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Results for “OSSIFICATION, PATHOLOGIC”

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At least 163 records · Page 9Linked to original sources
PubMed2004

Effect of Ascaris chymotrypsin inhibitor on fetal development of mice.

BALB/c mice were given daily doses of 40-80 mg of Ascaris chymotrypsin inhibitor /AChI/ per kg body weight from 12th until 15th day of gestation (stage of fetal development). It has been found that injection of AChI disturbed the course of pregnancy (bleeding from uterus, abortions, decreased body weight gain as compared to control /p < 0.05/). AChI exhibited embryotoxic effects (a high rate of intrauterine deaths, decreased number of living fetuses and mean fetal weight, delayed skeletal ossification, induced pathological changes of fetal organs and tissues). Congenital malformation (hydronephrosis) was noted in fetuses after injection of higher doses of the chymotrypsin inhibitor from Ascaris.

Abnormalities, Drug-Induced↗
PubMed1991

[The mechanism of the development of residual deformation and complications after the reduction of congenital hip dislocation in children and their conservative treatment].

There is described the mechanism of development of hip joint instability of different types and associated secondary complications. Conservative biomechanical approach of treatment of residual instability and its complications: enchondral growth and ossification, delay, pathologic restructuring and coxarthrosis, is proposed.

Adolescent↗
PubMedDate not supplied

Merging the old skeletal biology with the new. I. Intramembranous ossification, endochondral ossification, ectopic bone, secondary cartilage, and pathologic considerations.

Skeletogenesis and chondrogenesis result from a sequence of events involving epithelial-mesenchymal interaction, condensation, and differentiation. Types of bone and cartilage formation include: (1) intramembranous ossification, (2) endochondral ossification, (3) combined endochondral and intramembranous ossification, (4) heterotopic bone and cartilage formation, and (5) secondary cartilage formation. Pathologic conditions with bone and cartilage include: (1) benign and malignant tumors and (2) reactive osseous and cartilaginous metaplasia.

Animals↗
PubMedDate not supplied

Role of the ossification groove of Ranvier in normal and pathologic bone growth: a review.

According to Ranvier (1889), cells in the ossification groove originate in cartilage and differentiate to osteoblasts. He was supported by others until some authors stated after 1950 that the growth plate grows in width by apposition of cells from the groove. The apposition theory is still accepted in several textbooks. Our experiments with roentgen ray injury showed (1950) migration of cells toward the ossification groove in the germinal layer of the growth plate, a phenomenon not described by others. It was verified in normal bones with 35S (1967) and with vital staining (1993). In situ hybridization of bones in rabbits showed (1993) that cells in the groove and adjacent periosteum contain type II collagen messenger RNA (mRNA) characteristic of cartilage, a finding in accordance with Ranvier's views. The behavior of cells in the ossification groove plays a decisive role in the pathogenesis of several diseases of the growing skeleton.

Animals↗
PubMed1992

Pathology of spinal cord lesions caused by ossification of the posterior longitudinal ligament, with special reference to reversibility of the spinal cord lesion.

This report describes pathological findings of the spinal cord damage, with ossification of the posterior longitudinal ligament (OPLL), with special reference to reversibility of such lesions. Twenty-five autopsy cases associated with OPLL were examined, and the spinal cord damage was pathologically classified into four categories based on degree of destruction (stage 0-3). In stage 0 and stage 1, major pathological changes in the gray matter and the degree of compression on the spinal cord were well correlated to deformity of the anterior horn. In stage 2 and stage 3, neurons were almost completely obliterated and necrosis with cavitation were frequently observed. Destruction of the spinal cord in stage 2 and stage 3 is considered to be irreversible; therefore, surgical treatment is recommended at stage 0 or stage 1.

Calcinosis↗