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At least 163 records · Page 9Linked to original sources
PubMed2001

[Interstitial T1-weighted MR lymphography with use of the dendritic contrast agent Gadomer-17 in pigs].

PURPOSE: To investigate the enhancement of regional lymph nodes, lymph vessels and the thoracic duct after subcutaneous administration of the dendritic contrast agent Gadomer-17. MATERIALS AND METHODS: Interstitial T(1)-weighted MR lymphography was performed in 15 domestic pigs in a 1.5 T MR scanner using the body coil. The contrast agent was injected subcutaneously at a dose of 2.5, 10 and 20 micromol gadolinium/kg/bw (1.4 - 2.3 ml) in the hind legs of 5 pigs, respectively. T(1)-weighted coronal 3D-gradient-echo images were obtained 1 to 150 minutes and 24 hours after contrast material injection. RESULTS: Inguinal lymph nodes, iliac lymph nodes and lymph vessels showed peak enhancement within 10 minutes after subcutaneous administration of the contrast agent. The enhancement of the lymphatic system decreased slowly until 150 minutes post injection. The time-response study, which was performed for inguinal and iliac lymph nodes, revealed the best lymphographic effect for Gadomer-17 at a dose of 10 micromol gadolinium/kg/bw. At this dose the paraaortic lymph nodes and the thoracic duct were also best visualized. CONCLUSION: Interstitial administration of the evaluated dendritic contrast agent Gadomer-17 is highly efficient for the performance of T(1)-weighted MR lymphography in regional lymph nodes, lymph vessels and the thoracic duct.

Animals↗
PubMed1992

The clinical value of computed tomography and lymphography in detecting lymph node metastases from epithelial ovarian cancer.

We investigated the accuracy of both lymphography and computed tomography (CT) in detecting lymph node metastases in 58 patients with primary epithelial ovarian cancer (group a) and subsequently submitted to surgery including pelvic and/or lumbo-aortic lymphadenectomy. CT accuracy was also investigated in 41 patients with clinically suspected relapse of ovarian cancer (group b). In the first group (a) overall results in the pelvis were, respectively, for lymphography and CT: 94.8 vs 89.6% accuracy, 85.7 vs 57.1% sensitivity, 97.7 vs 100% specificity, 97.7 vs 100% positive predictive value and 95.5 vs 88% negative predictive value. In the lumbo-aortic region, we had: 88.8 vs 86.1% accuracy, 71.4 vs 64.2% sensitivity, 100% specificity and positive predictive value for both techniques, and 84.6 vs 81.6% negative predictive value. In the second group (b) CT accuracy, sensitivity and specificity were 90.2, 80 and 100%, respectively. CT, thanks to its high specificity and positive predictive value, can represent the method of choice for the evaluation of pelvic and lumbo-aortic lymph node metastases in untreated and relapsing ovarian cancer. CT demonstration of lymph node metastases can affect not only lesion staging, but also chemotherapy; different indications for lymphadenectomy may also depend on CT.

Adult↗
PubMed2003

Practical aspects of indirect lymphography and lymphoscintigraphy.

The objective of this presentation is to discuss practical issues related to the use of indirect lymphography and lymphoscintigraphy in the differential diagnosis of lymphedema. Indirect lymphography demonstrates the filling of initial lymphatics and of lymph collectors. Lymphoscintigraphy is utilized to generate morphological and functional imaging information about the lymphatic drainage. For the functional evaluation of lymphatic drainage, quantitative measurement of the lymph node uptake can be performed. The practical implications of these diagnostic interventions are discussed.

Edema↗
PubMed1976

The pulmonary capillary bed after lymphography.

A small series of patients underwent radio-isotope lung scanning before and after the bipedal injection of oily contrast medium for abdominal lymphography to assess known malignant disease. After lymphography the lung scans showed an increase of between 12 and 100% in the radioactivity recorded over the anterior chest. No change was recorded over the posterior aspect of the chest. It is suggested that the increase is a result of blockage of posteriorly placed pulmonary capillaries and diversion of blood flow to the anterior segments.

Contrast Media↗
PubMed1976

Lymphography and pelvic lymphadenectomy in carcinoma of the prostate.

20 of 45 new patients with prostatic carcinoma have undergone lymphography and lymphadenectomy to determine the N-category. The overall accuracy of lymphography was 75%. Lymphadenectomy was a safe procedure with minimal morbidity. Although it would be premature to recommend its universal adoption in the management of this disease, its further application and study seems desirable. Full TNM classification has proved to be of considerable value in the management of these patients. This study confirms that 50% of T3 MO tumours are free of lymph node metastases.

Humans↗
PubMed1973

Hospital topics. Pulmonary function after lymphography.

The effects of lymphography on ventilatory function and gas transfer factor were studied in nine patients. Serial measurements made up to one month showed no change in the forced expiratory volume in one second or vital capacity. A small but reversible fall in transfer factor was found. The greatest reduction was at 24 or 48 hours. It was concluded that patients with normal lungs are unlikely to encounter difficulties but that patients with severe lung disease require careful assessment before lymphography.

Adult↗
PubMed1977

Lymphography in patients with suspected malignancy or fever of unexplained origin.

Forty-four patients underwent bipedal lymphography for evaluation of fever of unexplained origin, or because a malignant tumor (usually lymphoma) was suspected clinically. Extensive prior medical evaluation was inconclusive. The lymphograms were of no apparent value in detecting the etiology of the illness. Reactive follicular hyperplasia was frequently seen and sometimes simulated lymphoma on the lymphogram. The primary value of lymphography in such cases is as an aid in planning biopsy and surgery.

Adult↗
PubMed1979

Lymphography in childhood rhabdomyosarcomas.

Forty-one children with subdiaphragmatic rhabdomyosarcoma underwent bipedal lymphography. Twenty-two (53.5%) of the lymphograms were interpreted as being positive. In our series, the lower limbs were the most common primary site of involvement, were more frequently involved by the alveolar histologic subtype which carries a poor prognosis, and were associated with a higher incidence of lymph node metastases. Positive lymphographic findings in this group of children were similar to those seen in both adults and children with other solid tumors, i.e., the presence of discrete lymph node filling defects. However, in 3 cases, abnormalities more characteristic of lymphoma were identified. Evaluation of lymph node metastases as demonstrated by lymphography has prognostic significance.

Abdominal Neoplasms↗
PubMed1983

Lymphography in the management of urologic tumors. Radiological-pathological correlation.

Of 59 patients undergoing lymphography as part of staging for urologic tumor (bladder carcinoma, prostate carcinoma, seminomatous and nonseminomatous testicular tumors), histological material was obtained in 38. Lymphography was shown to have a specificity of 95%, a sensitivity of 81%, and an overall accuracy of 89%. When lymph node regions were considered, the specificity was 99.2%, sensitivity 59%, and overall accuracy 91%. Causes of discrepancies between radiography and histology are evaluated and receiver operating characteristic curves are demonstrated.

Adult↗
PubMed1994

Percutaneous CT lymphography with perflubron: imaging efficacy in rabbits and monkeys.

PURPOSE: To evaluate the imaging efficacy of percutaneous lymphography performed with injection of perflubron emulsions and computed tomography (CT). MATERIALS AND METHODS: Thin-section CT was used to image lymph nodes in 116 rabbits and six monkeys. Quantitative measures of regional lymph node enhancement were obtained 4 hours to 21 days after subcutaneous injection of perflubron (0.1-0.5 mL per injection site). Lymph node enhancement was calculated in Hounsfield units and converted to bromine concentration with standards that were imaged at the same time. RESULTS: Excellent enhancement of regional lymph nodes in both groups of animals was obtained. Nodal enhancement was linearly related to dose and was sustained for 20 days; maximum enhancement was seen 2 days after injection. Massage of the injection site increased delivery of the perflubron emulsion to regional lymph nodes. CONCLUSION: In rabbits and monkeys, percutaneous CT lymphography effectively depicts the intranodal distribution of macrophages in normal lymph nodes.

Animals↗
PubMed1980

Antegrade testicular vein phlebography and funicular lymphography in testicular tumors.

Antegrade phlebography of a testicular vein in connection with orchidectomy was performed in 29 patients and funicular lymphography was successful in 26 of these. Eleven patients had retroperitoneal metastases and 18 were normal. The phlebographic and lymphographic findings in both groups are described and discussed as well as the collateral pathways in cases with stenosis of the testicular vein. Antegrade phlebography is recommended but funicular lymphography does not merit a place in the routine examinations of patients with testicular tumor.

Adult↗
PubMed1982

Pulmonary airflow obstruction following lymphography.

In a series of 27 patients a significant mean decrease of forced expiratory volume in one second (FEV1) was recorded at 1/2, 2, 4 and 24 hours after lymphography with an oily contrast medium, with a maximum mean decrease at 4 hours after injection. The decrease of FEV1 was greater in patients given large amounts of contrast medium at high injection speed. Furthermore, an excessive decrease was observed in patients with metastatic lymph nodes, while a less marked decrease of FEV1 was observed in patients treated with aspirin. No serious clinical side effects were observed. It is recommended that the injection speed and the total amount of contrast medium be limited as far as possible, especially in patients with severe airflow obstruction or with metastases in the lymphatic system. Oral administration of aspirin may limit the decrease in FEV1 following lymphography.

Adult↗
PubMedDate not supplied

Clinical results of lymphography in cancer of the uterine cervix. A retrospective study of 542 consecutive, unselected patients.

From 1961 to 1976, 542 patients were evaluated with foot lymphography for cancer of the cervix at the Istituto Nationale Tumori of Milan. A group of 341 patients had lymphangiography as part of the initial diagnostic work-up. The overall incidence of positive examinations was 25% (9% stage I, 29% stage II, 46% stage III, 50% stage IV). In the 115 patients who had pelvic surgery the overall diagnostic accuracy of lymphography was 88%, with 2 false positive and 12 false negative reports. A second group of 90 patients was evaluated in the follow-up without clinical evidence of disease, and the incidence of metastases was 17%. Finally, group of 111 patients was studied for recurrence, and in this group the incidence of metastases was 51%. As regards site of involvement, the external iliac chains were involved in 93 to 96% of the cases, the common iliac in 34 to 79%, and the para-aortic in 17 to 36% in the different clinical conditions. The highest incidence of para-aortic metastases was found in the clinically initial stages (I and II) and in the recurrences. The lymphographic involvement of the retroperitoneal nodes was usually limited to a single region (41%) or two regions (37%). Only in 22% of the positive cases was a diffuse involvement of the retroperitoneal node chains evident.

False Negative Reactions↗
PubMed1979

Restatement of lymphography in childhood: experience with 413 consecutive patients in ten years.

From January 1969 to June 1978, 413 children under 15 years of age underwent lymphography at the Istituto Nazionale Tumori of Milan. Successful lymphatic cannulation was accomplished in 97.7% (769/787) of the sites where it was attempted. No major or permanent complications were encountered. In those children undergoing biopsy of opacified lymph nodes, the lymphographic-histologic correlation was 94.5% (104/110). This study has shown that lymphography in childhood can be as readily performed as in the adult and that its diagnostic accuracy is acceptable. As in adults, it is useful in treatment planning, evaluating results of therapy, and detecting a recurrent tumor.

Adolescent↗
PubMed1977

The value of urography following lymphography in malignant diseases.

The need for urography following ascending pedal lymphography in malignant disease has been studied in 298 consecutive patients. Forty per cent of the urograms were abnormal. Urographic abnormalities due to the disease being investigated were heralded by abnormal lymphography except in four patients, three with carcinoma of the bladder and one with carcinoma of the cervix. The majority of abnormalities unrelated to the disease being investigated were of no significance. In a small number there was congenital malposition of the kidney so that it fell within the proposed field of treatment. It is concluded that it is unnecessary to do routine urography with every lymphogram. Indications for urography are abnormality or suspected abnormality of the lymphogram, failure to locate the kidneys on plain films and clinical indications such as carcinoma of the bladder or carcinoma of the cervix.

Adolescent↗
PubMed1984

The CT appearances of hepatic oil embolism following lymphography.

Four instances of lymphography complicated by hepatic oil embolism are presented. The subsequent computerised tomography appearances can be misleading: the oily contrast medium mimics hepatic calcification and this may be mistakenly thought to indicate calcified hepatic metastases. The correct diagnosis will become apparent if a history of lymphography is sought, and it is important to realise that, even on conventional radiography, hepatic oily contrast medium may remain visible for several months. Computerised tomography is a much more sensitive indicator of the presence of oily contrast medium in the liver, so the absence of detectable oil on conventional radiography is unhelpful. The mechanisms which are thought to lead to hepatic oil embolism are discussed because recognition of the circumstances leading to hepatic oil embolism and appreciation of the associated findings will provide further clues to the correct diagnosis.

Adult↗
PubMed1987

Staging of prostatic carcinoma with radionuclide bone scintigraphy and lymphography.

One hundred patients with histologically proven carcinoma of the prostate were examined by radionuclide bone scintigraphy and bipedal lymphography. In 27 cases the bone scintigram and lymphogram were positive, in 16 the bone scintigram only was positive and in 10 the lymphogram only was positive. Although radionuclide bone scintigraphy is the most useful single investigation for detecting metastatic spread from prostatic carcinoma, lymphography should be performed if the bone scintigram is negative, as it is likely to demonstrate nodal metastases in 18% of patients.

Bone Neoplasms↗
PubMed1991

Lymphography--current role in oncology.

A review of the use of lymphography at this hospital, a major oncology centre, is presented. The advent of computed tomography has brought a dramatic reduction in the number of lymphograms currently performed for diseases such as lymphoma, testicular tumours and gynaecological malignancies. This study analyses the reasons for this decline, and concludes that valuable information can still be obtained from lymphography in certain selected groups of patients.

Female↗