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PubMed1994

Effectiveness of SofScale Calculus Scaling Gel as an aid during dental scaling of teeth of dogs.

The effect of pre-scaling application of SofScale Calculus Scaling Gel was studied on teeth of cadaver dogs, comparing scaling time and effort among pre-treated and untreated pairs of teeth. Teeth with light, moderate and heavy calculus were studied, treated by either hand-scaling only or hand and ultrasonic scaling. No significant difference was found in overall mean time required, comparing SofScale treated and untreated teeth. Scaling time was faster for SofScale treated teeth with light calculus, and slower for SofScale treated teeth with heavy calculus. There were no differences observed in the effort required for scaling, comparing SofScale treated and untreated teeth.

Analysis of Variance↗
PubMed2003

Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).

Resilience may be viewed as a measure of stress coping ability and, as such, could be an important target of treatment in anxiety, depression, and stress reactions. We describe a new rating scale to assess resilience. The Connor-Davidson Resilience scale (CD-RISC) comprises of 25 items, each rated on a 5-point scale (0-4), with higher scores reflecting greater resilience. The scale was administered to subjects in the following groups: community sample, primary care outpatients, general psychiatric outpatients, clinical trial of generalized anxiety disorder, and two clinical trials of PTSD. The reliability, validity, and factor analytic structure of the scale were evaluated, and reference scores for study samples were calculated. Sensitivity to treatment effects was examined in subjects from the PTSD clinical trials. The scale demonstrated good psychometric properties and factor analysis yielded five factors. A repeated measures ANOVA showed that an increase in CD-RISC score was associated with greater improvement during treatment. Improvement in CD-RISC score was noted in proportion to overall clinical global improvement, with greatest increase noted in subjects with the highest global improvement and deterioration in CD-RISC score in those with minimal or no global improvement. The CD-RISC has sound psychometric properties and distinguishes between those with greater and lesser resilience. The scale demonstrates that resilience is modifiable and can improve with treatment, with greater improvement corresponding to higher levels of global improvement.

Adaptation, Psychological↗
PubMed2004

Dermo-epidermal interactions in reptilian scales: speculations on the evolution of scales, feathers, and hairs.

The dermal influence on the epidermis during scale formation in reptiles is poorly known. Cells of the superficial dermis are not homogeneously distributed beneath the epidermis, but are instead connected to specific areas of the epidermis. Dermal cells are joined temporarily or cyclically through the basement membrane, with the reactive region of the epidermis forming specific regions of dermo-epidermal interactions. In these regions morphoregulatory molecules may be exchanged between the dermis and the connected epidermis. Possible changes in the localization of these regions in the skin may result in the production of different appendages, in accordance with the genetic makeup of the epidermis in each species. Regions of dermo-epidermal interactions seem to move their position during development. A hypothesis on the development and evolution of scales, hairs, and feathers from sarcopterigian fish to amniotes is presented, based on the different localization and extension of regions of dermo-epidermal interactions in the skin. It is hypothesized that, during phylogenesis, possible variations in the localization and extension of these regions, from the large scales of basic amniotes to those of sauropsid amniotes, may have originated scales with hard (beta)-keratin. In extant reptiles, extended regions of dermo-epidermal interaction form most of the expanse of outer scale surface. It is hypothesized that the reduction of large regions of dermo-epidermal interactions into small areas in the skin were the origin of dermal condensations. In mammals, small regions of dermo-epidermal interactions have invaginated, forming the dermal papilla with the associated hair matrix epidermis. In birds, small regions of dermo-epidermal interactions have reduced the original scale surface of archosaurian scales, forming the dermal papilla. The latter has invaginated in association with the collar epidermis from which feathers were produced.

Animals↗
PubMed2005

Epidemiology of Fasciola gigantica and amphistomes in cattle on traditional, small-scale dairy and large-scale dairy farms in the southern highlands of Tanzania.

A longitudinal descriptive study was conducted to determine the prevalence and distribution of flukes (Fasciola gigantica and amphistomes) on traditional, large-scale and small-scale dairy cattle farms in Iringa district, southern highlands of Tanzania. Coprological examinations of different cohorts for the presence of fluke eggs were recorded monthly. Results indicated a significant influence of the type of management on the prevalence of both Fasciola and amphistomes. The prevalence of flukes was highest in the traditional system, moderate in the large-scale dairy system and lowest in the small-scale dairy system in most parts of the year. Adults and yearlings had the highest prevalence of flukes in all management systems throughout the year. The proportion of animals excreting amphistome eggs was always higher than that of animals excreting Fasciola eggs in all zones, villages, management systems, farms and age groups. The proportion of animals passing fluke eggs increased gradually from the early dry season and peaked at the end of the dry season and the early part of the rainy season. Strategic treatments against flukes are recommended in adults and yearlings only in traditional and large-scale dairy farms. Routine treatments of calves/weanlings in large-scale and traditional farms and zero-grazed small-scale dairy cattle farms might be unnecessary. For a cost-effective helminth control programme in the area, strategic treatments at the beginning of the dry season (June) and at the end of the dry/early rainy season (November/December) are recommended.

Animals↗
PubMed1995

The Descriptor Differential Scale of Pain Intensity: an evaluation of item and scale properties.

Improved methods for pain measurement have both theoretical and clinical importance. This study evaluated the Descriptor Differential Scale (DDS) of Pain Intensity, a recent methodology designed for assessing pain reports in clinical samples. Experiment 1 evaluated the sensitivity of the measure to small changes in electrocutaneous stimulation relative to a traditional visual analogue scale (VAS) of pain intensity. Additionally, direct psychophysical scaling methods were employed to determine ratio-scale values for the DDS sensory items in relation to the electrocutaneous stimuli. This ratio scale was cross-validated by comparison with previously published ratio-scaled data from cross-modality matching pain intensity judgement studies. Experiment 2 evaluated the performance of the measure in both experimental and clinical pain samples, as well as the similarity of item-response patterns in each of these samples. Results indicate that the DDS of Pain Intensity is sensitive to small changes in electrocutaneous stimulation, has consistent ratio-scale properties across two different psychophysical methods, and demonstrates similar item-response patterns across divergent experimental and clinical samples. The results support the validity of the sensory DDS as a measure of pain intensity.

Adult↗
PubMed1992

The development of a new small-scale smoke toxicity test method and its comparison with real-scale fire tests.

A comprehensive methodology has been developed for obtaining and using smoke toxicity data for fire hazard analysis. This bench-scale method can simulate diverse fire conditions and identify extremely toxic smoke under both pre- and post-flashover conditions. However, incidence data show that most of the fire deaths in the U.S. occur outside the room of fire origin from smoke and toxic gases that are generated from a fire under post-flashover conditions. Therefore, the most relevant real-scale combustion conditions to simulate in the bench-scale apparatus would be the post-flashover conditions which are achieved by using radiant heat, a high heat flux, and correcting the bench-scale carbon monoxide (CO) results to agree with CO yields observed in real-scale post-flashover fires. The number of test animals (Fischer 344 male rats) is minimized by using the N-Gas Model to estimate the LC50 value from the chemical analysis of the smoke. The current N-Gas Model predicts the toxicity of complex fire gas mixtures based on a large data base of experimental results of individual and mixed gases that include CO, CO2, reduced O2, HCN, HCl, HBr, and NOx. The prediction is checked with a small number of animal tests and an approximate LC50 value is determined. The bench-scale results have been validated with full-scale room wall burns of a limited number of materials of widely differing characteristics chosen to challenge the system. The toxic potency values are assessed to determine if the smoke from a material or product is unusually or extremely toxic and can then be used in computations of fire hazard.

Animals↗
PubMed1996

Outcome assessment in epilepsy: available rating scales for adults and methodological issues pertaining to the development of scales for childhood epilepsy.

During the past decade, several scales have been developed to improve the assessment of outcome in epilepsy. These scales were developed for adults and their reliability, validity and usefulness have been established. However, there is also a need for alternative measures of outcome in childhood epilepsy, especially a measure of seizure severity (SS) and measures pertaining to quality of life (QoL). Four of these adult scales are reviewed and compared to examine their applicability in childhood epilepsy. Two important methodological differences between them are discussed: (a) patient self-report vs. physician-based scales and (b) generic vs. disease-specific instruments. QoL in epilepsy is briefly reviewed. Severity of seizures and severity of side-effects are relatively neglected areas of importance to QoL in epilepsy. The existing instruments for adults are not appropriate for children in their present form. Some specific methodological issues, which are relevant for the development of scales for children with epilepsy, are subsequently discussed. New scales pertaining to physical and psychosocial aspects of QoL in childhood epilepsy are being developed. In the near future, data on their reliability, validity and usefulness will become available. A combination of scales focusing on specific aspects of QoL, including SS and severity of adverse effects, and more traditional clinical data may provide a more complete assessment of outcome in childhood epilepsy.

Adult↗
PubMed2004

A new amphipathy scale I. Determination of the scale from molecular dynamics data.

Two new amphipathy scales elaborated from molecular dynamics data are presented. Their applications contribute for the identification of the hydrophobic or hydrophilic regions in proteins solely from the primary structure. The new amphipathy coefficients (AC) reflect the side chain/solvent molecules configurational energies. A polar (water) and an apolar solvent, CCl4, were used resulting in the two ACwater and ACCCl4 scales. These solvents were chosen to simulate the aqueous phases and the transmembrane ambients of cellular membranes where the membrane proteins act. The new amphipathy scales were compared with some previous scales determined by different methods, which were also compared between them, indicating more than 90% of the correlation coefficients are less than 0.9: the scales are strictly dependent on the methodologies used in their determination. The ACCCl4 scale is related with the size of side chain amino acids while ACwater is related with the hydrophobicity of side chain amino acids. The quality of the scales was confirmed by an example of application where ACwater was able to identify correctly the transmembrane, hydrophobic regions of a membrane protein. These results also indicate that water is an important factor responsible for the tertiary structure of membrane proteins.

Amino Acids↗
PubMed2005

Cross-cultural adaptation of the Diabetes Management Self-Efficacy Scale for patients with type 2 diabetes mellitus: scale development.

BACKGROUND: As a profession, nurses are particularly concerned with cross-cultural influences that affect the health practices of populations. Although the international literature describes questionnaires and specific scales in health and disease behaviours, adequate Turkish-language instruments are scarce. Therefore, suitable Turkish-language instruments need to be developed or adapted for the Turkish population. OBJECTIVES: Study aim was to adapt a Dutch/English version of the diabetes management self-efficacy (SE) scale for use with a Turkish population and evaluate its psychometric properties. DESIGN: Methodological research design. SETTINGS: Attendants of an outpatient clinic of a university hospital in Turkey. PARTICIPANTS: A convenience sample of 110 patients with type 2 diabetes mellitus (DM). METHODS: Translation and back-translation of the original English instrument and content validation through a expert panel were the first two steps of the study. Third step was the psychometric testing of the adapted instrument by establishing internal consistency (Cronbach's alpha), stability (test-retest reliability), and construct validity (factor analysis). RESULTS: Content validity procedure resulted in a final scale that consisted of 20 items. Internal consistency of the total scale was coefficient alpha=0.88, and test-retest reliability with a 4-week time interval was r=0.91 (p<0.001). Factor analysis yielded three factors related to diet, exercise and medical treatment. Two relevant items of the scale, weight control and blood sugar control, however, had low reliability and validity scores. CONCLUSIONS: Although acceptable levels of reliability and validity of the Turkish version of the diabetes management SE scale for people with type 2 DM were reached, cultural factors appeared to play a role in the applicability of some items of the scale.

Analysis of Variance↗
PubMed2004

Scale-up of virus-like particles production: effects of sparging, agitation and bioreactor scale on cell growth, infection kinetics and productivity.

The baculovirus-insect cells expression system was used for the production of self-forming Porcine parvovirus (PPV) like particles (virus-like particles, VLPs) in serum-free medium. At 2l bioreactor scale an efficient production was achieved by infecting the culture at a concentration of 1.5 x 10(6)cells/ml using a low multiplicity of infection of 0.05 pfu per cell. In a continuous bioreactor, it was shown that the uninfected insect cells were not sensitive to local shear stress values up to 2.25 N/m2 at high Reynolds numbers (1.5 x 10(4)) in sparging conditions. Uninfected insect cells can be grown at scaled-up bioreactor at high agitation and sparging rates as long as vortex formation is avoided and bubble entrapment is minimized. An efficient process scale-up to 25 l bioreactor was made using constant shear stress criteria for scale-up. The kinetics of baculovirus infection at low multiplicity of infection, either at different cell concentration or at different scales, are very reproducible, despite the different turbulence conditions present in the bioreactor milieu. The results suggest that the infection kinetics is controlled by the rate of baculovirus-cell receptor attachment and is independent of the bioreactor hydrodynamic conditions. Furthermore, the achieved specific and volumetric productivities were higher at the 25 l scale when compared to the smaller scale bioreactor. Different rates of cell lysis after infection were observed and seem to fully explain both the shift in optimal harvest time and the increase in cell specific productivity. The results emphasize the importance of integrated strategies and engineering concepts in process development at bioreactor stage with the baculovirus insect cell system.

Animals↗
PubMed2004

Validity of pressure ulcer risk assessment scales; Cubbin and Jackson, Braden, and Douglas scale.

This study was to compare the validity of three pressure ulcer risk tools: Cubbin and Jackson, Braden, and Douglas scales. Data were collected three times per week from 48 to 72 h after admission based on the three pressure ulcer risk assessment scales and skin assessment tool developed by the Panel for the Prediction and Prevention of Pressure Ulcers (1994) from 112 intensive care unit (ICU) patients in a educational hospital Ulsan, Korea during December 11, 2000 to February 10, 2001. When a patient developed a pressure ulcer at the time of assessment, the patient was classified into 'pressure ulcer group', and when patients did not have a pressure ulcer until they died, moved to other wards or were discharged from the hospital, they were classified into 'not pressure ulcer group'. Four indices of validity and area under the curves (AUC) of receiver operating characteristic (ROC) were calculated. Based on the cut-off point presented by the developer, sensitivity, specificity, positive predictive value, negative predictive value were as follows: Cubbin and Jackson scale: 89%, 61%, 51%, 92%, respectively, Braden scale: 97%, 26%, 37%, 95%, respectively, and Douglas scale: 100%, 18%, 34%, 100%, respectively. AUCs of ROC curve were 0.826 for Cubbin and Jackson, 0.707 for Braden, and 0.791 for Douglas. Overall, the Cubbin and Jackson scale showed the best validity among scales tested and we recommended it for this ICU.

Activities of Daily Living↗
PubMed1997

The distance used for scaling disparities is the same as the one used for scaling retinal size.

To determine the physical size and global three-dimensional (3-D) shape of an object, retinal size and retinal disparity have to be scaled in accordance with the object's distance. We examined whether the distance used for scaling retinal disparity is the same as the distance used for scaling retinal size. Subjects adjusted the 3-D shape (size and depth) of a computer-simulated ellipsoid to match a tennis ball. Analysis of the errors when only the ellipsoid was visible in an otherwise completely dark room suggests that the distance used for scaling retinal disparity is indeed the same as that used for scaling retinal size. This was confirmed by showing that the correspondence between the distance used for scaling retinal disparity and that used for scaling retinal size does not improve when more information about distance is available (room lights on), although both distances are then much closer to the simulated distance. Finally, we show that this correspondence is not due to the use of distance-invariant higher order binocular information.

Cues↗
PubMed2003

Toward the development of a Mood Disorders Insight Scale: modification of Birchwood's Psychosis Insight Scale.

BACKGROUND: Insight has been defined as: (1) recognition of symptomatology, (2) the ability to attribute symptoms to a mental health disorder, and (3) complying with treatment. Insight is related to medication compliance, course of illness and outcome. Current instruments for measuring insight are limited to those that have been validated primarily in hospitalized patients with psychosis. Our objectives were to develop a reliable and valid self-report scale for use in outpatients or inpatients with mood disorders. Toward this end we made extensive revisions of the Birchwood et al. Insight Scale for Psychosis. METHODS: The scale was developed by modifying items from a previous self-report scale. Specifically, assumptions of hospitalizations, psychosis, and current symptomatology were removed and items related to mood state were added. The scale was included in a battery of measures completed by outpatients and inpatients participating in a study of mood stabilizer medications. RESULTS: Subjects (n=101, 66.3% female, median age 44 years) took approximately 2-3 min each to complete the scale. Overall scores were high (Mean=10.3 out of 12). Reliability was determined using test-retests (r=0.75, n=45). Validity testing was based mainly on clinician ratings (r=0.49, n=69). CONCLUSION: The new scale shows promise as a quick method for assessing insight in patients with mood disorders.

Adult↗
PubMed1997

The Neurotoxicity Scale--II. Results of a patient-based scale assessing neurotoxicity in patients with epilepsy.

The Neurotoxicity Scale was devised as a patient-based report scale to assess the adverse effects of antiepileptic drugs on cognitive function. In a previous report we reported the clinical validity of the scale, tested in a double-blind randomized study, using a benzodiazepine in normal volunteers. In the present study, the clinical sensitivity, construct validity and reliability of the scale was tested in patients with epilepsy. Patients (n = 189), selected from both participating centres, representative for the patients with chronic epilepsy were included in the study. Reliability was tested with Cronbachs alpha and yields an almost maximal score (.95). Clinical sensitivity was compared with the previous normal volunteer study and was evaluated as satisfactory. Construct validity showed a five-factor structure, explaining 66.5% of the variance, with 'fatigue and slowing' as the dominant factor. In line with the assumptions for this scale and with the results obtained in normal volunteers, the scale appears to be unsuitable for differential assessment of type or severity of drug-induced impairment. The most valid primary outcome measure is the overall score that renders a global ('all or nothing') evaluation indicating that a subject experiences cognitive impairment and associates this with the antiepileptic treatment. Other factors that may impair cognitive function, such as seizure frequency do not influence this score. The scale has therefore maximal applicability as a screening instrument in outpatient practice and in early (phase II, IIIa) drug trials.

Adult↗
PubMedDate not supplied

Chemical information based scaling of molecular descriptors: a universal chemical scale for library design and analysis.

Scaling is a difficult issue for any analysis of chemical properties or molecular topology when disparate descriptors are involved. To compare properties across different data sets, a common scale must be defined. Using several publicly available databases (ACD, CMC, MDDR, and NCI) as a basis, we propose to define chemically meaningful scales for a number of molecular properties and topology descriptors. These chemically derived scaling functions have several advantages. First, it is possible to define chemically relevant scales, greatly simplifying similarity and diversity analyses across data sets. Second, this approach provides a convenient method for setting descriptor boundaries that define chemically reasonable topology spaces. For example, descriptors can be scaled so that compounds with little potential for biological activity, bioavailability, or other drug-like characteristics are easily identified as outliers. We have compiled scaling values for 314 molecular descriptors. In addition the 10th and 90th percentile values for each descriptor have been calculated for use in outlier filtering.

Combinatorial Chemistry Techniques↗
PubMed2004

Fractal-based scaling and scale-invariant dispersion of peak concentrations of crop protection chemicals in rivers.

A new regulatory approach is needed to characterize peak pesticide concentrations in surface waters over a range of watershed scales. Methods now in common use rely upon idealized edge-of-field scenarios that ignore scaling effects. Although some watershed-scale regulatory models are available, their complexity generally prevents them from being used duringthe pesticide registration decision process, even though nearly all exposure to both humans and aquatic organisms can occur only at this scale. The theory of fractal geometry offers a simpler method for addressing this regulatory need. Mandelbrot described rivers as "space-filling curves" (Mandelbrot, B. B. The Fractal Geometry of Nature; Freeman: New York, 1983), a class of fractal objects implying two useful properties we exploit in this work. The first is a simple power-law relationship in which log-log plots of maximum daily concentrations as a function of watershed area tend to be linear with a negative slope. We demonstrate that the extrapolation of such plots down to smaller watersheds agrees with edge-of-field concentrations predicted using the Pesticide Root Zone Model, but only when the modeling results are properly adjusted for use intensity within the watershed. We also define a second useful property, "scale-invariant dispersion", in which concentrations are well described by a single analytical solution to the convective--dispersion equation, regardless of scale. Both of these findings make it possible to incorporate the effect of watershed scale directly into regulatory assessments.

Environment↗
PubMed2005

Extension of the self-consistent spectrophotometric basicity scale in acetonitrile to a full span of 28 pKa units: unification of different basicity scales.

The earlier compiled self-consistent spectrophotometric basicity scale in acetonitrile (AN) was expanded to range from 3.8 to 32.0 pK(a) units, that is 28 orders of magnitude. Altogether 54 new relative basicity measurements (DeltapK(a) measurements) were carried out and 37 new compounds were introduced to the scale (it now includes altogether 89 bases). The relative basicity of any two bases in the scale can be obtained by combining at least two independent sets of measurements. Multiple overlapping measurements make the results more reliable. The overall consistency (as defined earlier) of the measurements is s = 0.03 pK(a) units. Thorough analysis of all of our experimental data (DeltapK(a) values of this and earlier works) and experimental pK(a) data in AN available in the literature (works from the groups of Coetzee and Padmanabhan, Kolthoff and Chantooni, Jr., the Schwesinger group, Bren' et al. and some others, altogether 19 papers) was carried out. On the basis of this analysis the anchor point of the scale-pyridine-was shifted upward by 0.20 pK(a) units thereby also revising the absolute pK(a) values of all the bases on the scale. This way very good agreement between our relative data and the absolute pK(a) values of the abovementioned authors was obtained. The revised basicity scale was interconnected with the earlier published self-consistent acidity scale by DeltapK(a) measurements between acids and bases. The rms deviation between the directly measured DeltapK(a) values and the absolute pK(a) values of the compounds was 0.10 pK(a) units.

Journal Article↗
PubMed2002

The development of a scale to measure medical students' attitudes towards communication skills learning: the Communication Skills Attitude Scale (CSAS).

INTRODUCTION: There is little research identifying medical students' attitudes towards communication skills learning. This pilot study outlines the development of a new scale to measure attitudes towards communication skills learning. METHODS: First- and second-year medical students (n = 490) completed the 26-item Communication Skills Attitude Scale (CSAS) and 39 students completed the CSAS on a second occasion. Factor analysis was conducted to determine the factors underpinning the scale. The internal consistency of the subscales was determined using alpha coefficients. The test-retest reliability of the individual scale items were determined using weighted kappa coefficients and the test-retest reliability of the subscales were established using intraclass correlation coefficients. RESULTS: Maximum likelihood extraction with direct oblimin rotation resulted in a 2-factor scale with 13 items on each subscale. Factor I represented positive attitudes towards communication skills learning and factor II represented negative attitudes. Subscale I had an internal consistency of alpha=0.873 and an intraclass correlation of 0.646 (P < 0.001). Subscale II had an internal consistency of alpha=0.805 and an intraclass correlation of 0.771 (P < 0.001). The majority of items on the positive (n=9, 69.2%) and the negative attitude subscales (n=8, 61.5%) possessed moderate test-retest reliability. DISCUSSION: The development of a new and reliable scale to identify medical students' attitudes towards communication skills learning will enable researchers to explore the relationships between medical students' attitudes and their demographic and education-related characteristics. Further work is needed to validate this scale among a broader population of medical students.

Adolescent↗