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The present status of spinal fusion in the treatment of lumbar intervertebral joint disorders.

Every type of fusion has its enthusiastic supporters. Unfortunately, the literature includes comparative analyses of various fusion procedures. Much of the effort spent in the clinical assessment of spinal fusion must be reinvested; neither the indications for diskectomy nor spinal fusion have been sufficiently clear-cut and accurately recorded. Moreover, spinal fusions often have not been applied to treat the disorder or to correct the deformity. It is essential at the outset to establish the mechanical fault; this is achieved only by a thorough understanding of the underlying pathologic lesion. Diagnosis follows a careful history and physical examination assisted by plain radiographs, lateral radiographs in flexion and extension, radiographs (anteroposterior in left and right lateral bending), and by information obtained from the CAT scan. We have designed a protocol for a prospective investigation wherein a specific fault with a specific etiology and pathologic anatomy is identified and submitted to a surgical procedure in a specified sequence. In future reviews, emphasis must be paid to selection of patients, the individual joint requiring stabilization and the type of fusion performed. Only then can we put this theoretically effective procedure to the acid test of objective clinical evaluation.

Back Pain↗

The failure of ethylene oxide gas-sterilized freeze-dried bone graft for thoracic and lumbar spinal fusion.

Thirty-seven patients underwent posterior and/or posterolateral spinal fusion using ethylene oxide gas-sterilized freeze-dried bank bone graft. Thirteen patients had discogenic back pain, eight with prior failed laminectomy procedures, and five undergoing initial spinal surgery. Six patients had isthmic spondylolisthesis, three with associated radicular complaints, and two patients had degenerative spondylolisthesis. Seven patients with spinal fractures and nine patients with scoliosis underwent spinal fusion with associated instrumentation. Pseudarthroses were detected in 28 patients (76%), and 18 patients (49%) underwent pseudarthrosis repair procedures using autogenous iliac bone graft. At surgery, the prior gas-sterilized freeze-dried bone graft was noted to have been almost completely resorbed. Ethylene oxide sterilization has been found experimentally in animal models to damage the osteoinductive ability of bone grafts. Ethylene oxide gas-sterilized freeze-dried bank bone graft is inferior to autogenous bone graft or bank bone graft preserved and/or sterilized by other methods. Its use in thoracic or lumbar posterior or posterolateral fusion cannot be recommended.

Adolescent↗

Experimental posterolateral spinal fusion with porous ceramics and mesenchymal stem cells.

Alternatives to autogenous bone graft for spinal fusion have been investigated for many years. It has been shown that osteoconductive materials alone do not give a rate of fusion which is comparable to that of autogenous bone graft. We analysed the effectiveness of porous ceramic loaded with cultured mesenchymal stem cells as a new graft material for spinal fusion in an animal model. Posterolateral fusion was carried out at the L4/L5 level in 40 White New Zealand rabbits using one of the following graft materials: porous ceramic granules plus cultured mesenchymal stem cells (group I); ceramic granules plus fresh autogenous bone marrow (group II); ceramic granules alone (group II); and autogenous bone graft (group IV). The animals were killed eight weeks after surgery and the spines were evaluated radiographically, by a manual palpation test and by histological analysis. The rate of fusion was significantly higher in group I compared with group III and higher, but not significantly, in group I compared with groups II and IV. In group I histological analysis showed newly formed bone in contact with the implanted granules and highly cellular bone marrow between the newly formed trabecular bone. In group II, thin trabeculae of newly formed bone were present in the peripheral portion of the fusion mass. In group III, there was a reduced amount of newly formed bone and abundant fibrous tissue. In group IV, there were thin trabeculae of newly formed bone close to the decorticated transverse processes and dead trabecular bone in the central portion of the fusion mass. In vitro cultured mesenchymal stem cells may be loaded into porous ceramic to make a graft material for spinal fusion which appears to be more effective than porous ceramic alone. Further studies are needed to investigate the medium- to long-term results of this procedure, its feasibility in the clinical setting and the most appropriate carrier for mesenchymal stem cells.

Animals↗

Changes in bone architecture during spinal fusion: three years follow-up and the role of cage stiffness.

STUDY DESIGN: A morphometrical analysis of microcomputed tomography-based reconstructions of bone from the fusion zone in spinal cages. OBJECTIVE: To describe the architectural changes of the fusing bone tissue in time and to study the effect of cage stiffness on the development of the bone architecture within the cage. SUMMARY OF BACKGROUND DATA: Interbody fusion within spinal cages is routinely evaluated as either successful or not successful. The quality of the fusion, however, strongly depends on the architecture (i.e., structure and density) of the bone tissue within the cage. Bone architecture obviously changes during the fusion process, and cage stiffness is known to play a pivotal role. METHODS: Nine bone samples were available from a long-term in vivo study on resorbable spinal cages in Dutch milk goats described elsewhere. Follow-up periods of 3, 6, 12, 24, 30, and 36 months were considered for cages made of titanium or Poly L-Lactic Acid. The specimens were scanned with a resolution of 13 microm in a microcomputed tomography system. From the resulting reconstructions, the bone density; trabecular thickness, spacing, and number; connectivity density; and structure model index were assessed. RESULTS: We found a homogenization of all bone structure indexes along the spinal axis with time, and remarkably faster in the Poly L-Lactic Acid cages than in the titanium cages. After longer follow-up periods, a coarser bone structure with larger trabecular thickness and intertrabecular spacing was found. The structure model index appeared to be sensitive for nonunions. CONCLUSIONS: More "mature" spinal fusions showed a coarser and more homogeneous bone structure. High cage stiffness had a deteriorating effect on the fusion rate. The structure model index appears to be an interesting parameter for quantifying the quality of bone in the fusion zone.

Animals↗

The effect of varied electrical current densities on lumbar spinal fusions in dogs.

BACKGROUND CONTEXT: The use of electrical stimulation has been shown to increase the rate of successful spinal fusions. It is possible that increasing the current density of these stimulators may increase the speed and success rate of these fusions. PURPOSE: This study evaluated the effects of varied current densities on the speed and success rate of spinal fusion in dogs. STUDY DESIGN/SETTING: Three different current densities (0.83 microA/cm, 4 microA/cm and 10 microA/cm) were used to stimulate spinal fusions in a canine model over a 12-week period. OUTCOME MEASURES: Radiographic and histologic assessments were used to determine the degree of facet fusions at each time period. METHODS: Fifteen dogs underwent spinal facet fusion bilaterally at the level of L1-2 and L4-5. Each fusion site was electrically stimulated using one of three current densities. At 6, 9 and 12 weeks, the specimens were evaluated using high-resolution radiography and routine histology. The fusion masses were graded and then statistically evaluated. RESULTS: The results demonstrate a dose response of fusion mass scores to increasing current density. The highest current density (10 microA/cm) demonstrated a statistically higher fusion scores than the lowest currently density (0.83 microA/cm) at 6 weeks and statistically greater than both the middle (4 microA/cm) and lowest (0.83 microA/cm) current densities at 9 weeks. No differences were noted at 12 weeks, because all groups showed complete fusion. CONCLUSIONS: This controlled study suggests that speed of fusion may be further improved by increasing the current density of the electrical stimulation.

Animals↗

Metallic artifacts in magnetic resonance imaging of patients with spinal fusion. A comparison of implant materials and imaging sequences.

STUDY DESIGN: Devices for spinal fusion were compared with respect to their influence on magnetic resonance images. In addition, different magnetic resonance pulse sequences were evaluated to elicit their susceptibility to imaging artifacts. OBJECTIVES: To determine the implants with the least imaging artifacts as a recommendation for the spine surgeon and to assess the best imaging strategy for the radiologist. SUMMARY OF BACKGROUND DATA: For patients who have had surgical spinal fusion with instrumentation, magnetic resonance imaging is the most favorable diagnostic method. Unfortunately, metallic implants lead to severe degradation of image quality. These artifacts depend on the material of the implant and on the choice of the pulse sequence. METHODS: The fusion devices were mounted on a simple plastic phantom in various combinations and were imaged on 1.5-T magnetic resonance units. Frequently used types of plates and screws made of titanium or steel in various alloys were examined on the phantom with routinely used pulse sequences. The results of these examinations were compared with those in patient studies involving the same implants as well as the same pulse sequences. RESULTS: The least imaging artifacts were caused by titanium implants, especially when using shorter screws, wider screw placement, and thinner titanium plates. Nevertheless, there were distinct image distortions that could lead to erroneous image interpretation. The best images were acquired by spin echo (T1), turbo spin echo (T1, T2), and half Fourier single shot turbo spin echo (HASTE) sequences. Sequences containing any gradient echo components (gradient echo or turbo gradient and spin echo sequence or frequency-selective fat saturation techniques) resulted in the highest amount of image degradation. CONCLUSION: By choosing appropriate spinal fusion devices as well as pulse sequences, postoperative magnetic resonance imaging examinations can give acceptable results, in spite of the presence of metallic implants.

Adolescent↗

High dose nonsteroidal anti-inflammatory drugs compromise spinal fusion.

PURPOSE: Although nonsteroidal anti-inflammatory drugs (NSAIDs) provide benefit to patients following spinal fusion surgery, their routine administration has remained controversial due to concerns about possible deleterious effects on bone healing. The goal of this retrospective study was to assess the incidence of non-union following the perioperative administration of ketorolac, celecoxib, or rofecoxib. METHODS: We retrospectively analyzed the data of 434 patients receiving perioperative ketorolac (20-240 mg.day(-1)), celecoxib (200-600 mg.day(-1)), rofecoxib (50 mg.day(-1)), or no NSAIDs in the five days following spinal fusion surgery. RESULTS: There were no significant differences in the incidence of non-union among the groups that received no NSAIDs (11/130; 8.5%), celecoxib 5/60; 8.3%), or rofecoxib (9/124; 7.3%). In contrast, 23/120 of patients (19.2%) that received ketorolac had a higher incidence (P < 0.001) of non-union compared to non-NSAID users. However, only 3/50 patients (6%) receiving low-dose ketorolac (< or = 110 mg.day(-1)) resulted in non-union which was not significantly different from non-NSAID users. Patients administered higher doses of ketorolac (120-240 mg.day(-1)) resulted in a higher incidence (P < 0.0001) of non-union (20/70; 29%) compared to non-NSAID users. For those patients developing non-union, there was a higher incidence comparing smokers vs non-smokers (P < 0.0001) and one level fusion vs two level fusions (P < 0.001). CONCLUSIONS: This study revealed that the short-term perioperative administration of celecoxib, rofecoxib, or low-dose ketorolac (< or = 110 mg.day(-1)) had no significant deleterious effect on non-union. In contrast, higher doses of ketorolac (120-240 mg.day(-1)), history of smoking, and two level vertebral fusions resulted in a significant increase in the incidence of non-union following spinal fusion surgery.

Adult↗

Bleeding and coagulation changes during spinal fusion surgery: a comparison of neuromuscular and idiopathic scoliosis patients.

OBJECTIVE: Major blood loss is common during spinal fusion surgery. We have previously demonstrated that patients with neuromuscular scoliosis have more blood loss and greater transfusion requirement than those with idiopathic scoliosis. Our objective is to study the relationships between etiology of scoliosis, blood loss, and coagulation changes in children and adolescents undergoing spinal fusion surgery. DESIGN: Prospective, observational study. SETTING: University teaching hospital. PATIENTS: A total of 25 patients, 11 with neuromuscular and 14 with idiopathic scoliosis, undergoing spinal fusion surgery. INTERVENTIONS: Blood was obtained preoperatively, 2 and 4 hrs intraoperatively, and 2 and 24 hrs postoperatively for prothrombin time, partial thromboplastin time, thrombin time, platelet count, D-dimer, factor VII and VIII activity, thrombin-antithrombin III complex, and protein induced by vitamin K absence. Changes in coagulation over time were analyzed by repeated-measures analysis of variance. Comparisons between groups were made using independent t-tests. RESULTS: Neuromuscular scoliosis patients had significantly greater blood loss than idiopathic scoliosis patients (median blood loss, 78% of total blood volume; range, 25-127% vs. 20%, 2-82%; p < .001). Prothrombin time increased over time in both groups and was higher in the neuromuscular than the idiopathic group both preoperatively and postoperatively (p < .05). Factor VII activity decreased over time in both groups (p < .001) and was lower in the neuromuscular than the idiopathic group during surgery (p < .05). No changes in partial thromboplastin time, thrombin time, or factor VIII activity were observed. D-dimers were present in both groups by 4 hrs intraoperatively. Protein induced by vitamin K absence was not detected in any patient. CONCLUSIONS: Neuromuscular scoliosis patients have more blood loss during spinal fusion surgery than idiopathic scoliosis patients. The prolongation of prothrombin time and decrease in Factor VII activity suggest activation of the extrinsic coagulation pathway. Depletion of clotting factors during scoliosis surgery occurs to a greater extent in patients with underlying neuromuscular disease.

Journal Article↗

Demineralized bone matrix. Enhancement of spinal fusion.

A study was conducted to determine the ability of demineralized bone matrix gel to act as an osteoconductive/osteoinductive material to enhance canine spinal fusion. Seven dogs underwent posterior spinal fusion. Four-level fusions were performed with one of four procedures at each level: decortication alone, with gel added, with autograft, or with both gel and autograft. Dogs were killed at 6 weeks and early histologic response was studied. At untreated control sites, little bone formation was evident. Gel-filled sites showed abundant osteoid, with 60% of demineralized particles fused to or surrounded by new bone. Sites filled with autograft had more new bone, but there was more osteoid at gel-treated sites. Autograft augmented with gel showed the most vigorous response, with extensive bridging between demineralized particles, host bone, autograft, and new bone. Significantly less autograft was needed to induce a similar amount of new bone formation when gel was added. Use of the gel as an autograft extender may improve the chance for successful spinal fusion.

Animals↗

The surgical and medical perioperative complications of anterior spinal fusion surgery in the thoracic and lumbar spine in adults. A review of 1223 procedures.

STUDY DESIGN: A retrospective review of 1223 thoracic and lumbar anterior spinal fusions was performed from 1969 through 1992. OBJECTIVES: To document the incidence and specific types of perspective complications related to anterior spinal fusions. SUMMARY OF BACKGROUND DATA: Despite the increased use of anterior spinal surgery, there has been little documentation of the specific types and frequencies of the complications associated with its use. METHODS: All Minnesota Spine Center patients age 18 years or older who had anterior spinal fusions between the levels of T1 and S1 from August 1969 to June 1992 were reviewed for the occurrence of perioperative complications. Surgical approach and technique and associated comorbidity was recorded. RESULTS: The risk of a complication was increased for patients over age 60 years, for women, and for patients with multiple preexisting health problems. Serious complications, such as death (0.3%), paraplegia (0.2%), and deep wound infection (0.6%) were rare. The complication rate for complications that were directly attributed to the anterior spinal surgery was 11.5%. CONCLUSIONS: Anterior spinal fusion surgery is a safe procedure and can be used with confidence when the nature of a patient's spinal disorder dictates its use. Complications are often approach specific.

Adolescent↗

Posterior spinal fusion in paralytic scoliosis and myelomeningocele.

The Shriners Hospital, Lexington, KY, experience with posterior spinal fusion for scoliosis in 50 patients with myelomeningocele was reviewed. Six patients were fused with Harrington rods and 47 of 50 patients were treated with some form of segmental fixation. The complication rate was 48% (24/50) resulting in 1.48 procedures per patient. The deep infection rate was 8% (4/50) and the pseudarthrosis rate was 16% (8/50). The use of modern segmental instrumentation systems has improved the pseudarthrosis rates for posterior spinal fusion in scoliosis associated with myelomeningocele but not to the point of displacing the current approach of an anterior and posterior spinal fusion.

Adolescent↗

In vitro osteoblast proliferation as a predictor for spinal fusion mass.

BACKGROUND CONTEXT: The biological factors determining a successful spinal fusion have not yet been fully determined. PURPOSE: To determine the influence of graft cell vigor on fusion rate and fusion mass using in vitro osteoblast proliferation as a predictor. STUDY DESIGN: Animal study randomizing to posterolateral fusion with autograft with or without pedicle-screw instrumentation. PATIENT SAMPLE: Twenty adult Göttingen mini-pigs. OUTCOME MEASURES: Fusion rate measured both with X-ray and computed tomography (CT) as well as amount of fusion mass determined with three-dimensional CT. METHODS: Animals underwent posterolateral fusion with autograft either with or without pedicle-screw instrumentation. Additional graft was harvested for osteoblastlike cell culture. Cells were counted after 3 weeks, and their proliferative capacity was correlated to fusion rate and fusion amount. RESULTS: Cell count was significantly higher in the fused animals (p<.011). Furthermore, a tendency toward a positive correlation to fusion mass amount was observed (p<.091). CONCLUSIONS: The achievement of a solid spinal fusion using autograft is related to properties of the bone-forming cells in the graft and fusion bed. Most likely it is the number of cells and not their proliferative capacity that is the most important factor.

Animals↗

The syndrome of inappropriate antidiuretic-hormone secretion following spinal fusion.

Ten adolescent and preadolescent patients who underwent posterior spinal fusion for idiopathic scoliosis or spondylolisthesis were examined for the presence or absence of the postoperative syndrome of inappropriate antidiuretic-hormone secretion. For each patient, levels of serum sodium, serum osmolality, urine sodium, urine osmolality, and serum antidiuretic hormone were obtained preoperatively and postoperatively. The investigation clearly showed that the syndrome occurred in each patient, with the level of serum antidiuretic hormone being highest within a few hours postoperatively. This resulted in a reduction of urinary output, the reduction being maximum on the day of operation and the output gradually rising to normal over the next three days. This syndrome and its associated low postoperative urinary output is common after spinal fusion and should be treated with restriction of fluids rather than administration of increased amounts of fluid.

Adolescent↗

A review of spinal fusion for degenerative disc disease: need for alternative treatment approach of disc arthroplasty?

This article reviews the history of spinal fusion. The most common indication for fusion may be painful disc degeneration although the exact determination of this condition remains controversial. In the analysis of surgical fusion techniques, literature review has documented a higher rate of success in attaining successful fusion than in obtaining excellent clinical outcomes. Significant morbidity can be seen in the performance of spinal fusion. A limited number of patients presently undergoing spinal fusion will be candidates for disc arthroplasty, though indications for spinal arthroplasty are still evolving.

Arthroplasty, Replacement↗

A trial of desmopressin to reduce blood loss in patients undergoing spinal fusion for idiopathic scoliosis.

Desmopressin (DDAVP) has been reported to reduce bleeding in patients undergoing spinal fusion. To evaluate its efficacy in normal patients, 30 healthy young patients (ASA physical status I or II) undergoing spinal fusion for idiopathic scoliosis were randomly allocated to receive either 100 mL of physiologic saline solution (placebo group) or DDAVP (10 micrograms/m2 of body surface area) (DDAVP group) in a prospective, double-blind trial. Intraoperative blood loss was measured by weighing sponges and suction drainage and postoperative bleeding by wound drainage. The amount of blood loss expressed as a percent of the estimated blood volume was similar in both groups during the intraoperative period (67.0% +/- 28.8% [mean +/- SD] placebo group vs 57.4% +/- 26.5% DDAVP group), the postoperative period up to 24 h (32.5% +/- 6.4% placebo group vs 31.1% +/- 10.6% DDAVP group), and both periods (94.3% +/- 29.4% placebo group vs 88.2% +/- 30.7% DDAVP group). With the dose used in our study, we conclude that DDAVP does not reduce surgical bleeding in patients undergoing spinal fusion for idiopathic scoliosis.

Adolescent↗

Use of a novel beta-tricalcium phosphate-based bone void filler as a graft extender in spinal fusion surgeries.

Synthetic bone void fillers are gaining acceptance as graft extenders in spinal surgery. One such product is an ultraporous formulation of nanometer-sized particles of beta-tricalcium phosphate (beta-TCP). An ongoing prospective open-label, randomized, observer-blinded, comparative study evaluated the efficacy and safety of a novel beta-TCP bone void filler as an additive to autogenous bone graft material in patients undergoing spinal fusion. Posterolateral instrumented or noninstrumented spinal fusion was performed at a single level or multiple levels with or without additional interbody fusion. Patients received autogenous bone on 1 side and autogenous bone augmented with extender (in a 1:1 ratio based on the weight of the materials) on the opposite side, each patient serving as his or her own control. The graft material was placed at the level of the facet joints and the intertransverse processes. Patients were randomized to receive the extender on either the right or the left side. This article is a preliminary report on patients who have undergone this procedure.

Adult↗

[Freeze-dried allograft of posterior spinal fusion in patients with scoliosis].

OBJECTIVE: To observe the effectiveness and safety of allograft in posterior spinal fusion in patients with scoliosis. METHODS: 41 cases of 54 scoliosis patients with allograft for spinal fusion were followed up. The mean follow-up time is 16 months. Foreign body reaction was studied clinically and fusion status was assessed radiographically. RESULTS: There was no foreign body reaction significantly in all patients. Acute deep wound infection happened in one patient and no chronic deep wound infection occurred. There was no disease transferred by allograft in followed patients. New bone formation appeared after 4 months postoperatively in radiogram. At final follow-up, the mean angle of 3.4 degrees lost and minimal -1 degrees and maximal 6 degrees . Implants were fastened and did not loosen and fracture. CONCLUSIONS: Allograft for posterior spinal fusion in scoliosis patients was useful and safe.

Adolescent↗

Evaluation of cryopreserved bone and synthetic biomaterials in promoting spinal fusion.

The purpose of the study was to evaluate the use of cryopreserved allograft bone and tricalcium phosphate in promoting spinal fusion. Nine 20-30 lb swine underwent posterior spinal fusion at T5-T6, T13-T14, and L2-L3. Autogenous bone, cryopreserved allograft bone, or equal parts of allograft bone and tricalcium phosphate were added to the decorticated posterior elements. A total of 27 sites were prepared for fusion. The spines were retrieved at 6 months and evaluated for integrity and stability of the fusion sites by clinical examination, three-point bending tests, multiplanar radiographs, and undecalcified tetracycline-labeled and decalcified histologic sections. The nine sites that received autogenous bone were solidly fused. There were one clinical and two radiographic nonunions in the nine sites that received cryopreserved allograft bone. Sites that received a mixture of allograft bone and tricalcium phosphate demonstrated slight motion at two locations and radiographic evidence of fusion at all levels. The extent and degree of fusion was not site-specific. Three-point bending analysis did not demonstrate a significant trend as to site or materials specificity. No adverse histologic response was noted. Histologic sections and tetracycline labels confirmed abundant new bone formation at all sites at 6 months. Although autogenous bone remains the gold standard for use in spinal arthrodesis, this study demonstrates the value of cryopreserved allograft bone alone and in combination with tricalcium phosphate in promoting spinal fusion.

Animals↗