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PubMed2001

[Therapy of neurodermatitis (atopic dermatitis)].

Atopic dermatitis is a chronic-relapsing disease that often requires an individualized therapeutic approach. There are various treatment options that address known pathogenetic pathways and, when used in combination, are often very successfull. In view of the fact that a unifying pathogenic concept as well as a therapeutic regimen is not available to this very day, preventative measures that should be introduced in very early childhood. Therefore, one very important goal in treatment is to identify and eliminate triggering factors which include irritants, allergens and cutaneous bacterial, viral or fungial infections. The mainstay of therapy today are external emmollients, which when used appropriately, can reduce the need for systemic treatments. The reconvalescence can be speeded up by auxilliary therapies such as UVA or UVB, psychotherapeutical strategies such as stress reduction as well as so-called climate-("Klima") therapy.

Administration, Topical↗
PubMed2000

[Incidence of neurodermatitis (atopic dermatitis) in students starting school in Ostalbkreis in Baden-Württemberg].

The prevalence of atopic eczematous dermatitis differs considerably between countries. In a former study with preschool children the prevalence in Baden-Württemberg according to data from parent questionnaires was about 10 per cent. Taking into account the expected false positives and false negatives led to the approximated unbiased prevalence of 7 to 8 percent. To evaluate this estimate, the Health Department Ostalbkreis used the same questionnaire in a second study of the same age group. The questionnaires were self-administered by the parents during the medical examination before school entrance. The parents of positive administered cases (11.2 per cent) were asked for permission to contact the family doctor to have the diagnosis confirmed (or not). 75 per cent of the positive identified cases by questionnaires were confirmed by family doctors. Therefore, the prevalence of atopic eczematous dermatitis in preschool children aged six to seven years in the area of Ostalbkreis is about 8.5 per cent.

Child↗
PubMed1993

[The prevalence of neurodermatitis among school children in the Hannover administrative district].

A special questionnaire was developed to obtain up-to-date data on the prevalence of atopic dermatitis among children. It was validated by specialist diagnosis in 320 children, providing a diagnostic sensitivity and specificity of 97%. This questionnaire was used for all school entrants in 1990 in the Hanover District. A total of 4,916 children were examined and the questionnaire satisfactorily completed by a relative or guardian (usually the mother) of 4,651. The prevalence of atopic dermatitis was 11.8%, ranging from 8.4% to 17.3% among the 20 constituent communities. The regional differences were smaller than the scatter of diagnostic classifications by the school doctors and the reports of a positive history by the parents. The results demonstrate the validity of a systematic enquiry employing relevant diagnostic and anamnestic items.

Child↗
PubMed2001

The effect of topically applied aspirin on localized circumscribed neurodermatitis.

BACKGROUND: Lichen simplex chronicus is a troublesome intractable itchy dermatosis, which may persist despite intensive topical treatments. Recently it has been demonstrated that topical aspirin solution with dichloromethane has a significant antipruritic effect in an experimentally induced itch. OBJECTIVE: The aim of this double-blind, crossover placebo trial was to evaluate the efficacy of this solution in the treatment of lichen simplex chronicus. METHODS: Twenty-nine patients with lichen simplex chronicus of at least 3 months' duration that did not respond to topical corticosteroids were randomized in a double-blind fashion to receive aspirin/dichloromethane solution in treatment period 1 for 2 weeks followed by placebo in treatment period 2 or placebo followed by aspirin in period 2 with a crossover design after a 2-week washout. The patients rated the pruritus intensity before and during therapy with a visual analog scale; a blinded investigator performed photographic assessment. RESULTS: A significant therapeutic response was achieved in 11 (46%) of the patients who completed the study compared with 3 patients (12%) receiving placebo. Overall, aspirin-treated patients experienced an average decrease in the visual analog scale of 2.18 +/- 2.86 versus 0.69 +/- 2.31 of those receiving placebo. The difference between the 2 treatments for week 2 was significant (P =.03). CONCLUSION: The study suggests that topical aspirin/dichloromethane might be a practical treatment for lichen simplex chronicus.

Administration, Topical↗