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[Antibody reaction to inhalation vaccination of poultry against Newcastle disease].

Aerosol preparated from the AVIPEST vaccine by means of three types of aerosol generators was used for vaccination of 294 chickens of different age against the Newcastle disease in laboratory tests and 30 000 chickens at the age of two and three weeks under field conditions. The general and local antibody reactions to vaccination were evaluated on the basis of the determination of the content of hemagglutination-inhibition and neutralization antibodies in the blood serum and in respiratory-tract flushings. The level of secretory antibodies in the flushings from the respiratory tract, determined by the described original method, is an important parameter of the resistance level of the organism to infection. The highest average levels of antibody titres in serum and in flushings were obtained 14 to 21 days from vaccination (7-10 log2). The La Sota vaccination strain was eliminated from the organism after spray vaccination and immunized the non-vaccinated contact chicken. Revaccination increased and greatly prolonged immunity. All the chickens inoculated showed resistance to challenge infection whereas the control birds died within four to six days.

Aerosols↗

[Immunoprophylactic possibilities for the control of fowl coccidiosis].

Coccidiosis is a poultry disease causing considerable economic damage in poultry farming. At present coccidiosis is controlled by chemoprophylaxes. The problem of drug resistance has led to a growing interest in the development of vaccines for the control of these parasites. A review of new methods and developments in the immunological control of coccidiosis in poultry is given and discussed.

Animals↗

[Infectious disease factors in poultry].

The increased importance of multicausal diseases of poultry in the present time is due to a better control and prevention of the monocausal diseases and epidemics predominant in the past. This development is supported by the intensive methods of modern poultry husbandry, the high stocking densities and the improved performance of the poultry by genetic selection. Opportunistic as well as pathogenic organisms can be involved in the development of infectious factorial diseases. A variety of clinical signs can be observed. Above all immunosuppression accompanied by mixed infections and other factors causes health problems of great economical importance. Frequently series of events take place in the development of infectious factorial diseases, in the course of which a preceding disturbance acts as factor of further diseases. Some examples of diseases and syndroms are given to substantiate the multiple involvement of different factors and infections in the development of series of events.

Animal Husbandry↗

[Vaccination schemes against Newcastle disease in poultry].

Two schemes of vaccination against pseudo-pest (A and B) were tested on broiler-chickens and two schemes (C and D)--on parent form birds. Vaccine of the La Sota strain was used for the broilers and was administered twice at differing age after the spray method. For the parent birds La Sota strain vaccine was used also--twice after the spray method, plus a vaccine of the strain Komarov--twice intramuscularly and as aerosol (scheme C) and the vaccine strain La Sota spray and aerosol alone (scheme D). Immunity induced in birds after immunization was followed serologically by the titre of serum antihaemaglutinins and by provocation with a highly virulent pseudo-pest virus strain. The 4 schemes of immunization tested comparatively ensure solid immunity of birds to pseudo-pest. Better production index results were obtained from broiler chickens vaccinated after scheme B and parental form birds vaccinated after scheme C.

Aerosols↗