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Results for “Mefenamic Acid”

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PubMedDate not supplied

Effect of encapsulation of mefenamic acid with cationic Eudragit E on its bioavailability and gastric ulcerogenic activity in rabbits.

Encapsulation of mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug with cationic acrylic resin, Eudragit E, was carried out using a fluidized-bed granulator (Glatt AG). Three drug:polymer ratios were prepared using 50 ml of 1, 2.5 and 5 per cent w/v aqueous suspension of Eudragit to coat 100 mg powdered drug. The bioavailability of the coated and uncoated drug was studied using four groups of animals, each consisting of six male rabbits (2-2.5 kg). Investigations were performed using the rabbits to examine the effects of prolonged administration of the coated and the uncoated MFA with Eudragit E(1 and 5 per cent) in a dose of 100 mg filled in hard gelatin capsules. One capsule was given daily for 30 days. Plasma levels of MFA with Eudragit E were significantly higher than those of drug only. Meanwhile, 5 per cent w/v polymer coating afforded higher drug availability than 2.5 per cent w/v which induced a higher level than 1 per cent w/v. Chronic gastric ulcers with different severities were found in the internal mucosa of all animals. In addition, there were multiple erosions in the glandular mucosa of stomachs of rabbits receiving MFA within the treatment period. IN the control group the gastric photograph was normal in every instance. Despite the extensive morphological damage at the end of treatment, the observed changes in the stomach of rabbits given coated drug is less deleterious than that treated with uncoated drug. The results of this study indicate that the coating of MFA with cationic Eudragit E increases its bioavailability and decreases the probability of ulceration.(ABSTRACT TRUNCATED AT 250 WORDS)

Acrylic Resins↗
PubMed1987

Mefenamic acid enteropathy.

The clinical, radiological, and histological features of two patients with severe intestinal damage induced by mefenamic acid and mimicking coeliac disease are described. Symptoms rapidly reverted on withdrawal of the drug, and in one case, did not relapse during treatment with other non-steroidal anti-inflammatory drugs.

Aged↗
PubMed1983

Ion-pair partition chromatography of mefenamic acid with tetraalkylammonium cations: development of analytical method from extraction data.

The ion-pair partition properties of mefenamic acid with the methyl, ethyl, n-propyl, and n-butyl homologs of tetraalkylammonium cation were studied in relation to a model of an assay procedure for acidic drugs. Variables studied included identity and concentration of pairing ion and composition of extracting solvents. Resulting data were used to develop a partition chromatographic assay procedure. Standard recoveries averaged 99.01 +/- 0.82%. Assays of commercial capsules were reproducible.

Capsules↗
PubMedDate not supplied

[Effect of mefenamic acid and sodium salicylate on lymphocyte transformation due to phytohemagglutinin].

It is established in in-vitro experiments that mefenamic acid and sodium salicylate inhibit to an equal measure the cell immunity test, a reaction of blast transformation of lymphocytes. The effect increases with the higher concentration of the drugs under study and depends on the time they are introduced into the culture with respect to the introduction of the non-specific mitotic stimulant phytohemagglutinin.

Antibody Formation↗
PubMed1980

Mefenamic acid nephropathy.

Non-oliguric renal failure developed in six elderly women who had been prescribed 1--2 g of mefenamic acid daily for 2--6 weeks for the relief of musculoskeletal pain.

Aged↗
PubMed1987

Control of menorrhagia by the cyclo-oxygenase inhibitors naproxen sodium and mefenamic acid.

Thirty-five patients with menorrhagia were treated in a double-blind crossover study with naproxen sodium and mefenamic acid after measurement of their blood loss during control menstrual cycles. Treatment with these compounds reduced the excessive bleeding by an average of 46 and 47% respectively. Drugs in the prostaglandin synthetase inhibitor group are considered to have an important place in the treatment of menorrhagia.

Adolescent↗
PubMedDate not supplied

Drug targeting using non-magnetic and magnetic albumin-globulin mix microspheres of mefenamic acid.

Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemical parameters of the microspheres such as density, particle size distribution, surface topography and wall thickness, as well as the magnetite contained within the magnetic microspheres, have been determined. The infrared spectroscopic analysis confirmed the encapsulation of the drug and absence of free drug on the surface of the microspheres. The X-ray diffraction analysis confirmed that the crystallinity of the drug remained unchanged indicating thereby that no complex formation had taken place between core and coat materials. The in vitro release profiles of the microspheres have been studied. An attempt has also been made to check the in vivo efficacy in rats.

Albumins↗
PubMed1981

Effects of phenylbutazone and mefenamic acid on two classes of binding sites of 2-(4'-hydroxyphenylazo)benzoic acid on bovine serum albumin characterized by absorption spectra and circular dichroism spectra.

The competitive binding of phenylbutazone (PB) and mefenamic acid (MF) with 2-(4'-hydroxyphenylazo)benzoic acid (HABA) on bovine serum albumin (BSA) was studied by the investigation of the effects of these drugs on two bound forms of HABA, the azo and hydrazone forms. PB displaced preferentially the hydrazone form. MF displaced both the azo and hydrazone forms, though the azo form was preferentially displaced at the small molar ratio of MF to BSA. The binding constants of PB and MF obtained from the convenient spectrophotometry were dependent on the concentration of added drugs. These facts reflect the selective displacement of the azo and hydrazone forms. In connection with the absorption spectra of bound HABA, induced circular dichroism (CD) spectra of HABA-BSA complex were investigated. The induced CD spectra varied with the change of the molar ratio of HABA to BSA, indicating the presence of at least three different perturbed HABA molecules by BSA. The addition of PB and MF caused dramatic changes of the induced CD spectra of HABA-BSA complex. These spectral changes were discussed with the displacement of the azo and hydrazone forms.

Azo Compounds↗
PubMed2006

Voltammetric determination of mefenamic acid at lanthanum hydroxide nanowires modified carbon paste electrodes.

Lanthanum hydroxide nanowires modified carbon paste electrode (LNW/CPE) exhibiting an electrocatalytic response toward the oxidation of mefenamic acid (MFA) is described. The catalytic action of the LNW/CPE on the oxidation of MFA via one-electron and one-proton transfer is attributed to the formation of the porous construction and the increase of efficient surface of the electrode due to the adulteration of LNW with carbon powders. Using the LNW/CPE, a linear sweep voltammetric method for the determination of MFA and other drugs with diphenylamine parent is proposed. A linear range of 2.0 x 10(-11) to 4.0 x 10(-9)mol L(-1) is obtained along with a detection limit of 6.0 x 10(-12)mol L(-1).

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2002

Simultaneous spectrophotometric determination of mefenamic acid and paracetamol in a pharmaceutical preparation using ratio spectra derivative spectrophotometry and chemometric methods.

Four new methods are described for the simultaneous determination of mefenamic acid (MEF) and paracetamol (PAR) in their combination. In the first method, ratio spectra derivative method, analytical signals were measured at the wavelengths corresponding to either maximums or minimums for both drugs in the first derivative spectra of the ratio spectra obtained by dividing the standard spectrum of one of two drugs in 0.1 M NaOH:methanol (1:9). In the chemometric techniques, classical least-squares, inverse least-squares and principal component regression (PCR), the training was randomly prepared by using the different mixture compositions containing two drugs in 0.1 M NaOH:methanol (1:9). The absorbance data was obtained by the measurements at 13 points in the wavelength range 235-355 nm in the absorption spectra. Chemometric calibrations were constructed by the absorbance data and training set for the prediction of the amount of MEF and PAR in samples. In the third chemometric method, PCR, the covariance matrix corresponding to the absorbance data was calculated for the basis vectors and matrix containing the new coordinates. The obtained calibration was used to determine the title drugs in their mixture. Linearity range in all the methods was found to be 2-10 microg/ml of MEF and 4-20 microg/ml of PAR. Mean recoveries were found satisfactory (>99%). The procedures do not require any separation step. These methods were successfully applied to a pharmaceutical formulation, tablet, and the results were compared with each other.

Acetaminophen↗
PubMedDate not supplied

[A new method for treating rheumatoid arthritis patients by electrophoresis using mefenamic acid].

The paper provides clinical and experimental reasoning for application of a new treatment for rheumatoid arthritis (RA) implying electrophoresis of an anti-inflammatory drug mefenamic acid from dimexide solution. Complete and partial responses registered in 125 patients, reached 75%. With the new method it is possible to relieve pain, correct immunity and stop inflammation. The best effect was shown in an inactive disease and in activity phases I and II in adjuvant use of the method.

Adult↗
PubMed2005

The effects of mefenamic acid on the blood haemoglobin of the lizard, Uromastix hardwickii.

This study deals with the effect of 7.1 mg/day, 10.5 mg/day and 14 mg/day doses of mefenamic acid administered for 12 days to three groups of Uromastix hardwickii respectively. Individual blood samples were obtained from the anterior abdominal vein and hemoglobin content was determined. The hemoglobin in test was 5.1 g/100 ml compared to 8.0 g/100 ml of controls in experiment I and its amount remained almost similar in the case of experiment II, whereas, 4.5 g/100 ml was observed of test compared to 8.0 g/100 ml of their counterparts.

Animals↗
PubMed1986

Investigation of dressings developed for the treatment of alveolitis sicca dolorosa. Part 2: Influence of glycerol and PEG 200 on the properties of tablets and dressings comprising mefenamic acid and Nipagin P.

Some hydrogel dressings have been investigated to determine their utility for the treatment of painful dry tooth-socket (Alveolitis sicca dolorosa). As drugs mefenamic acid and Nipagin P have been applied. Hydrophilized methylcellulose, 5-15% glycerol or 5-20% PEG 200 were the filling and gel building material. It has been found, that the properties of the dressings depend on the content of the hydrophilizers. The half liberation time of the drugs under study ranges from 0.5 to 11 h, the swelling degree amounts to 366-400%, the washing out time runs to 80-140 min and the period of activity of the dressings inside the tooth-socket amounts to 24-48 h. The dressings show thixotropic properties and a high flow limit.

Bandages↗