Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Manubrium”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed1990

Dacron fabric-enveloped hydroxyapatite prosthesis for sternal tumor defect: an autopsy report.

A 38-year-old housewife with solitary plasmacytoma of the manubrium who underwent a subtotal sternectomy treated by resection of the lesion is reported. This was followed by replacement with a Dacron fabric-enveloped hydroxyapatite prosthesis. The Dacron fabric was sutured to the surrounding tissues, and then the clavicle was passed through the cylindrical-shaped Dacron fabric to form a sternoclavicular joint capsule. The patient returned to her daily life 3 months after the operation. She had no trouble in her daily living, without any dislocation of the sternoclavicular joints or any displacement of the artificial sternum. The autopsy examination about 1 year after the operation showed that the Dacron fabric enveloping the artificial sternum became stronger with time. The sternoclavicular joint also was stably fixed, and the Dacron fabric fulfilled its function as an artificial articular capsule and biologic fixation of the surrounding supporting tissues.

Adult↗
PubMed1986

Manubriosternal joint dislocation in rheumatoid arthritis: the role of thoracic kyphosis.

A case report of manubriosternal joint (MSJ) dislocation in a rheumatoid patient with thoracic kyphosis is presented together with a review of the relevant literature. Variations in the anatomical nature of the MSJ between normal individuals are described. In 43% of the population its characteristics are noted to be such that it may be involved in rheumatoid arthritis (RA). A joint thus involved can be dislocated by forces generated by longstanding thoracic kyphosis and transmitted to the manubrium via the first rib. Xeroradiographs of the MSJ region in our patient showed dislocation of the joint in the upright position and its subsequent reduction on lying the patient flat. We suggest that this demonstrated reduction is secondary to the lessening of the thoracic kyphosis that occurs in the supine position. It is concluded that in RA MSJ dislocation is a function of thoracic kyphosis.

Arthritis, Rheumatoid↗
PubMed1976

Resection and reconstruction of the sternum: case report.

The case history of a 67-year-old man who underwent a subtotal sternectomy for a tumour of the manubrium and left clavicle is reported. Histological examination revealed a highly undifferentiated metastatic carcinoma: the original tumour was not discovered but the patient was in good condition 10 months after operation. Adequate replacement and stabilization of the chest wall was obtained with autotransplantation of the tibia and muscle flaps.

Aged↗
PubMed1975

Psoriatic lesion of the sternal synchondrosis.

Radiography of the synchondrosis between the manubrium and the sternal body was performed in 29 patients with clinically certain psoriatic arthropathy. Tomography proved necessary for a detailed analysis. Erosive inflammatory lesions were detected in 18 cases; in 61 per cent of cases with a history of more than 5 years and in 71 per cent of cases with typical hand and feet arthropathy. It is concluded that the sternum is frequently involved in cases with roentgenologically typical psoriatic arthropathy.

Adult↗
PubMed2003

Anatomic landmarks for the cervical portion of the thoracic duct.

OBJECTIVE: Avoidance of injury to the thoracic duct during neurosurgical procedures involving the cervical region depends on a working knowledge of its location. This study evaluates superficial anatomic landmarks for the cervical portion of the thoracic duct that may be encountered in neurosurgery of the neck. METHODS: Fifteen dissections of human cadavers were performed to study the relationship between the proximal thoracic duct and superficial landmarks (e.g., the cricoid cartilage and sternal notch of the manubrium). RESULTS: The cervical portion of the thoracic duct was found to be approximated by a roughly 4.4-cm(2) region in the left supraclavicular area beginning approximately 2.0 cm lateral to the midline and 3.5 cm superior to the sternal notch, extending superiorly to a point roughly 3.5 cm from the midline and 2.5 cm inferior to the cricoid cartilage, and terminating within the venous system at a point approximately 4.5 cm lateral to the midline and 3.0 cm superior to the sternal notch. CONCLUSION: Through an increased appreciation for its location, injury to the thoracic duct may be minimized.

Aged↗
PubMed1989

Anterior approach to the upper thoracic vertebrae.

The anterior exposure of the upper thoracic spine using standard methods is often difficult and limited. We report our experience using a technique described by Sundaresan et al. (1984) in which the medial portion of one clavicle and part of the manubrium sterni are excised. In 10 cases we found this to be a useful and safe procedure.

Adult↗
PubMed1990

Effect of internal mammary artery mobilization on sternal blood flow.

Use of the internal mammary artery as a conduit for coronary artery bypass has enhanced this procedure in terms of prolonged graft patency. An earlier warning that use of both arteries would devascularize the sternum was based on postmortem radiologic imaging. This was complemented by a subsequent animal study employing isotopic microspheres. In the present clinical study, laser Doppler flowmetry was adapted to identify changes in blood supply to the left half of the divided manubrium sternum during separation of the left internal mammary artery from its chest wall attachment. Our finding of continued blood flow after this event suggests that complete devascularization of the sternum does not take place. Quality of sternal bone and surrounding tissues and clinical indications should remain as factors influencing use of one or both internal mammary arteries.

Humans↗
PubMed1999

Giant cell tumor of the sternum. Report of a case with a 17q isochromosome.

We report a case of giant cell tumor of the manubrium with radiological evidence of aggressiveness. Few cases of giant cell tumor of the sternum have been published. Extensive surgery offers the best hopes of recovery. Cytogenetic studies evidenced several clonal abnormalities including a 17q isochromosome. The TP53 suppressor gene is located at 17q13.1. Whether loss of one of the TP53 alleles may have contributed to the aggressive behavior of our patient's tumor is discussed.

Bone Neoplasms↗
PubMed1975

[Reconstruction of tracheal stenosis at thoracic inlet level (author's transl)].

Complex operative cases of tracheal stenosis in the region of the thoracic inlet are described. The stenosed tracheas were additionally constricted by: a dislocated osteomyelitic clavicle, which was tethered by scar-tissue; an osteoma of the manubrium sterni; a goitre, which was fixed into the thoracic inlet by scar tissue of an early childhood tracheostomy; and a retrosternal goitre. In two further cases the reconstruction of a long tracheal stenosis at the thoracic inlet was complicated by an existing paraplegia.

Adult↗
PubMed2000

Microvascular blood flow fluctuations during tilt table induced syncope.

Aim of this study is to investigate the changes, in the frequency domain, of microvasculature blood flow (BF) occurring in neurally mediated syncope. We studied 20 patients with history of recurrent syncope and 10 control subjects. Peripheral BF was measured (laser Doppler technique) in the palmar region (PBF) and the manubrium sterni (SBF), together with ECG, respiration activity (RA) and blood pressure (BP), at rest (5 minute) and during 70 degrees head-up tilt test. SBF and PBF appear to be characterized by oscillations around 0.16 Hz (0.15-0.19 Hz), that do not have correspondence in the other cardiovascular variability signals. Mean BF was not significantly altered in tilt negative, control and tilt positive groups (11 patients) during tilt. In the tilt positive group a decrease of mean PBF and SBF and an increase of the oscillation frequency of PBF and SBF was observed in close proximity of the development of symptoms.

Blood Flow Velocity↗
PubMed1988

Traumatic manubriosternal joint subluxations in two basketball players.

Two cases of traumatic manubriosternal joint subluxation without rib fractures in basketball players are illustrated. The incidence of this sport injury is rare. Accidental or intentional violent blows of the elbow to the body of the sternum is the mechanism of this injury. Radiographic analysis of the manubriosternal joint is discussed. Radiographically, the body of the sternum in each case has subluxated posteriorly. The athletes present pain directly at the manubriosternal joint; this may be aggravated by active thoracic hyperflexion or hyperextension. Ordinary or deep breathing does not cause discomfort. Palpation may reveal local tenderness that will be accentuated by ballottement against the manubrium. Conservative treatment consists of manipulative hyperflexion reduction supplemented with antiinflammatory or analgesic cream, cryotherapy, taping or with pad, strapping and rest.

Adult↗
PubMed1987

[Amyloid tumor of bone].

An osseous plasmocytoma was masked by an excessive tumor-like deposit of amyloid to such an extent that the primary disease was only diagnosed after histological examination of autopsy material from a 62 year old woman. The 20 cm in diameter tumor originated from the manubrium sterni. Other tumors were found in the ribs, right clavicle, thoracic and lumbal spine and in the left femur. A massive layer of amyloid was found in these tumors by microscopy. Plasma cells infiltrated the area between the amyloid plaques and the macroscopically tumor-free vertebral bodies. All other organs were free from amyloid.

Amyloidosis↗
PubMed1986

Primary septic arthritis of the manubriosternal joint in a heroin user.

A 20-year-old heroin user developed staphylococcus septic arthritis of the manubrium joint. The diagnosis was established by a culture of the infected tissue and blood culture. The clinical impression was aided by 99mTc radionuclide scintimetry. Early diagnosis localized the infection. Immediate antibiotic therapy solved a problem in the sternum that seems not to have been reported in the English literature.

Adult↗
PubMed1975

Solitary myeloma. A study of 10 black patients during an 8-year period.

Solitary myeloma of bone occurred in 10 Black patients during the 8-year period from 1967 to 1974. In 4 patients, the solitary myeloma involved the bones of the paranasal sinuses, in 3 patients the pelvis, and in 3 others the manubrium sterni. An IgG monoclonal gammopathy was present in the serum of 4 patients and Bence-Joanes proteinuria was found in 1 patient. Radiation therapy was the treatment of choice and the recommended tumour dosage is 4000-5000 rads. Serial measurements of serum and urine protein electrophoresis and immuno-electrophoresis were most helpful in determining when patients had achieved a complete remission. In 3 patients, 1 of whom died, the myeloma disseminated in periods varying from 26 months to 7 years. Nine patients are alive, of whom 7 are in complete remission, and 5 have lived for more than 5 years since the initial diagnosis of solitary myeloma.

Adult↗
PubMed1984

The Angle of Louis. A potential pitfall ("Louie's Hot Spot") in bone scan interpretation.

Evaluation of 100 consecutive Tc-99m MDP bone scans revealed in 36 patients a well defined area of increased accumulation of radiotracer at the Angle of Louis--the palpable ridge along the anterior surface of the sternum at the fibrocartilaginous junction of the sternum and manubrium. Twenty-five of the 36 patients had comparison radiographs; all were normal. None had sternal pain or a prior history of chest trauma. Increased uptake at the Angle of Louis ("Louie's Hot Spot") is a relatively common finding (36%) and should be recognized as a normal bone scan finding. It should not be confused with increased uptake due to an osseous abnormality, i.e., metastasis, degenerative disease, trauma, etc.

Adolescent↗
PubMedDate not supplied

Delayed tracheal reconstruction.

An extended area of stenosis of the upper mediastinal trachea, which normally would require extensive thoracic mobilization for primary anastomosis, was corrected by resection of the manubrium with the creation of a trough. This was closed in several stages utilizing embedded Marlex mesh and regional skin flaps. The development and modifications of this technique are discussed.

Adult↗
PubMed2000

Surgical treatment of recalcitrant radiation-induced gastric erosions.

BACKGROUND: Uncontrolled bleeding as a result of radiation gastritis in patients who have pharyngo-laryngo-esophagectomy and gastric pull-up is seldom reported. Surgical resection in the management of this condition has rarely been described. METHOD: A 66-year-old man with hypopharyngeal cancer was treated by pharyngo-laryngo-esophagectomy and gastric transposition. He received postoperative radiotherapy and had recurrent hemorrhagic gastritis, necessitating surgical resection. The manubrium was resected to access the mediastinal part of the gastric conduit. The diseased part of the gastric conduit was removed and a free jejunal graft was interposed to replace the resected stomach. RESULTS: Manubrial resection offered adequate access to the stomach transposed in the mediastinum, and the life-threatening bleeding gastritis was successfully controlled by surgical resection. CONCLUSION: Surgical resection of the radiation-damaged transposed stomach through a manubrial resection approach can safely be performed. Free jejunal graft is the choice of reconstruction of the circumferential defect.

Aged↗
PubMed1996

Estrogen pretreatment increases arachidonic acid release by bradykinin stimulated normal human osteoblast-like cells.

Eicosanoids are multifunctional autocrine/paracrine regulators of bone that are enzymatically derived from arachidonic acid (AA). The rate-limiting step in the eicosanoid biosynthetic pathways may be the release of AA from membrane glycerophospholipids by activated phospholipases. Free AA can serve as the substrate for cyclooxygenase(s) or lipoxygenases that catalyze the commitive steps in eicosanoid synthesis; alternatively, free AA may be used in reacylation processes, resulting in its reincorporation into cellular lipids. The hormones 17 beta-estradiol (17 beta-E2), dexamethasone (a synthetic glucocorticoid), and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) have been identified as regulators of AA metabolism, at various levels, in several tissues including bone. The possibility that these osteotropic steroids modulate the availability of free AA in bone cells was studied in the human osteoblast-like (hOB) cell model system. Following a 48-h steroid pretreatment, bradykinin or the calcium ionophore A23187 were used as agonists to stimulate hOB cell release of AA. The principal findings from these investigations were that (1) 17 beta-E2 pretreatment potentiated the appearance of free AA following bradykinin stimulation of the cells but, did not alter their response to A23187 stimulation; (2) dexamethasone pretreatment limited bradykinin-induced increases in free AA levels but did not alter cell response to A23187 stimulation; (3) hOB cells derived from different trabecular bone compartments (manubrium of the sternum, femoral head) differed quantitatively in their responses to bradykinin stimulation of AA release; and (4) 1,25(OH)2D3 did not effect AA release stimulated by either agonist. The ability of the steroids to modulate AA release by hOB cells suggests that these hormones may indirectly mediate bone cell responses to other osteotropic hormones that act through eicosanoid-dependent processes.

Arachidonic Acid↗