Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Rhodiola”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed2000

Selected herbals and human exercise performance.

Herbs have been used throughout history to enhance physical performance, but scientific scrutiny with controlled clinical trials has only recently been used to study such effects. The following herbs are currently used to enhance physical performance regardless of scientific evidence of effect: Chinese, Korean, and American ginsengs; Siberian ginseng, mahuang or Chinese ephedra; ashwagandha; rhodiola; yohimbe; CORDYCEPS: fungus, shilajit or mummio; smilax; wild oats; Muira puama; suma (ecdysterone); Tribulus terrestris; saw palmetto berries; beta-sitosterol and other related sterols; and wild yams (diosgenin). Controlled studies of Asian ginsengs found improvements in exercise performance when most of the following conditions were true: use of standardized root extracts, study duration (>8 wk, daily dose >1 g dried root or equivalent, large number of subjects, and older subjects. Improvements in muscular strength, maximal oxygen uptake, work capacity, fuel homeostasis, serum lactate, heart rate, visual and auditory reaction times, alertness, and psychomotor skills have also been repeatedly documented. Siberian ginseng has shown mixed results. Mahuang, ephedrine, and related alkaloids have not benefited physical performance except when combined with caffeine. Other herbs remain virtually untested. Future research on ergogenic effects of herbs should consider identity and amount of substance or presumed active ingredients administered, dose response, duration of test period, proper experimental controls, measurement of psychological and physiologic parameters (including antioxidant actions), and measurements of performance pertinent to intended uses.

Adolescent↗
PubMed2003

Screening of Mongolian plants for influence on amylase activity in mouse plasma and gastrointestinal tube.

Mongolian plants were screened for their influence on alpha-amylase activity in mouse plasma. Methanolic extracts of Geranium pratense, Rhodiola rosea, Ribes pullchelum and Vaccinium uliginosum inhibited the enzyme activity in isolated mouse plasma by greater than 40% and the effect was concentration dependent. Vaccinium uliginosum also showed a depressive effect on elevation of postprandial blood glucose to some extent.

Animals↗
PubMedDate not supplied

[A toxicological study of the preparation Phytomix-40].

The results of toxicological evaluation of the new plant preparation Phitomix-40 (PM-40) used in the treatment of cancer are presented. To prevent a patient's individual immunological responsiveness to some phytoadaptogens, the preparation comprises 40 plant extracts (Rhodiola r. L.; Juniperus C. L.; Helichrysum a. L; Viburnum o. L., etc.). Animal experiments demonstrated that PM-40 had a low toxicity; LD50 was more than 20 and 15 ml/kg for rats and mice, respectively.

Animals↗
PubMedDate not supplied

[The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test].

Antimutagenic activity of 20 and 40% ethanol extracts from the biomass of Rhodiola rosea, Polyscias filicifolia, Panax ginseng and Ungernia victoris cultured cells have been studied. DDDTDP, ethidium bromide, benz(a)pyrene, benzidine served as model mutagens for Salmonella typhimurium TA 98 strain (the latter two were tested in presence of metabolic activation system); for S. typhimurium TA 100 strain these were tio-tefa, bichromate potassium and sodium azide and heavy metal compounds (chlorides of manganese, zinc, cadmium, lead acetate) for both strains. Higher capacity of the extracts from the biomass of R. rosea and P. filicifolia to counteract gene mutations induced by various mutagens was demonstrated (ca. 90% inhibition in isolated cases). In the experiment with the metabolic activation most effective proved to be the extracts from the P. ginseng biomass (up to 34% and 47% mutagenicity inhibition).

Antimutagenic Agents↗
PubMedDate not supplied

[The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load].

The effect of rhodaxon, an adaptogen preparation based on the Rhodiola rosea extract, upon the physical and intellectual working capacity and psychoemotional state of foreign students during their study in a Russian high school was evaluated. It was established that rhodaxon administration provided increase in the amount of veloergometric work accomplished and reliably increased the kinesthesiometric sensitivity. The drug also lead to marked increased in the general condition and a decrease in the level of psychic fatigue and situational anxiety. On the whole, the pharmacological properties of the rhodaxon preparation studied coincided with those reported for the gold root extract. The fact that the rhodaxon preparation contains no ethyl alcohol extends possibilities of the clinical administration of the new preparation.

Adaptation, Physiological↗
PubMed1992

[The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich's adenocarcinoma to the liver in mice].

It was shown that the use of an anthracycline antibiotic--adriamycin in mice with metastatic involvement resulted in pronounced liver dysfunction, as suggested by a sharp increase in blood transaminase levels. In the same model, a hepatoprotector of plant origin--Rhodiola rosea extract--was shown to inhibit tumor dissemination. Combined application of adriamycin and the extract proved no inferior in terms of antimetastatic efficacy and nearly free from toxicity.

Animals↗
PubMedDate not supplied

[Mechanism of differential effect of low dose adaptogens on the functional activity of normal and transformed cellular elements in vitro].

Influence of water solutions of chemically pure adaptogen--synthetic analog of Rhodiola Rosea extract phenol composition (SAR) on functional activity of hemopoietic and tumor cells of mice with Ehrlich ascite cancer was studied in vitro. The periodical character of SAR effects was shown to be different for both types of cells, and at 1 x 10(-2) and 1 x 10(-26) M concentrations simultaneous stimulation of blood marrow cells colony-forming activity and inhibition of the latter in tumor elements was revealed. Essential changes of reactions of both cell types after adding the DNA-dependent RNA polymerase blocker Actinomycin D permit to suggest SAR effects to be connected with drug influence on the membrane RNA of the target cells.

Animals↗
PubMedDate not supplied

[The effect of low concentrations of adaptogen solutions on the functional activity of murine bone marrow cells in vitro].

Influence of water solutions of chemically pure adaptogens--a synthetic analog of Rhodiola rosea extract phenol combination (SAR) and Dibazol on the functional activity of mice hemopoietic cells in vitro was studied. A clear periodical character of drugs effects manifestation with a tendency to the stimulating activity domination was revealed. A reliable stimulation of clonogenic activity was in correlation with 4 x 10(-11) and 4 x 10(-15) adaptogens molecules in SAR and Dibazol solutions per 1 blood marrow cell. This phenomenon is suggested to be connected with the solvent (water) molecules changes and the formation of structures, keeping the information of adaptogenes with possible translation of the latter during the process of consistent dissolution of the solvent.

Animals↗
PubMed1989

[Decrease in the growth rate of Ehrlich's tumor and Pliss' lymphosarcoma with partial hepatectomy].

In experiments with transplantable tumors, partial hepatectomy, Rhodiola rosea extracts or their combination were shown to inhibit the rate of Ehrlich's tumor and Pliss' lymphosarcoma as well as dissemination of the latter. These effects are to a certain extent attributed to production of humoral factors by the liver inhibiting clonogenic activity of tumor cells in vivo and in vitro.

Animals↗
PubMedDate not supplied

[The action of adaptogenic plant preparations in experimental alloxan diabetes].

Experiments on mice and rats with alloxan diabetes were conducted for comparative assessment of the effectiveness of therapeutic use of adaptogenic plant pharmaceuticals as well as some other commonly used plant drugs. Of marked antidiabetic properties were root and leaf ginseng tincture (LGT), Echinopanax tincture, extracts of Eleutherococcus, Rhodiola (ER) and Leuzia which decreased the blood level of glucose in a CTT (5 g h of glucose per I kg of the animal body mass) from 17.15 to 11.19, 11.50, 12.72, 11.69, 13.47 mmol/l and increased the alloxan-reduced level of liver glycogen by 50-80% (P less than 0.05). Aralia and Schizandra tinctures for this diabetic model were ineffective. Yarrow, everlastings and birch leaf tea also possessed marked hypoglycemic and glycogen sparing properties. The most effective experimentally plant adaptogens LGT and ER increased the blood level of insulin in alloxan diabetic rats in a GTT from 16.75 up to 44.42, 35.31 microU/ml and decreased the level of glucagon from 495 to 195 and 138 pg/ml, respectively. The authors discussed mechanisms of antidiabetic, insulinotropic and hypoglucagonemic action of the effective plant pharmaceuticals and the prospects of their use in multimodality therapy of diabetes mellitus of type I.

Adaptation, Physiological↗
PubMedDate not supplied

[Pharmacology of the plant polyphenol epigalokhin].

Polymer proanthocyanidin from Rhodiola semenovii named epihalochin was found to exhibit a pronounced antihypoxic effect in different models of hypoxia (hypoxic, cytotoxic and hemic), to relieve the hypoxic isolated heart contracture. Therapeutic doses of epihalochin produced a transient lowering of arterial pressure, decreased to a certain degree heart rate and lengthened the phases of cardiac contractions.

Animals↗
PubMed1987

[Plasma beta-endorphin and stress hormones in stress and adaptation].

The experiments on white rats have shown that the induction of 4 hour stress produces an acute increase in beta-endorphin level, as well as characteristic changes in ACTH, cortisol, insulin, thyroxin and triiodothyronine concentrations. Different types of adaptation (training with short stress periods or injection of rhodiola rosea extract) promote a moderate increase in the amount of serum immunoreactive beta-endorphin, preventing its subsequent stress-induced elevation. Adaptation is characterized by a decrease or total prevention of hormonal changes peculiar to stress. The role of opioid neuropeptides in enhancing stress tolerance and the effect of adaptation factors are discussed.

Adaptation, Physiological↗
PubMedDate not supplied

[Antioxidant properties of a series of extracts from medicinal plants].

Investigation of antioxidant properties of some plants was carried out. A group of plants affected human central nervous system was studied in detail. Efficiency of plants as antioxidants was tested by the influence of their extracts on the yield of photochemiluminescence of Gly-Trp solutions. Antioxidant properties were examined under conditions when their own absorption was minimized. Riboflavin as additional sensitizer was used in this experiment for superoxide generation. The antioxidant effect was evaluated with regard to single dose of plant extracts and their concentration in human organism. The effect decreases in the following consequence: Hypericum > Eleutherococcus > Rhodiola > Leonurus > Aralia > Valeriana > Echinopanax > Schizandra > Panax gin-seng.

Antioxidants↗
PubMedDate not supplied

[The activity of the lipid peroxidation processes in the mucosa of the rat small intestine and its morphofunctional state under acute irradiation and the administration of combined preparations created on a base of highly dispersed silica].

Morphofunctional and biochemical studies were carried out on bastard male rats (weight 200-240 g). The results showed that X-ray irradiation had induced structural alterations and elevation of lipid peroxidation in small intestine. Using of complex preparations defended this organ against pathological damages. The first preparation provided rat organisms with 100 ml/kg of silica, 2 mg/kg of beta-carotene, 30 mg/kg of alpha-tocopherol and 0.2 mg/kg of natrium selenite. The second preparation provided 100 mg/kg of silica, 10 mg/kg of dry Rhodiola extract, 0.1 mg/kg of tincture of Lagochilus [correction of Ladohilli] inebrians and 0.05 ml/kg of tincture of Aralia mandshurica. The third preparation provided organism with 100 mg/kg of silica and 20 mg/kg of thiobenzimidazole derivative. All these preparations had produced marked pharmacological effect.

Acute Disease↗
PubMed2004

[Protective effects of salidroside on injury induced by hypoxia/hypoglycemia in cultured neurons].

OBJECTIVE: To study the protective effects of salidroside on injury induced by hypoxia/hypoglycemia in cultured SH-SY5Y cell. METHOD: Apoptosis and intracellular free calcium concentration ([Ca2+]i) were measured by flow cytometry, morphological changes and neuronal necrosis were observed with fluorescence microscope, and the lactic dehydrogenate (LDH) release was measured by LDH kits. RESULT: Hypoxia/hypoglycemia cultures for 2 hours induced neuronal apoptosis and necrosis. They were 18.59% (P < 0.01) and 4.94% (P < 0.01) respectively. There were morphological changes including chromatin condensation, nuclear fragmentation and formed apoptotic bodies after exposed to hypoxia/hypoglycemia for 2, 4, 6, 12 hours. After 2 hours of hypoxia/hypoglycemia, neuronal [Ca2+]i and the release of LDH were significantly increased. They were 8.46 nmol/L (P < 0.01) and 16.59% (P < 0.01) respectively. The effects were enhanced with the extending time of hypoxia/hypoglycemia. Salidroside might have significantly decreased the percentage of neuronal apoptosis and necrosis, reduced neuronal [Ca2+]i and the release of LDH. The effects of salidroside were strengthened with the increasing of Salidroside dosage. CONCLUSION: Salidroside has effect of anti-neuronal apoptosis. This effect might be related to its function of decreasing intracellular free calcium concentration.

Apoptosis↗
PubMed2005

[The effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption of dogs].

OBJECTIVE: To study the effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption for analyzing its underlying mechanism in the treatment of coronary heart disease. METHOD: A total of 20 dogs anesthetized with pentobarbital sodium (30 mg x kg(-1), i.v.) were evenly randomized into control group, low-dose Gadol (LDG) group, high-dose Gadol (HDG) group and Herbesser Injection group. The blood flow volume (BFV) of the left coronary artery and cardiac output (CO), left ventricular pressure (LVP), maximum ascending rate (dp/dtmax) of LVP, mean arterial pressure (MAP) of the femoral artery, oxygen contents of the coronary artery and coronary vein (venous sinus), oxygen consumption index (OCI), cardiac index (CI), coronary artery resistance (CAR) and total peripheral resistance (TPR) as well as oxygen utilization rate (OUR) were detected respectively. RESULT: After venous injection of Gadol, CAR, MAP, TPR, OCI, myocardial oxygen consumption and heart rate lowered significantly (P < 0.05-0.01), while BFV and blood oxygen content of the venous sinus increased considerably (P < 0.05-0.01) in comparison with pre-injection. No significant differences were found in LVP and myocardial contractivity between control group and LDG, and between control and HDG groups respectively. CONCLUSION: It showed dilation of the coronary artery and reduction of the cardiac afterload after injection of Gadol. Besides, CO and stroke volume increased considerably and the cardiac effective work was raised without any significant simultaneous increase of both myocardial contractility and LVP. A decrease in the myocardial oxygen consumption and reduction of OCI indicates an improvement of the oxygen supply of the myocardium, and a favorable regulation of the compliance of the cardiac vessels. As a result, the cardiovascular performance was ameliorated. The abovementioned improvement of these indexes may contribute to the therapeutic effect of Gadol in the treatment of coronary heart disease in clinic.

Animals↗