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At least 163 records · Page 9Linked to original sources
PubMed2000

Enhancing the uptake of chemotherapeutic drugs into tumors using an "artificial lymphatic system".

This paper presents findings from uptake studies to evaluate the ability of an "artificial lymphatic system" (ALS) to enhance large and small molecular weight drug transport into solid tumors and the therapeutic effect of the additional drug on their growth. These studies also served to test the effectiveness of an implantable multidrain ALS. Walker 256, Neuroblastoma, and Sarcoma dual-tumor models were used to evaluate the effect of ALS aspiration on the uptake of 3F8 monoclonal antibody, and doxorubicin. A tumor shrinkage experiment using Walker 256 dual tumors was used to evaluate the efficacy of an implantable ALS with cyclophosphamide chemotherapy. Drug uptake significantly increased in all aspirated tumors; 3F8 uptake was enhanced 37.4% in the Walker and 93.1% in the Neuroblastoma tumor lines (p<0.05). Doxorubicin uptake increased 23.2% in Sarcoma tumor (p<0.05). The shrinkage study demonstrated that one-drain aspirated tumors shrank 90% faster (p<0.01) than control tumors, while three-drain aspirated tumors shrank 123% faster than control tumors (p<0.01).

Animals↗
PubMedDate not supplied

[Pharmacologic agents that stimulate the drainage function of the lymphatic system].

Modern pharmacological agents used in experimental and practical medicine to stimulate the drainage function of the lymphatic system are discussed. Lymphotropic agents differ by the chemical structure and mechanism of action. Much attention is paid to the analysis of the agents possessing the osmotic effect. Particular emphasis is given to natural bioflavonoids including new polyphenol compounds produced from the Siberian plants.

Animals↗
PubMed2002

Tissue engineering of the lymphatic system.

The field of tissue engineering has seen tremendous expansion in the last decade. In the last several years, tissue-engineering strategies to treat diseases of skin, cartilage, bone, bladder, blood vessel, tendon, and other tissues have been described. However, tissue-engineering approaches to treat diseases of the lymphatic system are currently nonexistent. We propose that acellular tissues, either native or engineered, could be exploited as a platform for the study of lymphatic biology, and for lymphatic tissue engineering. While speculative, this type of experimental model system could prove powerful for dissecting molecular and cellular events surrounding tumor invasion of lymphatics, as well as lymphangiogenesis. Scaffolds seeded with genetically engineered lymphatic cells could also be implanted to repopulate lymphatic vasculature. In the future, the lymphatic system will surely be added to the list of tissues and organs that prove amenable to tissue-engineering therapies.

Animals↗
PubMed1977

The terminal pathway of the lymphatic system of the human heart.

Aantomical dissections in 9 human cadavers revealed the terminal pathway of the lymphatic system of the left ventricle to be constituted mainly by channels emptying into the right angulus venosus (junction of the internal jugular and subclavian veins) at the base of the right side of the neck. This observation has clinical implications because it has been shown that a sampling of cardiac lymph provides the best method for analyzing myocardial metabolic abnormalities and that drainage of cardiac lymph alleviates the myocardial changes produced by ischemic injury.

Adult↗
PubMed1985

[Roentgen anatomy of the lymphatic system].

The enormous advances in medicine in the last 30-40 years are chiefly attributable to the constant technical development in imaging and investigation techniques. The instruments offered by the industry, which must be renewed every ten years, the hunger of doctors for information and not least the high expectation of the patients must be reconciled with our action. Besides this rapid technical development in the sector of instrumental medicine, diagnostic and therapeutic techniques have been established in precisely the same period since the beginning of the 1950's, even in the field of the more patient-related medicine. These have proved to be epoch-making, especially in lymphology, namely lymphography and therapeutic lymphatic drainage. There is no doubt that the introduction of modern diagnostic techniques such as computer tomography and nuclear spin tomography has resulted in reduction of the indication for lymphography. However, even today it is still irreplaceable by other methods in diseases of the lymphatic system, in testicular tumors, and also in lymphedema. For this reason, we consider that it is appropriate that lymphography be recalled to memory as a selective technique for application in the lymphatic system.

Diagnosis, Differential↗
PubMed1976

Spontaneous tumors and common diseases in two colonies of Syrian hamsters. IV. Vascular and lymphatic systems and lesions of other sites.

Spontaneous tumors were found in the vascular and lymphatic systems upon systemic histologic examination of the cardiovascular, hematopoietic, and lymphatic tissues of Syrian hamsters from the Eppley (EC) and Hannover colonies (HC). The incidence of endothelial tumors (hemangioendotheliomas) was similar in both colonies and sexes. The hemangioendotheliomas generally originated in the liver and spleen. Malignant lymphomas developed in high incidences in both colonies; however, their morphology varied. Those in EC hamsters were of histiocytic and, to a lesser extent, plasmacytic types; in the HC lymphocytic and epithelioid cell types were also found. Among tumors of miscellaneous sites, Harderian gland adenomas occurred in almost equal frequencies in EC and HC hamsters, but predominated in males. Tumors of the bone and soft tissue were present only in EC hamsters, whereas skin neoplasms developed solely in HC hamsters.

Animals↗