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At least 163 records · Page 9Linked to original sources
PubMed1976

A study of taste and smell of heavy water (99.8%) in rats.

Restricted to heavy water (99.8%), rats drank it freely for the first day, then they drank progressively less and died within 14 days. When given a choice between distilled water and heavy water (99.8%) rats avoided heavy water partly by virtue of some deleterious effects of heavy water and partly by virtue of a faint smell of heavy water with which the untoward effects could be associated. Rats did not taste heavy water. Whether a higher viscosity of heavy water plays any part could not be determined. Apparently the low intensity of any untoward effects of heavy water and the faintness of its smell could explain the erratic variability of the reactions of rats to heavy water that put it in a different category from other substances tested so far.

Animals↗
PubMed1989

Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test.

The internal consistency reliability (ICR) of the 40-item University of Pennsylvania Smell Identification Test (UPSIT) and its 10-, 20-, and 30-item fractions was explored, as well as the relationships between the fractions and the entire 40-item test. Pearson correlation coefficients (rs) were computed among all independent combinations and permutations of the four 10-item UPSIT booklets using data from 774 subjects. The median r values of the 10- and 20-item combinations were used to establish the ICRs of the 10- and 20-item tests. The ICRs of the 30- and 40-item tests were estimated using the Spearman-Brown formula and the median rs of the 20-item combinations. Additional ICR estimates of the 40-item UPSIT were obtained from nonsymmetrical fractions using the Horst formula. The ICRs for the UPSIT and its 10-, 20-, and 30-item fractions were 0.922, 0.752, 0.855 and 0.898, respectively. No major sex differences emerged. Estimates of correlations between (1) single booklets and two-booklet combinations and (2) the 40-item UPSIT using Guilford's (1953) correction for nonindependence ranged from 0.812 to 0.871. Overall, these results indicate that (1) the UPSIT and its 10-, 20-, and 30-item fragments have very high ICRs and (2) individual UPSIT booklets or their combinations can be used to assess smell function in a reliable manner where extreme time constraints are present (e.g., in surveys and in brief neuropsychological test batteries).

Adult↗
PubMed1976

[Functional study on the sense of smell in patients with chronic liver disease].

In olfacto-odorimetrical examinations of 32 patients with chronic liver diseases (18 female and 14 male patients at the age of 23 to 77 years) 13 patients with a disturbed olfactory function were found. With one exclusion these patients suffered from liver cirrhosis. On the basis of the anamnesis in 10 of these patients a causal connection between disturbance of smelling and liver disease could be assumed. Out of this group with chronic active hepatitis of 10 patients only 1 patient had a disturbed olfactory function. In 8 patients with disturbed olfactory function suffering from liver cirrhosis a comparison of the olfactometrical findings with activity of GOT and GPT in the serum and the serum bilirubin content showed a correlation between possibilitiy of smelling and serum bilirubin level. Possible causes of appearing olfactory disturbances are demonstrated in short.

Adult↗
PubMed2001

[Disorders of taste and smell].

Disorders of taste and smell not only are uncomfortable to the person involved, e.g. because of an impaired hedonic and sensory experience of food or the continuous presence of a nasty taste, but can also result in loss of body weight and may have a negative influence on the quality of life. In this article both the physiology of chemosensory function and dysfunction of taste and smell are discussed as well as some clinical consequences and their treatment.

Ageusia↗
PubMed1975

[Radiogenic disorder in sense of smell (author's transl)].

The influence of radiotherapy on the sense of smell was investigated in 24 patient (age 28-80 years) with Elsberg's method. Out of 19 patients, who were measured 1-15 years after radiotherapy, the thresholds exceeded the normal range in no case, i.e. no permanent disturbance of smell after radiotherapy. In 5 patients, tested before, during and after irradiation, the thresholds rised continuously to the upper margin of the normal limit between 1,000 and 6,000 rads and, after the end of therapy returned to initial levels within 6-8 weeks.

Adult↗
PubMedDate not supplied

[Smell during speleologic isolation].

A smell evolution it is done from two isolation experiences, in a cave by a speologyst in Eastern Pyriness. The investigation verified the smell recovery from a person who is used to living in town with big pollution. This work was done with twenty four fragrant essences, twenty of them were oriented to olfactory nerve exploration and four of them to trigeminal response. These tests were done with each nostril separately.

Adult↗
PubMed2004

The physiology of taste and smell: how and why we sense flavors.

Taste and smell work together to identify the chemical composition of what we intend to ingest. In recent years, our understanding of the mammalian physiology of taste and smell has greatly increased. In addition to its intrinsic value, this increased understanding of the molecular and cellular basis of flavor recognition provides also a new view on our behavioral response to edible matter.

Animals↗
PubMed2004

Using the sense of smell in telemedical environments.

It is widely recognized in the medical community that the sense of smell plays a very important role in the diagnosis of various associated medical disorders. With the advent of computerized scent detection and scent production devices, smell as a medical diagnostic and educational tool could be carried over into the world of telemedicine, tele-surgery, and distance education.

Computer Peripherals↗
PubMed1989

Influence of nasal obstruction on smell function.

This article has reviewed studies that document a relationship between loss of smell function and disturbances in nasal airflow function. In some cases (for example, hypertrophied adenoids and nasal sinus disease), medical or surgical intervention appears to be useful in restoring some, if not all, of the smell loss associated with the disorder. In other cases (for example, septoplasty), empirical evidence of such efficacy is wanting. Given the current research interest on these topics, however, a clear understanding of both the positive and negative influences of surgical and medical interventions in most cases of obstructive nasal disease or malformities will be forthcoming.

Adenoidectomy↗
PubMed1994

Disorders of taste and smell.

Chemosensory dysfunction involves deficits in taste or smell. Aberrations in these senses can be quite distressing to the patient and can negatively impact on nutritional well-being. A thorough history and physical examination are important in isolating the etiology of the sensory loss from the numerous causes of taste and smell disorders. The diagnosis can be simplified by the fact that only a few causes (nasal and sinus disease, viral-induced loss, and head trauma) are responsible for the vast majority of chemosensory dysfunctions. Therapy is limited, but one should be aware of the existing medical and surgical treatment modalities.

Humans↗
PubMed2005

Differences between orthonasal and retronasal olfactory functions in patients with loss of the sense of smell.

OBJECTIVE: To investigate differences between orthonasal and retronasal olfaction in patients with loss of the sense of smell without taste complaints. DESIGN: Electrophysiological and psychophysical testing of orthonasal and retronasal olfactory functions. SETTING: Outpatient clinics. PATIENTS: A series of 18 patients who had olfactory loss due to various reasons but no "taste" complaints. MAIN OUTCOME MEASURES: Orthonasal and retronasal olfactory functions assessed by olfactory event-related potentials and psychophysical smell tests. RESULTS: Psychophysical testing revealed retronasal olfaction to be normal or slightly altered, whereas orthonasal olfaction was either absent or severely compromised. Findings from nasal endoscopic examinations and computed tomographic scans were within the reference range in all subjects. In response to orthonasal stimulation there were neither detectable olfactory event-related potentials nor any with small amplitudes, whereas olfactory event-related potentials in response to retronasal stimulation were clearly present in some patients. CONCLUSION: These clinical observations, together with the psychophysical and electrophysiological findings, suggest that orthonasal and retronasal olfaction might be processed differently.

Adult↗
PubMed2003

Postoperative taste and smell deficit after upper gastrointestinal cancer surgery--an unreported complication.

BACKGROUND AND OBJECTIVES: Patients undergoing upper gastrointestinal cancer surgery were noted to suffer loss of taste and/or smell, a previously unreported problem. Our aim was to investigate the extent of this phenomenon, quantify recovery time, and identify potentially associated factors. METHODS: In this retrospective study, a postal questionnaire was sent to all patients still alive after oesophagectomy or gastrectomy, with a minimum 1-year follow-up and no clinical or radiological evidence of recurrence. Data were analysed for prevalence of deficit in relation to operation, age, sex, respiratory complications, and disease stage. RESULTS: A total of 109/119 (92%) patients completed the questionnaire: 50 gastrectomies and 69 oesophagectomies. Ten patients were excluded with prior sensory deficit. Overall, 45/99 patients (45%) suffered deficit (M:F = 1.6:1). No association was found with type of surgery: deficits for subtotal gastrectomy, total gastrectomy, and oesophagectomy were 44, 46 and 46% respectively (chi(2) = 0.355, 2 df P > 0.5). No other parameter was associated, and full recovery occurred in 30 patients (67%) within a mean of 6 months. CONCLUSIONS: Loss of taste and smell occurs in nearly one-half of all cases after upper gastrointestinal surgery. The pathophysiology is unknown, but it resolves in most patients within 6-12 months. This complication should be discussed as part of informed consent for patients undergoing oesophagogastric cancer surgery.

Adult↗
PubMed1991

Food intake, eating-related complaints, and smell and taste sensations in patients with cancer of the lung, ovary and breast undergoing chemotherapy.

Nutritional status and energy and protein intake were studied in 52 patients with cancer of the breast, ovary or lung before, after 1, and after 3 cycles of aggressive chemotherapy. Pre-treatment intakes were somewhat lower than recommended and did not change after 3 cycles of chemotherapy, neither did nutritional status. Many patients had eating-related complaints, but these complaints did not increase significantly with chemotherapeutic treatment. In 31 patients electrical taste detection thresholds and chemical smell detection thresholds were measured before and after 3 cycles of chemotherapy. Changes in thresholds had no relation to changes in energy and protein intake. Perceived taste and smell changes were not reflected in chemosensory threshold values.

Journal Article↗
PubMed2004

Clinical assessment of patients with smell and taste disorders.

Clinical assessment of the patient who has smell and taste disorders requires understanding of the etiology of the olfactory and gustatory disorders. Available clinical tests of olfactory and gustatory systems allow detecting and measuring the degree of the sensory loss, but are unable to determine the cause and give neither prognostic information nor therapeutic guidance. With physical examination, however, clinical history can help to establish the diagnosis and guide the treatment if available. A clinician evaluating a patient who has smell and taste loss must understand that "taste" complaints usually are symptoms of an olfactory dysfunction. The distinction between true gustatory loss (bitter, sweet, salty, sour, or umami) and olfactory loss, the inability to perceive complex flavors of food, will help clarify the patient's diagnosis. Easy-to-administer tests are available for olfactory (eg, UPSIT) and gustatory testing (eg, spatial tests, taste sticks, tasting tablets). In rare circumstances, imaging studies (eg, MRI, CT) are indicated.

Aging↗
PubMed1990

Dietary evaluation of patients with smell and/or taste disorders.

The impact of smell and taste disorders on dietary habits and nutritional status has received limited research attention. This paper reports findings obtained from questionnaires and diet records completed by 40 healthy subjects and 118 patients with chemosensory dysfunction. Chemosensory disorders were frequently associated with decreases in food acceptability. Although dietary responses to these dysfunctions varied greatly, patients with distorted or phantom smell and/or taste sensations tended to report weight loss whereas those with simple sensory loss were more likely to report weight gain. Indices derived from diet records did not indicate that either group of patients was at substantial nutritional risk, but food frequency responses and estimates of body mass index were consistent with patient reports of changes in dietary patterns and weight. In addition, marked weight change and aberrant dietary practices were noted in individual patients. Thus, there were indications that chemosensory dysfunction may be associated with nutritionally important dietary alterations.

Adult↗
PubMed1984

The urine smell around patients with urinary incontinence. The production of ammonia in ordinary diapers and in diapers impregnated with copper acetate.

The foul smell of urine around patients with urine incontinence is thought to be due mainly to the production of ammonia from urea by bacterial ureases. The production of ammonia was thus measured by infrared spectrophotometry in control diapers and in test diapers impregnated with copper acetate (CA), after use by urine-incontinent patients with persistent bacteriuria. The CA-impregnated diapers produced significantly less ammonia than the control diapers. The CA-impregnated diapers were not bactericidal, however. The results are consistent with the hypothesis that the smell reduction of the CA-impregnated diapers is due to a bacteriostatic action or an inhibition of bacterial ureases by CA.

Aged↗
PubMed2003

Olfactory event-related potentials in normal subjects and patients with smell disorders.

We developed a device to record olfactory event-related potentials (OERP) from the human scalp. Methyl-cyclopentenolone was used as the odorant element. A total of 50 stimuli were delivered. Each stimulus lasted 0.5 sec and was delivered once every three inspirations. Normal OERPs were obtained with this device. The positive peak latencies were approximately 350 msec (P1) and 700 msec (P2), respectively. OERPs were also recorded in 40 patients with smell disorders. A positive response at about 300-400 msec was recorded in 7 patients (all females, 15-59 years old). The other 33 patients showed no response. The high potential area of this positive peak was located in the centro-occipital region of the scalp. The latency and the high potential area of this peak were similar to P1 recorded in normal subjects. The source of this peak was considered identical to that of P1. This may be a response to the trigeminal nerve during odor administration. P2 was not recorded in the patients with smell disorders. P2 may therefore be a response to the olfactory nerve.

Adolescent↗