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Subtyping of human red cell phosphoglucomutase locus 1 (PGM1) polymorphism: a third PGM1(1) allele common among Twa Pygmies from North Rwanda.

Seventy-eight Twa Pygmies from North Rwanda have been subtyped by acid starch gel electrophoresis for the polymorphism at the phosphoglucomutase locus 1 (PGM1). A third common PGM1(1) allele that has been named PGM1(1Twa) was detected in heterozygous association with both PGM1(1S) and PGM1(1F) alleles. The PGM1(1Twa) product is faster than those of the other two PGM1(1) alleles and has the same electrophoretic mobility as the rare PGM1(6) enzyme. The frequency of PGM1(1Twa) was found to be 0.45.

Alleles↗

[Incidence of intestinal parasitosis among the Batwa and Hutu pygmy tribes of Rwanda].

The AA have carried out an epidemiological investigation on the incidence of intestinal parasitosis in groups of populations belonging to the pygmoid tribes Batwa and Hutu living in the Northern and Southern regions of Rwanda (East Africa). Positivity for intestinal parasites (protozoa and/or helminths) reached 100% in the 309 subjects examined, no significant difference in prevalence being observed between the Northern and Southern groups. Among the protozoa, E. coli and E. histolytica were most commonly found, while trichocephalosis and ascaridiasis were the most frequently encountered helminthiasis. The occasional finding of Strongyloides fülleborni infestation should also be pointed out.

Cestode Infections↗

[Uterine rupture in Rwanda (apropos of 87 cases)].

The absence of obstetrical supervision and medical attention in dispensaries and health centers, the frequency of the hysterotomies are the reasons of numerous hysterorrhexis in Rwanda. This publication analyses the reasons and effects of this dreaded complications and proposes some prophylactic guidelines for this area of Africa, south of Sahara.

Adult↗

[Epidemic of Neisseria meningitidis cerebrospinal meningitis in the Ruhengeri health district (Rwanda)].

Rwanda is a central african country where mean altitude is high (1,800 m), dwelling scattered, and population density important (372/km2). In 1978, a CSM epidemic broke out and raged for 4 years. Death incidence was very noticeable: 223/100 000. Treatment by an unique doses of chloramphenicol proved to be effective. As a consequence of an experimental immunization campaign, limited to one township, local population immunity is still solid after three years.

Adolescent↗

[A new case of Plasmodium falciparum malaria resistance to chloroquine in Africa (Rwanda) (author's transl)].

Report of a case of P. falciparum malaria observed in Rwanda. Relapse and positive blood thick smear has been observed 8 days after the beginning of the treatment of the previous fit of fever by chloroquine. Authors recall the resistance criteria fixed by O.M.S. for antimalarial drugs and question wether drug-resistant malaria is not spreading in East-Africa, considering some similar cases reported in the region.

Chloroquine↗

[Recent detection of a schistosomiasis focus with S. mansoni in a high region of Rwanda (author's transl)].

A schistosomiasis focus infested by S. mansoni has been recently detected in the North-Western region of Rwanda (average altitude 1800 m). The soil is rich. The small homesteads are scattered. Only a part of the population, living on the bank of the lakes Bulera and Ruhondo, is mainly concerned with fishery. The endemy is not negligible, in spite of unfavourable climatic conditions, and of lakes water temperature never reaching 25 degrees C. But all other conditions required for the growth and the transmission of the parasite are present: mollusks are abundant, mainly Biomphalaria pfeifferi. An epidemiologic study carried out through stool exams among the water-side population (11.857 persons) demonstrated a low incidence of the disease. It is possible to conclude that there is no evident correlation between the schistosoma infestation and the disease incidence.

Adolescent↗

Four years of natural history of HIV-1 infection in african women: a prospective cohort study in Kigali (Rwanda), 1988-1993.

Clinical features and mortality due to human immunodeficiency virus type-1 (HIV-1) infection in women are described as part of a prospective 4-year cohort study on perinatal transmission of HIV in Kigali, Rwanda. Two hundred fifteen HIV-seropositive (HIV+) and 216 HIV-seronegative (HIV-) pregnant women were enrolled at delivery between November 1988 and June 1989. Clinical information collected during systematic quarterly examinations was compared. HIV antibody tests were performed at delivery and CD4/CD8 lymphocyte counts at 15 days' postpartum. HIV--women who seroconverted during the follow-up period were excluded from the analysis of the comparison group starting at the date of seroconversion. At enrollment, all HIV+ women were asymptomatic for acquired immune deficiency syndrome (AIDS). Incidence of tuberculosis was 2.9 per 100 women-years (WY) after 4 years of follow-up in HIV+ women versus 0.2 per 100 WY among HIV- women (relative risk, 18.2; 95% confidence interval 2.4-137.0). Among HIV+ women, the incidence of AIDS (World Health Organization clinical AIDS definition) was 3.5 per 100 WY. The mortality rate was 4.4 per 100 WY among HIV+ women versus 0.5 per 100 WY among HIV- women. Clinical AIDS was present in only half of the fatalities. Tuberculosis was a major cause of morbidity and mortality in these HIV+ African women. An early diagnosis and an appropriate treatment or prevention of tuberculosis should improve the quality of life of HIV-infected patients in Africa.

Adult↗

[Septic meningitis in children in Rwanda from 1983 to 1990. Retrospective study at the Kigali Hospital Center].

To assess septic meningitis in pediatric units in terms of the bacteriologic distribution, mortality, and groups at risk, we conducted a retrospective study in the pediatric department of the Kigali Hospital Center (Rwanda). Based on bacteriologic study of 1215 cerebrospinal fluid samples, there were 321 cases of septic meningitis due to identifiable germs and 68 involving cloudy fluid with no detectable germs, i.e. 1.5% of admissions to the Pediatric Unit of the Kigali Hospital Center. The most common organisms were pneumococcus (36.5%), Haemophilus influenzae (31%), salmonella (13%), and meningococcus (11.5%). Most of the children (75%) presenting septic meningitis were under the age of 5 years. Overall mortality was 38% with rates of 52% and 39% for cases involving pneumococcus and salmonella respectively. The predominant clinical symptoms of pneumococcus meningitis were coma (p:0.000055) and respiratory compromise (p:0.02). In contrast Haemophilus influenzae meningitis was associated with a lower incidence of coma (p:0.05) and malnutrition (p:0.017). Salmonella meningitis was characterized by a higher incidence of fever over 38.9 degrees C (p:0.025) and malnutrition (p:0.01). In patients with meningococcus meningitis, the incidence of convulsions appeared to be higher, at the threshold of statistical significance (p:0.052), whereas coma (p:0062) and respiratory distress (p:0.0024) were uncommon. Independently of etiology, no clinical symptom was associated with a statistically higher risk for death.

Adolescent↗

[An outbreak of Shigella dysenteriae type 1 dysentery in a refugee camp in Rwanda].

As a consequence of the civil war that devastated Burundi in October 1993, more than 300,000 refugees settled in the neighboring country of Rwanda. We describe the outbreak of dysentery due to Shigella dysenteriae type 1 (Sd1) that developed in Nzangwa, a camp hosting some 20,000 Burundese refugees. Between November 17, 1993 and March 10, 1994, 6,122 cases of bloody diarrhea were notified by the health information system of the camp. The overall attack rate was 32.3%, and the fatality rate was 3.8%. Children under five years of age were the most affected group of the population. All dysentery cases were treated with nalidixic acid for 5 days. The compliance assessment showed that less than 50% of the ambulatory patients completed the 5-day regimen. From 35 stool samples obtained from the refugees, seven Sd1 strains were isolated, of which three were multi-resistant to nalidixic acid. These results confirmed the morbidity and mortality of Sd1 outbreaks in the displaced populations of Central Africa. We also emphasize the difficulties in implementing effective prevention measures and appropriate case management strategies in this environment. To improve the management of patients in large Sd1 outbreaks with limited resources, we devised a clinical classification of cases according to the risk of dying.

Adolescent↗

Recognition of AIDS by health personnel in rural south-Rwanda.

The ability of rural health personnel to recognise AIDS related symptoms and signs according to the WHO clinical case definition (CCD) and its modified Rwandan version was tested in 4141 clinically suspected cases in South-Rwanda. The sensitivities of these CCDs for AIDS in adults were 33% (36%), the specificities 78% (76%), and the positive predictive values (ppv) 46%. For AIDS in children the sensitivities of the CCDs were 13% (16%), the specificities 94% (90%), and the ppv 44% (38%). While the specificities did not differ from those found in studies conducted by trained physicians, the low sensitivities and predictive values demand improvement of the training of the health personnel to diagnose AIDS related symptoms and signs, especially where laboratory tests are not available.

AIDS Serodiagnosis↗

Neurodevelopmental testing of children born to human immunodeficiency virus type 1 seropositive and seronegative mothers: a prospective cohort study in Kigali, Rwanda.

OBJECTIVE: The results of developmental testing of 218 children born to human immunodeficiency virus (HIV)-seropositive mothers and infected or uninfected themselves were compared with those of 218 children born to HIV-seronegative mothers in an ongoing cohort study in Kigali, Rwanda. METHODS: When the children were 6, 12, 18, and 24 months of age, a specific neurodevelopmental examination was performed blindly by study physicians assessing gross motor development, fine motor development, language acquisition, and social contacts. RESULTS: Only one acute severe HIV-related encephalopathy was identified among the 50 infected children. The proportion of abnormal neurologic examinations in HIV-infected children varied from 15% to 40% according to age and was always higher than in HIV-uninfected children born to HIV-seropositive and seronegative mothers (< or = 5% or less of abnormal examinations at each time period). After excluding those children with clinical acquired immunodeficiency syndrome (AIDS) from the analysis, the proportion of abnormal examinations in infected children was 12.5% at 6 months, 16% at 12 months, 20% at 18 months, and 9% at 24 months of age and was still more frequent than in HIV-uninfected children. The developmental delay was principally due to significantly lower gross motor scores. CONCLUSIONS: HIV-1-infected children are more frequently developmentally delayed than uninfected children during the first 2 years of life in this African population. This developmental delay is related to the AIDS stage of pediatric HIV infection.

Child Development↗

Persistent arthralgia and its association with HIV infection in Rwanda.

A prospective study of persistent arthralgia was carried out on 331 consecutive female patients admitted to the Department of Internal Medicine of the Centre Hospitalier de Kigali in Kigali, Rwanda. The aim of this study was to determine its association with HIV-1 infection and to describe its clinical characteristics. Ten additional HIV-1-seropositive patients with this condition attending the outpatient clinic were also included in the clinical study. Persistent arthralgia was significantly more common in HIV-1-seropositive hospitalized patients (14 of 209, 6.7%) than in HIV-1-seronegative hospitalized patients (one of 122, 0.8%; p = 0.02) and had a specificity and a positive predictive value for HIV-1 infection of 99.1% and 93.3%, respectively. HIV-1-related persistent arthralgia, studied in 24 patients in early as well as late stages of HIV-1 infection, commonly affected several and mainly large joints, was mostly distributed symmetrically, and was usually relieved with nonsteroidal antiinflammatory drugs. Recurrencies were noted in eight patients. In areas highly endemic for HIV-1, persistent arthralgia should be considered a probable manifestation of HIV-1 infection, and although it is uncommon, it can be regarded as a predictor of HIV-1 infection.

Adult↗

The disease pattern of elderly medical patients in Rwanda, central Africa.

In a study of the disease pattern of the elderly in Rwanda, all patients aged 60 or more, hospitalized in a one-year period at the Medical Department, University Hospital, Butare, were examined prospectively. One hundred and ninety-two patients were included; most were subsistence farmers having a mainly vegetarian diet and living in large families. Infections (37.5% of the patients) and liver cirrhosis (31.8%) were the problems most frequently encountered. Primary hepatocellular cancer was diagnosed in 5.7% of the patients and was the most frequent malignancy. The hospitalized elderly occupied 17.5% of the available beds in the Medical Department. Their disease pattern was different from that of younger patients, making heavier demands on the medical resources. Malaria and upper intestinal inflammation were less frequent in the elderly; liver cirrhosis, primary hepatocellular cancer, pneumonia, prostatic cancer, cardiovascular pathology, chronic renal pathology and chronic lung disease were more prevalent. Several age-related conditions frequently observed in industrialized countries (e.g. coronary heart disease, stroke, gallstones, renal cysts, dementia) were rare. The study thus illustrates the concept of 'secondary aging': to the primary changes induced by the aging process, additional alterations are added which depend upon the environment and the lifestyle, resulting in a varying disease pattern. Health policies thus must take into account that the demographic transition in developing countries may result in a pattern of diseases different from that seen in industrialized countries; care must be taken when transposing data obtained from elderly populations in industrialized countries.

Aged↗

An assessment of the nine-month lactational amenorrhea method (MAMA-9) in Rwanda.

This report presents a secondary data analysis based on prospectively collected records gathered during a field assessment that was carried out in Rwanda in August 1993. The assessment used service statistics and follow-up interviews to evaluate the efficacy of a modified lactational amenorrhea method (LAM) as a nine-month introductory postpartum natural family planning method. The program, carried out by Action Familiale Rwandaise (AFR), reflects high efficacy of the method in a compliant sample that sought this method followed by another form of family planning. These results are promising and provide guidance for the extended use of LAM past six months. Programmatic findings suggest that studies be conducted of the contribution of extended LAM to improved weaning practices, the high efficacy of continued reliance on substantial lactation and amenorrhea beyond nine months, and male involvement in LAM and breastfeeding.

Algorithms↗

Simple algorithms for the management of genital ulcers: evaluation in a primary health care centre in Kigali, Rwanda.

A cross-sectional study was conducted among 395 patients presenting with genital ulcers at a primary health care centre in Kigali, Rwanda. Using clinical data and the results of a rapid plasma reagin (RPR) test, we simulated the diagnostic outcome of two simple WHO flowcharts for the management of genital ulcers. These outcomes and a clinical diagnosis were then compared with the laboratory diagnosis based on culture for genital herpes and Haemophilus ducreyi and serology for syphilis. The prevalence of HIV infection was high (73%) but there was no difference between HIV-positive and HIV-negative patients in the clinical presentation and etiology of genital ulcer disease. The proportion of correctly managed chancroid and/or syphilis cases was 99% using a syndromic approach, 82.1% using a hierarchical algorithm including an RPR test, and 38.3% with a clinical diagnosis. In situations where no laboratory support is available, a simple syndromic approach is preferable to the clinical approach for the management of genital ulcer. If an RPR test can be included in the diagnostic strategy, patients with a reactive RPR test should be treated for both syphilis and chancroid infection.

Algorithms↗

[Psychological consequences of the 1994 massacres in Rwanda].

A research program on the prevalence of reactions of posttraumatic stress is described in this article. The program is specifically centered on the psychological consequences of the April 1994 events in Rwanda and the genocide that followed. It includes three psycho-epidemiologic studies: 1) a study of non-accompanied Rwandan children; 2) a study of a small group of belgian cooperants; and 3) a study of an important sample of belgian civilians and militaries having been through the rwandan events. The psychological impact of the rwandan events is described in terms of prevalence of symptoms of posttraumatic stress.

Adolescent↗

Mefloquine versus doxycycline for malaria prophylaxis in intermittent exposure of Israeli Air Force aircrew in Rwanda.

BACKGROUND: The issue of the best chemoprophylaxis agent for aircrew to use against malaria is still not settled. METHOD: We studied the patterns of use of both doxycycline and mefloquine in aviators and other aircrew for 2 mo during biweekly flights from Israel to Rwanda with a few hours' visits. Some 28 aviators and 15 non-aviator aircrew were treated with doxycycline and mefloquine, respectively, less than 12 h before the first flight and up to 4 wk after the last return. RESULTS: No case of malaria occurred within or after the operational period. Compliance was better for mefloquine than for doxycyline for the full period of the operation (100% vs. 75%, respectively). The rate of side effects, mostly gastrointestinal, was higher for doxycycline (39% vs. 13%, respectively) and was related mainly to the frequency of administration (daily vs. weekly). CONCLUSION: In situations involving frequent intermittent short-term visits to areas with substantial risk of acquiring malaria, we conclude that aircrew can safely take weekly mefloquine as prophylaxis.

Aerospace Medicine↗

Neurosurgery in Rwanda during a United Nations peace-keeping mission.

An analysis of the neurosurgical component of the medical support provided by a United Nations peace-keeping mission in Rwanda is presented. The Australian Defence Force contingent provided medical support to the United Nations and the civilian population. Eight hundred thirty-eight procedures were performed during 12 months. A wide range of surgery was encompassed, with neurosurgery accounting for 17 (2%) of the total operations: compound depressed fractured skull, 5; intracranial pressure monitor, 2; burr holes for acute head injury and chronic subdural hematoma, 2; skull osteomyelitis debridement, 1; rib-graft cranioplasty, 2; scalp rotation flap, 1; congenital myelomeningocele, 2; occipital meningocele, 1; craniofacial approach to Le Fort III fracture, 1. A broad range of neurosurgical procedures have been performed. The overall numbers of neurosurgical operations were small, but they were successfully performed by general surgeons. Familiarity with neurosurgery is necessary in predeployment training of military surgeons working in a remote location with limited resources.

Adult↗