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At least 163 records · Page 9Linked to original sources
PubMed1990

[Riems foot-and-mouth disease oil emulsion vaccines for swine. 1. Development and testing of highly effective and well-tolerated foot-and-mouth disease vaccine for swine using Dessauer oil adjuvants].

Swine plays a very particular role in FMD epizootiology. It is, therefore, absolutely necessary to have highly effective vaccines available for this species at all times. They have to ensure early buildup of long-lasting strong immunity even after one single application. Since the effectiveness of conventional adsorbate vaccines had proved to be insufficient, monovalent and trivalent oil emulsion vaccines were specifically developed of swine, using a GDR-made oil adjuvant. Stable immunity is very soon induced by them to endangered pig stock even against the immunologically problematic sub-types O1 and A5 after one single subcutaneous (s.c.) application of 2 ml (monovalent) or 5 ml (trivalent). Application establishes in s.c. connective tissue an oil emulsion depot that leads to formation of a vaccination granuloma. The immunocompetent cells identified in the latter are morphologically correlated to adjuvant action.

Adjuvants, Immunologic↗
PubMed1990

[Riems foot-and-mouth disease oil emulsion vaccines for swine. 2. Use of foot-and-mouth 2-component oil emulsion vaccines in practice].

Riems FMD two-component oil emulsion vaccine was subcutaneously applied (5 ml) under field conditions to 855 store pigs of different age groups (trivalent--O1, A5, C). It produced early onset of lasting strong immunity against the three above FMD virus types. General condition of the animals and their body weight development were not adversely affected. Pea-size to walnut-size vaccination granulomas were recorded on slaughter as locally delimited reactions in 15 to 20 percent of vaccinated animals and were found to be morphologically correlated to adjuvant action. They were easily removed from the carcasses by excision of the vaccination point, with only minor loss of slaughter substance.

Adjuvants, Immunologic↗
PubMed1989

[Should electronic mouth thermometers be used in routine everyday hospital practice? Usefulness of mouth thermometers].

An oral electronic thermometer was compared with Hg-thermometer used rectally in the daily clinical routine. The rectal temperatures were, on an average, 0.7 degrees C higher than the oral temperatures. In 27% of the cases, the difference between rectal and oral measurement was more than 1 degree C. The variations between the differences of oral and rectal temperature measurement were unacceptable. It is concluded that the precision of oral electronic thermometers was not found to be satisfactory, and employment of this apparatus can not be recommended in daily clinical work.

Electronics↗
PubMed1988

[Antigenic structure of the foot-and-mouth-disease virus. I. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth virus type O1K].

A series of overlapping peptides with the sequence of the immunodominant region of VP1 protein of FMDV strain O1K have been synthesized by the classical solution method. Peptides were purified by standard methods and used for immunization of guinea pigs. It is shown that the 136-152 and 136-148 segments provide antiviral protection in guinea pigs, both in the free state and conjugated with an immunogenic carrier. Results with uncoupled peptides indicated that these segments may form not only B-, but also T-cell affecting sites.

Animals↗
PubMed1988

[Antigenic structure of the foot-and-mouth disease virus. II. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth disease virus type A22].

Earlier we found that the immune response and antiviral protection from FMDV can be achieved by immunization with uncoupled FMDV peptides. In a search of approaches to animal protection from FMDV A22 strain we prepared a series of peptides corresponding to the putative antigenic determinants. Synthetic 131-149 and 140-149 sequences afforded 50 to 80% protection, both in the free state and conjugated with keyhole limpet hemocyanin. We believe that the 140-149 segment is so far the smallest peptide capable of eliciting specific antiviral protection without conjugation with a high molecular carrier.

Animals↗