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PubMedDate not supplied

Mineral metabolism and bone mineral content in rheumatoid arthritis. Effect of corticosteroids.

An evaluation of mineral metabolism was performed in 41 patients with RA and the pertinent data were compared to bone mineral content in patients either untreated or treated with different doses of corticosteroids. Our study confirms that osteoporosis is a common finding even in rheumatoid patients never treated with corticosteroids. Moreover, in patients treated with such drug the loss of bone mineral content was related to the dosage rather than to the length of treatment. In all cases no overt biochemical derangement was observed. According to our study, parathyroid hormone does not seem to influence the development of osteoporosis in rheumatoid arthritis, while a relative deficiency of calcitonin along with an inadequate vitamin D metabolism could play some role.

Adrenal Cortex Hormones↗

PubMed1979

[Respiratory tract diseases in coal miners. II. Chronic non-specific respiratory tract diseases in coal miners].

Miners of two coal mines were examined: mine "A"--2094 miners and mine "B"--1846 miners working underground. Both the examined population and work environment were thoroughly described in part I. Medical examinations involved disease history and occupational inquiry on a special questionnaire form, a part of this questionnaire being based on the BMRC questionnaire. In addition, spirometric examinations were conducted, VC, FEV1 was determined, and chest was X-rayed. Average PNChUO rate in both populations under examinations came to 16.5%; in the "A" mine it was significantly higher (19.1%), compared to the "B" mine--(13.5%). Obturative PNChUO constituted, on average, 1.7% of the total PNChUO rate in both mines and occurred more frequently in the "B" mine (2.1%), where work was more mechanized than in the "A" mine (1.3%). The highest PNChUO percentage was found in those working at most dusted work--stands. The PNChUO rate in its obturative form was found to be directly proportional to age and length of employment. No effect of PNChUO on the quality and rate of changes in EKG in those suffering from this disease was found.

Adult↗

PubMed2002

Differences in bone mineral density, bone mineral content, and bone areal size in fracturing and non-fracturing women, and their interrelationships at the spine and hip.

Osteoporotic fractures are a major public health problem, particularly in women. Bone mineral density (BMD), bone mineral content (BMC), and bone size have been regarded as important determinants of osteoporotic fractures. In 1449 women over age 30 years, we studied the detailed relationship, at the spine and hip, between BMD, BMC, and bone areal size (all measured by dual-energy X-ray absorptiometry) and compared their relative magnitudes in fracturing and non-fracturing individuals. We find that, (1) BMD and BMC are significantly higher at the spine and hip in non-fracturing women. Bone areal size is significantly larger at the spine in non-fracturing women; however, the significance disappears when adjustment is made for the significant difference of height (stature) between fracturing and non-fracturing women. In contrast to the spine, bone areal size is always significantly largerin fracturing women at the hip. (2) The relationship among BMD, BMC, and bone areal size is different at the spine and hip. Specifically, at the spine, BMD increases with bone areal size linearly. At the hip, BMD has a quadratic relationship with bone areal size, so that BMD increases at lower bone areal sizes, then (after an intermediate zone of values) decreases with increasing bone areal size. However, BMD adjusted for BMC always decreases with increasing bone areal size, as expected by the definition of BMD. With no adjustment for BMC, the increase in BMD with bone areal size is due to a more rapid increase of BMC than increasing bone areal size, thus explaining the observations of association of both larger BMD and larger bone areal size with stronger bone. (3) At the spine, 86.2% of BMD variation is attributable to BMC and 12.6% to bone areal size. At the hip, 98.0% of BMD variation is due to BMC and 1.1% due to bone areal size. The current study may be important in understanding the relationship among BMD, BMC, and bone size as risk determinants of osteoporotic fractures.

Absorptiometry, Photon↗

PubMed2006

Bone mineral content and mineral metabolism during cyclosporine treatment of nephrotic Syndrome.

OBJECTIVE: Although cyclosporine (Cy) has been associated with bone loss following transplantation, its effects on bone in growing children are largely unknown. STUDY DESIGN: Thirty-seven patients (2-16 years of age) with remitting nephrotic syndrome (NS), n = 16 receiving Cy for 39 +/- 27 months and n = 21 without Cy, underwent mineral metabolism and bone turnover assessment. In 28 of 37 patients, bone mineral density (BMD) was obtained while off corticosteroid therapy (Rx). RESULTS: Urinary calcium (Ca), phosphate (PO(4)), and magnesium (Mg) excretion was normal, but serum Mg was lower in patients receiving Cy (1.8 +/- 0.1 v 1.95 +/- 0.2 mg/dL, P < .05). BMD Z scores were similar at the spine (-0.45 +/- 0.74 v 0.04 +/- 0.9) and femur (-0.17 +/- 0.52 v 0.38 +/- 1.28) with no Z score <-2. Serum bone-specific alkaline phosphatase was normal, and N-telopeptide of type I collagen also normal, was higher on Cy (P < .05). Cumulative prednisone exposure was similar and had no significant effect on height and BMD Z scores. Length of Cy-Rx and time elapsed from onset of NS did not correlate with BMD, height Z score, or markers of bone turnover. CONCLUSIONS: In growing children with NS, during long-term Cy-Rx urinary wasting of Ca and Mg was absent and bone density was preserved.

Adolescent↗

PubMed2000

The effect of varying mix uniformity (simulated) of phytase on growth performance, mineral retention, and bone mineralization in chicks.

An 18-d experiment was conducted to determine the effect of varying mix uniformity of phytase on growth performance, mineral retention, and bone mineralization in chicks. Chicks (initial and final weights were 74.5 and 803.3 g) were allotted to seven treatments with six (Treatment 1) or seven (Treatments 2 to 7) replicates of seven chicks per replicate in a completely randomized design. Varying mix uniformity of phytase was simulated by alternately providing two diets with two different concentrations of microbial phytase; the diets were switched every 24 h. Treatments were: 1) positive control (CON) (Ca, 1.0%; available phosphorus (aP), 0.45%), 2) negative control (NEG) (Ca, 0.9%; aP, 0.35%), 3) NEG + 600 phytase units (FTU) daily (CV0), 4) NEG + 500 or 700 FTU (CV17), 5) NEG + 400 or 800 FTU (CV34), 6) NEG + 200 or 1,000 FTU (CV69), or 7) NEG + 0 or 1,200 FTU (CV103). Gain, feed intake, and bone breaking strength were similar (P > 0.15) in the CON and CV0 treatments, but these response variables were decreased in the NEG treatment (P < 0.01). Gain:feed was not affected by treatment (P = 0.15). Bone ash was decreased (P < 0.02) by the NEG and CV0 treatments compared with the CON diet, but chicks fed the CV0 diet had greater bone ash than those fed the NEG (P < 0.01) diet. Increasing FTU CV decreased bone breaking strength and bone ash (P < 0.01). Calcium and phosphorus retention (P < 0.08) and gain (P < 0.09) were numerically decreased, and phosphorus excretion was numerically increased (P < 0.07) as FTU CV increased. The difference between the CV0 and CV103 treatments was significant only for bone breaking strength and ash (P < 0.01). In conclusion, increasing phytase CV had little effect on growth performance, whereas bone ash and breaking strength and calcium and phosphorus retention and excretion decreased only at the most extreme CV.

6-Phytase↗

PubMed1995

Assessing total body protein, mineral, and bone mineral content from total body water and body density.

We hypothesized that investigators could assess bone mineral content (BMC), total body mineral (M), and protein (P) from body water (W) and density (DB) based on the theory of W. E. Siri (Advances in Biological and Medical Physics, 1956, p. 239-280 and Techniques for Measuring Body Composition, 1961, p. 223-224) for body composition analysis. Siri used one or more of the body components and the densities of the body, fat (F), W, M, and P to estimate one of the remaining fractional masses. We compared M, BMC, P. F, and fat-free mass (FFM) in 31 subjects (15 women and 16 men) computed from measurements of W and DB with [4-compartment (4C) model] and without [3-compartment (3C) model] BMC (from dual X-ray absorptiometry). 4C model P was calculated by difference (P = FFM - W - M). Mean difference (P > 0.05) ranged from 0.1 to 0.8%. Correlations [+/- standard error of estimate (%)] between 4C and 3C model values were significant (r = 0.907 +/- 8.8, 0.907 +/- 8.7, 0.969 +/- 6.6, 0.998 +/- 2.0, and 0.999 +/- 0.7% for M, BMC, P, F, and FFM, respectively). We concluded that investigators can assess M, BMC, and P from W and DB.

Adult↗

PubMed1988

Changes in mineral content, mineral deposition and vascular supply of the mandible after osteotomy.

Circulatory and skeletal damage in the form of a vertical osteotomy of the mandible, proximal to the entry of the inferior alveolar artery and mandibular perforantes, alone or in combination with unilateral or bilateral mucoperiosteal reflections were undertaken on young growing rats. Changes in mineral content and mineral deposition in the hard tissues of the mandibles were studied using microradiography and by labelling with tetracycline and lead acetate. Microangiography was performed to evaluate changes in the vascular supply. Resorption of the compact bone was seen in the central part of the compact bone, in the lower border of the mandible and in the incisal part of the alveolar bone. There was resorption of the cementum and dentin in the molar teeth. Remodelling processes were seen in the compact bone starting from vascular channels and on the surface of the bone trabeculae, ten days after osteotomy. Microangiography revealed that there is a collateral vascular system existing across the midline via the symphysis region, via submucosal tissue, via the mucoperiosteal pedicle to the inferior border of the mandible and via the network of small vessels in the periodontal membrane. It was concluded that the circulation to the peripheral parts of the mandible could in part be kept up by a retrograde flow in the collateral systems when the main circulation had ceased.

Angiography↗

PubMedDate not supplied

[The characteristics of the use of low-mineralization sodium chloride mineral water in the rehabilitative treatment of patients with the most common diseases of the internal organs].

The paper describes some therapeutic aspects of sodium chloride mineral water from the springs of Mirgorod (a balneological resort in Ukraine). Methodological approaches to the treatment of patients with most common visceral disease with bottled mineral Mirgorod water are outlined.

Cardiac Rehabilitation↗

PubMed1986

Mineral content of foods and total diets: the Selected Minerals in Foods Survey, 1982 to 1984.

The 234 foods of the FDA's Total Diet Study were collected four times per year form mid-1982 to mid-1984 and analyzed for 11 essential minerals. Daily intakes of the minerals were estimated for eight age-sex groups of the U.S. population. Levels of calcium, magnesium, iron, zinc, copper, and manganese were low (less than 80% of the RDA or below the low end of the Estimated Safe and Adequate Daily Dietary Intake range) for some or all age-sex groups. Those most at risk of low intakes were young children, teenage girls, adult women, and older women. Non-discretionary sodium intake exceeded the upper Estimated Safe and Adequate Daily Dietary Intake range for two age-sex groups, and iodine was considerably above the RDA for all age-sex groups. Levels of potassium, phosphorus, and selenium were adequate for all groups.

Diet Surveys↗

PubMed1995

[Evaluation of elemental and mineral composition of larynx thyroid cartilage in the period of its involutional mineralization].

The research has been conducted on the material of 170 larynx thyroid cartilages of persons in the age range from 19 to 99 years, applying the radiological method, spectroscopy, electyronic scanning microskopy and rentgenological diffractometry. The distribution of certain elements has been determined in fragments of thyroid cartilage with different progression of mineralization. It has been proved that the elemental composition of the examined thyroid cartilages depends on the individual age and the progression of mineralization, resulting from the age.

Adult↗

PubMed1997

[Microbiological condition of bottled natural mineral waters, drinking water, as well as water from mineral springs].

We are now in the midst of a critical discussion on the microbiological quality of bottled natural mineral water, springwater, so-called "table water" and drinking water. "Still" waters have high colony counts after long storage, whereas in carbonated bottled products multiplication of oligocarbophilic microorganisms is suppressed by carbon dioxide. Opportunistic species are also found in bottled water. Present knowledge as to whether they are contaminants or part of autochthonous flora is insufficient. Highly colonised foodstuffs and opportunistic species may be hazardous for immunosuppressed patients. Hence, it is claimed that existing legal microbiological criteria for bottled water are inadequate. High colony counts in foodstuffs do not necessarily imply poor microbiological quality a priori. Detection of an opportunist species does not justify classifying a food item as hazardous. Microbiological criteria for bottled water which are laid down in the Directive for Mineral and Table Water of the German Food Legislation Act (LMBG) were established based on recommendations by international microbiologists for the normal not oversensitive consumer. For more sensitive groups of consumers, for example babies, more severe criteria were set up. Immunosuppressed patients are another sensitive group, demanding special hygienic requirements for their surroundings. If the risk of infections for immunosuppressed patients cannot be reduced by other means, it might be useful to establish microbiological criteria for bottled water and of course for other foodstuffs as well. However, such criteria cannot be adequately applied to food for normal consumption, since otherwise many foods would have to be regarded as hazardous and could not be marketed because of legal prescriptions.

Drinking↗

PubMed1995

Evaluation of dual-energy X-ray absorptiometry bone mineral measurement--comparison of a single-beam and fan-beam design: the effect of osteophytic calcification on spine bone mineral density.

Dual energy X-ray absorptiometry (DXA) using a single-beam (SB) design is a well-established procedure for measuring bone mineral area density (BMD). Recently, fan beam (FB) techniques have become available to measure BMD. We evaluated the QDR1000 and QDR2000 densitometers with regard to precision and cross-compared values using single beam (SB) and FB techniques. To study the effect of osteoarthritic changes on bone measurement (BMC in g) and bone mineral area density (BMD in g/cm2), both parameters were measured in patients with and without osteophytic calcifications (OC) of the lumbar spine. Precision errors for BMD in vitro over 1 and 6 months using the QDR2000 were 0.4% and 0.6% for SB and 0.5% and 0.7% for the three FB modes. For QDR1000 only SB is available. Using this scan mode, the BMD difference (delta = 0.1%) in vitro between QDR1000 and QDR2000 was not significant. The short-term (same day) reproducibility of BMD in vivo was 0.85% for SB mode and 1.1% for FB scan mode (n = 33). The midterm (1 month) precision errors were 0.9% for SB and 1.5% for FB (n = 11). The spine BMD of 751 patients from our outpatient clinic and department of rheumatology was 1.7% lower with FB than with SB (0.878 +/- 0.137 versus 0.888 +/- 0.146 g/cm2). Lower (1.8%) BMD values were also found in the hip with FB compared to SB (0.805 +/- 0.111 versus 0.821 +/- 0.111 g/cm2). There was a highly significant (P < 0.00001) correlation between SB and FB on the spine (r = 0.99) and hip (r = 0.98) using the QDR2000. Correlations found QDR1000 and QDR2000 were lower on the spine (r = 0.97) and hip (r = 0.93).(ABSTRACT TRUNCATED AT 250 WORDS)

Absorptiometry, Photon↗

PubMed2001

[Quantitative computerized tomography of bone mineral density of the mandible. Imaging of topographic distribution of bone mineral density in automated segmentation of mandibular structures].

PURPOSE: Confirmation of a new technique for evaluating bone mineral density (BMD). Colored coded imaging of topographical distribution of bone mineral density in the spongy substance. METHOD: For 20 patients, dental CT examinations of the mandible were made in axial slices. Spongy substance and cortical bone pixels were automatically segmented at foramina mentalia level by means of threshold fixation. The segments were separated in areas relevant to implantology. For each region, BMD was measured by means of quantitative computed tomography (QCT). Spongiose substance of 20 mandibles was segmented by using three threshold intervals to image topographical BMD distribution. RESULTS: Cortical bone and spongy substance could be automatically segmented for 20 mandibles. BMD could be measured in each region. The results were comparable with those of other techniques. Three threshold intervals were segmented for 20 mandibles in the spongy substance to depict topographical BMD distribution. CONCLUSIONS: Areas of low BMD can be detected by imaging topographical BMD distribution. This way, subjective rating by the examiner is eliminated.

Adolescent↗

PubMed2003

Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study.

We examined the association of candidate gene polymorphisms with bone mineral density (BMD) and bone mineral content (BMC) in a cohort of 428 healthy non-Hispanic white children participating in the Iowa Bone Development Study, a longitudinal study of determinants of bone accrual in childhood. BMD and BMC measurements of the hip, spine and whole body were made using a Hologic 2000 Plus densitometer in 228 girls and 200 boys ages 4.5-6.5 years. Genotypes at 14 loci representing eight candidate genes [type I collagen genes (COL1A1 and COL1A2), osteocalcin, osteonectin, osteopontin, vitamin D receptor (VDR), estrogen receptor (ER), androgen receptor (AR)] were determined. Gender-specific and gender-combined prediction models for bone measures that included age, weight, height (and gender) were developed using multiple linear regression analysis. COL1A2 and osteocalcin genotypes were identified as having the strongest and most consistent association with BMD/BMC measures. Osteonectin, osteopontin and VDR translation initiation site polymorphisms were associated with some individual bone measures, but none of the associations was as consistent as those identified for the COL1A2 and osteocalcin genes. No association was identified with COL1A1 (RsaI and Sp1), VDR (BsmI) and ER polymorphisms (PvuII, XbaI, TA) and BMD/BMC. However, we identified significant gene-by-gene interaction effects involving the ER and both VDR and osteocalcin, which were associated with BMD/BMC. Our data suggest that genetic variation at multiple genetic loci is important in bone accrual in children. Moreover, the combination of genotypes as several loci may be as important as a single genotype for determining BMD and BMC.

Anthropometry↗

PubMed2005

Familial aggregation of bone mineral density and bone mineral content in a Chinese population.

Familial aggregation of bone mineral density (BMD) and bone mineral content (BMC) has been shown in twin and familial studies, but most sample sizes were small. We here report a large familial aggregation study in a Chinese population. A total of 13,973 siblings aged 25-64 years from 3,882 families were enrolled from Anhui, China. We assessed the whole-body, hip and lumbar spine BMD and BMC by dual-energy X-ray absorptiometry (DXA). Intra-class correlation coefficients of BMD and BMC between siblings varied among different skeletal sites and between different age groups of male sib-pairs and premenopausal and postmenopausal female sib-pairs, with a range of 0.228 to 0.397. The sibling recurrence risk ratio (lambdas) of osteoporosis was 2.6 in our population. We also evaluated the joint association of the BMD values of the first siblings and the second siblings with the risk of low BMD (defined as less than the 10th percentile of the same group population) of their younger siblings. If both the first and second siblings' BMDs were in the lowest tertile, the odd ratios (ORs) of low BMD in their subsequent siblings were 8.32 [95% confidence interval (CI) 5.59-12.39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults.

Absorptiometry, Photon↗

PubMed2006

The effect of prepubertal ovariohysterectomy on spine 1 mineral density and mineral content in puppies: a preliminary study.

This pilot study investigated early effects of prepubertal ovariohysterectomy on bone mineral density (BMD) and bone mineral content (BMC) of lumbar vertebraes (L2-L5 and L Total) and on serum biochemistry. Both prepubertal ovariohysterectomy (Group Po: n=3) and sham surgery (Group Lp: n=3) were performed at 10 weeks of age. Blood samplings, BMD and BMC measurements of L2, L3, L4, L5 and L Total were performed at 12, 16, 20 and 24 weeks of age. No significant difference (P>0.05) in BMD and BMC was observed between the groups during the experimental period. The difference in serum calcium and phosphorus concentrations was found to be statistically unsignificant (P>0.05). These results fail to demonstrate a difference in BMD and BMC of lumbar vertebraes (L2-L5) as well as serum calcium and phosphorus levels after prepubertal ovariohysterectomy until six months of age in mixed breed puppies, but they should be considered only descriptive because of the very low sample number and of the low power of the statistical analyses.

Animals↗

PubMed1998

Are menopausal symptoms associated with bone mineral density and changes in bone mineral density in premenopausal women?

BACKGROUND: The relationship between menopausal symptoms and bone mineral density (BMD) was examined in 290 premenopausal women, ages 44-50 years, participating in a randomized clinical trial of a dietary and exercise intervention: The Women's Healthy Lifestyle Project. METHODS: Information on hot flashes (presence, absence), menstrual cycles (irregular, regular) and menstrual flow per period (variable, same) over the past 6 months was collected at entry. Participants reporting at least one menopausal symptom were classified as symptomatic and compared to those having no symptoms. Bone mineral density (BMD) at the lumbar spine (L1-L4), total hip and whole-body were made at baseline and at 30 months using a dual-energy X-ray absorptiometer (Hologic QDR 2000 densitometer). RESULTS: Baseline BMD at the spine, hip and whole-body were significantly reduced in women reporting menopausal symptoms compared to asymptomatic women, after adjustment for age, weight and intervention status (all p < 0.05). Women with irregular menstrual cycles had greater annualized rates of bone loss at the spine and hip than asymptomatic women (spine, -0.77 (1.6)% per year vs. -0.19 (1.0)% per year, p = 0.0043; hip, -0.37 (1.1)% per year vs. -0.04 (1.0)% per year, p = 0.061), after adjustments for age, percent change in weight, intervention status, and baseline BMD. Similar findings were not found for whole-body BMD. CONCLUSIONS: These results suggest that menopausal symptoms are useful for the effective identification of premenopausal women at higher risk of low BMD and perhaps, of osteoporosis.

Absorptiometry, Photon↗

PubMed1999

Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry.

The presence of Sr in bone influences bone mineral density (BMD) and content (BMC) measurements by dual-energy X-ray absorptiometry (DXA). This interaction is of interest, since strontium ranelate (S12911) demonstrated positive effects on bone metabolism in various animal models of osteoporosis, and is currently being evaluated for treatment of postmenopausal osteoporosis. The present in vitro study aimed to determine adjustment factors for DXA measurements of BMC and BMD at different Sr concentrations in order to estimate the corresponding values that would have been measured without Sr. A series of mixtures of Ca and Sr hydroxyapatites were prepared, with biologically relevant Sr/Ca ratios ranging from 0 to 3.5 mol/mol%, and a constant total concentration of divalent cations (145 mmol). The mixtures were conditioned in plastic dishes 4.5 cm in diameter, to obtain an areal density close to the human vertebral mineral density of 0.7-1.1 g/cm(2). DXA measurements of the mixtures were made with a wide range of different instruments and various acquisition modes. A direct linear relationship (r(2) > 0.99) was found between strontium content and overestimation of BMD and BMC. There were no significant differences in adjustment factors for BMC or BMD between the different machines or acquisition modes, and the presence of Sr in the water bath used to mimic soft tissues did not affect the accuracy and precision of the method. This demonstrates that reliable DXA determinations of BMD may be carried out in the presence of Sr, and may be interpreted in terms of calcium hydroxyapatite equivalent if the bone Sr content of the measured bone is known. The same adjustment factor (10% overestimation for 1 mol/mol% Sr) can be used for all presently available types of instrument and acquisition modes.

Absorptiometry, Photon↗