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PubMed2005

Depression in the long-term course of schizophrenia.

Depressive symptoms are quantitatively and qualitatively among the most important characteristics of schizophrenia. The following contribution reports on the prevalence of depression in 107 patients of the ABC schizophrenia study over 12 years after first hospital admission, looks into a preponderance of depression at certain stages of the illness and the predictive value of depressive symptoms for course and outcome. All but one of the 107 patients experienced one to 10 episodes of depressed mood between index assessment and long-term follow-up. In any month of the observation period about 30-35% of the patients presented at least one symptom of the depressive core syndrome (depressive mood, loss of pleasure, loss of interests, loss of self-confidence, feelings of guilt, suicidal thoughts/suicide attempt). Depressive symptoms are particularly frequent during a psychotic episode at a rate of approximately 50%. There were moderate but statistically significant correlations between the amount of depressive symptoms during a psychotic episode and the frequency of relapses, defined by hospital admissions as well as the total length of inpatient treatment. Depression occurring in the interval was not associated with an increased need for inpatient treatment.

Adolescent↗
PubMed1997

First recovery in anorexia nervosa patients in the long-term course: a discrete-time survival analysis.

The results of a 12-year follow-up study of occurrence and timing of first recovery in 69 hospitalized patients with severe anorexia nervosa (AN) are presented. For the first time discrete-time survival analysis methods were used to determine the likelihood of recovery in AN patients. Furthermore, predictors gleaned from pretreatment-posttreatment studies of long-term outcome in AN could be evaluated as to their effect on a change in the time course structure of the likelihood of first recovery. Results show that AN condition did not improve until after 6 years after the first inpatient treatment in 50% of patients. However, a restricter-type AN and low serum creatinine levels were predictors for earlier recovery. One specific effect was that AN patients who show purging behavior in combination with additional social disturbances have a lower chance of recovering. The use of discrete-time survival analysis methodology in further prospective studies will contribute to the development of more tailored treatment of AN, which also takes the individual phase of illness and specific aspects of the symptomatology into account.

Anorexia Nervosa↗
PubMed1990

[Respiratory function in newly developed stenocardia and in long-term course of ischemic heart disease].

External respiration was evaluated in coronary patients with varying duration of the disease. Bronchial obstruction was not a rare finding especially in patients with a long history of angina pectoris. In most of the patients the obstruction was reversible as shown by respiration parameters upon inhalation of broncholytics with various mechanisms of action. Respiratory disorders were not associated with dyspnea, derangement of gaseous exchange and could not be attributed to attendant bronchopulmonary diseases, smoking as such patients had not been entered in the study. A 3-year follow-up was not indicative of spontaneous progression of bronchial obstruction.

Adult↗
PubMed2001

[Limitations and usefulness of coronary stents in diverse clinical conditions. Long-term course].

Since the introduction of balloon angioplasty, the acceptance and widespread application of coronary stents is the most important advance in interventional cardiology. The option of bail-out stenting has liberated interventionalists from the restrains of surgical stand-by. It has also allowed more aggressive balloon angioplasty and better short- and long-term results. This progress was enabled by improvements in deployment technique and antiplatelet therapy preventing most of the vexing problems of subacute stent thrombosis. Whereas initial registries and randomized trials focused on specific narrow patient populations, the clinical indications are broadening based on the results of new clinical trials that have focused on expanding populations, such as restenotic lesions, small vessels, total chronic occlusions, saphenous vein grafts stenoses, and acute ischemic syndromes. Despite this progress, a solution to the problem of in-stent restenosis, although less frequent than after balloon angioplasty alone, is still pending. In this review, we will discuss the process of restenosis which is the main indication for the use of stents, then we will analyze the application of stents in some particular clinical and anatomical situations and finally we will focus on in-stent restenosis which is the main limitation for stenting.

Acute Disease↗
PubMed1996

Importance of psychotic features to long-term course in major depressive disorder.

OBJECTIVE: Most efforts to describe the prognostic significance of psychotic features in depression have been limited to single assessments 1 year or less after the initial evaluation. However, the various biological and treatment response differences between patients with psychotic and nonpsychotic depression suggest that prognostic differences may be very long-term. METHOD: The 787 patients described here entered the study as they sought treatment at one of five academic medical centers; they had either RDC major depressive disorder or schizo-affective depression (other than the mainly schizophrenic subtype) and completed at least 6 months of follow-up. Of these, 144 (18.3%) had psychotic depression as defined here. Patients provided follow-up interviews at 6-month intervals for 5 years and annually thereafter; 98 of those with psychotic depression and 434 of those with non-psychotic depression were followed for 10 years. RESULTS: Those who began follow-up with psychotic depression had fewer weeks with minimal symptoms in each of the 10 years of follow-up and reported more psychosocial impairment at both 5 and 10 years. Both the index episode and the first recurrence of psychotic depression lasted longer than nonpsychotic episodes, but nonpsychotic episodes among previously psychotic individuals were relatively brief. Intervals between episodes were significantly shorter for patients who had ever been psychotic. CONCLUSIONS: Together with evidence that psychotic features are highly recurrent, these data show 1) that psychotic features denote a lifetime illness of greater severity and 2) that within individuals, psychotic features may emerge in only the more severe episodes.

Adult↗
PubMed1998

[Surgical diagnosis and therapy in patients with mediastinal space-occupying lesions. A retrospective analysis of 223 intervention with special reference to long-term course].

UNLABELLED: The diagnostic and therapeutic approach in patients with mediastinal masses (MM) treated at our institute between 1983 and 1993 was retrospectively reviewed. METHODS AND MATERIAL: 193 patients with MM (105 males and 88 females, average age 53, ranging from 16-81) underwent 223 interventions. Staging mediastinoscopies in lung cancer patients were ruled out. Long-term follow-up data were available in 123 of 162 cases with neoplastic MM (average follow-up time 5.5 years). Of all 223 surgical interventions 143 were diagnostic (53 parasternal mediastinotomies, 78 mediastinoscopies and 8 thoracoscopies) and 80 therapeutic (46 sternotomies and 34 posterolateral and a second half). The analysed period was splitted up in a first half (1983-1987) and second half (1988-1993) to study an eventual trend in the management of MM. RESULTS: The most frequent diagnoses were: thymoma (21%), malignant lymphoma (18%) and mediastinal sarcoidosis (14%). 43% of the MM were localized in the anterior, 46% in the middle and 7% in the posterior mediastinum. Thoracic pain, cough and dyspnoea represented the most common symptoms, leading to an invasive diagnostic procedure. 25% of the patients had no symptoms. The mortality and morbidity rate of all interventions was 3.4% and 18.7% respectively and concerned almost nerval injuries and postoperative respiratory failure. The percentage of direct tumor excisions increased from 21% during the first half of the period to 40% during the second half of the period, whereas diagnostic surgical interventions decreased from 57% to 44%. The percentage of total excisions after previous surgical biopsies decreased from 22% to 16%. In spite of the introduction of high resolution CT scan and MRI techniques during this time period no significant change in the use of presurgical diagnostic procedures was obvious. Fine needle biopsies and bronchoscopies were performed less frequent in the second half in comparison to the first half (11%, 7%, 29%, 13% respectively). From 123 patients with neoplastic disease data were available for long-term results. 35 had benign and 83 malignant histologies, in five cases dignity was unclear. 54% of these patients were disease-free at follow-up time, 10% had local recurrency or distant metastasis and 37% died during the observed time period. CONCLUSIONS: Surgical biopsy seems to remain the most important investigation for a successful interdisciplinary approach to MM. Overall morbidity and mortality rate of mediastinal surgery might appear remarkable but has to be related to the favorous long-term results after different individual treatment modalities in patients with mediastinal masses.

Adolescent↗
PubMed1994

[Short- and long-term course of heart transplantation recipients with severe dysfunction of the graft associated with acute rejection].

INTRODUCTION AND OBJECTIVES: Acute rejection is still a common cause of death after heart transplantation, in spite of cyclosporine. The aim of our study was to assess the incidence of severe graft dysfunction associated with acute rejection and the short and long-term outcome of these patients. METHODS: Ten of our 100 first heart transplant patients have developed rejection-induced severe cardiac dysfunction (left ventricular ejection fraction determined by echocardiography < 35% associated with 3A, 3B or 4 acute rejection). Clinical outcome, complications and evolution of left ventricular function were studied. RESULTS: Five patients were given intravenous methylprednisolone 500 to 1000 mg/day for 3 days. The other 5 patients had severe heart failure and received antilymphocyte antibodies. Three patients treated with methylprednisolone alone and one patient treated with antilymphocyte antibodies died within the first week after therapy. Left ventricular ejection fraction increased from 26 +/- 4% to 51 +/- 6% at 1 month after therapy in the 6 survivor patients. Four of the 6 survivor patients also died before 1 year after rejection (3 due to infection). Thus, long-term, overall mortality was 80%. CONCLUSIONS: Although favorable short-term results can be achieved in patients with rejection-induced severe cardiac dysfunction with immunosuppressive therapy (mainly antilymphocyte antibodies), long-term prognosis seems poor, due to the increased rate of life-threatening infections.

Acute Disease↗
PubMed1983

Incidence of abnormal EEG findings in patients with obstructions of the carotid artery and their prognostic value for the postoperative long-term course.

Between 1972 and 1980, a total of 706 patients were operated on at the Surgical Department of the University Hospital at Erlangen for chronic arteriosclerotic lesions, or kinking or coiling of the carotid artery; an evaluable preoperative EEG was recorded in 515 patients. Patients with an abnormal EEG revealed an increased early mortality rate, and a greater incidence of strokes in the long term. In patients with "controversial' indications for surgery, i.e., patients with asymptomatic carotid bruit, chronic cerebral ischemia, or nonhemispheric attacks, a low-grade increase in early mortality, the incidence of deaths, and the incidence of strokes in the long term, were established. Although an abnormal EEG cannot, by and large, be considered an absolute contraindication to surgery, it should, nevertheless, be a reason for carrying out a thorough internistic examination of the patient and for critically considering the surgical indications.

Arteriosclerosis↗
PubMed1994

[Long-term course following kidney transplantation].

The first 100 recipients of cadaveric renal allotransplants operated at our institution between 1964 and 1971 were retrospectively analyzed in terms of a long-term follow-up, complications and survival parameters. Patient and graft survival (indicated in parenthesis) after transplantation were 68% (58%) at 1 year, 50% (38%) at 5 years, 40% (27%) at 10 years, 32% (20%) at 15 years and 20% (13%) at 20 years. Half-life of graft survival was computed using two different mathematical models and was compared with the results of a control group operated in 1986. Half-life was 9.5 years for the study group and 13 years for the control group respectively.

Adolescent↗
PubMed1998

The long-term course of panic disorder and its predictors.

Whereas lifetime prevalence rates of panic disorder--as established in epidemiologic surveys--range between 1.6 and 3.5%, 1-month rates usually amount to much less than one half of the lifetime rates. This finding indicates that a substantial proportion of patients who had panic disorder at some stage in their life must have remitted. In contrast to these results, clinicians tend to regard panic disorder as a chronic condition because, as a rule, they see panic patients only several years after onset of the disorder. A number of small, prospective, long-term studies of such clinical populations indicate that after several years, between 17 and 70% of patients still have panic attacks, and between 36 and 82% have phobic avoidance. In the largest and longest follow-up study published to date, 45% of all patients showed an unremitting--although in a certain proportion waxing and waning--course, 24% followed a pattern of remissions and relapses, whereas 31% went back into a stable remission. The evidence of factors predicting the course of panic disorder in clinical populations suggests that long duration and agoraphobia at baseline--not the severity and frequency of panic attacks--are predictors of an unfavorable course. Additional studies are needed to determine whether personality factors, depression, and other variables are also of predictive relevance. Also, factors working during follow-up, such as positive and negative life events, coping behaviors, and treatment, should be considered in future studies.

Chronic Disease↗
PubMed1984

Long-term course of pulmonary arterial pressure in chronic obstructive pulmonary disease.

Ninety-three patients with severe chronic obstructive pulmonary disease (COPD) of the bronchitic (n = 74) or emphysematous type (n = 19), who all had arterial hypoxemia, underwent 2 right cardiac catheterizations in a clinical steady state, with a delay of 5 yr or more between the first and the last catheterization. No patients received long-term O2 therapy or pulmonary vasodilator drugs. Patients were divided into 2 groups according to the initial level of mean pulmonary artery pressure (Pap). Group 1 included 61 patients without initial pulmonary arterial hypertension (PAH), Pap being less than 20 mmHg; the average delay between the 2 catheterizations was 93.4 +/- 26.8 months. Group 2 included 32 patients with initial PAH (Pap greater than or equal to 20 mmHg), and the average delay was 85.0 +/- 26.0 months. The changes in Pap were small. They ranged from 15.5 +/- 2.4 to 19.6 +/- 7.0 mmHg in Group 1 (p less than 0.001) and from 25.8 +/- 5.6 to 27.8 +/- 9.5 mmHg in Group 2 (NS). The average increase in Pap was 0.65 mmHg/yr in Group 1 and 0.39 mmHg/yr in Group 2 (no statistical difference between the 2 groups). The other hemodynamic parameters (pulmonary capillary wedge pressure, right ventricle filling pressure, cardiac output) did not change. Hemodynamic "worsening," which was defined by an increase in Pap by greater than or equal to 5 mm Hg, was observed in 29% of the patients (n = 27). In these patients, there was a marked worsening of hypoxemia, which was not observed in the remaining 66 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2000

[Long-term course of liver rupture in preeclampsia. A case report].

A case report is presented of one preeclamptic patient with rupture of a big right subcapsular hematoma of the liver which was misdiagnosed with cholecystitis. A cesarean delivery was performed, which resulted is stillbirth, with abruptio placentae of 50%. The emergent treatment of the liver rupture was the right hepatic artery ligation, the postoperative development was favorable. Long term follow-up using ultrasound and liver function values were performed for 14 months and showed that the lesion has regressed with a normal hepatic imaging.

Adult↗
PubMed1995

Apparent failure of current intravesical chemotherapy prophylaxis to influence the long-term course of superficial transitional cell carcinoma of the bladder.

During the 4 decades since the first introduction of intravesical chemotherapy, 3,899 patients were enrolled in 22 randomized prospective controlled studies. Of these 22 studies 13 reported a statistically significant benefit of intravesical chemotherapy. With varying followup, the reported decrease in the incidence of patients with tumor recurrence averaged only 14% (range -3 to +43%). Unfortunately, long-term (5-year) studies show no decrease in the incidence of recurrent tumor. Maintenance chemotherapy has failed to improve these results and data suggest that a single early postoperative instillation may, in fact, be most effective. Among 10 studies that include progression data none showed decreased tumor progression, and overall among 2,011 randomized patients progression occurred in 7.5% of those receiving intravesical chemotherapy and 6.9% of those treated by surgery alone. Since intravesical chemotherapy has been demonstrated in animal models to be carcinogenic, these data raise the concern that intravesical chemotherapy might possibly be carcinogenic in humans. In the absence of demonstrated long-term benefit we question the advisability of routine prophylactic intravesical chemotherapy.

Administration, Intravesical↗
PubMed1989

[Locoregional recurrence of breast cancer. Long-term course of 49 cases treated by excision and omentoplasty].

Extensive local recurrence of breast cancer may require wide parietal resection, demanding the use of other tissues to compensate for the loss of substance. We preferably resort to omentoplasty when the defect is larger than 300 cm2. A group of 49 patients with recurrence of the tumor in the breasts (treated with omentoplasty) has been studied, with special emphasis on long-term results. In our series, 86% of the patients were followed up for more than 4 years, with an actuarial survival rate of 46% after 7 years. It thus appears that this procedure can be advocated for slow-developing cancers, the local recurrence of which is extensive and usually isolate for various reasons (most often a deficient initial local treatment).

Aged↗
PubMed1979

Long-term course of chloroquine retinopathy after cessation of medication.

Seven patients with chloroquine retinopathy were examined ten years after their therapy with chloroquine or hydroxychloroquine, or both, had been discontinued and an additional five patients with chloroquine retinopathy were similarly examined from two to eight years after their therapy had been discontinued. Visual acuity, visual fields, and ophthalmoscopic examinations were compared to those performed at the time therapy was discontinued. These long-term observations confirmed the previously published observations based on short-term studies that chloroquine retinopathy tends to remain stable after therapy is discontinued, although a few patients in the early stages of retinopathy may show regression and occasionally a patient with a more advanced stage of the disease may show progression.

Adult↗
PubMed2005

The long-term course of low-density lipoprotein cholesterol after initiation of statin treatment: retrospective database analysis over 3 years in health maintenance organization enrollees.

OBJECTIVES: Our primary objective was to obtain robust estimates of the low-density lipoprotein cholesterol (LDL-C) decrease from baseline over a long period (ie, 3 years) after initiation of statin treatment in a usual-care setting. Our secondary objective was to investigate the predictors of the LDL-C time course. METHODS: We retrospectively analyzed the data for a sample of enrollees in a health maintenance organization (HMO) who started statin treatment between October 1, 1995, and December 31, 1998. Using the HMO's claims database, we examined the LDL-C change from baseline (as measured at the prescribing physicians' discretion) and computed mean estimates every 6 months up to 3 years. We investigated potential predictors of the LDL-C time course (ie, age, sex, baseline LDL-C, previous treatment, prescribing physician's specialty, and most recent treatment) with a mixed model applied to longitudinal data. This model enabled us to impute missing data for all enrollees still being followed, including those who had stopped treatment, and to discuss the robustness of our findings. We applied 2 methods of imputation, assuming either of the following: (1) data were missing at random but could be estimated from the parameters in the mixed model, or (2) LDL-C returned to the baseline value > or =15 days after treatment cessation. RESULTS: We examined data from 3193 individuals. In most cases, the statin used was fluvastatin or pravastatin. The observed mean (95% CI) LDL-C decrease from baseline widened progressively from 23.6% (23.0%-24.3%) at 6 months to 28.0% (27.1%-28.9%) at 18 months and 30.2% (28.7%-31.7%) at 36 months after treatment initiation. These results remained robust after the imputation of missing data, with mean LDL-C reduction consistently >20% at each 6-month time point during the 3 years after treatment initiation. Variations as a function of baseline characteristics were limited (demographics) or explicable by extraneous factors (baseline LDL-C). There were predictable variations as a function of the most recent treatment. CONCLUSIONS: This analysis indicates a long-term reduction in LDL-C among a sample of HMO enrollees who initiated statin treatment in a usual-care setting. The results were robust after imputation of missing data, with mean decrease from baseline consistently >20% over 3 years. However, given the retrospective design of our study and the absence of a control group, we cannot determine how much of the decrease was attributable to treatment.

Aged↗
PubMed1992

Long-term course of hospitalization for schizophrenia: Part I. Risk for rehospitalization.

The probability of rehospitalization following the initial discharge on which a diagnosis of schizophrenia was made is described using data from psychiatric case registers in Victoria, Australia; Maryland, U.S.A.; Denmark; and Salford, England. The percentage eventually rehospitalized, after followup intervals as long as two decades, varies from about 50 to 80 percent in the four service systems. Survival curves for duration in the community without rehospitalization bend sharply in the period between 2 and 3 years following discharge in all four cohorts and are almost flat after 20 years. Early age of onset predicts higher risk for rehospitalization in multivariate proportional hazards models in each cohort. When age of onset is included as a covariate, neither gender nor marital status has consistent or statistically significant effects on risk for rehospitalization.

Adolescent↗