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147 records · Page 9Linked to original sources
PubMed1996

Transforming growth factor-beta 1 in a guanidine-extracted demineralized bone matrix carrier rapidly closes a rabbit critical calvarial defect.

Transforming growth factor beta 1 (TGF-beta 1) is a polyfunctional regulatory cytokine that has been shown to have roles in extracellular matrix interactions, soft tissue healing, and osteogenesis. Twenty-five microL of recombinant human TGF-beta 1 was added to guanidine-extracted demineralized bone matrix carrier and the implants were used to fill a 14-mm osteoperiosteal critical calvarial defect in New Zealand white rabbit model. The defects were allowed to heal over 4 weeks and the degree of new bone formation was assess by radiodensitometry and undecalcified bone histomorphometry techniques. Implants with TGF-beta 1 showed complete bridging of the gap with new bone in all cases, while the controls showed fibrous tissue repair of the gap with little or no new bone formation. These results demonstrate the ability of TGF-beta 1 to induce new bone in a brief time period in an inactive carrier.

Animals↗
PubMedDate not supplied

[Ultrasonic skull trepanation].

Experimental ultrasonic cranial trepanation was performed on 60 albino rats by means of a semi-automatic device, Y3T-1. The trepanation is altraumatic and does not need any considerable physical effort. A histological examination showed that the zone of bone necrosis along the edge of the cut surface was one third to one half that developing with the use of electric and pneumatic surgical instruments. The Y3T-1 device was used in operations on the skull in 78 patients. Resection trepanation of the skull was carried out in 55 patients, osteoplastic in 23. With the use of the ultrasonic device the time of the operation is shorter, a good hemostatic effect is produced, and no considerable physical effort is required on the part of the surgeon. A special catch incorporated in the device ensures safety of the operation. In reimplantation of an osteoperiosteal flap or in primary-delayed cranioplasty the use of an ultrasonic chisel for punctate osteosynthesis creates good conditions for bone tissue regeneration.

Animals↗
PubMed1996

Role of transforming growth factor beta (TGF-beta) in repairing of bone defects.

TGF-beta is a multifunctional cytokine that regulates many aspects of cellular function, including periosteal mesenchymal cell proliferation, differentiation. This experiment is to study its effects on bone defect repair. A rabbit radial bone defect model was used to evaluate the effect of TGF-beta, which was extracted and purified from bovine blood platelets, on the healing of a large segmental osteoperiosteal defect. A 1.5-centimeter segmental defect was created in the mid-upper part of the radial shaft of adult rabbits. The defect was filled with implant containing TGF-beta that consisted of carrier and bovine TGF-beta. Limbs served as controls received carrier alone. The defects were examined radiographically and histologically at 4, 8, 12, 16 and 20 weeks after implantation. The results showed that in TGF-beta implant group, the defect areas at 12 weeks post operation were bridged by uniform new bone and the cut ends of cortex could not be seen; while in control group, the defects remained clear. Only a small amount of new bone formed as a cap on the cut bone ends. In the experimental group, new lamellar and woven bone formed in continuity with the cut ends of the cortex. An early medullar canal appears to be forming and contained normal-appearancing marrow elements; while the control group displayed entirely fibrous tissue within the defect site. Remnants of the cancellous bone carrier were observed in the control specimen. These data demonstrate that exogenous TGF-beta initiate osteogenesis and stimulate the bone defects repair in animal model.

Animals↗