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159 records · Page 9Linked to original sources
PubMed1983

[Non-virilizing hormonal therapy in women with secondary disorders of sexual responsiveness].

26 women with secondary disturbance of sexual responsiveness were treated mainly with dehydroepiandrosterone preparations. The sexual tonus was tested before and after treatment by a sexual score system previously described. Urinary 17-ketosteroid and plasma testosterone fractions were controlled in 17 patients; these values were, in general, below the normal range before treatment. Treatment was considered to be successful in 17 patients, while in the remaining 9, who mainly belonged to the group of younger patients, no success was achieved. However, the results point out that therapeutic success with hormones of low biological activity can be expected only after numerous months of treatment. The pattern obtained on determination of hormonal parameters usually corresponded to the results of treatment.

Adult↗
PubMedDate not supplied

Potentialities and limitations of endocrine treatment in idiopathic oligozoospermia.

The effectiveness of various forms of endocrine treatment for idiopathic oligozoospermia and the action of kallikrein on sperm parameters were evaluated in a retrospective study including 321 individuals with normogonadotropic idiopathic oligozoospermia (sperm count less than 20 Mio/ml). Within a follow up of 3 years 67 conceptions were noted. 51 of them appeared to be treatment-related. The highest conception rate was recorded under tamoxifen. Systemic treatment of idiopathic normogonadotropic oligozoospermia seems to be very limited, since the pathogenetic mechanisms of tubular dysfunction in idiopathic oligozoospermia are still unknown and treatment remains empirical. Spontaneous variations of semen parameters and spontaneous conceptions of the partners of oligospermic males are often responsible for a misinterpretation of the interference of a pharmacological agent with the fertilizing ability of the ejaculate. Development of new treatment regimens and controlled clinical trials are necessary to improve the efficacy of endocrine treatment in idiopathic oligozoospermia.

Chorionic Gonadotropin↗
PubMed1977

[Oligozoospermia in Klinefelter's syndrome].

Case report of a 31 year old male with a 47-XXY-Klinefelter-syndrome which showed a maximum of 4,0 million spermatozoa/ml with a motility of up to 51% in his ejaculate. No rise of spermatozoa counts could be observed after 3x25 mg mesterolone/day over 8 weeks.

Adult↗
PubMed1997

Substitution of testosterone in a HIV-1 positive patient with hypogonadism and Wasting-syndrome led to a reduced rate of apoptosis.

Peripheral blood mononuclear cells from HIV infected individuals develop in vitro apoptosis to a much higher extent than healthy donors. Aside from the direct cytopathic effect of HIV, programmed cell death can be induced by such cytokine system imbalance as seen with increased levels of TNF-alpha or the Th1-->Th2-cytokine shift. However, wasting syndrome, which occurs in the majority of AIDS patients is associated with an enhanced expression of TNF-alpha and IL 6 as well. A 37-year-old AIDS patient suffering from wasting syndrome and hypogonadism was treated with 1 alpha-dihydrotestosterone. The rate of apoptotic peripheral blood mononuclear cells was determined before, during and after this therapy. After three weeks of androgen substitution therapy, the rate of spontaneous apoptosis was reduced to 34% and the ionomycin induced apoptosis to 52% of the rate of apoptotic cells at the beginning of the therapy. Moreover, the general and nutritional condition improved remarkably. Thus, we suggest that the use of anabolic drugs for the treatment of AIDS-associated wasting-syndrome would not only improve their general and nutritional condition, but might also prevent the loss of CD4+ T-cells through an inhibition of apoptosis.

Acquired Immunodeficiency Syndrome↗