomethionine as well as sodium selenite with tocopherole in combination before cryopreservation. The protective effect is attributed to the antioxydative and membrane stabilizing effectiveness of selenium and tocopherol.

Blood Preservation↗
PubMed1979

Mutagenic activity of selenium compounds.

The mutagenicities of selenate (SeO2/4-) and selenite (SeO2/3-) were determined by two bacterial assay systems: Kada's rec-assay and Ames's Salmonella test. In both assays, these compounds were found to be weak mutagens. In the Salmonella test, selenate (0.05 revertants/nmole) and selenite (0.2 revertants/nmole) gave rise to base-pair substitution.

Bacillus subtilis↗
PubMed2006

Laser desorption/ionization and laser ablation synthesis of new selenium oxide compounds from selenium(IV) dioxide.

Laser desorption/ionization (LDI) and/or laser ablation (LA) of selenium dioxide crystals or its mixtures with sodium peroxide were studied using a commercial matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. It was found that LDI and LA of selenium (IV) dioxide not only ionizes SeO(2), but also leads to the formation of several positively and negatively singly charged species: SeO(n) (+) (n = 0-2), Se(2) (+), SeO(n) (-) (n = 0-4), Se(2)O(n) (-) (n = 3-7), Se(3)O(n) (-) (n = 4-9), Se(4)O(n) (-) (n = 8-10). A rather high yield of selenium species in the positive ion mode, Se(m) (+) (m = 1-8) and Se(m)OH(+) (m = 3-7), was obtained by using the MALDI approach while the species detected in the negative ion mode, SeO(n) (-) (n = 0-4), Se(2)O(n) (-) (n = 3-7), Se(3)O(n) (-) (n = 4-9), and Se(4)O(n) (-) (n = 9, 10), were the same as those observed during LDI/LA of selenium dioxide. The addition of sodium peroxide to selenium dioxide with the aim of enhancing its oxidation and thus increasing the production of SeO(4) product resulted in extensive cationization of the species with sodium or potassium. The following positively and negatively charged species were identified: Se(+), Se(2) (+), Se(2)OH(+), Se(2)ONa(+), SeO(n) (-) (n = 0-3), and Se(2)O(n) (-) (n = 0, 1, 4). Also observed in mass spectra of such mixtures, various mixed sodium and/or potassium adducts with selenium oxide species, e.g. Se(2)O(4)K(2)Na(-), were identified. In all, 26 totally new species, Se(2)O(n) (-) (n = 3-6), Se(3)O(n) (-) (n = 4-9), Se(4)O(n) (-) (n = 8-10), Se(4)O(11)H(5) (-), Se(4)O(12)H(3) (-), Se(2)O(4)Na(-), Se(2)O(5)HNa(-), Se(2)O(5)HNa(2) (-), Se(3)O(6)K(2)Na(-), Se(3)O(6)K(2)Na(2) (-), Se(2)ONa(+), and Se(m)OH(+) (m = 3-7), were described for the first time. Also, for the first time, the formation of selenium(IV) diperoxide, O-O-Se-O-O or O(2)SeO(2), is described. The stoichiometries of the compounds generated were confirmed using isotopic pattern modeling.

Journal Article↗